{"id":"https://openalex.org/W4396591141","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po1-29-04","title":"Abstract PO1-29-04: Spatial tumor microenvironment profiling identifies immune features that correlate with response to T-DXd treatment in patients with metastatic breast cancer","display_name":"Abstract PO1-29-04: Spatial tumor microenvironment profiling identifies immune features that correlate with response to T-DXd treatment in patients with metastatic breast cancer","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396591141","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po1-29-04"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-po1-29-04","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po1-29-04","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-29-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101580545","display_name":"Hong Zhao","orcid":"https://orcid.org/0000-0001-8991-7824","observed_orcids":["https://orcid.org/0000-0001-8991-7824"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhao","raw_affiliation_strings":["1Houston Methodist;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist;","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034078193","display_name":"Matthew Vasquez","orcid":"https://orcid.org/0000-0001-9319-2686","observed_orcids":["https://orcid.org/0000-0001-9319-2686"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Vasquez","raw_affiliation_strings":["2Houston Methodist Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Houston Methodist Research Institute;","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034134465","display_name":"Jeffrey Zhang","orcid":"https://orcid.org/0000-0002-5792-383X","observed_orcids":["https://orcid.org/0000-0002-5792-383X"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Zhang","raw_affiliation_strings":["2Houston Methodist Research Institute;","4Emory University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Houston Methodist Research Institute;","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"4Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102658816","display_name":"Glori Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glori Das","raw_affiliation_strings":["2Houston Methodist Research Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Houston Methodist Research Institute;","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416286","display_name":"Ji\u2010Hoon Lee","orcid":"https://orcid.org/0000-0002-3542-3885","observed_orcids":["https://orcid.org/0000-0002-3542-3885"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Hoon Lee","raw_affiliation_strings":["3Georgia Institute of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Georgia Institute of Technology;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437986","display_name":"Yuan Gao","orcid":"https://orcid.org/0009-0004-7836-9120","observed_orcids":["https://orcid.org/0009-0004-7836-9120"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Gao","raw_affiliation_strings":["4Emory University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047571643","display_name":"Jilun Zhang","orcid":"https://orcid.org/0009-0004-2245-9688","observed_orcids":["https://orcid.org/0009-0004-2245-9688"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jilun Zhang","raw_affiliation_strings":["2Houston Methodist Research Institute;","4Emory University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Houston Methodist Research Institute;","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"4Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101914131","display_name":"Xiaoxian Li","orcid":"https://orcid.org/0000-0002-0995-1721","observed_orcids":["https://orcid.org/0000-0002-0995-1721","https://orcid.org/0009-0000-4621-1135"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxian Li","raw_affiliation_strings":["4Emory University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Emory University;","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025409813","display_name":"Jenny C. Chang","orcid":"https://orcid.org/0000-0002-0890-9302","observed_orcids":["https://orcid.org/0000-0002-0890-9302"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Chang","raw_affiliation_strings":["5Houston Methodist Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Houston Methodist Hospital","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015077092","display_name":"Stephen T.C. Wong","orcid":"https://orcid.org/0000-0001-9188-6502","observed_orcids":["https://orcid.org/0000-0001-9188-6502"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Wong","raw_affiliation_strings":["1Houston Methodist;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist;","institution_ids":["https://openalex.org/I1295876152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PO1","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.23319999873638153,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7990000247955322},{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6589999794960022},{"id":"https://openalex.org/keywords/spatial-immune-profiling","display_name":"spatial immune profiling","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7739999890327454},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/stroma","display_name":"stroma","score":0.5040000081062317},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nanostring-geomx","display_name":"NanoString GeoMx","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6518276929855347},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6454362273216248},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6206393241882324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.602586030960083},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5014266967773438},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.48578575253486633},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45105424523353577},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4424000680446625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38436341285705566},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3822716176509857},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29652154445648193},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.058946192264556885},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-po1-29-04","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po1-29-04","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-29-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411287052","https://openalex.org/W7162694677","https://openalex.org/W4400931289","https://openalex.org/W4281929196","https://openalex.org/W7148734376","https://openalex.org/W3096284298","https://openalex.org/W4415383334","https://openalex.org/W4388042461","https://openalex.org/W2915390763","https://openalex.org/W4396591286"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"It":[2],"is":[3,337],"unclear":[4],"which":[5,345],"patients":[6,30,57,98,325,393],"with":[7,76,86,96,114,278,326,339,387,394],"metastatic":[8,26,48,105,315,327,395],"breast":[9,328,396],"cancer":[10,397],"respond":[11],"to":[12,70,101,294,297,322,342,348,389],"the":[13,46,56,134,163,187,198,212,239,245,265,271,288,314,319,349,402],"new":[14],"antibody":[15],"drug":[16],"conjugate":[17],"T-DXd":[18,71,323,343,390],"treatment.":[19],"Methods:":[20],"We":[21],"profiled":[22],"22":[23,47,140],"pre-T-DXd":[24],"treatment":[25,295,320,391],"tissue":[27,106],"samples":[28],"from":[29],"using":[31],"Nanostring":[32],"GeoMX":[33],"digital":[34],"spatial":[35,137],"profiler":[36],"of":[37,55,111,133,139,170,287,301,352,354,401],"tumor":[38,120,316,379],"infiltrating":[39],"immune":[40,126,141,178,191,216,254,383],"cells":[41,127],"and":[42,63,79,89,92,125,143,151,182,228,258,283,311],"stroma":[43,145,290],"components.":[44],"Among":[45],"samples,":[49],"10":[50],"were":[51,58,65,99,117,173,260],"bone":[52],"metastases":[53,75,85,95],"7":[54],"defined":[59,66],"as":[60,67],"responder":[61],"(R)":[62],"3":[64,93,144],"non-responder":[68],"(NR)":[69],"treatment;":[72],"4":[73,82],"brain":[74],"2":[77,80,87,90],"R":[78,88,199,240,266,279],"NR;":[81],"lymph":[83],"node":[84],"NR,":[91],"liver":[94],"all":[97,204],"NR":[100,201,246,268],"T-DXd.":[102,298,355],"In":[103],"each":[104,156],"section,":[107],"6-8":[108],"circular":[109],"regions":[110],"interest":[112],"(ROI)":[113],"300\u00b5m":[115],"diameter":[116],"selected":[118],"by":[119],"epithepial":[121],"marker":[122,128],"(pan":[123],"CK)":[124],"(CD45)":[129],"throughout":[130],"different":[131,263],"areas":[132],"tumor.":[135],"The":[136],"quantification":[138],"markers":[142,192,255,291],"elements":[146],"(fibronectin,":[147],"fibroblast":[148],"activation":[149],"protein,":[150],"smooth":[152],"muscle":[153],"actin)":[154],"in":[155,196,238,244,264,270,280,313,324,392],"ROI":[157],"was":[158,276,292],"analyzed.":[159],"Results:":[160],"Based":[161],"on":[162],"segmented":[164],"CD45-positive":[165],"cell":[166],"numbers,":[167],"a":[168],"total":[169],"144":[171],"ROIs":[172,179,184],"classified":[174],"into":[175],"high":[176,282],"tumor-infiltrating":[177],"(high-TIL,":[180],"n=47)":[181],"low-TIL":[183,213,272,284],"(n=97).":[185],"Within":[186,211],"high-TIL":[188],"ROIs,":[189,214],"none":[190],"showed":[193,235],"significant":[194,236],"difference":[195],"either":[197],"or":[200],"group":[202,241,247],"across":[203],"metastasis":[205],"sites":[206,317],"(P":[207,248],">0.05,":[208],"Figure":[209,251],"1).":[210],"several":[215],"markers,":[217],"including":[218,256],"PD-L1,":[219,302],"PD-1,":[220,303],"CD3,":[221,304],"CD56,":[222,305],"CD20,":[223,306],"CD14,":[224,307],"CD11c,":[225,308],"CTLA-4,":[226,309],"CD45,":[227,310],"B2M":[229,312],"(Beta-2-microglobulin,":[230],"an":[231],"antigen":[232],"presentation":[233],"marker)":[234],"elevation":[237],"than":[242],"those":[243],"<":[249],"0.05,":[250],"2).":[252],"Other":[253],"CD4":[257],"CD8":[259],"not":[261],"significantly":[262],"vs.":[267],"groups":[269],"ROIs.":[273,285],"High":[274],"Ki-67":[275],"correlated":[277],"both":[281],"None":[286],"three":[289],"associated":[293,338],"response":[296,321,341,388],"Conclusions:":[299],"Enrichment":[300],"favors":[318],"cancer.":[329],"Our":[330],"study":[331],"provides":[332],"novel":[333],"evidence":[334],"that":[335,385],"immune-suppression":[336],"patients\u2019":[340],"treatment,":[344],"may":[346],"due":[347],"unique":[350],"mechanism":[351],"action":[353],"Citation":[356],"Format:":[357],"Hong":[358],"Zhao,":[359],"Matthew":[360],"Vasquez,":[361],"Jeffrey":[362],"Zhang,":[363,371],"Glori":[364],"Das,":[365],"Ji-Hoon":[366],"Lee,":[367],"Yuan":[368],"Gao,":[369],"Jilun":[370],"Xiaoxian":[372],"Li,":[373],"Jenny":[374],"Chang,":[375],"Stephen":[376],"Wong.":[377],"Spatial":[378],"microenvironment":[380],"profiling":[381],"identifies":[382],"features":[384],"correlate":[386],"[abstract].":[398],"In:":[399],"Proceedings":[400],"2023":[403,409],"San":[404,412],"Antonio":[405],"Breast":[406],"Cancer":[407,418],"Symposium;":[408],"Dec":[410],"5-9;":[411],"Antonio,":[413],"TX.":[414],"Philadelphia":[415],"(PA):":[416],"AACR;":[417],"Res":[419],"2024;84(9":[420],"Suppl):Abstract":[421],"nr":[422],"PO1-29-04.":[423]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-03T00:00:00"}