{"id":"https://openalex.org/W4396548416","doi":"https://doi.org/10.1097/hjh.0000000000003737","title":"Multiple drug intolerance in antihypertensive patients: what is known and what is missing","display_name":"Multiple drug intolerance in antihypertensive patients: what is known and what is missing","publication_year":2024,"publication_date":"2024-04-11","ids":{"openalex":"https://openalex.org/W4396548416","doi":"https://doi.org/10.1097/hjh.0000000000003737","pmid":"https://pubmed.ncbi.nlm.nih.gov/38690922"},"language":"en","primary_location":{"id":"doi:10.1097/hjh.0000000000003737","doi":"https://doi.org/10.1097/hjh.0000000000003737","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000003737","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038905963","display_name":"Alice Palermiti","orcid":"https://orcid.org/0000-0003-0860-280X","observed_orcids":["https://orcid.org/0000-0003-0860-280X"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alice Palermiti","raw_affiliation_strings":["Laboratory of Clinical Pharmacology and Pharmacogenetics","to Dr Alice Palermiti, Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Turin 10149, Italy. Tel: +39 0114393979/+39 0114393867"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology and Pharmacogenetics","institution_ids":[]},{"raw_affiliation_string":"to Dr Alice Palermiti, Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Turin 10149, Italy. Tel: +39 0114393979/+39 0114393867","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032097689","display_name":"Marco Pappaccogli","orcid":"https://orcid.org/0000-0003-4107-8122","observed_orcids":["https://orcid.org/0000-0003-4107-8122"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Pappaccogli","raw_affiliation_strings":["Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073643153","display_name":"Franco Rabbia","orcid":"https://orcid.org/0000-0002-6589-8216","observed_orcids":["https://orcid.org/0000-0002-6589-8216"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Rabbia","raw_affiliation_strings":["Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076836884","display_name":"Antonio D\u2019Avolio","orcid":"https://orcid.org/0000-0002-1321-4126","observed_orcids":["https://orcid.org/0000-0002-1321-4126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio D\u2019Avolio","raw_affiliation_strings":["Laboratory of Clinical Pharmacology and Pharmacogenetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology and Pharmacogenetics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091030548","display_name":"Franco Veglio","orcid":"https://orcid.org/0000-0002-6654-6247","observed_orcids":["https://orcid.org/0000-0002-6654-6247"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Veglio","raw_affiliation_strings":["Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032097689","https://openalex.org/A5038905963"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":0.344,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.36923077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"42","issue":"8","first_page":"1289","last_page":"1297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-intolerance","display_name":"drug intolerance","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9309999942779541},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7730000019073486},{"id":"https://openalex.org/keywords/uncontrolled-hypertension","display_name":"uncontrolled hypertension","score":0.8349999785423279},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/renal-denervation","display_name":"renal denervation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/multidisciplinary-management","display_name":"multidisciplinary management","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9563086032867432},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7384583950042725},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.68657386302948},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6314595937728882},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5770445466041565},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5750592947006226},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.45317795872688293},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42545580863952637},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27417486906051636},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.243351548910141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18854624032974243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/hjh.0000000000003737","doi":"https://doi.org/10.1097/hjh.0000000000003737","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000003737","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:38690922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38690922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/1974850","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2318/1974850","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W39026146","https://openalex.org/W97874221","https://openalex.org/W1870019315","https://openalex.org/W1931696915","https://openalex.org/W1968819665","https://openalex.org/W1986932113","https://openalex.org/W1993938145","https://openalex.org/W2001572602","https://openalex.org/W2016611713","https://openalex.org/W2021124220","https://openalex.org/W2026178152","https://openalex.org/W2044477775","https://openalex.org/W2047752822","https://openalex.org/W2059563370","https://openalex.org/W2063280109","https://openalex.org/W2078379767","https://openalex.org/W2083126683","https://openalex.org/W2090798025","https://openalex.org/W2091849821","https://openalex.org/W2091870760","https://openalex.org/W2095587358","https://openalex.org/W2098638016","https://openalex.org/W2117448324","https://openalex.org/W2122255653","https://openalex.org/W2126346033","https://openalex.org/W2133238086","https://openalex.org/W2134739816","https://openalex.org/W2153972688","https://openalex.org/W2171245517","https://openalex.org/W2172216861","https://openalex.org/W2188930280","https://openalex.org/W2205531850","https://openalex.org/W2298992190","https://openalex.org/W2318801492","https://openalex.org/W2327883739","https://openalex.org/W2331077836","https://openalex.org/W2347135823","https://openalex.org/W2399404195","https://openalex.org/W2435193784","https://openalex.org/W2496624180","https://openalex.org/W2550720962","https://openalex.org/W2555963264","https://openalex.org/W2593335783","https://openalex.org/W2595338898","https://openalex.org/W2609381431","https://openalex.org/W2789603460","https://openalex.org/W2791812125","https://openalex.org/W2810943327","https://openalex.org/W2901167364","https://openalex.org/W2906108284","https://openalex.org/W2912063736","https://openalex.org/W2972401245","https://openalex.org/W3013841246","https://openalex.org/W4249909393","https://openalex.org/W4282938819","https://openalex.org/W4283327617","https://openalex.org/W4293084779","https://openalex.org/W4313544530","https://openalex.org/W6676550427","https://openalex.org/W6687569540"],"related_works":["https://openalex.org/W4413950900","https://openalex.org/W2729212192","https://openalex.org/W2327883739","https://openalex.org/W4282938819","https://openalex.org/W7117752968","https://openalex.org/W2609381431","https://openalex.org/W4410587820","https://openalex.org/W7217582851","https://openalex.org/W1870019315","https://openalex.org/W3037243188"],"abstract_inverted_index":{"Drug":[0],"allergy":[1],"and":[2,56,80,102,126,133],"intolerance":[3,23],"are":[4],"increasingly":[5],"recognized":[6],"as":[7,109],"significant":[8],"public":[9],"health":[10],"concerns,":[11],"leading":[12],"to":[13,30,53,129],"adverse":[14,28],"reactions":[15,29],"in":[16,47,61,88,100,137],"patients":[17],"undergoing":[18],"pharmacological":[19],"treatments.":[20],"Multiple":[21],"drug":[22,35],"syndrome":[24],"(MDIS),":[25],"characterized":[26],"by":[27,119],"at":[31],"least":[32],"three":[33],"different":[34],"classes":[36],"without":[37],"a":[38,43,97],"clear":[39],"immunological":[40],"mechanism,":[41],"poses":[42],"substantial":[44],"challenge,":[45],"particularly":[46],"hypertensive":[48,138],"patients.":[49,139],"Despite":[50],"its":[51],"link":[52],"suboptimal":[54],"adherence":[55],"uncontrolled":[57],"blood":[58],"pressure,":[59],"MDIS":[60,87],"the":[62,89,94,121],"context":[63,90],"of":[64,91,96],"hypertension":[65],"remains":[66],"insufficiently":[67],"explored.":[68],"This":[69],"review":[70,117],"synthesizes":[71],"existing":[72],"literature":[73],"on":[74],"MDIS,":[75,135],"emphasizing":[76,120],"clinical":[77,127],"characteristics,":[78],"pathogenesis,":[79],"psychiatric":[81],"comorbidity.":[82],"Furthermore,":[83],"it":[84],"delves":[85],"into":[86],"hypertension,":[92],"highlighting":[93],"importance":[95],"multidisciplinary":[98],"approach":[99],"diagnosis":[101],"management,":[103],"including":[104],"innovative":[105],"therapeutic":[106,111],"strategies":[107],"such":[108],"novel":[110],"algorithms":[112],"or":[113],"renal":[114],"denervation.":[115],"The":[116],"concludes":[118],"necessity":[122],"for":[123],"further":[124],"research":[125],"trials":[128],"enhance":[130],"our":[131],"understanding":[132],"address":[134],"especially":[136]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-02T00:00:00"}
