{"id":"https://openalex.org/W4396599201","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-22-09","title":"Abstract PO5-22-09: Positive pegulicianine fluorescence rate in the lumpectomy cavity correlates with tumor distance to margins in excised tissue","display_name":"Abstract PO5-22-09: Positive pegulicianine fluorescence rate in the lumpectomy cavity correlates with tumor distance to margins in excised tissue","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396599201","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-22-09"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-po5-22-09","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-22-09","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-22-09","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079009302","display_name":"Irene Wapnir","orcid":"https://orcid.org/0000-0003-2062-2854","observed_orcids":["https://orcid.org/0000-0003-2062-2854"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Wapnir","raw_affiliation_strings":["1Stanford Cancer Institute/Stanford University, Stanford, California, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford Cancer Institute/Stanford University, Stanford, California, United States;","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072004172","display_name":"E. Shelley Hwang","orcid":"https://orcid.org/0000-0003-0204-2012","observed_orcids":["https://orcid.org/0000-0003-0204-2012"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Shelley Hwang","raw_affiliation_strings":["2Duke University, Durham, North Carolina, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Duke University, Durham, North Carolina, United States;","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Hunt","raw_affiliation_strings":["3The University of Texas MD Anderson Cancer Center, Houston, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The University of Texas MD Anderson Cancer Center, Houston, Texas, United States;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802152183","display_name":"Novant Health","ror":"https://ror.org/04nv2wh79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I4210158401","display_name":"Novant Health Forsyth Medical Center","ror":"https://ror.org/04mm17p39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802152183","https://openalex.org/I4210158401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Carr","raw_affiliation_strings":["4Novant Health, Winston-Salem NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Novant Health, Winston-Salem NC;","institution_ids":["https://openalex.org/I2802152183","https://openalex.org/I4210158401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070196572","display_name":"Peter William Blumencranz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Blumencranz","raw_affiliation_strings":["5Baycare Medical Group;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Baycare Medical Group;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050597922","display_name":"Manna Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096706","display_name":"Lumicell (United States)","ror":"https://ror.org/00xaj7311","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096706"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manna Chang","raw_affiliation_strings":["6Lumicell;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Lumicell;","institution_ids":["https://openalex.org/I4210096706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058592583","display_name":"Kate Porta Smith","orcid":"https://orcid.org/0000-0002-1685-2051","observed_orcids":["https://orcid.org/0000-0002-1685-2051"]},"institutions":[{"id":"https://openalex.org/I4210096706","display_name":"Lumicell (United States)","ror":"https://ror.org/00xaj7311","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096706"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Smith","raw_affiliation_strings":["7Lumicell, Inc;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Lumicell, Inc;","institution_ids":["https://openalex.org/I4210096706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103496352","display_name":"Jorge M. Ferrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096706","display_name":"Lumicell (United States)","ror":"https://ror.org/00xaj7311","country_code":"US","type":"company","lineage":["https://openalex.org/I4210096706"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Ferrer","raw_affiliation_strings":["7Lumicell, Inc;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Lumicell, Inc;","institution_ids":["https://openalex.org/I4210096706"]}]},{"author_position":"last","author":{"id":null,"display_name":"Barbara Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Smith","raw_affiliation_strings":["8Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PO5","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.35420000553131104,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.14970000088214874,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-guided-surgery","display_name":"fluorescence-guided surgery","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lumpectomy-cavity","display_name":"lumpectomy cavity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.8289999961853027},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6060000061988831},{"id":"https://openalex.org/keywords/surgical-margin-assessment","display_name":"surgical margin assessment","score":0.40400001406669617},{"id":"https://openalex.org/keywords/residual-tumor-detection","display_name":"residual tumor detection","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2779572924","wikidata":"https://www.wikidata.org/wiki/Q542022","display_name":"Lumpectomy","level":5,"score":0.784136176109314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4842471778392792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4662206470966339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3723028302192688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1986701786518097},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15234649181365967},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.08579111099243164}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-po5-22-09","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-22-09","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-22-09","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4367180315","https://openalex.org/W4280546732","https://openalex.org/W4382244121","https://openalex.org/W4221102510","https://openalex.org/W4407168758","https://openalex.org/W2807257543","https://openalex.org/W2946915147","https://openalex.org/W3093341083","https://openalex.org/W7129657485","https://openalex.org/W7154682422"],"abstract_inverted_index":{"Abstract":[0],"Title:":[1],"Positive":[2,293,490,532],"pegulicianine":[3,26,153,186,211,257,368,403,423,533],"fluorescence":[4,27,131,212,231,334,344,404,424,493,534],"rate":[5,236,335,345,400,494,535],"in":[6,16,48,69,74,122,214,316,324,336,377,405,432,435,471,536,546],"the":[7,38,49,53,63,70,79,123,134,137,145,193,215,235,239,251,260,281,311,361,374,381,385,393,396,399,406,417,426,443,452,472,483,537,553],"lumpectomy":[8,50,71,197,216,284,397,454,497,501,506,538],"cavity":[9,51,105,203,217,407,491,539],"correlates":[10,540],"with":[11,90,155,255,265,276,338,354,541],"tumor":[12,58,120,138,300,305,357,375,389,414,470,509,542],"distance":[13,135,543],"to":[14,44,96,149,190,245,259,392,428,437,455,544],"margins":[15,93,99,204,271,275,294,340,450,460,503,510,545],"excised":[17,206,547],"tissue":[18,431,548],"Background:":[19],"A":[20],"randomized,":[21],"two-arm":[22],"pivotal":[23,146,165],"study":[24,147,166],"of":[25,55,86,88,114,152,185,195,209,253,263,360,395,401,422,442,448,482,485,552],"guided":[28,126,474],"surgery":[29,173],"(pFGS)":[30],"at":[31,207,237,380,416],"14":[32],"US":[33],"sites":[34,208],"was":[35,198,248,346],"conducted":[36],"using":[37,219],"Lumicell":[39,64,102,124,201,240],"Direct":[40],"Visualization":[41],"System":[42],"(DVS)":[43],"identify":[45],"residual":[46,67],"cancer":[47,68,226,303],"after":[52,451],"standard":[54,194],"care":[56,196],"(SoC)":[57],"excision.":[59],"We":[60,128,141,327],"reported":[61],"that":[62,130,233],"DVS":[65,103,125,241,473],"detects":[66],"cavity,":[72],"including":[73],"orientations":[75,254,264,337],"pathologically":[76],"negative":[77,98,267,440,459,502],"on":[78,278,280,289,299,356,508],"SoC":[80,92,283,453,496,500,505],"specimen.":[81,285],"In":[82],"addition,":[83],"15%":[84],"(9":[85],"62)":[87],"patients":[89,117,169],"positive":[91,210,230,256,270,274,333,339,343,362,402,449,498],"were":[94,205,287,295],"converted":[95],"final":[97,458],"by":[100,371],"taking":[101],"directed":[104],"margins,":[106,268,499],"avoiding":[107],"a":[108,220,290,329,439,462],"second":[109,463],"unnecessary":[110],"surgery.":[111,191],"Interestingly,":[112],"8":[113],"these":[115,433],"9":[116],"had":[118],"no":[119,469],"found":[121,328],"specimens.":[127],"hypothesize":[129],"decreases":[132],"as":[133,250,297],"from":[136,144,310],"boundary":[139],"increases.":[140],"analyzed":[142],"data":[143],"(NCT03686215)":[148],"assess":[150],"correlation":[151],"signal":[154,213,258],"tumor-to-margin":[156],"distance,":[157],"and":[158,224,272,304,376,504],"its":[159],"potential":[160],"clinical":[161],"value.":[162],"Methods:":[163],"The":[164,229,342,446],"enrolled":[167],"406":[168],"undergoing":[170],"breast":[171,178],"conserving":[172],"(BCS)":[174],"for":[175,301,313,495],"stage":[176],"0-III":[177],"cancers.":[179],"Patients":[180],"received":[181],"an":[182],"IV":[183],"injection":[184],"2-6":[187],"hours":[188],"prior":[189],"After":[192],"completed,":[199],"additional":[200],"DVS-guided":[202],"walls":[218],"hand-held":[221],"imaging":[222],"device":[223],"patient-calibrated":[225],"detection":[227],"software.":[228],"rate,":[232],"is,":[234],"which":[238],"indicates":[242],"areas":[243,434],"suspected":[244],"contain":[246],"cancer,":[247],"calculated":[249],"ratio":[252],"total":[261],"number":[262],"(1)":[266],"(2)":[269],"(3)":[273],"ink":[277,298,355,507],"tumor,":[279],"initial":[282],"Calculations":[286],"made":[288],"per-margin":[291],"basis.":[292],"defined":[296],"invasive":[302,382],"less":[306],"than":[307],"2":[308],"mm":[309],"margin":[312,363,441],"ductal":[314],"carcinoma":[315],"situ":[317],"(DCIS)":[318],"alone.":[319],"Results:":[320],"Results":[321],"are":[322],"presented":[323],"Table":[325,488],"1.":[326],"statistically":[330],"significant":[331],"higher":[332,348],"(p=0.044).":[341],"even":[347,465],"(21.1%)":[349],"when":[350,388,411,466],"only":[351],"considering":[352],"cases":[353],"(a":[358],"subset":[359],"group).":[364],"Discussion:":[365],"By":[366],"design,":[367],"is":[369,390,413,468],"activated":[370],"enzymes":[372],"within":[373],"stromal":[378],"cells":[379],"front":[383],"surrounding":[384],"tumor.":[386],"Thus,":[387],"closer":[391],"edge":[394],"specimen,":[398],"increases,":[408],"being":[409],"highest":[410],"there":[412,467],"present":[415],"inked":[418],"margin.":[419],"This":[420],"feature":[421],"guides":[425],"surgeon":[427],"resect":[429],"more":[430],"order":[436],"achieve":[438],"required":[444],"width.":[445],"conversion":[447],"appropriately":[456],"wide":[457],"prevents":[461],"surgery,":[464],"margins.":[475],"These":[476],"findings":[477],"have":[478],"strengthened":[479],"our":[480],"understanding":[481],"utility":[484],"this":[486],"technology.":[487],"1":[489],"wall":[492],"Citation":[511],"Format:":[512],"Irene":[513],"Wapnir,":[514],"E":[515],"Shelley":[516],"Hwang,":[517],"Kelly":[518],"Hunt,":[519],"David":[520],"Carr,":[521],"Peter":[522],"Blumencranz,":[523],"Manna":[524],"Chang,":[525],"Kate":[526],"Smith,":[527],"Jorge":[528],"Ferrer,":[529],"Barbara":[530],"Smith.":[531],"[abstract].":[549],"In:":[550],"Proceedings":[551],"2023":[554,560],"San":[555,563],"Antonio":[556],"Breast":[557],"Cancer":[558,569],"Symposium;":[559],"Dec":[561],"5-9;":[562],"Antonio,":[564],"TX.":[565],"Philadelphia":[566],"(PA):":[567],"AACR;":[568],"Res":[570],"2024;84(9":[571],"Suppl):Abstract":[572],"nr":[573],"PO5-22-09.":[574]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-05-03T00:00:00"}