{"id":"https://openalex.org/W4396587112","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-19-08","title":"Abstract PO5-19-08: Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial","display_name":"Abstract PO5-19-08: Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396587112","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-19-08"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-po5-19-08","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-19-08","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-19-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007002927","display_name":"Heather L. McArthur","orcid":"https://orcid.org/0000-0002-0201-3871","observed_orcids":["https://orcid.org/0000-0002-0201-3871"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather McArthur","raw_affiliation_strings":["1UT Southwestern, Dallas, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Southwestern, Dallas, Texas, United States;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042082543","display_name":"Jorge Henrique Santos Leal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Henrique Santos Leal","raw_affiliation_strings":["2Oncocl\u00ednicas, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Oncocl\u00ednicas, Brazil;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027836515","display_name":"Isaac S. Chan","orcid":"https://orcid.org/0000-0003-2623-3163","observed_orcids":["https://orcid.org/0000-0003-2623-3163"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac Chan","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061962242","display_name":"Nisha G Unni","orcid":"https://orcid.org/0000-0003-1549-4720","observed_orcids":["https://orcid.org/0000-0003-1549-4720"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nisha Unni","raw_affiliation_strings":["4University of Texas Southwestern Medical Center, Dallas, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Texas Southwestern Medical Center, Dallas, Texas, United States;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063600668","display_name":"Stephen Lawrence Shiao","orcid":"https://orcid.org/0000-0001-7586-2885","observed_orcids":["https://orcid.org/0000-0001-7586-2885"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Shiao","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029534019","display_name":"Joshua James Gruber","orcid":"https://orcid.org/0000-0002-8642-6074","observed_orcids":["https://orcid.org/0000-0002-8642-6074"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Gruber","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065222917","display_name":"Samira K. Syed","orcid":"https://orcid.org/0000-0002-4645-7749","observed_orcids":["https://orcid.org/0000-0002-4645-7749"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samira Syed","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014371234","display_name":"Namrata Peswani","orcid":"https://orcid.org/0009-0006-5918-1805","observed_orcids":["https://orcid.org/0009-0006-5918-1805"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Namrata Peswani","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008905848","display_name":"Navid Sadeghi","orcid":"https://orcid.org/0000-0002-7786-8786","observed_orcids":["https://orcid.org/0000-0002-7786-8786"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navid Sadeghi","raw_affiliation_strings":["4University of Texas Southwestern Medical Center, Dallas, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Texas Southwestern Medical Center, Dallas, Texas, United States;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081394817","display_name":"Glenda Maria Delgado Ramos","orcid":"https://orcid.org/0000-0002-7439-4415","observed_orcids":["https://orcid.org/0000-0002-7439-4415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenda Delgado","raw_affiliation_strings":["6UTSW;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UTSW;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050743837","display_name":"Dawn Klemow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Klemow","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039500399","display_name":"Reva Kakkar Basho","orcid":"https://orcid.org/0000-0002-4132-7523","observed_orcids":["https://orcid.org/0000-0002-4132-7523"]},"institutions":[{"id":"https://openalex.org/I4405253461","display_name":"Ellison Medical Institute","ror":"https://ror.org/00pfj7a95","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405253461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reva Basho","raw_affiliation_strings":["7The Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, USA, Los Angeles, California, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7The Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, USA, Los Angeles, California, United States;","institution_ids":["https://openalex.org/I4405253461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006071406","display_name":"Meredith Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Carter","raw_affiliation_strings":["3University of Texas Southwestern Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas Southwestern Medical Center;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111187039","display_name":"Mai Badran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mai Badran","raw_affiliation_strings":["6UTSW;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UTSW;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081724500","display_name":"Nasir Qureshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nasir Qureshi","raw_affiliation_strings":["8UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER SIMMONS CANCER CENTER, Dallas, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER SIMMONS CANCER CENTER, Dallas, Texas, United States;","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107398652","display_name":"Jessica Curtin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Curtin","raw_affiliation_strings":["6UTSW;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UTSW;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joshua Weese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Weese","raw_affiliation_strings":["6UTSW;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UTSW;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Rice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111451","display_name":"Oncotherapeutics (United States)","ror":"https://ror.org/01s33dn56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Rice","raw_affiliation_strings":["9Oncotherapeutics;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Oncotherapeutics;","institution_ids":["https://openalex.org/I4210111451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033380289","display_name":"Michelle Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Phillips","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075070960","display_name":"David W. Chan","orcid":"https://orcid.org/0000-0002-6951-3467","observed_orcids":["https://orcid.org/0000-0002-6951-3467"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Chan","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061205710","display_name":"Hugo Hool","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo Hool","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022029940","display_name":"Dorothy J. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy Park","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062700636","display_name":"Mary El-Masry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary El-Masry","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109576591","display_name":"Philomena F. McAndrew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philomena McAndrew","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052786666","display_name":"Swati Sikaria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati Sikaria","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018738915","display_name":"Laura M. Spring","orcid":"https://orcid.org/0000-0001-8904-3514","observed_orcids":["https://orcid.org/0000-0001-8904-3514"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Spring","raw_affiliation_strings":["10Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":["10Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030308961","display_name":"Mourad Tighiouart","orcid":"https://orcid.org/0000-0001-8021-5690","observed_orcids":["https://orcid.org/0000-0001-8021-5690"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mourad Tighiouart","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035442509","display_name":"Farnaz Dadmanesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farnaz Dadmanesh","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109315401","display_name":"Armando E. Giuliano","orcid":"https://orcid.org/0000-0002-5421-945X","observed_orcids":["https://orcid.org/0000-0002-5421-945X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armando Giuliano","raw_affiliation_strings":["5Cedars-Sinai Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Cedars-Sinai Medical Center;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112703495","display_name":"Katherine G. Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141130","display_name":"New Mexico Cancer Center","ror":"https://ror.org/03emyr182","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210141130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Sanchez","raw_affiliation_strings":["11New Mexico Cancer Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11New Mexico Cancer Center;","institution_ids":["https://openalex.org/I4210141130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107857731","display_name":"David L. Page","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Page","raw_affiliation_strings":["12Robert W. Franz Cancer Research Center and Alliance, Portland, Oregon, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Robert W. Franz Cancer Research Center and Alliance, Portland, Oregon, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PO5","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9660000205039978},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":0.9879999756813049},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9259999990463257},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9380000233650208},{"id":"https://openalex.org/keywords/axillary-lymph-node-response","display_name":"axillary lymph node response","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5410000085830688},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.5640000104904175},{"id":"https://openalex.org/keywords/tumor-infiltrating-neutrophils","display_name":"tumor-infiltrating neutrophils","score":0.5820000171661377},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.5709999799728394},{"id":"https://openalex.org/keywords/tumor-infiltrating-b-cells","display_name":"tumor-infiltrating B cells","score":0.5910000205039978},{"id":"https://openalex.org/keywords/tumor-infiltrating-treg-cells","display_name":"tumor-infiltrating Treg cells","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.8974666595458984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7842569351196289},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.6214033961296082},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5757359266281128},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4998176097869873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49604758620262146},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.47667932510375977},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4365845322608948},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4259323477745056},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.30186164379119873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27371692657470703}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-po5-19-08","doi":"https://doi.org/10.1158/1538-7445.sabcs23-po5-19-08","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-19-08","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322771612","https://openalex.org/W4249577962","https://openalex.org/W2978186977","https://openalex.org/W4411289485","https://openalex.org/W4379284129","https://openalex.org/W2944776474","https://openalex.org/W3013417770","https://openalex.org/W1982825879","https://openalex.org/W4220919149","https://openalex.org/W3083171953"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Immune":[2],"checkpoint":[3],"inhibition":[4],"(ICI)":[5],"is":[6,263,288],"synergistic":[7],"with":[8,21,83,93,123,244,417],"HER2-directed":[9,19],"therapy":[10,20],"in":[11,30,47,56,294],"pre-clinical":[12],"models.":[13],"Clinically,":[14],"pembrolizumab":[15],"(K)-mediated":[16],"ICI":[17,38],"plus":[18,95,198],"trastuzumab":[22],"(H)":[23],"was":[24,228,235],"safe":[25],"and":[26,53,71,81,108,134,143,167,182,230,251,297,309,323],"demonstrated":[27],"modest":[28],"activity":[29,43],"H-resistant":[31],"HER2-positive":[32],"(HER2+)":[33],"metastatic":[34],"breast":[35,129,296,318],"cancer.":[36],"Because":[37],"may":[39,61,86],"confer":[40,67],"more":[41],"robust":[42],"when":[44],"administered":[45,55],"earlier":[46],"the":[48,57,77,88,106,240,267,276,295,431],"course":[49],"of":[50,65,79,110,217,259,335,430],"disease,":[51],"H":[52,80,94,162],"K":[54,82,199],"curative-intent,":[58],"treatment-naive":[59],"setting":[60],"allow":[62],"for":[63,90,159],"de-escalation":[64],"cytotoxics;":[66],"life-long,":[68],"tumor-specific":[69],"immunity;":[70],"ultimately,":[72],"improve":[73],"cure":[74],"rates.":[75],"Moreover,":[76],"synergy":[78],"paclitaxel":[84],"(T)":[85],"overcome":[87],"need":[89],"dual":[91],"HER2-blockade":[92],"pertuzumab":[96],"(P).":[97],"In":[98,150,192,209],"this":[99,233],"randomized,":[100],"multicenter,":[101],"phase":[102],"II,":[103],"open-label":[104],"trial":[105],"efficacy":[107,226,336],"safety":[109,322],"neoadjuvant":[111],"THP":[112,197],"vs":[113,115],"THP-K":[114],"TH-K":[116],"are":[117,131,273],"explored.":[118],"Methods:":[119],"Patients":[120],"(pts)":[121],"\u226518y":[122],"previously":[124],"untreated,":[125],"stage":[126],"II-III,":[127],"HER2+":[128],"cancer":[130,312],"being":[132],"randomized":[133],"stratified":[135],"by":[136,307],"clinical":[137,282],"nodal":[138],"status":[139,146],"(positive":[140,147],"vs.":[141,148],"negative)":[142],"hormone":[144],"receptor":[145],"negative).":[149],"arm":[151,193,210,221,234,249,256],"A,":[152],"pts":[153,195,212,219,246,253,272],"receive":[154,196,213],"T":[155],"at":[156,163,177,200],"80mg/m2":[157],"weekly":[158],"12":[160],"weeks,":[161],"8mg/Kg":[164],"(loading":[165,180],"dose)":[166,181],"then":[168,183],"6mg/Kg":[169],"every":[170,185,202],"3":[171,174,186,189,203],"weeks":[172,187,204,265],"x":[173,188,205],"doses,":[175],"P":[176],"840":[178],"mg":[179],"420mg/Kg":[184],"doses":[190,207],"(THP).":[191],"B,":[194],"200mg":[201],"4":[206],"(THP-K).":[208],"C,":[211,222],"TH-K.":[214],"After":[215,270],"enrollment":[216,231],"22":[218],"to":[220,232,239,248,255],"a":[223],"prespecified":[224],"interim":[225],"analysis":[227],"conducted,":[229],"subsequently":[236],"terminated.":[237],"Enrollment":[238],"other":[241],"arms":[242],"continues":[243],"32/58":[245],"enrolled":[247,254],"A":[250],"33/58":[252],"B":[257],"as":[258],"2/14/2023.":[260],"Definitive":[261],"surgery":[262,320],"3-6":[264],"after":[266],"last":[268],"dose.":[269],"surgery,":[271],"treated":[274],"per":[275,280],"treating":[277],"physician\u2019s":[278],"discretion":[279],"local":[281],"standard.":[283],"The":[284],"primary":[285],"end":[286,302],"point":[287],"pathologic":[289],"complete":[290],"response":[291],"(pCR)":[292],"rate":[293,306],"axilla":[298],"(ypT0/Tis":[299],"ypN0).":[300],"Secondary":[301],"points":[303],"include":[304],"pCR":[305],"ypT0ypN0":[308],"ypT0/Tis,":[310],"residual":[311],"burden":[313],"index,":[314],"event":[315],"free":[316],"survival,":[317],"conserving":[319],"rate,":[321],"overall":[324],"survival.":[325],"Exploratory":[326],"correlative":[327],"studies":[328],"will":[329],"characterize":[330],"potential":[331],"immune":[332],"biomarkers":[333],"predictive":[334],"and/or":[337],"toxicity.":[338],"Funding":[339],"sources:":[340],"BCRF,":[341],"Merck":[342],"NCT03747120":[343],"Citation":[344],"Format:":[345],"Heather":[346],"McArthur,":[347],"Jorge":[348],"Henrique":[349],"Santos":[350],"Leal,":[351],"Isaac":[352],"Chan,":[353,387],"Nisha":[354],"Unni,":[355],"Stephen":[356],"Shiao,":[357],"Joshua":[358,380],"Gruber,":[359],"Samira":[360],"Syed,":[361],"Namrata":[362],"Peswani,":[363],"Navid":[364],"Sadeghi,":[365],"Glenda":[366],"Delgado,":[367],"Dawn":[368],"Klemow,":[369],"Reva":[370],"Basho,":[371],"Meredith":[372],"Carter,":[373],"Mai":[374],"Badran,":[375],"Nasir":[376],"Qureshi,":[377],"Jessica":[378],"Curtin,":[379],"Weese,":[381],"Stephanie":[382],"Rice,":[383],"Michelle":[384],"Phillips,":[385],"David":[386,410],"Hugo":[388],"Hool,":[389],"Dorothy":[390],"Park,":[391],"Mary":[392],"El-Masry,":[393],"Philomena":[394],"McAndrew,":[395],"Swati":[396],"Sikaria,":[397],"Laura":[398],"Spring,":[399],"Aditya":[400],"Bardia,":[401],"Mourad":[402],"Tighiouart,":[403],"Farnaz":[404],"Dadmanesh,":[405],"Armando":[406],"Giuliano,":[407],"Katherine":[408],"Sanchez,":[409],"Page.":[411],"Neoadjuvant":[412],"HER2-targeted":[413],"Therapy":[414],"+/-":[415],"Immunotherapy":[416],"Pembrolizumab":[418],"(neoHIP):":[419],"An":[420],"Open":[421],"Label":[422],"Randomized":[423],"Phase":[424],"II":[425],"Trial":[426],"[abstract].":[427],"In:":[428],"Proceedings":[429],"2023":[432,438],"San":[433,441],"Antonio":[434],"Breast":[435],"Cancer":[436,447],"Symposium;":[437],"Dec":[439],"5-9;":[440],"Antonio,":[442],"TX.":[443],"Philadelphia":[444],"(PA):":[445],"AACR;":[446],"Res":[448],"2024;84(9":[449],"Suppl):Abstract":[450],"nr":[451],"PO5-19-08.":[452]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-05-03T00:00:00"}