{"id":"https://openalex.org/W4396555324","doi":"https://doi.org/10.55627/pmc.003.01.0296","title":"Biomarker-Guided Drug Repurposing and Molecular Validation of Angiotensin-2 Receptor Type-1 in Brain Tumor","display_name":"Biomarker-Guided Drug Repurposing and Molecular Validation of Angiotensin-2 Receptor Type-1 in Brain Tumor","publication_year":2023,"publication_date":"2023-06-30","ids":{"openalex":"https://openalex.org/W4396555324","doi":"https://doi.org/10.55627/pmc.003.01.0296"},"language":"en","primary_location":{"id":"doi:10.55627/pmc.003.01.0296","doi":"https://doi.org/10.55627/pmc.003.01.0296","is_oa":true,"landing_page_url":"https://doi.org/10.55627/pmc.003.01.0296","pdf_url":null,"source":{"id":"https://openalex.org/S4387285447","display_name":"Precision Medicine Communications","issn_l":"2958-5821","issn":["2958-5821","2958-583X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Precision Medicine Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.55627/pmc.003.01.0296","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048101548","display_name":"Kiran Konain","orcid":"https://orcid.org/0000-0002-1084-7630","observed_orcids":["https://orcid.org/0000-0002-1084-7630"]},"institutions":[{"id":"https://openalex.org/I24542750","display_name":"Khyber Medical University","ror":"https://ror.org/00nv6q035","country_code":"PK","type":"education","lineage":["https://openalex.org/I24542750"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kiran Konain","raw_affiliation_strings":["Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan","institution_ids":["https://openalex.org/I24542750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004970725","display_name":"Muhammad Faheem","orcid":"https://orcid.org/0000-0001-8653-3817","observed_orcids":["https://orcid.org/0000-0001-8653-3817"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Faheem","raw_affiliation_strings":["Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, ND 58202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, ND 58202, USA","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kamran Ullah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamran Ullah","raw_affiliation_strings":["Department of Neurosurgery, Muhammad Teaching Hospital, Peshawar 25100, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Muhammad Teaching Hospital, Peshawar 25100, Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010946373","display_name":"Shahid Ayub","orcid":"https://orcid.org/0000-0003-4479-0027","observed_orcids":["https://orcid.org/0000-0003-4479-0027"]},"institutions":[{"id":"https://openalex.org/I24542750","display_name":"Khyber Medical University","ror":"https://ror.org/00nv6q035","country_code":"PK","type":"education","lineage":["https://openalex.org/I24542750"]},{"id":"https://openalex.org/I4403386779","display_name":"Khyber Girls Medical College","ror":"https://ror.org/05c08zp36","country_code":"PK","type":"education","lineage":["https://openalex.org/I4403386779"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shahid Ayub","raw_affiliation_strings":["A. Department of Neurosurgery, Muhammad Teaching Hospital, Peshawar 25100, Pakistan. B. Khyber Girls Medical College, Khyber Medical University, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. Department of Neurosurgery, Muhammad Teaching Hospital, Peshawar 25100, Pakistan. B. Khyber Girls Medical College, Khyber Medical University, Peshawar, Pakistan","institution_ids":["https://openalex.org/I24542750","https://openalex.org/I4403386779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049770908","display_name":"Jawad Ahmed","orcid":"https://orcid.org/0000-0003-3074-1953","observed_orcids":["https://orcid.org/0000-0003-3074-1953"]},"institutions":[{"id":"https://openalex.org/I24542750","display_name":"Khyber Medical University","ror":"https://ror.org/00nv6q035","country_code":"PK","type":"education","lineage":["https://openalex.org/I24542750"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Jawad Ahmed","raw_affiliation_strings":["Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan","institution_ids":["https://openalex.org/I24542750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063449324","display_name":"Zilli Huma","orcid":"https://orcid.org/0000-0001-9184-0133","observed_orcids":["https://orcid.org/0000-0001-9184-0133"]},"institutions":[{"id":"https://openalex.org/I24542750","display_name":"Khyber Medical University","ror":"https://ror.org/00nv6q035","country_code":"PK","type":"education","lineage":["https://openalex.org/I24542750"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zilli Huma","raw_affiliation_strings":["Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan","institution_ids":["https://openalex.org/I24542750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069097413","display_name":"Aneela Javed","orcid":"https://orcid.org/0000-0003-0280-0610","observed_orcids":["https://orcid.org/0000-0003-0280-0610"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Aneela Javed","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025990099","display_name":"Tanzila Khan","orcid":"https://orcid.org/0000-0002-7957-5944","observed_orcids":["https://orcid.org/0000-0002-7957-5944"]},"institutions":[{"id":"https://openalex.org/I4210143646","display_name":"Ingham Institute","ror":"https://ror.org/03y4rnb63","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210143646"]},{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tanzila Khan","raw_affiliation_strings":["A. School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. B. Medical Oncology, Ingham Institute of Applied Medical Research, Liverpool, NSW 2170, Australia. C. Centre of Circulating Tumour Cells Diagnostics & Research, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. B. Medical Oncology, Ingham Institute of Applied Medical Research, Liverpool, NSW 2170, Australia. C. Centre of Circulating Tumour Cells Diagnostics & Research, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia","institution_ids":["https://openalex.org/I4210143646","https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078008097","display_name":"Deema Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Deema Hussain","raw_affiliation_strings":["A. Neurooncology Translational Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia. B. Department of Medical Laboratory Sciences, Faculty, of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. Neurooncology Translational Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia. B. Department of Medical Laboratory Sciences, Faculty, of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090315354","display_name":"Ishaq Nasib Khan","orcid":"https://orcid.org/0000-0001-6110-9403","observed_orcids":["https://orcid.org/0000-0001-6110-9403"]},"institutions":[{"id":"https://openalex.org/I24542750","display_name":"Khyber Medical University","ror":"https://ror.org/00nv6q035","country_code":"PK","type":"education","lineage":["https://openalex.org/I24542750"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ishaq N Khan","raw_affiliation_strings":["A. Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan. B. Taxes A&M Health Science Center, Joe H. Reynolds Medical Sciences Build, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. Cancer Cell Culture & Precision Oncomedicine Lab, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan. B. Taxes A&M Health Science Center, Joe H. Reynolds Medical Sciences Build, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I24542750"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7219,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67406005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"3","issue":"1","first_page":"27","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/telmisartan","display_name":"telmisartan","score":0.9369999766349792},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.871999979019165},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6880000233650208},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6921489834785461},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.6811172962188721},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6574505567550659},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5593022704124451},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4677208960056305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38671553134918213},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3563670516014099},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26916930079460144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20937052369117737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08342048525810242},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55627/pmc.003.01.0296","doi":"https://doi.org/10.55627/pmc.003.01.0296","is_oa":true,"landing_page_url":"https://doi.org/10.55627/pmc.003.01.0296","pdf_url":null,"source":{"id":"https://openalex.org/S4387285447","display_name":"Precision Medicine Communications","issn_l":"2958-5821","issn":["2958-5821","2958-583X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Precision Medicine Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55627/pmc.003.01.0296","doi":"https://doi.org/10.55627/pmc.003.01.0296","is_oa":true,"landing_page_url":"https://doi.org/10.55627/pmc.003.01.0296","pdf_url":null,"source":{"id":"https://openalex.org/S4387285447","display_name":"Precision Medicine Communications","issn_l":"2958-5821","issn":["2958-5821","2958-583X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Precision Medicine Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1587286343","https://openalex.org/W1972650937","https://openalex.org/W1972725492","https://openalex.org/W1985649534","https://openalex.org/W1994302475","https://openalex.org/W1994421856","https://openalex.org/W2018338404","https://openalex.org/W2024380057","https://openalex.org/W2031542499","https://openalex.org/W2048510427","https://openalex.org/W2054051862","https://openalex.org/W2083077388","https://openalex.org/W2094825563","https://openalex.org/W2111180661","https://openalex.org/W2122383415","https://openalex.org/W2123758471","https://openalex.org/W2134899427","https://openalex.org/W2148884688","https://openalex.org/W2160374151","https://openalex.org/W2161505534","https://openalex.org/W2166571722","https://openalex.org/W2178438150","https://openalex.org/W2183358035","https://openalex.org/W2438973966","https://openalex.org/W2439395286","https://openalex.org/W2462053388","https://openalex.org/W2476832080","https://openalex.org/W2611961794","https://openalex.org/W2737455679","https://openalex.org/W2767891136","https://openalex.org/W2954540684","https://openalex.org/W3083147931","https://openalex.org/W3094640617","https://openalex.org/W3128048583","https://openalex.org/W4200011645"],"related_works":["https://openalex.org/W4379967210","https://openalex.org/W4400837077","https://openalex.org/W4243104695","https://openalex.org/W2953397621","https://openalex.org/W3200794875","https://openalex.org/W4416581718","https://openalex.org/W4308977022","https://openalex.org/W6901906478","https://openalex.org/W7128911759","https://openalex.org/W4400763375"],"abstract_inverted_index":{"Glioma,":[0],"the":[1,11,48,78,85,142,159,196,202,234],"most":[2,12],"frequent":[3],"and":[4,36,42,64,72,101,181,223,228],"malignant":[5,146],"brain":[6],"tumor,":[7],"is":[8,29],"one":[9],"of":[10,15,21,51,61,133,141,220,236],"lethal":[13],"forms":[14],"cancer.":[16],"Among":[17],"a":[18,131,214],"wide":[19],"range":[20],"aberrantly":[22],"expressed":[23],"genes,":[24],"Angiotensin-2":[25],"Receptor":[26],"Type-1":[27],"(AGTR1)":[28],"reported":[30],"to":[31,104,138],"be":[32,241],"up-regulated":[33],"in":[34,92,145,158,201,216,252],"glioma":[35,106,147,179,253],"associated":[37],"with":[38,84,189,213],"aggressive":[39],"tumor":[40],"traits":[41],"progression.":[43],"The":[44,81,151,185],"current":[45],"study":[46],"evaluates":[47],"anticancer":[49],"potential":[50],"commonly":[52],"used":[53],"angiotensin":[54],"receptor":[55],"blocker":[56],"(ARB)":[57],"telmisartan.":[58],"A":[59],"total":[60],"eleven,":[62],"Food":[63],"Drug":[65],"Administration":[66],"(FDA)":[67],"approved":[68],"ARBs":[69],"were":[70,75],"selected,":[71],"eight":[73],"drugs":[74],"docked":[76],"against":[77,249],"AGTR1":[79,156,209,250],"receptor.":[80],"antihypertensive":[82],"drug":[83,197],"highest":[86],"docking":[87],"score":[88],"was":[89,99,114,136,162,187,210],"selected":[90],"for":[91,172,208,225],"vitro":[93,123],"experimentation.":[94],"Half":[95],"maximal":[96],"inhibitory":[97,125,247],"concentration":[98],"determined":[100,115],"subsequently":[102],"applied":[103],"patient-derived":[105],"cell":[107,143,149,193,254],"lines.":[108,150,194,255],"Quantitative":[109],"gene":[110],"expression":[111,157,251],"post-drug":[112],"treatment":[113],"through":[116],"real-time":[117],"polymerase":[118],"chain":[119],"reaction":[120],"(PCR).":[121],"In":[122],"growth":[124],"assays":[126],"revealed":[127],"that":[128,155,243],"telmisartan":[129,244],"at":[130],"dose":[132],"45\u00b10.06":[134],"\u03bcM":[135],"able":[137],"inhibit":[139],"50%":[140],"population":[144],"U87":[148],"PCR":[152],"results":[153],"show":[154],"untreated":[160],"sample":[161,173],"high,":[163],"as":[164],"evidenced":[165],"by":[166],"2-\u0394\u0394Ct":[167],"values":[168],"(342.4,":[169],"138.5,":[170],"1467.3)":[171],"IK148-Glioblastma":[174],"multiform":[175],"(GBM),":[176],"IK163-low":[177],"grade":[178],"(LGG),":[180],"IK231-Medulloblastoma":[182],"(MDB),":[183],"respectively.":[184,231],"comparison":[186],"made":[188],"positive":[190],"control":[191],"U-87":[192],"Following":[195],"treatment,":[198],"an":[199],"increase":[200],"cycle":[203],"threshold":[204],"(Ct)":[205],"mean":[206,217],"value":[207],"observed,":[211],"coinciding":[212],"decrease":[215],"fold":[218],"changes":[219],"0.06\u00b10.8,":[221],"0.5\u00b12.0,":[222],"0.02\u00b10.02":[224],"GBM,":[226],"LGG,":[227],"MDB":[229],"samples,":[230],"Based":[232],"on":[233],"findings":[235],"this":[237],"study,":[238],"it":[239],"can":[240],"concluded":[242],"exhibits":[245],"successful":[246],"effects":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-02T00:00:00"}
