{"id":"https://openalex.org/W4396602385","doi":"https://doi.org/10.1158/1940-6207.capr-24-0055","title":"Diet Modulates the Gut Microbiome, Metabolism, and Mammary Gland Inflammation to Influence Breast Cancer Risk","display_name":"Diet Modulates the Gut Microbiome, Metabolism, and Mammary Gland Inflammation to Influence Breast Cancer Risk","publication_year":2024,"publication_date":"2024-05-03","ids":{"openalex":"https://openalex.org/W4396602385","doi":"https://doi.org/10.1158/1940-6207.capr-24-0055","pmid":"https://pubmed.ncbi.nlm.nih.gov/38701438","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11372361"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.capr-24-0055","doi":"https://doi.org/10.1158/1940-6207.capr-24-0055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-24-0055","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/1940-6207.capr-24-0055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089785249","display_name":"Alana A. Arnone","orcid":"https://orcid.org/0000-0001-8881-0726","observed_orcids":["https://orcid.org/0000-0001-8881-0726"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alana A. Arnone","raw_affiliation_strings":["Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1"],"raw_orcid":"https://orcid.org/0000-0001-8881-0726","affiliations":[{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743760","display_name":"Adam S. Wilson","orcid":"https://orcid.org/0009-0001-8408-7478","observed_orcids":["https://orcid.org/0009-0001-8408-7478"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S. Wilson","raw_affiliation_strings":["Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1"],"raw_orcid":"https://orcid.org/0009-0001-8408-7478","affiliations":[{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027276690","display_name":"David R. Soto\u2010Pantoja","orcid":"https://orcid.org/0000-0003-0107-7678","observed_orcids":["https://orcid.org/0000-0003-0107-7678"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Soto-Pantoja","raw_affiliation_strings":["Atrium Health Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 3","Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 2","Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1"],"raw_orcid":"https://orcid.org/0000-0003-0107-7678","affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 3","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 2","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025967603","display_name":"Katherine Loree Cook","orcid":"https://orcid.org/0000-0001-6241-0214","observed_orcids":["https://orcid.org/0000-0001-6241-0214"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine L. Cook","raw_affiliation_strings":["Atrium Health Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 3","Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 2","Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1"],"raw_orcid":"https://orcid.org/0000-0001-6241-0214","affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 3","institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 2","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 1","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025967603"],"corresponding_institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":null,"apc_paid":null,"fwci":3.1938,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.9403938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"9","first_page":"415","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.7139999866485596},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.984000027179718},{"id":"https://openalex.org/keywords/mammary-inflammation","display_name":"mammary gland inflammation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.824999988079071},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/high-sugar-diet","display_name":"high-sugar diet","score":0.7509999871253967},{"id":"https://openalex.org/keywords/lard","display_name":"lard","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dietary-fat","display_name":"dietary fat","score":0.6370000243186951},{"id":"https://openalex.org/keywords/linseed-oil","display_name":"linseed oil","score":0.9049999713897705},{"id":"https://openalex.org/keywords/safflower-oil","display_name":"safflower oil","score":0.9639999866485596},{"id":"https://openalex.org/keywords/coconut-oil","display_name":"coconut oil","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dmba-induced-mammary-tumors","display_name":"DMBA-induced mammary tumors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/firmicutes-bacteroidetes-ratio","display_name":"Firmicutes/Bacteroidetes ratio","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7233863472938538},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.674957275390625},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.67332923412323},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6652930974960327},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.6216714382171631},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5715550184249878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44493168592453003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4338315427303314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4130752384662628},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4011309742927551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35635632276535034},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32328182458877563},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2861306667327881}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.capr-24-0055","doi":"https://doi.org/10.1158/1940-6207.capr-24-0055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-24-0055","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11372361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11372361","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11372361/pdf/capr-24-0055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"},{"id":"pmid:38701438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38701438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer prevention research (Philadelphia, Pa.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.capr-24-0055","doi":"https://doi.org/10.1158/1940-6207.capr-24-0055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-24-0055","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2577419345","display_name":null,"funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320313862","funder_display_name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center"},{"id":"https://openalex.org/G3058200945","display_name":null,"funder_award_id":"BC210715","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G331206807","display_name":null,"funder_award_id":"133727-RSG-19-150-01-LIB","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G7068040066","display_name":null,"funder_award_id":"BC190271","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7263932585","display_name":null,"funder_award_id":"RSG\u201016\u2010204\u201001\u2010NEC","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878203","display_name":"Training Program in Immunology and Pathogenesis","funder_award_id":"T32AI007401","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306481","display_name":"Prevent Cancer Foundation","ror":"https://ror.org/03jpt8f29"},{"id":"https://openalex.org/F4320313862","display_name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center","ror":"https://ror.org/0512csj88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396602385.pdf","grobid_xml":"https://content.openalex.org/works/W4396602385.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1506646939","https://openalex.org/W1579591484","https://openalex.org/W1772797960","https://openalex.org/W1965037168","https://openalex.org/W1965515326","https://openalex.org/W1968528693","https://openalex.org/W2027263644","https://openalex.org/W2061658502","https://openalex.org/W2067184340","https://openalex.org/W2078378773","https://openalex.org/W2108718991","https://openalex.org/W2117457769","https://openalex.org/W2118733706","https://openalex.org/W2121472083","https://openalex.org/W2136417551","https://openalex.org/W2158294624","https://openalex.org/W2288938787","https://openalex.org/W2325564376","https://openalex.org/W2341244791","https://openalex.org/W2346945925","https://openalex.org/W2407944718","https://openalex.org/W2493607481","https://openalex.org/W2517354772","https://openalex.org/W2620098478","https://openalex.org/W2740616896","https://openalex.org/W2782599553","https://openalex.org/W2790152383","https://openalex.org/W2798109075","https://openalex.org/W2894133314","https://openalex.org/W2894834821","https://openalex.org/W2920974035","https://openalex.org/W2924917805","https://openalex.org/W2985219249","https://openalex.org/W2998606622","https://openalex.org/W3046780653","https://openalex.org/W3046846325","https://openalex.org/W3096586635","https://openalex.org/W3111322366","https://openalex.org/W3114900196","https://openalex.org/W3120949185","https://openalex.org/W3139075597","https://openalex.org/W3157893392","https://openalex.org/W3164246975","https://openalex.org/W3166851355","https://openalex.org/W3186747227","https://openalex.org/W3195115132","https://openalex.org/W3201096757","https://openalex.org/W3205985231","https://openalex.org/W4224983728","https://openalex.org/W4225706840","https://openalex.org/W4281614790","https://openalex.org/W4303621924","https://openalex.org/W4307233918","https://openalex.org/W4311861713","https://openalex.org/W4317502668","https://openalex.org/W4382752836","https://openalex.org/W4384664104"],"related_works":["https://openalex.org/W3164246975","https://openalex.org/W4396611892","https://openalex.org/W2894834821","https://openalex.org/W2949897460","https://openalex.org/W7042273431","https://openalex.org/W2982088927","https://openalex.org/W4389435444","https://openalex.org/W3127536591","https://openalex.org/W2785341864","https://openalex.org/W1551182022"],"abstract_inverted_index":{"Several":[0],"studies":[1],"indicate":[2],"a":[3],"strong":[4],"link":[5],"between":[6,196],"obesity":[7],"and":[8,19,34,65,90,108,119,131,143,163,201],"the":[9,43,63,144,156,184,194,198],"risk":[10],"of":[11,158,175,186],"breast":[12,53,66,124,150,176,189],"cancer.":[13],"Obesity":[14],"decreases":[15],"gut":[16,50,145,199],"microbial":[17],"biodiversity":[18],"modulates":[20],"Bacteroidetes-to-Firmicutes":[21],"phyla":[22],"proportional":[23],"abundance,":[24],"suggesting":[25],"that":[26,169],"increased":[27],"energy-harvesting":[28],"capacity":[29],"from":[30],"indigestible":[31],"dietary":[32,138],"fibers":[33],"elevated":[35],"lipopolysaccharide":[36],"bioavailability":[37],"may":[38],"promote":[39],"inflammation.":[40,120,204],"To":[41],"address":[42],"limited":[44],"evidence":[45],"linking":[46],"diet-mediated":[47],"changes":[48],"in":[49],"microbiota":[51],"to":[52,58,149],"cancer":[54,67,125,177,190],"risk,":[55,191],"we":[56,154],"aimed":[57],"determine":[59],"how":[60,137],"diet":[61,127,159,187],"affects":[62],"microbiome":[64,106],"risk.":[68,152,178],"For":[69],"ten":[70],"weeks,":[71],"female":[72],"3-week-old":[73],"BALB/c":[74],"mice":[75],"were":[76],"fed":[77],"six":[78],"different":[79],"diets":[80],"(control,":[81],"high-sugar,":[82],"lard,":[83],"coconut":[84],"oil,":[85,89],"lard":[86,91],"+":[87,92],"flaxseed":[88],"safflower":[93],"oil).":[94],"Fecal":[95],"16S":[96],"sequencing":[97],"was":[98],"performed":[99],"for":[100],"each":[101],"group.":[102],"Diet":[103],"shifted":[104,116],"fecal":[105],"populations":[107],"modulated":[109,129],"mammary":[110,132,202],"gland":[111,133,203],"macrophage":[112,117,164],"infiltration.":[113],"Fecal-conditioned":[114],"media":[115],"polarity":[118],"In":[121],"our":[122],"DMBA-induced":[123],"model,":[126],"differentially":[128],"tumor":[130,151],"metabolism.":[134],"We":[135],"demonstrated":[136],"patterns":[139],"change":[140],"metabolic":[141],"outcomes":[142],"microbiota,":[146],"possibly":[147],"contributing":[148],"Furthermore,":[153],"showed":[155],"influence":[157],"on":[160,188,193],"metabolism,":[161],"inflammation,":[162],"polarity.":[165],"This":[166],"study":[167,182],"suggests":[168],"dietary-microbiome":[170],"interactions":[171],"are":[172],"key":[173],"mediators":[174],"Prevention":[179],"Relevance:":[180],"Our":[181],"demonstrates":[183],"impact":[185],"focusing":[192],"interplay":[195],"diet,":[197],"microbiome,":[200]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-04T00:00:00"}