{"id":"https://openalex.org/W4396561555","doi":"https://doi.org/10.7554/elife.97216.1","title":"A direct experimental test of Ohno\u2019s hypothesis","display_name":"A direct experimental test of Ohno\u2019s hypothesis","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396561555","doi":"https://doi.org/10.7554/elife.97216.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.97216.1","doi":"https://doi.org/10.7554/elife.97216.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97216.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.97216.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031049461","display_name":"Ljiljana Mihajlovic","orcid":"https://orcid.org/0009-0007-5921-9831","observed_orcids":["https://orcid.org/0009-0007-5921-9831"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ljiljana Mihajlovic","raw_affiliation_strings":["Department of Fundamental Microbiology, University of Lausanne"],"raw_orcid":"https://orcid.org/0009-0007-5921-9831","affiliations":[{"raw_affiliation_string":"Department of Fundamental Microbiology, University of Lausanne","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008246227","display_name":"Bharat Ravi Iyengar","orcid":"https://orcid.org/0000-0002-8983-4153","observed_orcids":["https://orcid.org/0000-0002-8983-4153"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Bharat Ravi Iyengar","raw_affiliation_strings":["Department of Evolutionary Biology and Environmental Studies, University of Zurich","Institute for Evolution and Biodiversity, University of M\u00fcnster"],"raw_orcid":"https://orcid.org/0000-0002-8983-4153","affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology and Environmental Studies, University of Zurich","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute for Evolution and Biodiversity, University of M\u00fcnster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065713831","display_name":"Florian Baier","orcid":"https://orcid.org/0000-0002-1323-9833","observed_orcids":["https://orcid.org/0000-0002-1323-9833"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Florian Baier","raw_affiliation_strings":["Department of Fundamental Microbiology, University of Lausanne"],"raw_orcid":"https://orcid.org/0000-0002-1323-9833","affiliations":[{"raw_affiliation_string":"Department of Fundamental Microbiology, University of Lausanne","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083080645","display_name":"I\u00e7vara Barbier","orcid":"https://orcid.org/0000-0001-6814-2871","observed_orcids":["https://orcid.org/0000-0001-6814-2871"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"I\u00e7vara Barbier","raw_affiliation_strings":["Department of Fundamental Microbiology, University of Lausanne"],"raw_orcid":"https://orcid.org/0000-0001-6814-2871","affiliations":[{"raw_affiliation_string":"Department of Fundamental Microbiology, University of Lausanne","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088322338","display_name":"Justyna Iwaszkiewicz","orcid":"https://orcid.org/0000-0003-3494-589X","observed_orcids":["https://orcid.org/0000-0003-3494-589X"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Justyna Iwaszkiewicz","raw_affiliation_strings":["Molecular Modeling Group, Swiss Institute of Bioinformatics"],"raw_orcid":"https://orcid.org/0000-0003-3494-589X","affiliations":[{"raw_affiliation_string":"Molecular Modeling Group, Swiss Institute of Bioinformatics","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049236772","display_name":"Vincent Zoete","orcid":"https://orcid.org/0000-0002-2336-6537","observed_orcids":["https://orcid.org/0000-0002-2336-6537"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["BE","CH"],"is_corresponding":false,"raw_author_name":"Vincent Zoete","raw_affiliation_strings":["Department of Oncology UNIL-CHUV, Ludwig Institute for Cancer Research, University of Lausanne","Molecular Modeling Group, Swiss Institute of Bioinformatics"],"raw_orcid":"https://orcid.org/0000-0002-2336-6537","affiliations":[{"raw_affiliation_string":"Department of Oncology UNIL-CHUV, Ludwig Institute for Cancer Research, University of Lausanne","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I2802229882","https://openalex.org/I4210117758","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Molecular Modeling Group, Swiss Institute of Bioinformatics","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840","observed_orcids":["https://orcid.org/0000-0003-4299-3840"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Andreas Wagner","raw_affiliation_strings":["Department of Evolutionary Biology and Environmental Studies, University of Zurich","The Santa Fe Institute, Santa Fe","The Swiss Institute of Bioinformatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology and Environmental Studies, University of Zurich","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Santa Fe Institute, Santa Fe","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028014828","display_name":"Yolanda Schaerli","orcid":"https://orcid.org/0000-0002-9083-7343","observed_orcids":["https://orcid.org/0000-0002-9083-7343"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yolanda Schaerli","raw_affiliation_strings":["Department of Fundamental Microbiology, University of Lausanne"],"raw_orcid":"https://orcid.org/0000-0002-9083-7343","affiliations":[{"raw_affiliation_string":"Department of Fundamental Microbiology, University of Lausanne","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.996999979019165},{"id":"https://openalex.org/keywords/mutational-robustness","display_name":"mutational robustness","score":0.9430000185966492},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.7680000066757202},{"id":"https://openalex.org/keywords/deleterious-mutations","display_name":"deleterious mutations","score":0.7459999918937683},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9549999833106995},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.5320000052452087},{"id":"https://openalex.org/keywords/phenotypic-evolution","display_name":"phenotypic evolution","score":0.6970000267028809},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.640999972820282},{"id":"https://openalex.org/keywords/beneficial-mutations","display_name":"beneficial mutations","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5469425916671753},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.42138904333114624},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.4039709270000458},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3382015526294708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23215511441230774},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1479887068271637}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.97216.1","doi":"https://doi.org/10.7554/elife.97216.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97216.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.97216.1","doi":"https://doi.org/10.7554/elife.97216.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.97216.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G27314608","display_name":"A modular synthetic biology platform for engineering  patterned bacterial living materials","funder_award_id":"200532","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5839119369","display_name":null,"funder_award_id":"10.3030/739874","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G6292397405","display_name":"Evolutionary Synthetic Biology: System drift in action","funder_award_id":"175608","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8012102804","display_name":"Robustness and weakened selection in the adaptive evolution of fluorescent proteins","funder_award_id":"172887","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1520883967","https://openalex.org/W1576382666","https://openalex.org/W1913240517","https://openalex.org/W1920973730","https://openalex.org/W1963858560","https://openalex.org/W1968762427","https://openalex.org/W1970711298","https://openalex.org/W1974144765","https://openalex.org/W1977972739","https://openalex.org/W1988625445","https://openalex.org/W1988714210","https://openalex.org/W1996423252","https://openalex.org/W1996490834","https://openalex.org/W1997850663","https://openalex.org/W1999889695","https://openalex.org/W2003890287","https://openalex.org/W2005233159","https://openalex.org/W2019591778","https://openalex.org/W2023926109","https://openalex.org/W2024120506","https://openalex.org/W2035733413","https://openalex.org/W2038012561","https://openalex.org/W2038464976","https://openalex.org/W2045641296","https://openalex.org/W2046575349","https://openalex.org/W2051768616","https://openalex.org/W2052051563","https://openalex.org/W2056613057","https://openalex.org/W2074231493","https://openalex.org/W2084119008","https://openalex.org/W2098949725","https://openalex.org/W2103111028","https://openalex.org/W2103954643","https://openalex.org/W2105232382","https://openalex.org/W2112945902","https://openalex.org/W2120861203","https://openalex.org/W2128312954","https://openalex.org/W2130323007","https://openalex.org/W2132629607","https://openalex.org/W2134667534","https://openalex.org/W2152075687","https://openalex.org/W2154406573","https://openalex.org/W2161551288","https://openalex.org/W2163949203","https://openalex.org/W2164832298","https://openalex.org/W2178953203","https://openalex.org/W2379594833","https://openalex.org/W2767044445","https://openalex.org/W2768782574","https://openalex.org/W2770011498","https://openalex.org/W2890052694","https://openalex.org/W2898806520","https://openalex.org/W2953318516","https://openalex.org/W2968499116","https://openalex.org/W3010383642","https://openalex.org/W3014560444","https://openalex.org/W3109790889","https://openalex.org/W4214600619","https://openalex.org/W4283268244","https://openalex.org/W4304991042","https://openalex.org/W4312077096","https://openalex.org/W4367312628","https://openalex.org/W4377966726"],"related_works":["https://openalex.org/W2116117655","https://openalex.org/W4399435465","https://openalex.org/W2166085889","https://openalex.org/W2559952886","https://openalex.org/W4388364879","https://openalex.org/W2051768616","https://openalex.org/W7098711953","https://openalex.org/W3175983147","https://openalex.org/W7096323376","https://openalex.org/W7096292736"],"abstract_inverted_index":{"Abstract":[0],"Gene":[1],"duplication":[2,44],"drives":[3],"evolution":[4,55,184,209],"by":[5,33,196,210],"providing":[6],"raw":[7],"material":[8],"for":[9,72],"proteins":[10],"with":[11],"novel":[12],"functions.":[13],"The":[14],"oldest":[15],"and":[16,25,51,107,114,128,167,173,213],"historically":[17],"most":[18],"influential":[19],"hypothesis":[20,39,74],"about":[21],"the":[22,54,112,119,157],"evolutionary":[23,116],"fate":[24],"potential":[26],"of":[27,56,85,105,118,130,135,176,208],"duplicated":[28],"genes":[29,47,94],"has":[30],"been":[31],"proposed":[32],"Susumu":[34],"Ohno":[35],"in":[36,99],"1970.":[37],"This":[38],"essentially":[40],"posits":[41],"that":[42,62],"gene":[43,68,141,152,191,211],"can":[45],"help":[46],"tolerate":[48],"new":[49,57],"mutations":[50,64,172,179],"thus":[52],"facilitates":[53],"phenotypes":[58],"Competing":[59],"hypotheses":[60],"argue":[61],"deleterious":[63,197],"will":[65],"usually":[66],"inactivate":[67],"duplicates":[69],"too":[70],"rapidly":[71,193],"Ohno\u2019s":[73,86,136,218],"to":[75,205,217],"work.":[76],"Here,":[77],"we":[78,89],"provide":[79],"a":[80,96,150,155],"first":[81],"direct":[82],"experimental":[83,203],"test":[84,206],"hypothesis.":[87,219],"Specifically,":[88],"evolved":[90,164],"one":[91,190],"or":[92],"two":[93,140],"encoding":[95],"fluorescent":[97],"protein":[98],"Escherichia":[100],"coli":[101],"through":[102,122],"multiple":[103],"rounds":[104],"mutagenesis":[106],"selection.":[108],"We":[109],"then":[110],"analyzed":[111],"genotypic":[113],"phenotypic":[115,166,183],"dynamics":[117],"evolving":[120],"populations":[121,138,159],"high-throughput":[123],"DNA":[124],"sequencing,":[125],"biochemical":[126],"assays,":[127],"engineering":[129],"selected":[131],"variants.":[132],"In":[133],"support":[134],"hypothesis,":[137],"carrying":[139,149],"copies":[142],"displayed":[143],"higher":[144,165],"mutational":[145],"robustness":[146],"than":[147],"those":[148],"single":[151],"copy.":[153],"As":[154],"consequence,":[156],"double-copy":[158],"experienced":[160],"relaxed":[161],"purifying":[162],"selection,":[163],"genetic":[168],"diversity,":[169],"carried":[170],"more":[171],"accumulated":[174],"combinations":[175],"key":[177],"beneficial":[178],"earlier.":[180],"However,":[181],"their":[182],"was":[185],"not":[186],"accelerated,":[187],"possibly":[188],"because":[189],"copy":[192],"became":[194],"inactivated":[195],"mutations.":[198],"Our":[199],"work":[200],"provides":[201],"an":[202],"platform":[204],"models":[207],"duplication,":[212],"it":[214],"supports":[215],"alternatives":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-02T00:00:00"}