{"id":"https://openalex.org/W4396586805","doi":"https://doi.org/10.1158/1538-7445.sabcs23-ps18-01","title":"Abstract PS18-01: Stage Advancement and The Rate of Growth Associated with Preoperative Delay in Patients Having Breast Cancer","display_name":"Abstract PS18-01: Stage Advancement and The Rate of Growth Associated with Preoperative Delay in Patients Having Breast Cancer","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396586805","doi":"https://doi.org/10.1158/1538-7445.sabcs23-ps18-01"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs23-ps18-01","doi":"https://doi.org/10.1158/1538-7445.sabcs23-ps18-01","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-ps18-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045210326","display_name":"Richard J. Bleicher","orcid":"https://orcid.org/0000-0001-7343-932X","observed_orcids":["https://orcid.org/0000-0001-7343-932X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Bleicher","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112414330","display_name":"Karen J Ruth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Ruth","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091821771","display_name":"Austin David Williams","orcid":"https://orcid.org/0000-0002-2299-3061","observed_orcids":["https://orcid.org/0000-0002-2299-3061"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Williams","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048218662","display_name":"Eric A. Ross","orcid":"https://orcid.org/0000-0002-0890-2418","observed_orcids":["https://orcid.org/0000-0002-0890-2418"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Ross","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083166466","display_name":"Andrea S. Porpiglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Porpiglia","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046754494","display_name":"Allison A. Aggon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Aggon","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006443362","display_name":"Mary T. Pronovost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Pronovost","raw_affiliation_strings":["2Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States;","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076423491","display_name":"Dennis Ricky Holmes","orcid":"https://orcid.org/0000-0002-8336-244X","observed_orcids":["https://orcid.org/0000-0002-8336-244X"]},"institutions":[{"id":"https://openalex.org/I4210131228","display_name":"Adventist Health Glendale","ror":"https://ror.org/03kr0f697","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210131228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Holmes","raw_affiliation_strings":["3Adventist Health Glendale, Glendale, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Adventist Health Glendale, Glendale, CA, United States","institution_ids":["https://openalex.org/I4210131228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"9_Supplement","first_page":"PS18","last_page":"01"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7397000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7397000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/preoperative-delay","display_name":"preoperative delay","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-upstaging","display_name":"tumor upstaging","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nodal-upstaging","display_name":"nodal upstaging","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.8930000066757202},{"id":"https://openalex.org/keywords/clinical-staging-accuracy","display_name":"clinical staging accuracy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/pathological-staging","display_name":"pathological staging","score":0.6190000176429749},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.8460000157356262},{"id":"https://openalex.org/keywords/time-to-surgery","display_name":"time to surgery","score":0.5770000219345093},{"id":"https://openalex.org/keywords/stage-at-diagnosis","display_name":"stage at diagnosis","score":0.4020000100135803},{"id":"https://openalex.org/keywords/national-cancer-database","display_name":"National Cancer Database","score":0.5989999771118164},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.5820000171661377},{"id":"https://openalex.org/keywords/axillary-staging","display_name":"axillary staging","score":0.4950000047683716},{"id":"https://openalex.org/keywords/timing-of-adjuvant-therapy","display_name":"adjuvant therapy timing","score":0.4230000078678131},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.48899999260902405},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8790000081062317},{"id":"https://openalex.org/keywords/health-disparities","display_name":"health disparities","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.770618736743927},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6793135404586792},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6490113735198975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6177126169204712},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4159456491470337},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.36365681886672974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34985828399658203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04547092318534851},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs23-ps18-01","doi":"https://doi.org/10.1158/1538-7445.sabcs23-ps18-01","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs23-ps18-01","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412596668","https://openalex.org/W3139075357","https://openalex.org/W2030343386","https://openalex.org/W2186493186","https://openalex.org/W2973026232","https://openalex.org/W2885361478","https://openalex.org/W3047268691","https://openalex.org/W1494695685","https://openalex.org/W2061714531","https://openalex.org/W3125066266"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"For":[2,238,318,360],"every":[3,319,428],"delay":[4,58,146,253,323,497],"interval":[5,402],"between":[6,51,115,144,270,324],"breast":[7,107,545,555],"cancer":[8,49,108,148,546],"diagnosis":[9,52,271,325],"and":[10,26,53,55,81,117,136,147,198,213,232,272,284,308,326,351,372,382,443,457,478,491,512,558,586],"surgery":[11,111,273,295],"we":[12],"have":[13],"previously":[14],"found":[15,498],"a":[16,400,473,506],"relative":[17],"decline":[18],"in":[19,121,194,369,476,499,595],"disease-specific":[20,490],"survival":[21,28],"of":[22,29,48,66,170,188,248,292,300,303,306,310,322,394,403,421,431,435,480,510,544,589,603],"26%":[23],"(60":[24],"d)":[25],"overall":[27,492],"9-10%":[30],"(30":[31],"d).":[32],"There":[33],"is,":[34],"however,":[35],"little":[36,75],"explanation":[37],"for":[38,142,223,330,334,338,345,353,367,417,427,438,464],"this.":[39],"In":[40,289,391],"our":[41],"experience,":[42],"patients":[43,239,293,398,412],"focus":[44],"on":[45,251],"the":[46,122,127,133,267,290,328,363,392,488,527,604],"likelihood":[47,479,509],"growth":[50,193,261,514],"surgery,":[54,327],"whether":[56],"preoperative":[57,145,252,496,531,550],"might":[59],"lead":[60],"to":[61,95,131,156,160,181,256,409,419,448,529,541],"upstaging,":[62,149,332],"with":[63,219,240,279,399,472,495,592],"nodal":[64,287],"status":[65],"particular":[67],"concern":[68],"when":[69,462],"they":[70,563],"are":[71,470],"clinically":[72,395],"node-negative.":[73],"With":[74,502],"published":[76],"data":[77,85,540],"about":[78,552],"delay-associated":[79,508],"upstaging":[80,368,418,477,511,560],"no":[82,206],"large-scale":[83],"national":[84,129],"determining":[86],"how":[87,553],"fast":[88,554],"tumors":[89,200,312,355,447,504,556],"grow,":[90],"this":[91],"study":[92],"was":[93,173,274,296,452],"performed":[94,297],"determine":[96],"these":[97],"rates.":[98,262],"Methods:":[99],"Patients":[100,139,596],"\u226518":[101],"years":[102],"old":[103],"having":[104,281,286,505],"stage":[105,167,466],"0-III":[106],"who":[109],"received":[110],"as":[112,151,203,520],"first":[113],"treatment":[114],"2010":[116],"2020":[118],"were":[119,140,201,217,254,313,336,375,407],"reviewed":[120,141],"National":[123],"Cancer":[124,599,609,620],"Database":[125],"(NCDB),":[126],"largest":[128],"dataset":[130],"contain":[132],"needed":[134],"clinical":[135,166,171,177,233,465],"pathologic":[137,182,209],"staging.":[138],"correlation":[143],"defined":[150],"an":[152,414],"increase":[153,475],"from":[154],"cT":[155],"pT":[157],"or":[158,235],"cN":[159],"pN":[161],"stages,":[162],"after":[163],"assessing":[164],"baseline":[165],"inaccuracy.":[168],"Accuracy":[169],"staging":[172],"determined":[174],"by":[175,533],"comparing":[176],"stages":[178,183],"at":[179,184,483],"presentation":[180],"surgeries":[185],"\u226415":[186,298,404],"days":[187,276,299,321,430],"diagnosis,":[189,301],"assuming":[190],"negligible":[191],"tumor":[192,249,260,331,521],"that":[195],"period.":[196],"cN3":[197],"cT3":[199],"excluded":[202],"there":[204],"is":[205],"higher":[207,489,507],"size-dependent":[208],"stage.":[210,237],"Upstaging":[211],"probabilities":[212],"odds":[214],"ratios":[215],"(ORs)":[216],"estimated":[218],"logistic":[220],"regression,":[221],"adjusted":[222,244,333,364,415],"age,":[224],"race,":[225],"Hispanic":[226],"ethnicity,":[227],"gender,":[228],"histology,":[229],"grade,":[230],"phenotype,":[231],"T":[234],"N":[236],"delays":[241,469,516,532],">15":[242],"days,":[243,405],"linear":[245],"regression":[246],"coefficients":[247],"size":[250,522],"used":[255],"estimate":[257],"primary":[258,282,446],"invasive":[259,361,445],"Results:":[263],"Among":[264],"1,040,197":[265],"patients,":[266],"median":[268],"time":[269],"34":[275],"(IQR":[277],"23-49),":[278],"11.6%":[280],"tumoral":[283],"14.6%":[285],"upstaging.":[288],"10.2%":[291],"where":[294],"13.9%":[302],"DCIS,":[304],"11.5%":[305],"cT1,":[307],"4.5%":[309],"cT2":[311,354,444],"upstaged":[314,408],"(p":[315],"<":[316,389],"0.0001).":[317,359,390],"30":[320,429],"ORs":[329,366],"covariates,":[335],"1.09":[337],"DCIS":[339],"(95%CI":[340,347,356,377,380,384,423],"1.07-1.10,":[341],"p<":[342,349,358,425],"0.0001),":[343,350],"1.12":[344,376],"cT1":[346],"1.10-1.14,":[348],"1.16":[352],"1.14-1.19,":[357],"tumors,":[362],"30-d":[365,436],"HR+,":[370],"HER2+,":[371],"TN":[373],"primaries":[374],"1.11-1.14),":[378],"1.11":[379],"1.07-1.15),":[381],"1.19":[383],"1.15-1.23),":[385],"respectively":[386],"(individual":[387],"p\u2019s":[388],"9.8%":[393],"N0":[396],"(cN0)":[397],"diagnosis-to-surgery":[401],"14.2%":[406],"node-positive.":[410],"cN0":[411],"had":[413],"OR":[416],"node-positive":[420,482],"1.06":[422],"1.05-1.07,":[424],"0.0001)":[426],"delay.":[432],"The":[433,587],"number":[434],"intervals":[437],"cT1mi,":[439],"cT1a,":[440],"cT1b,":[441],"cT1c":[442],"grow":[449,557],"1":[450],"mm":[451],"7.8,":[453],"7.1,":[454],"3.9,":[455],"2.8,":[456],"2.0,":[458],"respectively.":[459],"Conclusions:":[460],"Even":[461],"accounting":[463],"inaccuracy,":[467],"longer":[468],"associated":[471,494],"quantifiable":[474],"becoming":[481],"surgery.":[484],"This":[485,524],"may":[486],"explain":[487],"mortality":[493],"prior":[500],"studies.":[501],"larger":[503],"faster":[513],"rates,":[515],"become":[517],"more":[518],"problematic":[519],"increases.":[523],"information":[525],"reinforces":[526],"need":[528],"minimize":[530],"demonstrating":[534],"their":[535,559],"consequences.":[536],"It":[537],"also":[538],"provides":[539],"address":[542],"some":[543],"patients\u2019":[547],"most":[548],"pressing":[549],"concerns":[551],"potentials":[561],"while":[562],"await":[564],"treatment.":[565],"Citation":[566],"Format:":[567],"Richard":[568],"Bleicher,":[569],"Karen":[570],"Ruth,":[571],"Austin":[572],"Williams,":[573],"Eric":[574],"Ross,":[575],"Andrea":[576],"Porpiglia,":[577],"Allison":[578],"Aggon,":[579],"Mary":[580],"Pronovost,":[581],"Dennis":[582],"Holmes.":[583],"Stage":[584],"Advancement":[585],"Rate":[588],"Growth":[590],"Associated":[591],"Preoperative":[593],"Delay":[594],"Having":[597],"Breast":[598,608],"[abstract].":[600],"In:":[601],"Proceedings":[602],"2023":[605,611],"San":[606,614],"Antonio":[607],"Symposium;":[610],"Dec":[612],"5-9;":[613],"Antonio,":[615],"TX.":[616],"Philadelphia":[617],"(PA):":[618],"AACR;":[619],"Res":[621],"2024;84(9":[622],"Suppl):Abstract":[623],"nr":[624],"PS18-01.":[625]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-03T00:00:00"}
