{"id":"https://openalex.org/W4396599685","doi":"https://doi.org/10.1158/1538-7445.sabcs23-rf01-08","title":"Abstract RF01-08: A randomized, open-label phase III trial Evaluating Low-Dose Vs standard-dose Olanzapine with triple Antiemetic therapy for Prevention of highly emetogenic chemotherapy- induced Nausea and vomiting in solid tumors (OLAnzaPiNE)","display_name":"Abstract RF01-08: A randomized, open-label phase III trial Evaluating Low-Dose Vs standard-dose Olanzapine with triple Antiemetic therapy for Prevention of highly emetogenic chemotherapy- induced Nausea and vomiting in solid tumors (OLAnzaPiNE)","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396599685","doi":"https://doi.org/10.1158/1538-7445.sabcs23-rf01-08"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-rf01-08","doi":"https://doi.org/10.1158/1538-7445.sabcs23-rf01-08","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-rf01-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091717418","display_name":"Jyoti Bajpai","orcid":"https://orcid.org/0000-0001-7657-3460","observed_orcids":["https://orcid.org/0000-0001-7657-3460"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyoti Bajpai","raw_affiliation_strings":["1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090457748","display_name":"Venkatesh Kapu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Venkatesh Kapu","raw_affiliation_strings":["1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111085493","display_name":"Sushmita Rath","orcid":"https://orcid.org/0000-0002-9931-4338","observed_orcids":["https://orcid.org/0000-0002-9931-4338"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sushmita Rath","raw_affiliation_strings":["1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India;","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089435105","display_name":"Sravan Kumar","orcid":"https://orcid.org/0009-0002-2281-0891","observed_orcids":["https://orcid.org/0009-0002-2281-0891"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sravan Kumar","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059467220","display_name":"Anbarasan Sekar","orcid":"https://orcid.org/0000-0001-7665-261X","observed_orcids":["https://orcid.org/0000-0001-7665-261X"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anbarasan Sekar","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037574638","display_name":"Anne Srikanth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srikanth Anne","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089016306","display_name":"Akash Pawar","orcid":"https://orcid.org/0000-0003-0797-8098","observed_orcids":["https://orcid.org/0000-0003-0797-8098"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Pawar","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112744373","display_name":"Sujay Srinivas","orcid":"https://orcid.org/0000-0001-9981-364X","observed_orcids":["https://orcid.org/0000-0001-9981-364X"]},"institutions":[{"id":"https://openalex.org/I2800098698","display_name":"Tata Memorial Hospital","ror":"https://ror.org/010842375","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sujay Srinivas","raw_affiliation_strings":["3Tata memorial hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Tata memorial hospital;","institution_ids":["https://openalex.org/I2800098698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012491839","display_name":"PRABHAT GHANSHYAM BHARGAVA","orcid":"https://orcid.org/0000-0002-6440-2186","observed_orcids":["https://orcid.org/0000-0002-6440-2186"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabhat Bhargava","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108139551","display_name":"Seema Gulia","orcid":"https://orcid.org/0000-0001-5871-7395","observed_orcids":["https://orcid.org/0000-0001-5871-7395"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Seema Gulia","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031032220","display_name":"Rajiv Sarin","orcid":"https://orcid.org/0000-0002-6405-8282","observed_orcids":["https://orcid.org/0000-0002-6405-8282"]},"institutions":[{"id":"https://openalex.org/I2800098698","display_name":"Tata Memorial Hospital","ror":"https://ror.org/010842375","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajiv Sarin","raw_affiliation_strings":["4Tata Memorial Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Tata Memorial Hospital;","institution_ids":["https://openalex.org/I2800098698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048611916","display_name":"Rajendra Achyut Badwe","orcid":"https://orcid.org/0000-0002-0480-2831","observed_orcids":["https://orcid.org/0000-0002-0480-2831"]},"institutions":[{"id":"https://openalex.org/I2800098698","display_name":"Tata Memorial Hospital","ror":"https://ror.org/010842375","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajendra Badwe","raw_affiliation_strings":["5Tata Memorial Centre, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Tata Memorial Centre, India","institution_ids":["https://openalex.org/I2800098698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058903725","display_name":"Sudeep Gupta","orcid":"https://orcid.org/0000-0002-6742-6378","observed_orcids":["https://orcid.org/0000-0002-6742-6378"]},"institutions":[{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudeep Gupta","raw_affiliation_strings":["2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tata Memorial Centre, Homi Bhabha National Institute (HBNI);","institution_ids":["https://openalex.org/I200207707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"RF01","last_page":"08"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.8980000019073486},{"id":"https://openalex.org/keywords/highly-emetogenic-chemotherapy","display_name":"highly emetogenic chemotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7950000166893005},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.9279999732971191},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.8555946350097656},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.8498566150665283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8280566930770874},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.741539716720581},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.7029862403869629},{"id":"https://openalex.org/C2779924295","wikidata":"https://www.wikidata.org/wiki/Q5090630","display_name":"Chemotherapy-induced nausea and vomiting","level":4,"score":0.6102786064147949},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.49212759733200073},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.4636690616607666},{"id":"https://openalex.org/C2780574406","wikidata":"https://www.wikidata.org/wiki/Q621834","display_name":"Aprepitant","level":4,"score":0.4298696517944336},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.38749635219573975},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3793238401412964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3348207175731659},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.07137039303779602},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.04908528923988342}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-rf01-08","doi":"https://doi.org/10.1158/1538-7445.sabcs23-rf01-08","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-rf01-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390919581","https://openalex.org/W3202242133","https://openalex.org/W4405406800","https://openalex.org/W7152683377","https://openalex.org/W7220886262","https://openalex.org/W2723449659","https://openalex.org/W6968432657","https://openalex.org/W4401331613","https://openalex.org/W2977641350","https://openalex.org/W4399069272"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Chemotherapy":[2],"induced":[3,595],"nausea":[4,153],"and":[5,117,176,183,192,203,268,275,350,364,378,392,405,450,508,544,597],"vomiting":[6,598],"(CINV)":[7],"is":[8,69,494,509],"a":[9,58,73,243,256,530],"major":[10,55],"adverse":[11],"event":[12],"for":[13,80,171,589],"cancer":[14],"patients.":[15],"Olanzapine":[16,584],"(OLZ)":[17],"in":[18,31,72,122,155,161,174,188,206,266,300,303,317,322,338,343,357,361,389,457,480,500,521,599],"standard":[19],"10":[20,421],"mg":[21,415,463],"dose":[22,60,65,491],"along":[23],"with":[24,34,63,103,139,251,306,315,418,511,538,585],"triple":[25,586],"antiemetics":[26],"(TAE),":[27],"has":[28],"shown":[29],"effectiveness":[30],"treating":[32],"CINV":[33,502],"highly":[35,592],"emetogenic":[36,593],"chemotherapy":[37,85,219],"(HEC),":[38],"however,":[39,461],"significant":[40,232,425,474],"day":[41,101,455],"time":[42],"somnolence":[43],"(DTS)":[44],"precludes":[45],"its":[46],"widespread":[47],"use.":[48],"Steroids":[49],"related":[50],"side":[51],"effects":[52],"are":[53,264],"another":[54],"concern.":[56],"Hence,":[57],"lower":[59],"of":[61,137,146,186,201,224,228,231,246,271,286,297,313,476,505,536,591,606],"OLZ,":[62],"single":[64],"(SD)":[66],"steroid":[67,532],"use":[68,145,185,200,227,250],"worth":[70],"exploring":[71],"randomized":[74,87],"fashion.":[75],"Methods":[76],"Solid":[77],"tumors":[78,601],"planned":[79],"anthracycline-cyclophosphamide":[81],"&":[82],"high-dose":[83],"cisplatin":[84],"was":[86,127,440],"(1:1)":[88],"to":[89,128,167,211,221,497,513],"receive":[90],"either":[91],"10mg":[92,304,325,341,360,388,483,498],"OLZ":[93],"(standard":[94],"arm)":[95,99],"or":[96,151],"2.5mg":[97,301,323,339,358,481],"(experimental":[98],"till":[100],"4":[102],"TAE":[104],"regimen":[105,535],"[5-hydroxytryptamine":[106],"type":[107],"3":[108],"(5-HT3)":[109],"receptor":[110,120],"antagonists,":[111],"dexamethasone":[112],"(SD,":[113],"without":[114,503],"delayed":[115,177,506],"doses),":[116],"neurokinin-1":[118],"(NK1)":[119],"antagonists]":[121],"both":[123,162,458],"arms.":[124],"Primary":[125],"objective":[126],"evaluate":[129],"Complete":[130],"control":[131,195],"rate":[132,180],"(CCR)":[133],"defined":[134,214],"as":[135,215,416,529],"proportion":[136],"subjects":[138,288,299,522],"no":[140,144,150,184,197,199,204],"emetic":[141],"episodes":[142],"(EE),":[143],"rescue":[147],"medications":[148],"(RM),":[149],"mild":[152],"assessed":[154],"overall":[156,429],"phase":[157,577],"(OP)":[158],"=0-120":[159],"hours(h)":[160],"groups.":[163],"Secondary":[164],"objectives":[165,235],"were":[166,236,278,289,294,346,366],"compare":[168],"two":[169],"groups":[170],"the":[172,252,459,468,607],"CCR":[173,316,337],"acute(AP)":[175],"phase(DP);Complete":[178],"response":[179],"(CRR)=no":[181],"EE":[182],"RM":[187,249],"AP(0-":[189],"24h),":[190],"DP(25-120h)":[191],"OP;":[193,209],"Total":[194],"rate(TCR)=":[196],"EE,":[198,226,248,273],"RM,":[202],"nausea)":[205],"AP,":[207,344,362,390],"DP,":[208,391],"Time":[210],"treatment":[212],"failure(TTF),":[213],"mean":[216],"duration":[217],"from":[218,454],"initiation":[220],"first":[222],"episode":[223],"nausea,":[225,247,272],"RM;":[229],"Incidence":[230],"daytime":[233],"somnolence(DTS).Tertiary":[234],"effect":[237,475],"on":[238,255,428,442,466],"appetite":[239,478],"loss.":[240],"Subjects":[241,412],"maintained":[242],"daily":[244],"record":[245],"severity":[253],"graded":[254],"four-category":[257],"scale.":[258],"Statistical":[259],"analysis":[260],"CCR,":[261],"CRR,":[262],"TCR":[263,385],"given":[265],"counts":[267],"proportions.":[269],"Occurrence":[270],"DTS":[274,427,439,514],"their":[276],"grades":[277,430],"compared":[279,417],"using":[280],"Chi-square":[281],"test.":[282],"Results":[283],"A":[284,574],"total":[285],"275":[287],"enrolled,":[290],"among":[291],"them":[292],"267":[293],"analyzable,":[295],"inclusive":[296],"132":[298],"and135":[302],"arms":[305,326,342],"well-balanced":[307],"baseline":[308],"characteristics":[309,543],"(Table":[310],"1)":[311],"Proportion":[312],"patients":[314],"OP":[318,365,393],"(Primary":[319],"end":[320],"point)":[321],"vs.":[324,330,340,348,352,359,368,373,381,387,395,400,408,433,482,486],"were,":[327],"44.7":[328],"%":[329,332,370,380,397,407],"43.7":[331],"(P":[333,375,402],"=":[334,376,403],"0.87)":[335],"respectively.":[336,355,384,411],"DP":[345,363],"50%":[347],"48.9%(p=0.856)":[349],"50.8%":[351],"58.5%":[353],"(P=0.203)":[354],"CRR":[356],"56.1%":[367],"57":[369],"(P=0.872),":[371],"55.3%":[372],"63%":[374],"0.203),":[377],"50.8":[379],"51.1%":[382],"(P=0.954),":[383],"in2.5mg":[386],"were25%":[394],"23":[396],"(P=0.697),":[398],"20.5%":[399],"22%":[401],"0.725),":[404],"13.6":[406],"15.6%":[409],"(P=0.657),":[410],"receiving":[413,420,523],"2.5":[414,462],"those":[419],"mg,":[422],"had":[423],"statistically":[424,473],"decreased":[426],"65.2%vs":[431],"89.6%":[432],"(p":[434,447],"<":[435,448],"0.001);":[436],"severe":[437,519],"grade":[438],"more":[441],"day1":[443],"i.e.,":[444,484],"4.5%vs.":[445],"40%":[446],"0.001)":[449],"although":[451],"successively":[452],"reduced":[453,477],"2-5":[456],"arms,":[460],"fared":[464],"better":[465],"all":[467,517],"days":[469],"(table":[470],"1).":[471],"No":[472],"noted":[479],"17.4%":[485],"24.4":[487],"%(p=0.208)":[488],"Conclusion":[489],"Low":[490],"olanzapine":[492,499],"(2.5mg)":[493],"non":[495],"inferior":[496],"controlling":[501],"requirement":[504],"steroids,":[507],"superior":[510],"respect":[512],"(all":[515],"days,":[516],"grades,":[518],"grades)":[520],"HEC.":[524,539],"This":[525],"merits":[526],"wide":[527],"recognition":[528],"new":[531],"sparing":[533],"antiemetic":[534],"choice":[537],"Demographic":[540],"data,":[541],"Clinical":[542],"Outcomes":[545],"Citation":[546],"Format:":[547],"Jyoti":[548],"Bajpai,":[549],"Venkatesh":[550],"Kapu,":[551],"Sushmita":[552],"Rath,":[553],"Sravan":[554],"Kumar,":[555],"Anbarasan":[556],"Sekar,":[557],"Srikanth":[558],"Anne,":[559],"Akash":[560],"Pawar,":[561],"Sujay":[562],"Srinivas,":[563],"Prabhat":[564],"Bhargava,":[565],"Seema":[566],"Gulia,":[567],"Rajiv":[568],"Sarin,":[569],"Rajendra":[570],"Badwe,":[571],"Sudeep":[572],"Gupta.":[573],"randomized,":[575],"open-label":[576],"III":[578],"trial":[579],"Evaluating":[580],"Low-Dose":[581],"Vs":[582],"standard-dose":[583],"Antiemetic":[587],"therapy":[588],"Prevention":[590],"chemotherapy-":[594],"Nausea":[596],"solid":[600],"(OLAnzaPiNE)":[602],"[abstract].":[603],"In:":[604],"Proceedings":[605],"2023":[608,614],"San":[609,617],"Antonio":[610],"Breast":[611],"Cancer":[612,623],"Symposium;":[613],"Dec":[615],"5-9;":[616],"Antonio,":[618],"TX.":[619],"Philadelphia":[620],"(PA):":[621],"AACR;":[622],"Res":[624],"2024;84(9":[625],"Suppl):Abstract":[626],"nr":[627],"RF01-08.":[628]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-03T00:00:00"}