{"id":"https://openalex.org/W4396578477","doi":"https://doi.org/10.1158/2767-9764.25738383","title":"Figure S1 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression","display_name":"Figure S1 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression","publication_year":2024,"publication_date":"2024-05-02","ids":{"openalex":"https://openalex.org/W4396578477","doi":"https://doi.org/10.1158/2767-9764.25738383"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.25738383","doi":"https://doi.org/10.1158/2767-9764.25738383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25738383","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.25738383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000763228","display_name":"Naveen Kumar Tangudu","orcid":"https://orcid.org/0000-0001-9153-5825","observed_orcids":["https://orcid.org/0000-0001-9153-5825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naveen Kumar Tangudu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9153-5825","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059449652","display_name":"Raquel Buj","orcid":"https://orcid.org/0000-0002-8355-6666","observed_orcids":["https://orcid.org/0000-0002-8355-6666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raquel Buj","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8355-6666","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524803","display_name":"Hui Wang","orcid":"https://orcid.org/0009-0006-1418-4658","observed_orcids":["https://orcid.org/0009-0006-1418-4658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1418-4658","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038541421","display_name":"Jiefei Wang","orcid":"https://orcid.org/0000-0002-8500-1197","observed_orcids":["https://orcid.org/0000-0002-8500-1197","https://orcid.org/0000-0002-2709-5332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiefei Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8500-1197","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049047003","display_name":"Aidan R. Cole","orcid":"https://orcid.org/0000-0001-9647-0848","observed_orcids":["https://orcid.org/0000-0001-9647-0848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aidan R. Cole","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9647-0848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045881922","display_name":"Apoorva Uboveja","orcid":"https://orcid.org/0000-0002-8037-9676","observed_orcids":["https://orcid.org/0000-0002-8037-9676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Apoorva Uboveja","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8037-9676","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021684499","display_name":"Richard S. Fang","orcid":"https://orcid.org/0009-0001-9559-9735","observed_orcids":["https://orcid.org/0009-0001-9559-9735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Fang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-9559-9735","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009406861","display_name":"Amandine Amalric","orcid":"https://orcid.org/0000-0002-2856-1446","observed_orcids":["https://orcid.org/0000-0002-2856-1446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amandine Amalric","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2856-1446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065276857","display_name":"Baixue Yang","orcid":"https://orcid.org/0009-0008-0333-5144","observed_orcids":["https://orcid.org/0009-0008-0333-5144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baixue Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-0333-5144","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069471737","display_name":"Adam G. Chatoff","orcid":"https://orcid.org/0000-0002-7954-9527","observed_orcids":["https://orcid.org/0000-0002-7954-9527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Chatoff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7954-9527","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095737720","display_name":"Claudia Veronica Da Silva Crispim","orcid":"https://orcid.org/0000-0003-3422-1568","observed_orcids":["https://orcid.org/0000-0003-3422-1568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia V. Crispim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3422-1568","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000778757","display_name":"Peter Sajjakulnukit","orcid":"https://orcid.org/0000-0002-8556-7481","observed_orcids":["https://orcid.org/0000-0002-8556-7481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Sajjakulnukit","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8556-7481","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021877193","display_name":"Maureen A. Lyons","orcid":"https://orcid.org/0009-0002-9070-9445","observed_orcids":["https://orcid.org/0009-0002-9070-9445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maureen A. Lyons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-9070-9445","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085410951","display_name":"Kristine L. Cooper","orcid":"https://orcid.org/0000-0002-8172-1648","observed_orcids":["https://orcid.org/0000-0002-8172-1648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristine Cooper","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8172-1648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024845751","display_name":"Nadine Hempel","orcid":"https://orcid.org/0000-0002-5574-8783","observed_orcids":["https://orcid.org/0000-0002-5574-8783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadine Hempel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5574-8783","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085494535","display_name":"Costas Andreas Lyssiotis","orcid":"https://orcid.org/0000-0001-9309-6141","observed_orcids":["https://orcid.org/0000-0001-9309-6141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Costas A. Lyssiotis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9309-6141","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004781857","display_name":"Uma R. Chandran","orcid":"https://orcid.org/0000-0002-0817-9880","observed_orcids":["https://orcid.org/0000-0002-0817-9880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uma R. Chandran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0817-9880","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068779075","display_name":"Nathaniel W. Snyder","orcid":"https://orcid.org/0000-0001-5643-8747","observed_orcids":["https://orcid.org/0000-0001-5643-8747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathaniel W. Snyder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5643-8747","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050786653","display_name":"Katherine M. Aird","orcid":"https://orcid.org/0000-0002-5828-2325","observed_orcids":["https://orcid.org/0000-0002-5828-2325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine M. Aird","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5828-2325","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.871999979019165},{"id":"https://openalex.org/keywords/cancer-dependency-map","display_name":"DepMap","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.5823226571083069},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.4772886335849762},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4719856381416321},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.46903976798057556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43462955951690674},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4339955449104309},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.42796558141708374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37173712253570557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24172478914260864},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11808869242668152},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09729698300361633},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2767-9764.25738383","doi":"https://doi.org/10.1158/2767-9764.25738383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25738383","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.25738383.v1","doi":"https://doi.org/10.1158/2767-9764.25738383.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/2767-9764.25738383.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25738383","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figure_S1_from_i_De_Novo_i_Purine_Metabolism_is_a_Metabolic_Vulnerability_of_Cancers_with_Low_p16_Expression/25738383","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.25738383","doi":"https://doi.org/10.1158/2767-9764.25738383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25738383","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396578478","https://openalex.org/W4396578301","https://openalex.org/W4396578397","https://openalex.org/W4396578403","https://openalex.org/W4394857104","https://openalex.org/W4396578455","https://openalex.org/W4396578316","https://openalex.org/W4396578479","https://openalex.org/W4396578452","https://openalex.org/W4396578525"],"abstract_inverted_index":{"Knockdown":[0],"of":[1],"p16":[2],"or":[3],"Cdkn2a":[4],"in":[5],"human":[6],"and":[7,13],"mouse":[8],"melanoma":[9],"cell":[10],"lines,":[11],"respectively,":[12],"DepMap":[14],"dependency":[15],"score":[16],"data":[17],"based":[18],"on":[19],"CDKN2A":[20],"expression.":[21],"Related":[22],"to":[23],"Figure":[24],"1.":[25]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-03T00:00:00"}
