{"id":"https://openalex.org/W4396558099","doi":"https://doi.org/10.1016/j.neuroscience.2024.04.015","title":"Trim14-I\u03baB\u03b1 Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients","display_name":"Trim14-I\u03baB\u03b1 Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396558099","doi":"https://doi.org/10.1016/j.neuroscience.2024.04.015","pmid":"https://pubmed.ncbi.nlm.nih.gov/38697463"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2024.04.015","doi":"https://doi.org/10.1016/j.neuroscience.2024.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2024.04.015","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4396558099"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuroscience.2024.04.015","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103001164","display_name":"Zheng Niu","orcid":"https://orcid.org/0000-0002-7592-8933","observed_orcids":["https://orcid.org/0000-0002-7592-8933"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Niu","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":"https://orcid.org/0000-0002-7592-8933","affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102664100","display_name":"Shu-Ting Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Ting Qu","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124872690","display_name":"Jia-Hao Dai","orcid":"https://orcid.org/0009-0007-6106-8649","observed_orcids":["https://orcid.org/0009-0007-6106-8649"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Hao Dai","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360112","display_name":"Ke Wang","orcid":"https://orcid.org/0000-0002-2824-1047","observed_orcids":["https://orcid.org/0000-0002-2824-1047","https://orcid.org/0009-0002-8612-548X","https://orcid.org/0000-0002-2698-0284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke Wang","raw_affiliation_strings":["Department of Pain, Suzhou Wuzhong People's Hospital, Suzhou 215128, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain, Suzhou Wuzhong People's Hospital, Suzhou 215128, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602453","display_name":"Yun Liu","orcid":"https://orcid.org/0000-0002-8158-3783","observed_orcids":["https://orcid.org/0000-0002-8158-3783"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Liu","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103132163","display_name":"Long Chen","orcid":"https://orcid.org/0009-0009-8327-4827","observed_orcids":["https://orcid.org/0009-0009-8327-4827"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Chen","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036339709","display_name":"Yu Song","orcid":"https://orcid.org/0000-0003-1083-4263","observed_orcids":["https://orcid.org/0000-0003-1083-4263"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Song","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ren Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ren Sun","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024478935","display_name":"Zhenhua Xu","orcid":"https://orcid.org/0000-0002-2921-5043","observed_orcids":["https://orcid.org/0000-0002-2921-5043"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen-Hua Xu","raw_affiliation_strings":["Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China. Electronic address: zhenhua_email@163.com","Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China. Electronic address: zhenhua_email@163.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Center for Translational Medicine, Department of Anesthesiology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215600, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100377409","display_name":"Hailong Zhang","orcid":"https://orcid.org/0000-0002-8720-2734","observed_orcids":["https://orcid.org/0000-0002-8720-2734"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-Long Zhang","raw_affiliation_strings":["Center of Translational Medicine and Clinical Laboratory, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215123, China. Electronic address: hlzhang76@suda.edu.cn","Center of Translational Medicine and Clinical Laboratory, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":"https://orcid.org/0000-0002-8720-2734","affiliations":[{"raw_affiliation_string":"Center of Translational Medicine and Clinical Laboratory, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215123, China. Electronic address: hlzhang76@suda.edu.cn","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]},{"raw_affiliation_string":"Center of Translational Medicine and Clinical Laboratory, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024478935","https://openalex.org/A5100377409"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":1.5911,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79185559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"548","issue":null,"first_page":"39","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim14","display_name":"TRIM14","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chronic-inflammatory-pain","display_name":"chronic inflammatory pain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.949999988079071},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.7329999804496765},{"id":"https://openalex.org/keywords/peripheral-sensitization","display_name":"peripheral sensitization","score":0.9670000076293945},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":1.0},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.7549999952316284},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.703000009059906},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8105354309082031},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.7368084192276001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6923166513442993},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6603777408599854},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.5055923461914062},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.477947473526001},{"id":"https://openalex.org/C2777831278","wikidata":"https://www.wikidata.org/wiki/Q540571","display_name":"Fibromyalgia","level":2,"score":0.47605085372924805},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.4751334488391876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3875945806503296},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.35567283630371094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32665306329727173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1995818018913269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14456135034561157},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.13529008626937866},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.13465473055839539},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1268303394317627},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0990544855594635},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070584","descriptor_name":"Tripartite Motif Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066148","descriptor_name":"Spinal Cord Dorsal Horn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroscience.2024.04.015","doi":"https://doi.org/10.1016/j.neuroscience.2024.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2024.04.015","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:38697463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38697463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroscience.2024.04.015","doi":"https://doi.org/10.1016/j.neuroscience.2024.04.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2024.04.015","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G642756586","display_name":null,"funder_award_id":"82201575","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7487548735","display_name":null,"funder_award_id":"ZJGQNKJ202204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1229823848","https://openalex.org/W1960809236","https://openalex.org/W1973425911","https://openalex.org/W2020909982","https://openalex.org/W2050369574","https://openalex.org/W2242954604","https://openalex.org/W2257742265","https://openalex.org/W2573216293","https://openalex.org/W2761160116","https://openalex.org/W2786697307","https://openalex.org/W2791649391","https://openalex.org/W2799956012","https://openalex.org/W2893509582","https://openalex.org/W2903645842","https://openalex.org/W2915828703","https://openalex.org/W2944494203","https://openalex.org/W2947880540","https://openalex.org/W2970496886","https://openalex.org/W2986148998","https://openalex.org/W3000068311","https://openalex.org/W3038813220","https://openalex.org/W3047711972","https://openalex.org/W3201435727","https://openalex.org/W3203586501","https://openalex.org/W3211786700","https://openalex.org/W4211167004","https://openalex.org/W4220676747","https://openalex.org/W4282946071","https://openalex.org/W4292299854","https://openalex.org/W4293537593","https://openalex.org/W4306255067","https://openalex.org/W4307582059","https://openalex.org/W4311134296","https://openalex.org/W4311794321","https://openalex.org/W4317438751","https://openalex.org/W4318929901","https://openalex.org/W4377087243","https://openalex.org/W4377695128","https://openalex.org/W4378746242","https://openalex.org/W4385699264","https://openalex.org/W4389141928","https://openalex.org/W6754536579"],"related_works":["https://openalex.org/W4399575982","https://openalex.org/W4309933701","https://openalex.org/W3001725605","https://openalex.org/W7155166511","https://openalex.org/W2313394087","https://openalex.org/W2991989633","https://openalex.org/W1229823848","https://openalex.org/W2366312814","https://openalex.org/W4214823354","https://openalex.org/W2094390668"],"abstract_inverted_index":{"Chronic":[0],"inflammatory":[1,47,89,166,182],"pain":[2,28,77,90,146,167],"is":[3],"the":[4,16,37,45,53,65,74,82,100,114,145],"highest":[5],"priority":[6],"for":[7,180],"people":[8],"with":[9,69,81],"osteoarthritis":[10,70],"when":[11],"seeking":[12],"medical":[13],"attention.":[14],"Despite":[15],"availability":[17],"of":[18,67,76,84,116,131,151],"NSAIDs":[19],"and":[20,24,71,73,106,111,142,144,148,171],"glucocorticoids,":[21],"central":[22],"sensitization":[23,26],"peripheral":[25],"make":[27],"increasingly":[29],"difficult":[30],"to":[31,134,164],"control.":[32],"Previous":[33],"studies":[34],"have":[35],"identified":[36],"ubiquitination":[38],"system":[39],"as":[40],"an":[41],"important":[42],"role":[43],"in":[44,64,99,112],"chronic":[46,165,181],"pain.":[48,183],"Our":[49],"study":[50],"displayed":[51],"that":[52,94,160,172],"E3":[54],"ubiquitin":[55],"ligase":[56],"tripartite":[57],"motif-containing":[58],"14":[59],"(Trim14)":[60],"was":[61,78,96,123,140],"abnormally":[62],"elevated":[63],"serum":[66],"patients":[68],"pain,":[72],"degree":[75,83],"positively":[79],"correlated":[80],"Trim14":[85,95,126,132,136,161,173],"elevation.":[86,127],"Furthermore,":[87],"CFA-induced":[88],"rat":[91],"model":[92],"showed":[93],"significantly":[97,154],"increased":[98],"L3-5":[101],"spinal":[102],"dorsal":[103,107],"horn":[104],"(SDH)":[105],"root":[108],"ganglion":[109],"(DRG),":[110],"turn":[113],"inhibitor":[115],"nuclear":[117],"factor":[118],"Kappa-B":[119],"isoform":[120],"\u03b1":[121],"(I\u03baB\u03b1)":[122],"decreased":[124],"after":[125],"After":[128],"intrathecal":[129],"injection":[130],"siRNA":[133],"inhibit":[135],"expression,":[137],"I\u03baB\u03b1":[138],"expression":[139],"reversed":[141],"increased,":[143],"behaviors":[147,150],"anxiety":[149],"rats":[152],"were":[153],"relieved.":[155],"Overall,":[156],"these":[157],"findings":[158],"suggested":[159],"may":[162,174],"contribute":[163],"by":[168],"degrading":[169],"I\u03baB\u03b1,":[170],"become":[175],"a":[176],"novel":[177],"therapeutic":[178],"target":[179]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-05-02T00:00:00"}