{"id":"https://openalex.org/W4396559932","doi":"https://doi.org/10.1002/psc.3610","title":"A stability\u2010indicating method development and validation for the determination of related substances in novel synthetic decapeptide by HPLC","display_name":"A stability\u2010indicating method development and validation for the determination of related substances in novel synthetic decapeptide by HPLC","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396559932","doi":"https://doi.org/10.1002/psc.3610","pmid":"https://pubmed.ncbi.nlm.nih.gov/38689387"},"language":"en","primary_location":{"id":"doi:10.1002/psc.3610","doi":"https://doi.org/10.1002/psc.3610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psc.3610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psc.3610","source":{"id":"https://openalex.org/S184443419","display_name":"Journal of Peptide Science","issn_l":"1075-2617","issn":["1075-2617","1099-1387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Peptide Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psc.3610","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101770307","display_name":"Ramesh Pawar","orcid":"https://orcid.org/0009-0003-7870-8420","observed_orcids":["https://orcid.org/0009-0003-7870-8420"]},"institutions":[{"id":"https://openalex.org/I3132999081","display_name":"Marwadi University","ror":"https://ror.org/030dn1812","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132999081"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramesh Pawar","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India"],"raw_orcid":"https://orcid.org/0009-0003-7870-8420","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India","institution_ids":["https://openalex.org/I3132999081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037275895","display_name":"Sunil R. Tivari","orcid":"https://orcid.org/0000-0002-9549-7122","observed_orcids":["https://orcid.org/0000-0002-9549-7122"]},"institutions":[{"id":"https://openalex.org/I3132999081","display_name":"Marwadi University","ror":"https://ror.org/030dn1812","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132999081"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunil Tivari","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India","institution_ids":["https://openalex.org/I3132999081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095964005","display_name":"Divya Panchani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3132999081","display_name":"Marwadi University","ror":"https://ror.org/030dn1812","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132999081"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Divya Panchani","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India","institution_ids":["https://openalex.org/I3132999081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012160037","display_name":"Jayanti Makasana","orcid":"https://orcid.org/0000-0001-5959-3419","observed_orcids":["https://orcid.org/0000-0001-5959-3419"]},"institutions":[{"id":"https://openalex.org/I3132999081","display_name":"Marwadi University","ror":"https://ror.org/030dn1812","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132999081"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jayanti Makasana","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Marwadi University, Rajkot, Gujarat, India","institution_ids":["https://openalex.org/I3132999081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012160037"],"corresponding_institution_ids":["https://openalex.org/I3132999081"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":0.7567,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57675068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"10","first_page":"e3610","last_page":"e3610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decapeptide","display_name":"decapeptide","score":0.8410000205039978},{"id":"https://openalex.org/keywords/related-substances","display_name":"related substances","score":0.7620000243186951},{"id":"https://openalex.org/keywords/impurity-determination","display_name":"impurity determination","score":0.6230000257492065},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.9639999866485596},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.4970000088214874},{"id":"https://openalex.org/keywords/stress-testing","display_name":"stress testing","score":0.6579999923706055},{"id":"https://openalex.org/keywords/reversed-phase-hplc","display_name":"reversed-phase HPLC","score":0.7490000128746033},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6137620806694031},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.585460901260376},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5716423392295837},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5561538338661194},{"id":"https://openalex.org/C2983406500","wikidata":"https://www.wikidata.org/wiki/Q7604347","display_name":"Stationary phase","level":2,"score":0.512031614780426},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4640440344810486},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36935973167419434},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07777905464172363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06695494055747986},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/psc.3610","doi":"https://doi.org/10.1002/psc.3610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psc.3610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psc.3610","source":{"id":"https://openalex.org/S184443419","display_name":"Journal of Peptide Science","issn_l":"1075-2617","issn":["1075-2617","1099-1387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Peptide Science","raw_type":"journal-article"},{"id":"pmid:38689387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38689387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of peptide science : an official publication of the European Peptide Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/psc.3610","doi":"https://doi.org/10.1002/psc.3610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psc.3610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psc.3610","source":{"id":"https://openalex.org/S184443419","display_name":"Journal of Peptide Science","issn_l":"1075-2617","issn":["1075-2617","1099-1387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Peptide Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396559932.pdf","grobid_xml":"https://content.openalex.org/works/W4396559932.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W31592851","https://openalex.org/W1860382351","https://openalex.org/W1975046677","https://openalex.org/W1981000246","https://openalex.org/W2016499224","https://openalex.org/W2022164454","https://openalex.org/W2037825842","https://openalex.org/W2059126503","https://openalex.org/W2063627483","https://openalex.org/W2073581330","https://openalex.org/W2082306468","https://openalex.org/W2090241936","https://openalex.org/W2090612463","https://openalex.org/W2096956521","https://openalex.org/W2106714479","https://openalex.org/W2141254638","https://openalex.org/W2144624130","https://openalex.org/W2148140368","https://openalex.org/W2186101263","https://openalex.org/W2320556745","https://openalex.org/W2337777524","https://openalex.org/W2739354616","https://openalex.org/W2911936342","https://openalex.org/W3120960768","https://openalex.org/W3169341997","https://openalex.org/W4214923084","https://openalex.org/W4224211290","https://openalex.org/W4255970233","https://openalex.org/W4321033094","https://openalex.org/W4385255133","https://openalex.org/W6902932655"],"related_works":["https://openalex.org/W4400831165","https://openalex.org/W2328862282","https://openalex.org/W2090241936","https://openalex.org/W7162454841","https://openalex.org/W3201187902","https://openalex.org/W4416170013","https://openalex.org/W2102958452","https://openalex.org/W1484918569","https://openalex.org/W6968357133","https://openalex.org/W2772421536"],"abstract_inverted_index":{"In":[0],"the":[1,23,29,39,58,62,105,137,171],"present":[2],"scenario,":[3],"peptide":[4],"is":[5],"an":[6,36],"emerging":[7],"field":[8],"of":[9,22,28,44,61,64,91,110,136,170],"research":[10],"having":[11],"vast":[12],"therapeutic":[13,40],"applications.":[14],"Diverse":[15],"impurities":[16],"may":[17,34],"rise":[18],"from":[19],"various":[20],"stages":[21],"synthesis":[24],"process":[25],"and":[26,42,54,73,100,151,167],"storage":[27],"peptides.":[30],"Because":[31],"these":[32,111],"contaminants":[33],"have":[35,131],"impact":[37],"on":[38,127],"safety":[41],"effectiveness":[43],"peptides":[45],"in":[46,104],"their":[47],"approaching":[48],"applications,":[49],"they":[50],"must":[51],"be":[52,162,175],"identified":[53],"carefully":[55],"monitored.":[56],"Considering":[57],"pharmaceutical":[59],"importance":[60],"extent":[63],"peptides,":[65],"we":[66],"were":[67,102],"motivated":[68],"to":[69],"synthesize":[70],"a":[71,75,115,118],"decapeptide":[72],"establish":[74,114],"novel":[76],"gradient":[77],"reversed-phase":[78],"high-performance":[79],"liquid":[80],"chromatography":[81],"(RP-HPLC)":[82],"method":[83,143,160],"for":[84,107,134,154,164,177],"its":[85,92,155],"analysis":[86,166],"along":[87],"with":[88],"efficient":[89],"separation":[90,109],"six":[93],"related":[94],"impurities.":[95,112],"Different":[96],"buffers,":[97],"organic":[98],"modifiers,":[99],"columns":[101],"used":[103],"tests":[106],"good":[108],"To":[113],"stability-indicating":[116],"method,":[117],"stress":[119],"study":[120],"was":[121],"also":[122],"conducted.":[123],"The":[124,141,158],"International":[125],"Conference":[126],"Harmonization":[128],"(ICH)":[129],"guidelines":[130],"been":[132],"followed":[133],"validation":[135],"developed":[138],"analytical":[139],"method.":[140],"validated":[142],"revealed":[144],"sufficient":[145],"accuracy,":[146],"specificity,":[147],"linearity,":[148],"robustness,":[149],"precision,":[150],"high":[152],"sensitivity":[153],"intended":[156],"use.":[157],"proposed":[159],"could":[161],"appropriate":[163],"routine":[165],"stability":[168],"assessment":[169],"decapeptide,":[172],"which":[173],"might":[174],"useful":[176],"further":[178],"scientific":[179],"investigation.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-02T00:00:00"}