{"id":"https://openalex.org/W4396587760","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po3-04-03","title":"Abstract PO3-04-03: Drug Holidays in Patients with HER-2 Positive Metastatic Breast Cancer","display_name":"Abstract PO3-04-03: Drug Holidays in Patients with HER-2 Positive Metastatic Breast Cancer","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396587760","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po3-04-03"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-po3-04-03","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po3-04-03","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-04-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026676216","display_name":"Saba Kurtom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saba Kurtom","raw_affiliation_strings":["1University of Pittsburgh,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Pittsburgh,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009784421","display_name":"Kaz\u0131m \u015eenol","orcid":"https://orcid.org/0000-0001-6273-0664","observed_orcids":["https://orcid.org/0000-0001-6273-0664"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kazim Senol","raw_affiliation_strings":["2Uludag University, Medical Faculty, General Surgery, Bursa, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Uludag University, Medical Faculty, General Surgery, Bursa, Turkey,","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092908988","display_name":"Qurat Ul Ain Sabih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qurat Ul Ain Sabih","raw_affiliation_strings":["1University of Pittsburgh,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Pittsburgh,","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021174211","display_name":"Efe Sezg\u0131n","orcid":"https://orcid.org/0000-0002-8000-7485","observed_orcids":["https://orcid.org/0000-0002-8000-7485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Efe Sezgin","raw_affiliation_strings":["3Breast Health Working Group International,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Breast Health Working Group International,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044108002","display_name":"Adam Brufsky","orcid":"https://orcid.org/0000-0001-8080-7960","observed_orcids":["https://orcid.org/0000-0001-8080-7960","https://orcid.org/0009-0006-2725-3579"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Brufsky","raw_affiliation_strings":["4UPMC Hillman Cancer Center, University of Pittsburgh Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4UPMC Hillman Cancer Center, University of Pittsburgh Medical Center,","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109480860","display_name":"Vikram C. Gorantla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Gorantla","raw_affiliation_strings":["5University of Pittsburgh Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Pittsburgh Medical Center,","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113169602","display_name":"Shannon Puhalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Puhalla","raw_affiliation_strings":["6UPMC Hillman Cancer Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UPMC Hillman Cancer Center,","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014469642","display_name":"Atilla Soran","orcid":"https://orcid.org/0000-0002-3398-7230","observed_orcids":["https://orcid.org/0000-0002-3398-7230"]},"institutions":[{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Atilla Soran","raw_affiliation_strings":["7UPMC Department of Surgery, Breast Health Working Group International"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7UPMC Department of Surgery, Breast Health Working Group International","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PO3","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-holidays","display_name":"drug holidays","score":0.9539999961853027},{"id":"https://openalex.org/keywords/her2-positive-metastatic-breast-cancer","display_name":"HER2-positive metastatic breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6790000200271606},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6320000290870667},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.621999979019165},{"id":"https://openalex.org/keywords/estrogen-receptor-status","display_name":"estrogen receptor status","score":0.41600000858306885},{"id":"https://openalex.org/keywords/progesterone-receptor-status","display_name":"progesterone receptor status","score":0.9980000257492065},{"id":"https://openalex.org/keywords/conventional-chemotherapy","display_name":"cytotoxic chemotherapy","score":0.5210000276565552},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.8546212911605835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7936320304870605},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6372634172439575},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5532255172729492},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5401190519332886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5027201175689697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4710618853569031},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14147046208381653}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-po3-04-03","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po3-04-03","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-04-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322774820","https://openalex.org/W4396587506","https://openalex.org/W7129275893","https://openalex.org/W2734334343","https://openalex.org/W1977758857","https://openalex.org/W2060243747","https://openalex.org/W4410455879","https://openalex.org/W4372257387","https://openalex.org/W4411288368","https://openalex.org/W1978986213"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Treatment":[2,24],"of":[3,13,50,69,143,149,161,170,256,280,297,347,365,413,431,443,447,488,503,538,562,606],"HER-2":[4,598],"positive":[5,101],"metastatic":[6,99],"breast":[7,102],"cancer":[8,103],"(MBC)":[9],"involves":[10],"the":[11,67,79,140,159,168,189,262,276,302,314,328,333,337,345,371,379,401,408,424,435,478,521,529,534,607],"use":[12,296],"HER-2-targeted":[14],"therapy":[15,145,253,352,426,540],"in":[16,152,261,275,336,370,507,528,544,595],"combination":[17],"with":[18,98,211,247,251,423,445,468,484,516,552,597],"cytotoxic":[19],"chemotherapy":[20],"and/or":[21],"hormone":[22,171],"therapy.":[23,172],"duration":[25],"for":[26,73,146,205,214,241,320,536],"HER2-targeted":[27,76,155,252],"agents":[28],"is":[29,513],"not":[30,310,388,514],"standardized,":[31],"and":[32,78,84,104,108,163,188,208,219,228,287,305,342,427,455,509,560],"patients":[33,74,94,118,153,246,259,366,414,444],"are":[34,567],"often":[35],"kept":[36],"on":[37,81,125,350],"these":[38,571],"drugs":[39],"indefinitely.":[40],"Drug":[41,593],"holidays":[42,72],"can":[43,53],"be":[44,54],"initiated":[45],"due":[46],"to":[47,58,65,184,195,301,307,331,343,378,451,477,569],"poor":[48],"tolerance":[49],"drug":[51,60,71,130,135,263,339,348,373,380,436,460,480,505,530,554],"or":[52,132,178],"considered":[55],"when":[56],"trying":[57],"limit":[59],"toxicity.":[61],"Our":[62],"study":[63,92],"aims":[64],"determine":[66],"safety":[68],"utilizing":[70],"receiving":[75,154],"therapies":[77],"effect":[80],"overall":[82,465],"survival":[83,109,334,466,526],"disease":[85,396,422,448,453,457],"progression.":[86],"Methods":[87],"Study":[88],"Design":[89],"This":[90,157],"retrospective":[91],"included":[93],"who":[95,367],"were":[96,119,201,222,254,260,368],"diagnosed":[97],"HER2":[100],"had":[105,128,415,420,429,439],"complete":[106],"clinical":[107],"data":[110],"available":[111],"within":[112,327,520],"UPMC":[113],"Magee":[114],"Women\u2019s":[115],"Hospital.":[116],"The":[117,175,199,232,295,395,459],"divided":[120],"into":[121],"two":[122,315,402],"groups":[123,316,403],"based":[124],"whether":[126],"they":[127],"a":[129,147,359,362,440,504],"holiday":[131,136,264,340,349,374,381,410,437,461,481,506,531,555],"not.":[133],"A":[134],"was":[137,182,193,235,271,325,358],"defined":[138],"as":[139,203,209],"temporary":[141],"cessation":[142,169,353,537],"antiHER2":[144,351,539],"minimum":[148],"three":[150],"months":[151],"treatments.":[156],"involved":[158],"discontinuation":[160],"earlier-":[162],"later-line":[164],"medications":[165],"without":[166],"considering":[167],"Statistical":[173],"Analysis":[174,519],"chi-square":[176],"test":[177,181,192],"Fisher's":[179],"exact":[180],"used":[183,194],"compare":[185,196],"categorical":[186,206],"variables":[187,207],"Mann-Whitney":[190],"U":[191],"continuous":[197,215],"variables.":[198,216],"results":[200],"reported":[202],"proportions":[204],"medians":[210],"25th-75th":[212,473,491],"percentiles":[213],"Survival":[217],"rates":[218],"Hazard":[220],"ratios":[221],"estimated":[223],"using":[224],"Kaplan-Meier":[225],"log-rank":[226],"tests":[227],"Cox":[229],"models,":[230],"respectively.":[231],"significance":[233,391],"level":[234],"set":[236],"at":[237],"p":[238],"<":[239,405],"0.05":[240,319],"all":[242,321],"analyses.":[243],"Results":[244],"83":[245],"HER2+":[248,511],"MBC":[249,512],"treated":[250],"identified,":[255],"which":[257],"54":[258],"group.":[265],"Of":[266],"noted":[267],"patient":[268],"variables,":[269],"there":[270],"no":[272,338,372,479,525],"significant":[273],"difference":[274,335,386,527],"tumor":[277],"histology,":[278],"distribution":[279],"estrogen":[281],"receptor":[282,289],"(ER)":[283],"status":[284,291,397],"(p=":[285,494],"0.38)":[286],"progesterone":[288],"(PR)":[290],"(p":[292,317,392,404],"=":[293,393],"0.64).":[294],"hormonotherapy,":[298],"immunotherapy,":[299],"radiotherapy":[300,306],"primary":[303],"tumor,":[304],"metastasis":[308],"did":[309,387],"significantly":[311,399],"differ":[312],"between":[313,400],">":[318],"comparisons).":[322],"Subgroup":[323],"analysis":[324],"conducted":[326],"hormonotherapy":[329,522,543],"subgroup":[330,523],"assess":[332],"group":[341,375,382,438,462,482],"evaluate":[344],"impact":[346],"while":[354,418,541],"continuing":[355,542],"hormonotherapy.":[356],"There":[357],"trend":[360],"towards":[361],"higher":[363,441,464],"proportion":[364,442],"deceased":[369],"(62%)":[376],"compared":[377,450,476],"(42%),":[383],"although":[384],"this":[385,545],"reach":[389],"statistical":[390],"0.16).":[394],"differed":[398],"0.0001).":[406],"In":[407,433],"no-drug":[409],"group,":[411,532],"72%":[412],"progressive":[416,452],"disease,":[417],"20%":[419],"stable":[421,456,508],"anti-HER2":[425],"7%":[428],"no-evidence":[430,446],"disease.":[432],"contrast,":[434],"(48%)":[449],"(38%)":[454],"(14%).":[458],"demonstrated":[463],"(61%":[467],"median":[469,485],"follow-up":[470,486],"1719":[471],"days":[472,490],"percentile:":[474,492],"963-2222)":[475],"(39%":[483],"time":[487],"803":[489],"216-1510)":[493],"0.04).":[495],"Conclusion":[496],"Overall,":[497],"our":[498],"findings":[499],"suggest":[500],"that":[501],"utilization":[502],"NED":[510],"associated":[515],"decreased":[517],"survival.":[518],"indicated":[524],"highlighting":[533],"potential":[535,564],"specific":[546],"subgroup.":[547],"However":[548],"further":[549],"prospective":[550],"studies":[551],"long":[553],"intervals,":[556],"larger":[557],"sample":[558],"size,":[559],"control":[561],"other":[563],"confounding":[565],"factors":[566],"needed":[568],"validate":[570],"results.":[572],"Citation":[573],"Format:":[574],"Saba":[575],"Kurtom,":[576],"Kazim":[577],"Senol,":[578],"Qurat":[579],"Ul":[580],"Ain":[581],"Sabih,":[582],"Efe":[583],"Sezgin,":[584],"Adam":[585],"Brufsky,":[586],"Vikram":[587],"Gorantla,":[588],"Shannon":[589],"Puhalla,":[590],"Atilla":[591],"Soran.":[592],"Holidays":[594],"Patients":[596],"Positive":[599],"Metastatic":[600],"Breast":[601,611],"Cancer":[602,612,623],"[abstract].":[603],"In:":[604],"Proceedings":[605],"2023":[608,614],"San":[609,617],"Antonio":[610],"Symposium;":[613],"Dec":[615],"5-9;":[616],"Antonio,":[618],"TX.":[619],"Philadelphia":[620],"(PA):":[621],"AACR;":[622],"Res":[624],"2024;84(9":[625],"Suppl):Abstract":[626],"nr":[627],"PO3-04-03.":[628]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-05-03T00:00:00"}
