{"id":"https://openalex.org/W4396562243","doi":"https://doi.org/10.1158/2159-8290.25728981.v1","title":"Figure S26 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer","display_name":"Figure S26 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396562243","doi":"https://doi.org/10.1158/2159-8290.25728981.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.25728981.v1","doi":"https://doi.org/10.1158/2159-8290.25728981.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25728981.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.25728981.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056480807","display_name":"Minae An","orcid":"https://orcid.org/0009-0007-9575-7952","observed_orcids":["https://orcid.org/0009-0007-9575-7952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minae An","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9575-7952","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000794179","display_name":"Arnav Mehta","orcid":"https://orcid.org/0000-0002-0313-2848","observed_orcids":["https://orcid.org/0000-0002-0313-2848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnav Mehta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0313-2848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064163183","display_name":"Byung\u2010Hoon Min","orcid":"https://orcid.org/0000-0001-8048-361X","observed_orcids":["https://orcid.org/0000-0001-8048-361X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byung Hoon Min","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8048-361X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080460440","display_name":"You Jeong Heo","orcid":"https://orcid.org/0000-0002-7966-711X","observed_orcids":["https://orcid.org/0000-0002-7966-711X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You Jeong Heo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7966-711X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013368701","display_name":"Samuel J. Wright","orcid":"https://orcid.org/0009-0006-4892-5338","observed_orcids":["https://orcid.org/0009-0006-4892-5338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel J. Wright","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-4892-5338","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041404612","display_name":"Milan Parikh","orcid":"https://orcid.org/0000-0003-1336-7883","observed_orcids":["https://orcid.org/0000-0003-1336-7883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milan Parikh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1336-7883","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055242594","display_name":"Lynn Bi","orcid":"https://orcid.org/0000-0002-8955-8208","observed_orcids":["https://orcid.org/0000-0002-8955-8208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynn Bi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8955-8208","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007213477","display_name":"Hyuk Lee","orcid":"https://orcid.org/0000-0003-4271-7205","observed_orcids":["https://orcid.org/0000-0003-4271-7205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyuk Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4271-7205","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042789749","display_name":"Tae Jun Kim","orcid":"https://orcid.org/0000-0001-8101-9034","observed_orcids":["https://orcid.org/0000-0001-8101-9034","https://orcid.org/0009-0004-1092-9291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae Jun Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8101-9034","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073142902","display_name":"Song-Yi Lee","orcid":"https://orcid.org/0009-0009-8123-4100","observed_orcids":["https://orcid.org/0009-0009-8123-4100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Song-Yi Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-8123-4100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030376827","display_name":"Jeonghyeon Moon","orcid":"https://orcid.org/0000-0002-5384-4077","observed_orcids":["https://orcid.org/0000-0002-5384-4077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeonghyeon Moon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5384-4077","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086721384","display_name":"Ryan Jin-hyung Park","orcid":"https://orcid.org/0000-0003-4725-2937","observed_orcids":["https://orcid.org/0000-0003-4725-2937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan J. Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4725-2937","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017157410","display_name":"Matthew R. Strickland","orcid":"https://orcid.org/0000-0001-7845-0712","observed_orcids":["https://orcid.org/0000-0001-7845-0712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew R. Strickland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7845-0712","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003283147","display_name":"Woong\u2010Yang Park","orcid":"https://orcid.org/0000-0003-4234-0380","observed_orcids":["https://orcid.org/0000-0003-4234-0380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woong-Yang Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4234-0380","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065244228","display_name":"Won Ki Kang","orcid":"https://orcid.org/0000-0002-0049-8086","observed_orcids":["https://orcid.org/0000-0002-0049-8086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Won Ki Kang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0049-8086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055431215","display_name":"Kyoung\u2010Mee Kim","orcid":"https://orcid.org/0000-0002-1162-9205","observed_orcids":["https://orcid.org/0000-0002-1162-9205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyoung-Mee Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1162-9205","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026351538","display_name":"Seung Tae Kim","orcid":"https://orcid.org/0000-0001-7335-1846","observed_orcids":["https://orcid.org/0000-0001-7335-1846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seung Tae Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7335-1846","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071611972","display_name":"Samuel Jacob Klempner","orcid":"https://orcid.org/0000-0002-4062-0808","observed_orcids":["https://orcid.org/0000-0002-4062-0808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel J. Klempner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4062-0808","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019406140","display_name":"Jeeyun Lee","orcid":"https://orcid.org/0000-0002-4911-6165","observed_orcids":["https://orcid.org/0000-0002-4911-6165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeeyun Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4911-6165","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immune-remodeling","display_name":"immune remodeling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.8579999804496765},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cxcl13","display_name":"CXCL13","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6660000085830688},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.9527542591094971},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6026130318641663},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5602763891220093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47822731733322144},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4772591292858124},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.42731761932373047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40435606241226196},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3398556709289551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2118012011051178},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.17445021867752075}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.25728981.v1","doi":"https://doi.org/10.1158/2159-8290.25728981.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25728981.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25728981","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figure_S26_from_Early_Immune_Remodeling_Steers_Clinical_Response_to_First-Line_Chemoimmunotherapy_in_Advanced_Gastric_Cancer/25728981","pdf_url":"https://figshare.com/articles/journal_contribution/Figure_S26_from_Early_Immune_Remodeling_Steers_Clinical_Response_to_First-Line_Chemoimmunotherapy_in_Advanced_Gastric_Cancer/25728981","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.25728981.v1","doi":"https://doi.org/10.1158/2159-8290.25728981.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25728981.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396543696","https://openalex.org/W4396562292","https://openalex.org/W4396544202","https://openalex.org/W4396544218","https://openalex.org/W4396544060","https://openalex.org/W4396543620","https://openalex.org/W4396543867","https://openalex.org/W4396543666","https://openalex.org/W4396543719","https://openalex.org/W4396543841"],"abstract_inverted_index":{"Figure":[0],"S26.":[1],"(A)":[2],"Proportion":[3,55,84,112],"of":[4,29,56,85,113,142],"CD8":[5,50,57,91],"T":[6,58,92,115,120,146],"cells":[7,59,147],"in":[8,70,95,123,144,148],"non-responder":[9,71,96],"and":[10,32,41,51,68,72,89,97,117],"responder":[11,73,98],"patients":[12,99,128,153],"split":[13,100,129,154],"by":[14,101,130,155],"timepoint.":[15,102,131,156],"Statistical":[16,75,103,132,157],"comparisons":[17,104,133,158],"performed":[18,77,105,134,159],"using":[19,78,106,135,160],"a":[20,79,107,136,161],"Wilcoxon":[21,80,108,137,162],"signed-rank":[22,81,109,138,163],"test.":[23,82,110,139,164],"(B)":[24],"Multiplexed":[25],"immunofluorescence":[26],"(mIF)":[27],"images":[28],"BL,":[30,66],"FU1":[31,67],"FU2":[33,69],"samples":[34],"from":[35,62],"two":[36],"patients,":[37],"E40":[38],"(slow":[39],"progressor)":[40],"E41":[42],"(fast":[43],"progressor),":[44],"staining":[45],"for":[46],"panCK,":[47],"PD-L1,":[48],"CD4,":[49],"Granzyme":[52],"B.":[53],"(C)":[54],"macrophages,":[60],"obtained":[61],"mIF":[63],"images,":[64],"at":[65],"patients.":[74],"comparison":[76],"(D)":[83],"naive,":[86],"memory,":[87],"effector":[88],"exhausted":[90],"cell":[93,116,121],"subsets":[94,122],"(E)":[111],"regulatory":[114],"Th1":[118],"CD4":[119,145],"fast":[124,149],"v.s.":[125,150],"slow":[126,151],"progressor":[127,152],"(F)":[140],"Expression":[141],"CXCL13":[143]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-05-02T00:00:00"}