{"id":"https://openalex.org/W4396571069","doi":"https://doi.org/10.1016/j.celrep.2024.114172","title":"Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity","display_name":"Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396571069","doi":"https://doi.org/10.1016/j.celrep.2024.114172","pmid":"https://pubmed.ncbi.nlm.nih.gov/38703366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11450637"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2024.114172","doi":"https://doi.org/10.1016/j.celrep.2024.114172","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2024.114172","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2024.114172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101693711","display_name":"Mingxuan Wang","orcid":"https://orcid.org/0000-0002-1107-4035","observed_orcids":["https://orcid.org/0000-0002-1107-4035"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingxuan Wang","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008991970","display_name":"Peter Jendrichovsky","orcid":"https://orcid.org/0000-0003-1761-161X","observed_orcids":["https://orcid.org/0000-0003-1761-161X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Jendrichovsky","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035148429","display_name":"Patrick O. Kanold","orcid":"https://orcid.org/0000-0002-7529-5435","observed_orcids":["https://orcid.org/0000-0002-7529-5435"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick O. Kanold","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: pkanold@jhmi.edu"],"raw_orcid":"https://orcid.org/0000-0002-7529-5435","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: pkanold@jhmi.edu","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035148429"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":5460,"currency":"USD","value_usd":5460},"apc_paid":{"value":5460,"currency":"USD","value_usd":5460},"fwci":0.7263,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64761326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"43","issue":"5","first_page":"114172","last_page":"114172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auditory-cortex","display_name":"auditory cortex","score":0.8579999804496765},{"id":"https://openalex.org/keywords/auditory-discrimination-learning","display_name":"auditory discrimination learning","score":0.9160000085830688},{"id":"https://openalex.org/keywords/primary-auditory-cortex","display_name":"primary auditory cortex","score":0.7350000143051147},{"id":"https://openalex.org/keywords/neural-representation","display_name":"neural representations","score":0.6610000133514404},{"id":"https://openalex.org/keywords/wide-field-calcium-imaging","display_name":"wide-field calcium imaging","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mouse-auditory-cortex","display_name":"mouse auditory cortex","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tone-discrimination","display_name":"tone discrimination","score":0.5019999742507935},{"id":"https://openalex.org/keywords/learning-rate","display_name":"learning rate","score":0.6639999747276306},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2780297895","wikidata":"https://www.wikidata.org/wiki/Q18676","display_name":"Auditory cortex","level":2,"score":0.802498996257782},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.760971188545227},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5497291088104248},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.5265446305274963},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.5077561140060425},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4809814691543579},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4536646008491516},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4487532377243042},{"id":"https://openalex.org/C2780583480","wikidata":"https://www.wikidata.org/wiki/Q1366327","display_name":"Tone (literature)","level":2,"score":0.4472895860671997},{"id":"https://openalex.org/C3020799230","wikidata":"https://www.wikidata.org/wiki/Q160289","display_name":"Auditory perception","level":3,"score":0.42699721455574036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.332427442073822},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2230665385723114},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.21555373072624207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12852782011032104},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11306452751159668},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001307","descriptor_name":"Auditory Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004193","descriptor_name":"Discrimination Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2024.114172","doi":"https://doi.org/10.1016/j.celrep.2024.114172","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2024.114172","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:38703366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38703366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11450637","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11450637","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11450637/pdf/nihms-2000504.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2024.114172","doi":"https://doi.org/10.1016/j.celrep.2024.114172","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2024.114172","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G125215859","display_name":"HIGH THROUGHPUT HOME CAGE PLATFORMS FOR INVESTIGATING NEUROPSYCHIATRIC DISORDERS IN MICE","funder_award_id":"R21MH116450","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000883881","display_name":"Dynamic processing of sound in auditory cortex","funder_award_id":"R01DC017785","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1549813206","https://openalex.org/W1963769676","https://openalex.org/W1964987303","https://openalex.org/W1970177188","https://openalex.org/W1979376827","https://openalex.org/W1981764347","https://openalex.org/W1993455493","https://openalex.org/W1993769180","https://openalex.org/W1999324548","https://openalex.org/W2003487400","https://openalex.org/W2011454762","https://openalex.org/W2014570184","https://openalex.org/W2016760508","https://openalex.org/W2021338128","https://openalex.org/W2024392023","https://openalex.org/W2026354811","https://openalex.org/W2030260413","https://openalex.org/W2031142338","https://openalex.org/W2035121338","https://openalex.org/W2039096434","https://openalex.org/W2060962935","https://openalex.org/W2061592617","https://openalex.org/W2073662222","https://openalex.org/W2079735306","https://openalex.org/W2081939415","https://openalex.org/W2096451472","https://openalex.org/W2096803959","https://openalex.org/W2102554680","https://openalex.org/W2108025725","https://openalex.org/W2121283470","https://openalex.org/W2136431242","https://openalex.org/W2158698691","https://openalex.org/W2163589983","https://openalex.org/W2171332611","https://openalex.org/W2171671176","https://openalex.org/W2269310131","https://openalex.org/W2424252555","https://openalex.org/W2500893882","https://openalex.org/W2591995004","https://openalex.org/W2738621096","https://openalex.org/W2747279431","https://openalex.org/W2766608784","https://openalex.org/W2786993517","https://openalex.org/W2790594482","https://openalex.org/W2912439398","https://openalex.org/W2939938327","https://openalex.org/W2940161606","https://openalex.org/W2949985012","https://openalex.org/W2950115284","https://openalex.org/W2950205567","https://openalex.org/W2953005186","https://openalex.org/W3008841585","https://openalex.org/W3013054311","https://openalex.org/W3024533393","https://openalex.org/W3038960790","https://openalex.org/W3080921101","https://openalex.org/W3105651744","https://openalex.org/W3130386793","https://openalex.org/W3140433485","https://openalex.org/W3162385788","https://openalex.org/W3189948526","https://openalex.org/W4220739643","https://openalex.org/W4220959290","https://openalex.org/W4280610200","https://openalex.org/W4281644510","https://openalex.org/W4281684055","https://openalex.org/W4293582084","https://openalex.org/W4311304913","https://openalex.org/W4313830768","https://openalex.org/W4315620587","https://openalex.org/W4384499802","https://openalex.org/W4386317616","https://openalex.org/W4388948160","https://openalex.org/W4389445685","https://openalex.org/W4391305578","https://openalex.org/W4410535301"],"related_works":["https://openalex.org/W2027111467","https://openalex.org/W2337377319","https://openalex.org/W4402610820","https://openalex.org/W3003587225","https://openalex.org/W1883912008","https://openalex.org/W2014764196","https://openalex.org/W2316259077","https://openalex.org/W7213487088","https://openalex.org/W2006364660","https://openalex.org/W1979376827"],"abstract_inverted_index":{"Changes":[0],"in":[1,4,18,61,81,89],"sound-evoked":[2],"responses":[3,17,60],"the":[5,44,82,90,121],"auditory":[6,85,93],"cortex":[7],"(ACtx)":[8],"occur":[9],"during":[10,52],"learning,":[11],"but":[12],"how":[13],"learning":[14,122,128],"alters":[15,129],"neural":[16,45],"different":[19],"ACtx":[20,50,63,108,133],"subregions":[21,51],"and":[22,37,70,95,100,114],"changes":[23,110],"their":[24],"interactions":[25],"is":[26],"unclear.":[27],"To":[28],"address":[29],"these":[30],"questions,":[31],"we":[32],"developed":[33],"an":[34],"automated":[35],"training":[36],"widefield":[38],"imaging":[39],"system":[40],"to":[41,144],"longitudinally":[42],"track":[43],"activity":[46],"of":[47,67,78],"all":[48],"mouse":[49],"a":[53],"tone":[54],"discrimination":[55],"task.":[56],"We":[57],"find":[58],"that":[59,127],"primary":[62,99,143],"are":[64,103],"highly":[65],"informative":[66],"learned":[68,87],"stimuli":[69,88],"behavioral":[71,79,140],"outcomes":[72,80],"throughout":[73],"training.":[74,106],"In":[75],"contrast,":[76],"representations":[77],"dorsal":[83,91],"posterior":[84],"field,":[86,94],"anterior":[92],"inter-regional":[96],"correlations":[97],"between":[98,112,132],"higher-order":[101,145],"areas":[102],"enhanced":[104],"with":[105,120],"Moreover,":[107],"response":[109],"vary":[111],"stimuli,":[113],"such":[115],"differences":[116],"display":[117],"lag":[118],"synchronization":[119],"rate.":[123],"These":[124],"results":[125],"indicate":[126],"functional":[130],"connections":[131],"subregions,":[134],"inducing":[135],"region-specific":[136],"modulations":[137],"by":[138],"propagating":[139],"information":[141],"from":[142],"areas.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-03T00:00:00"}