{"id":"https://openalex.org/W4396590993","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po4-25-04","title":"Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)","display_name":"Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396590993","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po4-25-04"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-po4-25-04","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po4-25-04","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-25-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052187738","display_name":"Saranya Chumsri","orcid":"https://orcid.org/0000-0001-7117-1446","observed_orcids":["https://orcid.org/0000-0001-7117-1446"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saranya Chumsri","raw_affiliation_strings":["1Mayo Clinic, Jacksonville;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024788589","display_name":"Tracy R. Shachner","orcid":"https://orcid.org/0000-0003-2665-6123","observed_orcids":["https://orcid.org/0000-0003-2665-6123"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Shachner","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448027","display_name":"Zhuo Li","orcid":"https://orcid.org/0000-0002-5911-8893","observed_orcids":["https://orcid.org/0000-0002-5911-8893"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo Li","raw_affiliation_strings":["1Mayo Clinic, Jacksonville;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023752531","display_name":"Nadine Norton","orcid":"https://orcid.org/0000-0002-3848-4288","observed_orcids":["https://orcid.org/0000-0002-3848-4288"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Norton","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027821205","display_name":"Alvaro Moreno\u2010Aspitia","orcid":"https://orcid.org/0000-0002-2317-2580","observed_orcids":["https://orcid.org/0000-0002-2317-2580"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro Moreno-Aspitia","raw_affiliation_strings":["3Mayo Clinic, Jacksonville, Florida, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Mayo Clinic, Jacksonville, Florida, United States;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057155689","display_name":"Gerardo Col\u00f3n\u2010Otero","orcid":"https://orcid.org/0000-0002-9159-2421","observed_orcids":["https://orcid.org/0000-0002-9159-2421"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerardo Colon-Otero","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith Perez","raw_affiliation_strings":["4Mayo","Mayo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Mayo","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Mayo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080600800","display_name":"Aziza Nassar","orcid":"https://orcid.org/0000-0002-6678-9329","observed_orcids":["https://orcid.org/0000-0002-6678-9329"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aziza Nassar","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026692399","display_name":"E. Aubrey Thompson","orcid":"https://orcid.org/0000-0002-9001-4240","observed_orcids":["https://orcid.org/0000-0002-9001-4240"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Thompson","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Knutson","raw_affiliation_strings":["2Mayo Clinic;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mayo Clinic;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PO4","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mhc-class-i-expression","display_name":"MHC class I expression","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":1.0},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adjuvant-trastuzumab","display_name":"adjuvant trastuzumab","score":0.8889999985694885},{"id":"https://openalex.org/keywords/n9831-trial","display_name":"N9831 trial","score":0.8709999918937683},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.7739999890327454},{"id":"https://openalex.org/keywords/stromal-tumor-infiltrating-lymphocytes","display_name":"stromal tumor-infiltrating lymphocytes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.593999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7037449479103088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6228541135787964},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6019962430000305},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49253687262535095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48427480459213257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42606014013290405},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4228828251361847},{"id":"https://openalex.org/C2778431023","wikidata":"https://www.wikidata.org/wiki/Q878249","display_name":"Alliance","level":2,"score":0.4212648868560791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34538835287094116},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.27093207836151123},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22945529222488403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17642369866371155},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0967508852481842},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-po4-25-04","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po4-25-04","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-25-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282959170","https://openalex.org/W7130683406","https://openalex.org/W4376613864","https://openalex.org/W7100464168","https://openalex.org/W7129407582","https://openalex.org/W2734928468","https://openalex.org/W4411287706","https://openalex.org/W2912070755","https://openalex.org/W4280596065","https://openalex.org/W4411136320"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Tertiary":[2,581],"lymphoid":[3,12,17],"structure":[4],"(TLS)":[5],"is":[6,43,66,80],"an":[7,535],"organized":[8],"form":[9],"of":[10,26,89,130,160,236,265,335,448,476,497,521,528,534,600],"ectopic":[11],"aggregates":[13],"(LA)":[14],"with":[15,29,37,57,118,147,241,269,289,325,353,360,371,379,402,406,434,438,452,457,465,473,487,490,507,518],"secondary":[16],"organ":[18],"structure.":[19],"Several":[20],"studies":[21,83],"showed":[22,85],"that":[23,485],"the":[24,77,86,124,208,474,519,525,532,601],"presence":[25,520],"TLS":[27,47,62,115,489],"associates":[28],"improved":[30,270,290,354,453,503],"outcomes":[31,49,122,372,454,504],"in":[32,50,68,92,97,116,123,132,138,150,223,226,231,273,293,304,319,322,356,373,432,455,531,587,593],"multiple":[33],"cancers":[34],"when":[35,76,281,463,505],"treated":[36,56,137,464,506],"immune":[38,171,317,481,538],"checkpoint":[39],"inhibitors.":[40],"However,":[41,280,364],"data":[42,111],"currently":[44],"limited":[45],"regarding":[46],"and":[48,63,71,109,121,143,164,200,212,217,229,249,256,343,386,416,427,470,479,494,513,577,585],"HER2+":[51,459],"breast":[52,93,99,460],"cancer":[53,94],"patients":[54],"(pts)":[55],"adjuvant":[58],"trastuzumab.":[59,508],"Furthermore,":[60],"distinguishing":[61],"simple":[64],"LA":[65,131,211,220,237,266,286,326,361,378,403,410,435,449,478,491],"challenging":[67],"standard":[69],"hematoxylin":[70],"eosin":[72],"(H&E)":[73],"staining,":[74],"particularly":[75,462],"germinal":[78],"center":[79],"absent.":[81],"Emerging":[82],"also":[84],"prognostic":[87],"value":[88],"MHC":[90,119,161,215,413,510,574],"expression":[91,120,166,334,399,496],"but":[95,253,302],"mainly":[96],"triple-negative":[98],"cancer.":[100],"In":[101],"this":[102],"study,":[103],"we":[104,395,483],"evaluated":[105,222,315,396],"integrated":[106],"pathological":[107,477],"quantification":[108],"genomic":[110,471],"to":[112,157,206],"assess":[113],"functional":[114,488,522],"association":[117,209],"N9831":[125,151,595],"trial.":[126],"Methods:":[127],"Pathological":[128],"evaluation":[129],"H&E":[133],"slides":[134],"from":[135],"pts":[136,225,321,359,376,456,486],"Arm":[139,144,227,232,294,305,323,357,374],"A":[140,228,295,445],"(chemotherapy":[141,146],"alone)":[142],"C":[145,306,324,358,375],"concurrent":[148],"trastuzumab)":[149],"was":[152,155,221,238,287,450],"performed.":[153],"NanoString":[154],"used":[156,205],"quantify":[158],"mRNA":[159],"class":[162,414,511],"I":[163,415,512,576],"II":[165,417,514,578],"as":[167,169],"well":[168],"TLS-related":[170,316,480],"genes,":[172,482],"including":[173],"IFNG,":[174],"ICOSLG,":[175],"CXCL13,":[176],"CXCR3,":[177],"BCL6,":[178],"IL21R,":[179],"ICOS,":[180],"PDCD1,":[181],"CXCR5,":[182],"CXCL9,":[183],"TBX21,":[184],"CD38,":[185],"CXCL10,":[186],"CLXCL11,":[187],"IL21,":[188],"CD200,":[189],"CD19,":[190],"MS4S1.":[191],"Wilcoxon":[192],"rank":[193],"sum":[194],"test,":[195,197],"Chi-squared":[196],"Kaplan-Meier":[198],"method,":[199],"Cox":[201,260],"regression":[202,261],"model":[203],"were":[204,267,351,367,429],"evaluate":[207],"between":[210,400],"baseline":[213],"characteristics,":[214],"expression,":[216],"outcomes.":[218],"Results:":[219],"526":[224],"485":[230],"C.":[233],"Greater":[234],"number":[235,447],"significantly":[239,369,430,502],"associated":[240,268,288,352,370,451,517],"stromal":[242],"tumor-infiltrating":[243],"lymphocytes":[244],"(sTILs),":[245],"hormone":[246],"receptor":[247],"negative,":[248],"higher":[250,333,431,495],"tumor":[251],"grade,":[252],"not":[254,303,368],"stage":[255],"age.":[257],"Using":[258,468],"multivariable":[259],"analysis,":[262],"increasing":[263],"numbers":[264],"recurrence-free":[271],"survival":[272],"both":[274],"arms":[275],"combined":[276],"(RFS,":[277],"p":[278,300,311,341,349,384,392],"0.028).":[279],"evaluating":[282],"each":[283],"arm":[284],"separately,":[285],"RFS":[291,355],"only":[292],"(HR":[296,307,337,345,388],"0.6,":[297],"95%CI":[298,309,339,347,382,390],"0.43-0.84,":[299],"0.003)":[301],"0.72,":[308],"0.47-1.1,":[310],"0.134).":[312],"We":[313],"further":[314],"genes":[318,366],"252":[320],"\u2265":[327,362,404,436,492],"1.":[328,363],"As":[329],"a":[330],"continuous":[331],"variable,":[332],"BCL6":[336,380,408,440,498],"0.61,":[338],"0.41-0.92,":[340],"0.019)":[342],"IL21R":[344,387,500],"0.78,":[346],"0.62-0.98,":[348],"0.03)":[350],"these":[365],"without":[377],"(HR1.07,":[381],"0.67-1.71,":[383],"0.776)":[385],"0.96,":[389],"0.71-1.29,":[391],"0.775).":[393],"Moreover,":[394],"differential":[397],"gene":[398],"tumors":[401,433],"1":[405,437,493],"high":[407,439],"vs.":[409],"0.":[411],"All":[412],"(HLA":[418],"A,":[419],"B,":[420],"C,":[421],"E,":[422],"DQ,":[423],"DM,":[424],"DO,":[425],"DP,":[426],"DQ)":[428],"(p":[441],"<":[442],"0.001).":[443],"Conclusion:":[444],"greater":[446],"early-stage":[458],"cancer,":[461],"chemotherapy":[466],"alone.":[467],"histologic":[469],"integration":[472],"combination":[475],"identified":[484],"or":[499],"had":[501],"High":[509],"expressions":[515],"are":[516],"TLS,":[523],"underscoring":[524],"crucial":[526],"role":[527],"antigen":[529],"presentation":[530],"generation":[533],"effective":[536],"adaptive":[537],"response.":[539],"Support:":[540],"U10":[541,543],"CA180821,":[542],"CA180882,":[544],"U24":[545],"CA196171,":[546],"https://acknowledgments.alliancefound.org;":[547],"Genentech;":[548],"Clinicaltrials.gov":[549],"Id:":[550],"NCT00005970":[551],"Citation":[552],"Format:":[553],"Saranya":[554],"Chumsri,":[555],"Tracy":[556],"Shachner,":[557],"Zhuo":[558],"Li,":[559],"Nadine":[560],"Norton,":[561],"Alvaro":[562],"Moreno-Aspitia,":[563],"Gerardo":[564],"Colon-Otero,":[565],"Edith":[566],"Perez,":[567],"Aziza":[568],"Nassar,":[569],"E.":[570],"Thompson,":[571],"Keith":[572],"Knutson.":[573],"Class":[575],"Expression,":[579],"Functional":[580],"Lymphoid":[582],"Structure":[583],"(TLS),":[584],"Outcomes":[586],"Early-Stage":[588],"HER2-Positive":[589],"(HER2+)":[590],"Breast":[591,605],"Cancer":[592,606,617],"NCCTG":[594],"(Alliance)":[596],"[abstract].":[597],"In:":[598],"Proceedings":[599],"2023":[602,608],"San":[603,611],"Antonio":[604],"Symposium;":[607],"Dec":[609],"5-9;":[610],"Antonio,":[612],"TX.":[613],"Philadelphia":[614],"(PA):":[615],"AACR;":[616],"Res":[618],"2024;84(9":[619],"Suppl):Abstract":[620],"nr":[621],"PO4-25-04.":[622]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-05-03T00:00:00"}