{"id":"https://openalex.org/W4396541576","doi":"https://doi.org/10.1021/acsinfecdis.4c00115","title":"Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies","display_name":"Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4396541576","doi":"https://doi.org/10.1021/acsinfecdis.4c00115","pmid":"https://pubmed.ncbi.nlm.nih.gov/38691668"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.4c00115","doi":"https://doi.org/10.1021/acsinfecdis.4c00115","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.4c00115","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsinfecdis.4c00115","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080418679","display_name":"Krittika Ralhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krittika Ralhan","raw_affiliation_strings":["ACS International India Pvt. Ltd., Pune 411044, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACS International India Pvt. Ltd., Pune 411044, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014693026","display_name":"Kavita A. Iyer","orcid":"https://orcid.org/0000-0002-8476-0036","observed_orcids":["https://orcid.org/0000-0002-8476-0036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kavita A. Iyer","raw_affiliation_strings":["ACS International India Pvt. Ltd., Pune 411044, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACS International India Pvt. Ltd., Pune 411044, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016554031","display_name":"Leilani M. Lotti Diaz","orcid":"https://orcid.org/0000-0001-5955-9595","observed_orcids":["https://orcid.org/0000-0001-5955-9595"]},"institutions":[{"id":"https://openalex.org/I190567190","display_name":"American Chemical Society","ror":"https://ror.org/059dqb057","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I190567190"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leilani Lotti Diaz","raw_affiliation_strings":["CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0001-5955-9595","affiliations":[{"raw_affiliation_string":"CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I190567190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042204477","display_name":"Robert E. Bird","orcid":"https://orcid.org/0000-0001-6965-975X","observed_orcids":["https://orcid.org/0000-0001-6965-975X"]},"institutions":[{"id":"https://openalex.org/I190567190","display_name":"American Chemical Society","ror":"https://ror.org/059dqb057","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I190567190"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Bird","raw_affiliation_strings":["CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0001-6965-975X","affiliations":[{"raw_affiliation_string":"CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I190567190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095959676","display_name":"Ankush Maind","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ankush Maind","raw_affiliation_strings":["ACS International India Pvt. Ltd., Pune 411044, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACS International India Pvt. Ltd., Pune 411044, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042101684","display_name":"Qiongqiong Angela Zhou","orcid":"https://orcid.org/0000-0001-6711-369X","observed_orcids":["https://orcid.org/0000-0001-6711-369X"]},"institutions":[{"id":"https://openalex.org/I190567190","display_name":"American Chemical Society","ror":"https://ror.org/059dqb057","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I190567190"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qiongqiong Angela Zhou","raw_affiliation_strings":["CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0001-6711-369X","affiliations":[{"raw_affiliation_string":"CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I190567190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042101684"],"corresponding_institution_ids":["https://openalex.org/I190567190"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":5.177,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.97138153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"5","first_page":"1483","last_page":"1519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.08489999920129776,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antibiotic-resistance-mechanisms","display_name":"antibiotic resistance mechanisms","score":0.8600000143051147},{"id":"https://openalex.org/keywords/bibliometrics","display_name":"bibliometric analysis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.621999979019165},{"id":"https://openalex.org/keywords/research-trends","display_name":"research trends","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5575312376022339},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5558665990829468},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5501152873039246},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.41170600056648254},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3560919165611267},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.350985586643219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30427682399749756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28109776973724365},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.22809705138206482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20988517999649048},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.18654006719589233},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.16197547316551208}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.4c00115","doi":"https://doi.org/10.1021/acsinfecdis.4c00115","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.4c00115","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:38691668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38691668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11091902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11091902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acsinfecdis.4c00115","doi":"https://doi.org/10.1021/acsinfecdis.4c00115","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.4c00115","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Industry, innovation and infrastructure","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/9"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":357,"referenced_works":["https://openalex.org/W14069750","https://openalex.org/W51550641","https://openalex.org/W194343785","https://openalex.org/W241934223","https://openalex.org/W258250165","https://openalex.org/W978761036","https://openalex.org/W1206216030","https://openalex.org/W1499482268","https://openalex.org/W1548559854","https://openalex.org/W1892779545","https://openalex.org/W1928104178","https://openalex.org/W1966875539","https://openalex.org/W1967601930","https://openalex.org/W1968177206","https://openalex.org/W1970640469","https://openalex.org/W1974394752","https://openalex.org/W1974665363","https://openalex.org/W1975372142","https://openalex.org/W1975948453","https://openalex.org/W1979999342","https://openalex.org/W1981185465","https://openalex.org/W1983719379","https://openalex.org/W1986022664","https://openalex.org/W1989531597","https://openalex.org/W1990697265","https://openalex.org/W1991727417","https://openalex.org/W1998742798","https://openalex.org/W2002132188","https://openalex.org/W2006013291","https://openalex.org/W2007322603","https://openalex.org/W2008541744","https://openalex.org/W2009089119","https://openalex.org/W2010474964","https://openalex.org/W2010598074","https://openalex.org/W2011280022","https://openalex.org/W2014821208","https://openalex.org/W2017016334","https://openalex.org/W2019293613","https://openalex.org/W2025662936","https://openalex.org/W2026274581","https://openalex.org/W2028389268","https://openalex.org/W2029137696","https://openalex.org/W2031223726","https://openalex.org/W2032189553","https://openalex.org/W2032724724","https://openalex.org/W2033843473","https://openalex.org/W2035377568","https://openalex.org/W2037637974","https://openalex.org/W2037664114","https://openalex.org/W2038935803","https://openalex.org/W2039766960","https://openalex.org/W2040895520","https://openalex.org/W2044512869","https://openalex.org/W2045825103","https://openalex.org/W2051261828","https://openalex.org/W2052147832","https://openalex.org/W2055088408","https://openalex.org/W2059154739","https://openalex.org/W2064252200","https://openalex.org/W2067092006","https://openalex.org/W2068372433","https://openalex.org/W2070300719","https://openalex.org/W2070496300","https://openalex.org/W2081354838","https://openalex.org/W2081885526","https://openalex.org/W2082064308","https://openalex.org/W2084364244","https://openalex.org/W2084717327","https://openalex.org/W2087865186","https://openalex.org/W2089997464","https://openalex.org/W2090369174","https://openalex.org/W2093649670","https://openalex.org/W2095415823","https://openalex.org/W2095675572","https://openalex.org/W2096369133","https://openalex.org/W2097306188","https://openalex.org/W2098300761","https://openalex.org/W2101217433","https://openalex.org/W2104396548","https://openalex.org/W2105819052","https://openalex.org/W2107151561","https://openalex.org/W2108530765","https://openalex.org/W2108638835","https://openalex.org/W2109427414","https://openalex.org/W2113342653","https://openalex.org/W2113711383","https://openalex.org/W2115590956","https://openalex.org/W2116214229","https://openalex.org/W2116464526","https://openalex.org/W2117795567","https://openalex.org/W2118904810","https://openalex.org/W2126331514","https://openalex.org/W2128433990","https://openalex.org/W2129200622","https://openalex.org/W2131869707","https://openalex.org/W2132281308","https://openalex.org/W2142440440","https://openalex.org/W2143256071","https://openalex.org/W2144238593","https://openalex.org/W2151921983","https://openalex.org/W2151923665","https://openalex.org/W2153164725","https://openalex.org/W2155344369","https://openalex.org/W2159293433","https://openalex.org/W2159817785","https://openalex.org/W2169627488","https://openalex.org/W2171142540","https://openalex.org/W2171975065","https://openalex.org/W2189116376","https://openalex.org/W2193465684","https://openalex.org/W2233236537","https://openalex.org/W2262983945","https://openalex.org/W2273297198","https://openalex.org/W2298318901","https://openalex.org/W2314425775","https://openalex.org/W2316777574","https://openalex.org/W2318091958","https://openalex.org/W2318337237","https://openalex.org/W2320579939","https://openalex.org/W2322612584","https://openalex.org/W2331980215","https://openalex.org/W2336000990","https://openalex.org/W2341166238","https://openalex.org/W2347102183","https://openalex.org/W2416290591","https://openalex.org/W2418153528","https://openalex.org/W2440036510","https://openalex.org/W2460894723","https://openalex.org/W2465188286","https://openalex.org/W2496660393","https://openalex.org/W2509014851","https://openalex.org/W2523611868","https://openalex.org/W2535276585","https://openalex.org/W2556967912","https://openalex.org/W2560290738","https://openalex.org/W2586590237","https://openalex.org/W2589067428","https://openalex.org/W2600121819","https://openalex.org/W2605392951","https://openalex.org/W2605616341","https://openalex.org/W2605946455","https://openalex.org/W2606111779","https://openalex.org/W2610162525","https://openalex.org/W2616825195","https://openalex.org/W2620525720","https://openalex.org/W2627093682","https://openalex.org/W2726340259","https://openalex.org/W2733572144","https://openalex.org/W2755440815","https://openalex.org/W2766262938","https://openalex.org/W2766432315","https://openalex.org/W2769118269","https://openalex.org/W2770783793","https://openalex.org/W2774708386","https://openalex.org/W2778606863","https://openalex.org/W2782780688","https://openalex.org/W2784913318","https://openalex.org/W2785104789","https://openalex.org/W2789912955","https://openalex.org/W2790773084","https://openalex.org/W2793322717","https://openalex.org/W2799714015","https://openalex.org/W2805821823","https://openalex.org/W2808135224","https://openalex.org/W2809215976","https://openalex.org/W2811512821","https://openalex.org/W2813910014","https://openalex.org/W2832214819","https://openalex.org/W2883455341","https://openalex.org/W2885492105","https://openalex.org/W2886456503","https://openalex.org/W2891057921","https://openalex.org/W2897109701","https://openalex.org/W2897558467","https://openalex.org/W2898654474","https://openalex.org/W2900331994","https://openalex.org/W2900649343","https://openalex.org/W2905468129","https://openalex.org/W2912906332","https://openalex.org/W2913940689","https://openalex.org/W2917456970","https://openalex.org/W2920137369","https://openalex.org/W2924062259","https://openalex.org/W2925280433","https://openalex.org/W2925800094","https://openalex.org/W2934656438","https://openalex.org/W2938387685","https://openalex.org/W2945534183","https://openalex.org/W2945926743","https://openalex.org/W2949725538","https://openalex.org/W2950541901","https://openalex.org/W2955136322","https://openalex.org/W2958530108","https://openalex.org/W2959593012","https://openalex.org/W2965551365","https://openalex.org/W2968981812","https://openalex.org/W2974050033","https://openalex.org/W2974428678","https://openalex.org/W2974734470","https://openalex.org/W2974758152","https://openalex.org/W2978499777","https://openalex.org/W2991573081","https://openalex.org/W2995123180","https://openalex.org/W2995949565","https://openalex.org/W2996818947","https://openalex.org/W2998807596","https://openalex.org/W3001093580","https://openalex.org/W3004140701","https://openalex.org/W3004763185","https://openalex.org/W3007565704","https://openalex.org/W3009179423","https://openalex.org/W3011255411","https://openalex.org/W3014667241","https://openalex.org/W3015079070","https://openalex.org/W3015601786","https://openalex.org/W3016325272","https://openalex.org/W3017832761","https://openalex.org/W3017856136","https://openalex.org/W3021389291","https://openalex.org/W3033835965","https://openalex.org/W3039877229","https://openalex.org/W3042585943","https://openalex.org/W3046343137","https://openalex.org/W3048865162","https://openalex.org/W3049266455","https://openalex.org/W3081936009","https://openalex.org/W3082074638","https://openalex.org/W3083008593","https://openalex.org/W3087318638","https://openalex.org/W3088313863","https://openalex.org/W3091342337","https://openalex.org/W3091821365","https://openalex.org/W3094868867","https://openalex.org/W3098557317","https://openalex.org/W3107825098","https://openalex.org/W3109379743","https://openalex.org/W3114876786","https://openalex.org/W3114969372","https://openalex.org/W3119892653","https://openalex.org/W3120005507","https://openalex.org/W3127646014","https://openalex.org/W3128879566","https://openalex.org/W3131147063","https://openalex.org/W3132250597","https://openalex.org/W3132606228","https://openalex.org/W3133738380","https://openalex.org/W3135440766","https://openalex.org/W3136987411","https://openalex.org/W3149125421","https://openalex.org/W3151594924","https://openalex.org/W3151653919","https://openalex.org/W3153274461","https://openalex.org/W3154004596","https://openalex.org/W3157613085","https://openalex.org/W3157902053","https://openalex.org/W3172728545","https://openalex.org/W3182195134","https://openalex.org/W3187995032","https://openalex.org/W3188490926","https://openalex.org/W3191877236","https://openalex.org/W3195760101","https://openalex.org/W3195990121","https://openalex.org/W3196265058","https://openalex.org/W3196876619","https://openalex.org/W3197063311","https://openalex.org/W3198303770","https://openalex.org/W3199353171","https://openalex.org/W3204315556","https://openalex.org/W3204458363","https://openalex.org/W3206941570","https://openalex.org/W3207035420","https://openalex.org/W3207100594","https://openalex.org/W3207781598","https://openalex.org/W3208022610","https://openalex.org/W3214678853","https://openalex.org/W3215562998","https://openalex.org/W4200052719","https://openalex.org/W4200222243","https://openalex.org/W4200447289","https://openalex.org/W4205747301","https://openalex.org/W4206097133","https://openalex.org/W4206677002","https://openalex.org/W4206772668","https://openalex.org/W4210703176","https://openalex.org/W4210753338","https://openalex.org/W4211086589","https://openalex.org/W4211126900","https://openalex.org/W4211238958","https://openalex.org/W4220821289","https://openalex.org/W4220999127","https://openalex.org/W4221054046","https://openalex.org/W4224509126","https://openalex.org/W4229051450","https://openalex.org/W4229668867","https://openalex.org/W4230357700","https://openalex.org/W4238192220","https://openalex.org/W4242318543","https://openalex.org/W4246270606","https://openalex.org/W4247513553","https://openalex.org/W4281677682","https://openalex.org/W4281722003","https://openalex.org/W4281842559","https://openalex.org/W4281878660","https://openalex.org/W4281905145","https://openalex.org/W4283032742","https://openalex.org/W4283160013","https://openalex.org/W4283331844","https://openalex.org/W4283380404","https://openalex.org/W4283394484","https://openalex.org/W4283797626","https://openalex.org/W4285677225","https://openalex.org/W4286697248","https://openalex.org/W4287500177","https://openalex.org/W4294176229","https://openalex.org/W4297243263","https://openalex.org/W4309214205","https://openalex.org/W4311471854","https://openalex.org/W4311738758","https://openalex.org/W4312138773","https://openalex.org/W4313488703","https://openalex.org/W4318217938","https://openalex.org/W4318340549","https://openalex.org/W4319241531","https://openalex.org/W4319924575","https://openalex.org/W4321596055","https://openalex.org/W4323055026","https://openalex.org/W4323055055","https://openalex.org/W4323055058","https://openalex.org/W4323055079","https://openalex.org/W4323055087","https://openalex.org/W4323055112","https://openalex.org/W4323055117","https://openalex.org/W4323055137","https://openalex.org/W4323318816","https://openalex.org/W4323568636","https://openalex.org/W4323636662","https://openalex.org/W4367624633","https://openalex.org/W4379966703","https://openalex.org/W4381252028","https://openalex.org/W4381893827","https://openalex.org/W4382343918","https://openalex.org/W4383872739","https://openalex.org/W4384818632","https://openalex.org/W4385638331","https://openalex.org/W4386283595","https://openalex.org/W4386285219","https://openalex.org/W4386325609","https://openalex.org/W4386510257","https://openalex.org/W4387357646","https://openalex.org/W4388701688","https://openalex.org/W4389991855","https://openalex.org/W4390570560","https://openalex.org/W4391116946","https://openalex.org/W4391492783","https://openalex.org/W4392455443","https://openalex.org/W4392463455","https://openalex.org/W4404858400"],"related_works":["https://openalex.org/W2955020749","https://openalex.org/W2029063045","https://openalex.org/W2507683919","https://openalex.org/W2076505260","https://openalex.org/W4226193097","https://openalex.org/W4320037900","https://openalex.org/W4297123388","https://openalex.org/W3032187068","https://openalex.org/W4221083638","https://openalex.org/W3152803520"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,16,40,66,77,104],"effective":[3],"antibacterial":[4,48,105,118],"solutions":[5],"has":[6,71],"become":[7],"paramount":[8],"in":[9,13,31,47],"maintaining":[10],"global":[11,78],"health":[12],"this":[14,126],"era":[15],"increasing":[17],"bacterial":[18,33],"threats":[19],"and":[20,116],"rampant":[21],"antibiotic":[22],"resistance.":[23],"Traditional":[24],"antibiotics":[25,113],"have":[26,51],"played":[27],"a":[28],"significant":[29],"role":[30],"combating":[32],"infections":[34],"throughout":[35],"history.":[36],"However,":[37],"the":[38,53,58,62,86,101,109,123,129,137],"emergence":[39],"novel":[41,115],"resistant":[42],"strains":[43],"necessitates":[44],"constant":[45],"innovation":[46],"research.":[49],"We":[50],"analyzed":[52],"data":[54,90],"on":[55,84],"antibacterials":[56],"from":[57,111],"CAS":[59,87],"Content":[60,88],"Collection,":[61],"largest":[63],"human-curated":[64],"collection":[65],"published":[67],"scientific":[68,79],"knowledge,":[69],"which":[70],"proven":[72],"valuable":[73],"for":[74,91],"quantitative":[75],"analysis":[76,82],"knowledge.":[80],"Our":[81],"focuses":[83],"mining":[85],"Collection":[89],"recent":[92],"publications":[93],"(since":[94],"2012).":[95],"This":[96],"article":[97],"aims":[98],"to":[99,114,131,135],"explore":[100],"intricate":[102],"landscape":[103],"research":[106],"while":[107],"reviewing":[108],"advancement":[110],"traditional":[112],"emerging":[117],"strategies.":[119],"By":[120],"delving":[121],"into":[122],"resistance":[124],"mechanisms,":[125],"paper":[127],"highlights":[128],"need":[130],"find":[132],"alternate":[133],"strategies":[134],"address":[136],"growing":[138],"concern.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}