{"id":"https://openalex.org/W4396561233","doi":"https://doi.org/10.1097/tp.0000000000005040","title":"Normothermic Ex Vivo Heart Perfusion With Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Improves Graft Function in Donation After Circulatory Death Hearts","display_name":"Normothermic Ex Vivo Heart Perfusion With Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Improves Graft Function in Donation After Circulatory Death Hearts","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396561233","doi":"https://doi.org/10.1097/tp.0000000000005040","pmid":"https://pubmed.ncbi.nlm.nih.gov/38685203"},"language":"en","primary_location":{"id":"doi:10.1097/tp.0000000000005040","doi":"https://doi.org/10.1097/tp.0000000000005040","is_oa":true,"landing_page_url":"https://doi.org/10.1097/tp.0000000000005040","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/tp.0000000000005040","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350968","display_name":"Zhong Zhang","orcid":"https://orcid.org/0000-0002-5605-4951","observed_orcids":["https://orcid.org/0000-0002-5605-4951"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong Zhang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095964417","display_name":"Jianqiang Ji","orcid":"https://orcid.org/0009-0005-6808-7768","observed_orcids":["https://orcid.org/0009-0005-6808-7768"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqiang Ji","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042860700","display_name":"Xuan Pan","orcid":"https://orcid.org/0000-0002-8308-8495","observed_orcids":["https://orcid.org/0000-0002-8308-8495"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Pan","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039595431","display_name":"Chuanjie Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanjie Niu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104124243","display_name":"Liwei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Xu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009448562","display_name":"Wenrui Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenrui Lei","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047477852","display_name":"Zifeng Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zifeng Zeng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102823560","display_name":"Qiong Chen","orcid":"https://orcid.org/0000-0001-8295-6337","observed_orcids":["https://orcid.org/0000-0001-8295-6337"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Chen","raw_affiliation_strings":["Precision Medical Center of Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medical Center of Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingbao Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingbao Peng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100561062","display_name":"Zheng Shaoyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaoyi Zheng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595839","display_name":"Jun Lu","orcid":"https://orcid.org/0000-0002-9878-9091","observed_orcids":["https://orcid.org/0000-0002-9878-9091"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Lu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006681326","display_name":"Pengyu Zhou","orcid":"https://orcid.org/0000-0002-6415-125X","observed_orcids":["https://orcid.org/0000-0002-6415-125X"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pengyu Zhou","raw_affiliation_strings":["Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006681326","https://openalex.org/A5100561062","https://openalex.org/A5101595839"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":3.7671,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.93705543,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"108","issue":"11","first_page":"2209","last_page":"2221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.968999981880188},{"id":"https://openalex.org/keywords/umbilical-cord-mesenchymal-stem-cells","display_name":"human umbilical cord mesenchymal stem cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/donation-after-circulatory-death","display_name":"donation after circulatory death","score":0.9340000152587891},{"id":"https://openalex.org/keywords/heart-preservation","display_name":"heart preservation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9340000152587891},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/donor-heart","display_name":"donor heart","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.8499879837036133},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8052979111671448},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7039568424224854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6974934339523315},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6291077136993408},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5712805986404419},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.531633734703064},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4969048798084259},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46761950850486755},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4222368597984314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22963744401931763},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22920534014701843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17372143268585205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14654898643493652},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009926","descriptor_name":"Organ Preservation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014470","descriptor_name":"Umbilical Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/tp.0000000000005040","doi":"https://doi.org/10.1097/tp.0000000000005040","is_oa":true,"landing_page_url":"https://doi.org/10.1097/tp.0000000000005040","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:38685203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38685203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/tp.0000000000005040","doi":"https://doi.org/10.1097/tp.0000000000005040","is_oa":true,"landing_page_url":"https://doi.org/10.1097/tp.0000000000005040","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3503928469","display_name":null,"funder_award_id":"2022A1515011747","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1860614662","https://openalex.org/W2051395985","https://openalex.org/W2093261411","https://openalex.org/W2140526577","https://openalex.org/W2219898540","https://openalex.org/W2605232906","https://openalex.org/W2621011311","https://openalex.org/W2904639093","https://openalex.org/W2912418307","https://openalex.org/W2913637697","https://openalex.org/W2932598846","https://openalex.org/W2969685486","https://openalex.org/W2977509189","https://openalex.org/W2989015345","https://openalex.org/W2990771434","https://openalex.org/W2998904710","https://openalex.org/W3005104290","https://openalex.org/W3012266935","https://openalex.org/W3037257681","https://openalex.org/W3087454342","https://openalex.org/W3093409876","https://openalex.org/W3099006618","https://openalex.org/W3119240526","https://openalex.org/W3131688670","https://openalex.org/W3165339364","https://openalex.org/W3167408212","https://openalex.org/W3184798423","https://openalex.org/W3185130105","https://openalex.org/W3197285805","https://openalex.org/W4200265887","https://openalex.org/W4205500885","https://openalex.org/W4210781173","https://openalex.org/W4220711829","https://openalex.org/W4220960180","https://openalex.org/W4223982689","https://openalex.org/W4224295245","https://openalex.org/W4225261148","https://openalex.org/W4235644230","https://openalex.org/W4246643724","https://openalex.org/W4280573396","https://openalex.org/W4281621292","https://openalex.org/W4283396611","https://openalex.org/W4283460574","https://openalex.org/W4288685222","https://openalex.org/W4309617250","https://openalex.org/W4318818957","https://openalex.org/W4327715159","https://openalex.org/W4379617776","https://openalex.org/W4386776685","https://openalex.org/W4386968622","https://openalex.org/W6770940875"],"related_works":["https://openalex.org/W4394719157","https://openalex.org/W4309617250","https://openalex.org/W4404245778","https://openalex.org/W1982056837","https://openalex.org/W3185130105","https://openalex.org/W2102522097","https://openalex.org/W4401388520","https://openalex.org/W3081670429","https://openalex.org/W3082333771","https://openalex.org/W7118190907"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,62],"investigate":[5,129],"the":[6,50,54,63,96,102,119,130,137,178,185,201,206,218,250],"cardioprotective":[7],"effect":[8],"of":[9,98,118,132,167,208],"exosomes":[10],"derived":[11],"from":[12],"human":[13],"umbilical":[14],"cord":[15],"mesenchymal":[16],"stem":[17],"cells":[18,183],"on":[19],"donation":[20],"after":[21,124,173,226],"circulatory":[22],"death":[23],"(DCD)":[24],"hearts":[25,139,169],"preserved":[26,74],"with":[27,75,149,177,233],"normothermic":[28,99],"ex":[29],"vivo":[30],"heart":[31,37,88,121,125,174,242],"perfusion":[32],"(EVHP)":[33],"in":[34,101,136,184,200,249],"a":[35,68,237],"rat":[36],"transplantation":[38,175],"model.":[39],"METHODS:":[40],"Thirty-two":[41],"male":[42],"Lewis":[43],"rats":[44,59],"were":[45,60],"divided":[46],"into":[47,83,95,198],"2":[48],"groups:":[49],"control":[51,103,179],"group":[52,187,203],"and":[53,80,115,164,211,215,239],"exosome":[55,92,105,150,186,196,202,227,234],"group.":[56,106,180],"The":[57,147,181],"donor-heart":[58],"subjected":[61],"DCD":[64,168,241,251],"procedure":[65],"by":[66,143],"suffering":[67],"15-min":[69],"warm":[70],"ischemia":[71],"injury,":[72],"subsequently":[73],"EVHP":[76,100,231],"for":[77],"90":[78,171],"min,":[79],"then":[81],"transplanted":[82],"recipients":[84],"via":[85],"abdominal":[86],"heterotopic":[87],"transplantation.":[89,126],"Vehicle":[90],"or":[91,104],"was":[93,224],"added":[94,197],"perfusate":[97,199],"We":[107],"evaluated":[108],"left":[109,157],"ventricular":[110,158],"graft":[111],"function,":[112],"myocardial":[113,116,133,182,246],"inflammation,":[114],"apoptosis":[117],"donor":[120,138],"1.5":[122],"h":[123],"Furthermore,":[127,195],"we":[128],"alternation":[131],"gene":[134],"expression":[135],"between":[140],"both":[141],"groups":[142],"transcriptome":[144],"sequencing.":[145],"RESULTS:":[146],"treatment":[148],"significantly":[151,204],"enhanced":[152],"cardiac":[153],"function":[154],"through":[155],"increasing":[156],"developed":[159],"pressure,":[160],"dp/dt":[161,165],"max":[162],",":[163],"min":[166,172],"at":[170],"compared":[176],"exhibited":[188],"an":[189],"orderly":[190],"arrangement":[191],"without":[192],"obvious":[193],"edema.":[194],"attenuated":[205],"level":[207],"inflammatory":[209],"response":[210],"apoptosis.":[212],"Transcriptome":[213],"sequencing":[214],"RT-qPCR":[216],"showed":[217],"phosphoinositide":[219],"3-kinase/protein":[220],"kinase":[221],"B":[222],"pathway":[223],"activated":[225],"treatment.":[228],"CONCLUSIONS:":[229],"Normothermic":[230],"combined":[232],"can":[235],"be":[236],"promising":[238],"novel":[240],"preservation":[243],"strategy,":[244],"alleviating":[245],"ischemia-reperfusion":[247],"injury":[248],"heart.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-02T00:00:00"}