{"id":"https://openalex.org/W4396589702","doi":"https://doi.org/10.1038/s41598-024-60872-3","title":"Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson\u2019s disease biomarker panel","display_name":"Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson\u2019s disease biomarker panel","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396589702","doi":"https://doi.org/10.1038/s41598-024-60872-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/38693432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11063140"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-60872-3","doi":"https://doi.org/10.1038/s41598-024-60872-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-60872-3","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-024-60872-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078728420","display_name":"Kuan\u2010Wei Peng","orcid":"https://orcid.org/0000-0003-1985-9694","observed_orcids":["https://orcid.org/0000-0003-1985-9694"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuan-Wei Peng","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002375815","display_name":"Allison Klotz","orcid":"https://orcid.org/0000-0002-3361-7627","observed_orcids":["https://orcid.org/0000-0002-3361-7627"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Klotz","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039399228","display_name":"Arcan G\u00fcven","orcid":"https://orcid.org/0000-0002-3407-3609","observed_orcids":["https://orcid.org/0000-0002-3407-3609"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arcan Guven","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033179774","display_name":"Unnati Kapadnis","orcid":"https://orcid.org/0009-0005-3692-703X","observed_orcids":["https://orcid.org/0009-0005-3692-703X"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Unnati Kapadnis","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090228421","display_name":"Shobha Ravipaty","orcid":"https://orcid.org/0009-0001-7161-1568","observed_orcids":["https://orcid.org/0009-0001-7161-1568"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobha Ravipaty","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082607061","display_name":"Vladimir Tolstikov","orcid":"https://orcid.org/0000-0002-0445-884X","observed_orcids":["https://orcid.org/0000-0002-0445-884X"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Tolstikov","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074058213","display_name":"Vijetha Vemulapalli","orcid":"https://orcid.org/0009-0005-9460-102X","observed_orcids":["https://orcid.org/0009-0005-9460-102X","https://orcid.org/0000-0001-6247-2167"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijetha Vemulapalli","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057656484","display_name":"Leonardo O. Rodrigues","orcid":"https://orcid.org/0000-0001-8009-5174","observed_orcids":["https://orcid.org/0000-0001-8009-5174"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonardo O. Rodrigues","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455573","display_name":"Hongyan Li","orcid":"https://orcid.org/0000-0001-9006-2499","observed_orcids":["https://orcid.org/0000-0001-9006-2499"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyan Li","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028743743","display_name":"Mark D. Kellogg","orcid":"https://orcid.org/0000-0003-1868-2153","observed_orcids":["https://orcid.org/0000-0003-1868-2153"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D. Kellogg","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","Department of Laboratory Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","Department of Pathology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038787152","display_name":"Farah Kausar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farah Kausar","raw_affiliation_strings":["Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081505748","display_name":"Linda Rees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67391869","display_name":"Neurocrine Biosciences (United States)","ror":"https://ror.org/05d84mm26","country_code":"US","type":"company","lineage":["https://openalex.org/I67391869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Rees","raw_affiliation_strings":["Neurocrine Biosciences, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurocrine Biosciences, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I67391869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074830972","display_name":"Rangaprasad Sarangarajan","orcid":"https://orcid.org/0000-0001-9403-9421","observed_orcids":["https://orcid.org/0000-0001-9403-9421"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rangaprasad Sarangarajan","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112724343","display_name":"Birgitt Sch\u00fcle","orcid":"https://orcid.org/0000-0002-9952-5776","observed_orcids":["https://orcid.org/0000-0002-9952-5776"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Birgitt Sch\u00fcle","raw_affiliation_strings":["Department of Pathology, Stanford School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112208182","display_name":"J. William Langston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Langston","raw_affiliation_strings":["Department of Pathology, Stanford School of Medicine, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035028100","display_name":"Paula P. Narain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Narain","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058081424","display_name":"Niven R. Narain","orcid":"https://orcid.org/0000-0001-6769-1748","observed_orcids":["https://orcid.org/0000-0001-6769-1748"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niven R. Narain","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008685777","display_name":"Michael A. Kiebish","orcid":"https://orcid.org/0000-0002-5678-0072","observed_orcids":["https://orcid.org/0000-0002-5678-0072"]},"institutions":[{"id":"https://openalex.org/I4405267205","display_name":"BPGbio, Inc. (United States)","ror":"https://ror.org/01npdv581","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267205"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Kiebish","raw_affiliation_strings":["BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA. michael.kiebish@bpgbio.com","BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA. michael.kiebish@bpgbio.com","institution_ids":["https://openalex.org/I4405267205"]},{"raw_affiliation_string":"BPGbio, 500 Old Connecticut Path, Framingham, MA, 01701, USA","institution_ids":["https://openalex.org/I4405267205"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008685777"],"corresponding_institution_ids":["https://openalex.org/I4405267205"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":2.8431,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.90885154,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"10036","last_page":"10036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/n-acetylputrescine","display_name":"N-acetylputrescine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/biomarker-panel","display_name":"biomarker panel","score":0.8870000243186951},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/smell-impairment","display_name":"smell impairment","score":0.421999990940094},{"id":"https://openalex.org/keywords/anxiety-and-depression","display_name":"anxiety and depression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/rem-sleep-behavior-disorder","display_name":"REM sleep behavior disorder","score":0.9480000138282776},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7003811597824097},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6987967491149902},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6583784818649292},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6094653606414795},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.512591540813446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4191742241382599},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37700676918029785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.250215083360672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2458459734916687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22357085347175598},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-024-60872-3","doi":"https://doi.org/10.1038/s41598-024-60872-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-60872-3","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2021.07.23.453542","doi":"https://doi.org/10.1101/2021.07.23.453542","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.07.23.453542","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/23/2021.07.23.453542.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11063140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11063140","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11063140/pdf/41598_2024_Article_60872.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38693432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38693432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7ef1ad93078f4891b7305fd1f6d91e67","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7ef1ad93078f4891b7305fd1f6d91e67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-60872-3","doi":"https://doi.org/10.1038/s41598-024-60872-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-60872-3","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396589702.pdf","grobid_xml":"https://content.openalex.org/works/W4396589702.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W62865870","https://openalex.org/W1572230556","https://openalex.org/W1845447069","https://openalex.org/W1920030402","https://openalex.org/W1967111894","https://openalex.org/W1992654016","https://openalex.org/W2010998231","https://openalex.org/W2042988254","https://openalex.org/W2048444499","https://openalex.org/W2077151956","https://openalex.org/W2092509793","https://openalex.org/W2094043851","https://openalex.org/W2110851571","https://openalex.org/W2119841530","https://openalex.org/W2130487306","https://openalex.org/W2139869364","https://openalex.org/W2145954079","https://openalex.org/W2164497502","https://openalex.org/W2166281097","https://openalex.org/W2207405009","https://openalex.org/W2419387266","https://openalex.org/W2469189563","https://openalex.org/W2554162271","https://openalex.org/W2587271278","https://openalex.org/W2592045243","https://openalex.org/W2607011574","https://openalex.org/W2611138580","https://openalex.org/W2741564780","https://openalex.org/W2784734859","https://openalex.org/W2796389302","https://openalex.org/W2888009474","https://openalex.org/W2895530851","https://openalex.org/W2896544753","https://openalex.org/W2909364225","https://openalex.org/W2948899251","https://openalex.org/W2968035162","https://openalex.org/W2972937106","https://openalex.org/W2999501685","https://openalex.org/W3173176443"],"related_works":["https://openalex.org/W4213076694","https://openalex.org/W4214819895","https://openalex.org/W3190923788","https://openalex.org/W4410192135","https://openalex.org/W4402669323","https://openalex.org/W7168754686","https://openalex.org/W4362506627","https://openalex.org/W4387467504","https://openalex.org/W4388922141","https://openalex.org/W3166951515"],"abstract_inverted_index":{"Parkinson's":[0,38,62,84,165],"disease":[1,85,122,173,184],"is":[2],"a":[3,19,30,47],"progressive":[4],"neurodegenerative":[5],"disorder":[6],"in":[7,13,18,95,120,163,182],"which":[8,64],"loss":[9],"of":[10,32,36,61,99,128,135,154,172,179],"dopaminergic":[11],"neurons":[12],"the":[14,59,66,72,146,177],"substantia":[15],"nigra":[16],"results":[17],"clinically":[20],"heterogeneous":[21],"group":[22],"with":[23,29,41,97],"variable":[24],"motor":[25],"and":[26,53,78,87,104,124,139,151,175],"non-motor":[27],"symptoms":[28],"degree":[31],"misdiagnosis.":[33],"Only":[34],"3-25%":[35],"sporadic":[37],"patients":[39,86,123],"present":[40,73],"genetic":[42],"abnormalities":[43],"that":[44],"could":[45],"represent":[46],"risk":[48],"factor,":[49],"thus":[50],"environmental,":[51],"metabolic,":[52],"other":[54],"unknown":[55],"causes":[56],"contribute":[57],"to":[58],"pathogenesis":[60],"disease,":[63,166],"highlights":[65],"critical":[67],"need":[68],"for":[69,168],"biomarkers.":[70],"In":[71],"study,":[74],"we":[75],"prospectively":[76],"collected":[77],"analyzed":[79],"plasma":[80],"samples":[81],"from":[82],"194":[83],"197":[88],"age-matched":[89],"non-diseased":[90],"controls.":[91],"N-acetyl":[92],"putrescine":[93],"(NAP)":[94],"combination":[96],"sense":[98],"smell":[100],"(B-SIT),":[101],"depression/anxiety":[102],"(HADS),":[103],"acting":[105],"out":[106],"dreams":[107],"(RBD1Q)":[108],"clinical":[109,138],"measurements":[110],"demonstrated":[111,142],"combined":[112],"diagnostic":[113,158],"utility.":[114],"NAP":[115,140],"was":[116],"increased":[117],"by":[118],"28%":[119],"Parkinsons":[121],"exhibited":[125],"an":[126,133,143,152,169],"AUC":[127,148],"0.72":[129],"as":[130,132],"well":[131],"OR":[134,153],"4.79.":[136],"The":[137,156],"panel":[141,159],"area":[144],"under":[145],"curve,":[147],"=":[149],"0.9":[150],"20.4.":[155],"assessed":[157],"demonstrates":[160],"combinatorial":[161],"utility":[162],"diagnosing":[164],"allowing":[167],"integrated":[170],"interpretation":[171],"pathophysiology":[174],"highlighting":[176],"use":[178],"multi-tiered":[180],"panels":[181],"neurological":[183],"diagnosis.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-05-03T00:00:00"}
