{"id":"https://openalex.org/W4396535136","doi":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","title":"ImoHS : Etude de l'immunomodulation de la r\u00e9ponse immunitaire dans l'Hidrad\u00e9nite suppur\u00e9e et Evaluation in vitro et ex vivo d'une nouvelle strat\u00e9gie th\u00e9rapeutique","display_name":"ImoHS : Etude de l'immunomodulation de la r\u00e9ponse immunitaire dans l'Hidrad\u00e9nite suppur\u00e9e et Evaluation in vitro et ex vivo d'une nouvelle strat\u00e9gie th\u00e9rapeutique","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4396535136","doi":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c"},"language":"fr","primary_location":{"id":"doi:10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","doi":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","is_oa":false,"landing_page_url":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lille (2022-....)","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.theses.fr/2023ULILS116/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000000649","display_name":"Marie Lamiaux","orcid":"https://orcid.org/0000-0002-7696-3511","observed_orcids":["https://orcid.org/0000-0002-7696-3511"]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie Lamiaux","raw_affiliation_strings":["Universit\u00e9 de Lille (2022-....)"],"raw_orcid":"https://orcid.org/0000-0002-7696-3511","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lille (2022-....)","institution_ids":["https://openalex.org/I2279609970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000000649"],"corresponding_institution_ids":["https://openalex.org/I2279609970"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12731","display_name":"Hidradenitis Suppurativa and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12731","display_name":"Hidradenitis Suppurativa and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8370000123977661},{"id":"https://openalex.org/keywords/skin-dysbiosis","display_name":"skin dysbiosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.5450000166893005},{"id":"https://openalex.org/keywords/th1-th17-cytokines","display_name":"Th1/Th17 cytokines","score":0.8050000071525574},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.6660000085830688},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.671999990940094},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.6919999718666077},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8788459300994873},{"id":"https://openalex.org/C2776002364","wikidata":"https://www.wikidata.org/wiki/Q341999","display_name":"Hidradenitis suppurativa","level":3,"score":0.7188388109207153},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.670750617980957},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5482072830200195},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47954389452934265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4336867928504944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.366929292678833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31889021396636963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08827951550483704},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08129090070724487},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07290565967559814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","doi":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","is_oa":false,"landing_page_url":"https://doi.org/10.70675/4c284a14zd5b0z40b9zab5cz431490212c2c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universit\u00e9 de Lille (2022-....)","raw_type":"dissertation"},{"id":"pmh:2023ULILS116","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2023ULILS116/document","pdf_url":"http://www.theses.fr/2023ULILS116/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:HAL:tel-04563446v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-04563446","pdf_url":"https://theses.hal.science/tel-04563446v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunologie. Universit\u00e9 de Lille, 2023. Fran\u00e7ais. ⟨NNT : 2023ULILS116⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:lilloa.univ-lille.fr:20.500.12210/113980","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12210/113980","pdf_url":null,"source":{"id":"https://openalex.org/S4306402203","display_name":"LillOA (Universit\u00e9 de Lille (University Of Lille))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210123514","host_organization_name":"Centre d'\u00c9tudes en Civilisations, Langues et Lettres \u00c9trang\u00e8res","host_organization_lineage":["https://openalex.org/I4210123514"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:2023ULILS116","doi":null,"is_oa":true,"landing_page_url":"http://www.theses.fr/2023ULILS116/document","pdf_url":"http://www.theses.fr/2023ULILS116/document","source":{"id":"https://openalex.org/S4406923047","display_name":"theses.fr (ABES)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396535136.pdf","grobid_xml":"https://content.openalex.org/works/W4396535136.grobid-xml"},"referenced_works_count":430,"referenced_works":["https://openalex.org/W36388105","https://openalex.org/W86744805","https://openalex.org/W158997302","https://openalex.org/W1532206496","https://openalex.org/W1544249031","https://openalex.org/W1576903429","https://openalex.org/W1580811574","https://openalex.org/W1581869568","https://openalex.org/W1601453379","https://openalex.org/W1621422713","https://openalex.org/W1639521477","https://openalex.org/W1678211544","https://openalex.org/W1785821026","https://openalex.org/W1825622469","https://openalex.org/W1842002390","https://openalex.org/W1853529910","https://openalex.org/W1867780443","https://openalex.org/W1905011311","https://openalex.org/W1906314843","https://openalex.org/W1914523963","https://openalex.org/W1924842828","https://openalex.org/W1954770639","https://openalex.org/W1963731011","https://openalex.org/W1964523952","https://openalex.org/W1967146410","https://openalex.org/W1968956851","https://openalex.org/W1969179523","https://openalex.org/W1969199357","https://openalex.org/W1970785085","https://openalex.org/W1971292240","https://openalex.org/W1972828805","https://openalex.org/W1972872350","https://openalex.org/W1973966753","https://openalex.org/W1974028547","https://openalex.org/W1974642492","https://openalex.org/W1975048321","https://openalex.org/W1976639539","https://openalex.org/W1978573819","https://openalex.org/W1979364731","https://openalex.org/W1982793777","https://openalex.org/W1983570871","https://openalex.org/W1983663861","https://openalex.org/W1985091308","https://openalex.org/W1989021197","https://openalex.org/W1989070304","https://openalex.org/W1989428978","https://openalex.org/W1990429560","https://openalex.org/W1993686673","https://openalex.org/W1993722622","https://openalex.org/W1993772630","https://openalex.org/W1994490127","https://openalex.org/W1994937037","https://openalex.org/W1995004385","https://openalex.org/W1996601924","https://openalex.org/W1996921234","https://openalex.org/W1997458644","https://openalex.org/W1998568385","https://openalex.org/W2000304913","https://openalex.org/W2001534065","https://openalex.org/W2003048936","https://openalex.org/W2005359518","https://openalex.org/W2006522099","https://openalex.org/W2006650732","https://openalex.org/W2007121925","https://openalex.org/W2010127983","https://openalex.org/W2011569383","https://openalex.org/W2011824801","https://openalex.org/W2015095309","https://openalex.org/W2015280752","https://openalex.org/W2015645194","https://openalex.org/W2016827757","https://openalex.org/W2016852684","https://openalex.org/W2018608147","https://openalex.org/W2018922598","https://openalex.org/W2022851321","https://openalex.org/W2024170200","https://openalex.org/W2027907732","https://openalex.org/W2028151516","https://openalex.org/W2028469832","https://openalex.org/W2031211461","https://openalex.org/W2031363300","https://openalex.org/W2033223516","https://openalex.org/W2035053917","https://openalex.org/W2035388701","https://openalex.org/W2038996902","https://openalex.org/W2039402835","https://openalex.org/W2039748798","https://openalex.org/W2040769492","https://openalex.org/W2041021823","https://openalex.org/W2043948736","https://openalex.org/W2044168765","https://openalex.org/W2048115636","https://openalex.org/W2048674504","https://openalex.org/W2051347106","https://openalex.org/W2051653190","https://openalex.org/W2061982698","https://openalex.org/W2064645845","https://openalex.org/W2065688950","https://openalex.org/W2067224821","https://openalex.org/W2068176248","https://openalex.org/W2068517386","https://openalex.org/W2068733899","https://openalex.org/W2069034215","https://openalex.org/W2070976096","https://openalex.org/W2071125490","https://openalex.org/W2072432297","https://openalex.org/W2072561567","https://openalex.org/W2073560278","https://openalex.org/W2073638852","https://openalex.org/W2075158987","https://openalex.org/W2077650954","https://openalex.org/W2078482635","https://openalex.org/W2079512289","https://openalex.org/W2080780073","https://openalex.org/W2081226722","https://openalex.org/W2085492743","https://openalex.org/W2086332533","https://openalex.org/W2089081860","https://openalex.org/W2089701444","https://openalex.org/W2094807512","https://openalex.org/W2097147259","https://openalex.org/W2097977905","https://openalex.org/W2100039832","https://openalex.org/W2102174483","https://openalex.org/W2102429140","https://openalex.org/W2104502109","https://openalex.org/W2104750008","https://openalex.org/W2106248075","https://openalex.org/W2110755088","https://openalex.org/W2118379843","https://openalex.org/W2120041410","https://openalex.org/W2123002444","https://openalex.org/W2128927218","https://openalex.org/W2130509509","https://openalex.org/W2131010873","https://openalex.org/W2135025266","https://openalex.org/W2136194743","https://openalex.org/W2139008734","https://openalex.org/W2139122813","https://openalex.org/W2139316812","https://openalex.org/W2143464311","https://openalex.org/W2143772132","https://openalex.org/W2144110603","https://openalex.org/W2150359704","https://openalex.org/W2151734986","https://openalex.org/W2152712946","https://openalex.org/W2153972223","https://openalex.org/W2155565450","https://openalex.org/W2155779547","https://openalex.org/W2158193558","https://openalex.org/W2159662576","https://openalex.org/W2160790213","https://openalex.org/W2160965670","https://openalex.org/W2161757863","https://openalex.org/W2162222490","https://openalex.org/W2163545413","https://openalex.org/W2163702740","https://openalex.org/W2164101851","https://openalex.org/W2164386185","https://openalex.org/W2165098251","https://openalex.org/W2167195670","https://openalex.org/W2167260825","https://openalex.org/W2174285875","https://openalex.org/W2174399689","https://openalex.org/W2175027747","https://openalex.org/W2175969345","https://openalex.org/W2176280211","https://openalex.org/W2192166578","https://openalex.org/W2196534710","https://openalex.org/W2212183969","https://openalex.org/W2224237734","https://openalex.org/W2229987747","https://openalex.org/W2268620035","https://openalex.org/W2278726896","https://openalex.org/W2291471126","https://openalex.org/W2298241043","https://openalex.org/W2332279567","https://openalex.org/W2346273970","https://openalex.org/W2346389198","https://openalex.org/W2404485673","https://openalex.org/W2406935300","https://openalex.org/W2415577238","https://openalex.org/W2425256395","https://openalex.org/W2434614051","https://openalex.org/W2442629634","https://openalex.org/W2465289519","https://openalex.org/W2468925656","https://openalex.org/W2478467838","https://openalex.org/W2495880885","https://openalex.org/W2503109448","https://openalex.org/W2507832634","https://openalex.org/W2513564307","https://openalex.org/W2514996992","https://openalex.org/W2518233086","https://openalex.org/W2519170034","https://openalex.org/W2522143990","https://openalex.org/W2524637936","https://openalex.org/W2525236467","https://openalex.org/W2528209295","https://openalex.org/W2538707220","https://openalex.org/W2551701381","https://openalex.org/W2556792921","https://openalex.org/W2560048914","https://openalex.org/W2562477545","https://openalex.org/W2564584078","https://openalex.org/W2568133249","https://openalex.org/W2588013596","https://openalex.org/W2589392019","https://openalex.org/W2591601356","https://openalex.org/W2592265273","https://openalex.org/W2592494139","https://openalex.org/W2594274861","https://openalex.org/W2605630275","https://openalex.org/W2612431515","https://openalex.org/W2612802596","https://openalex.org/W2617357797","https://openalex.org/W2621879589","https://openalex.org/W2623388110","https://openalex.org/W2626543821","https://openalex.org/W2653859450","https://openalex.org/W2655262992","https://openalex.org/W2694182897","https://openalex.org/W2725763230","https://openalex.org/W2739511152","https://openalex.org/W2739516504","https://openalex.org/W2747461977","https://openalex.org/W2751719338","https://openalex.org/W2756574903","https://openalex.org/W2757445169","https://openalex.org/W2758853776","https://openalex.org/W2761117934","https://openalex.org/W2766258897","https://openalex.org/W2767163492","https://openalex.org/W2767255486","https://openalex.org/W2768740770","https://openalex.org/W2768999540","https://openalex.org/W2769099241","https://openalex.org/W2769616975","https://openalex.org/W2771121740","https://openalex.org/W2774922248","https://openalex.org/W2775272419","https://openalex.org/W2779623922","https://openalex.org/W2781818639","https://openalex.org/W2784432887","https://openalex.org/W2784511455","https://openalex.org/W2787878396","https://openalex.org/W2789700984","https://openalex.org/W2791877080","https://openalex.org/W2792610378","https://openalex.org/W2793997328","https://openalex.org/W2795098196","https://openalex.org/W2795509260","https://openalex.org/W2796086379","https://openalex.org/W2797429263","https://openalex.org/W2801988652","https://openalex.org/W2802264603","https://openalex.org/W2803157626","https://openalex.org/W2804712565","https://openalex.org/W2806089094","https://openalex.org/W2806141204","https://openalex.org/W2810656889","https://openalex.org/W2810942360","https://openalex.org/W2861983196","https://openalex.org/W2883424449","https://openalex.org/W2884427630","https://openalex.org/W2885678300","https://openalex.org/W2885906939","https://openalex.org/W2886268674","https://openalex.org/W2888376450","https://openalex.org/W2889122827","https://openalex.org/W2891334292","https://openalex.org/W2898809981","https://openalex.org/W2899010137","https://openalex.org/W2899016064","https://openalex.org/W2900127993","https://openalex.org/W2900362695","https://openalex.org/W2902348876","https://openalex.org/W2903052440","https://openalex.org/W2907779785","https://openalex.org/W2907893309","https://openalex.org/W2908669769","https://openalex.org/W2912119260","https://openalex.org/W2914048336","https://openalex.org/W2914479886","https://openalex.org/W2914935595","https://openalex.org/W2922238701","https://openalex.org/W2934154532","https://openalex.org/W2936970414","https://openalex.org/W2944091076","https://openalex.org/W2944276014","https://openalex.org/W2946640310","https://openalex.org/W2948150201","https://openalex.org/W2948320314","https://openalex.org/W2949025651","https://openalex.org/W2953907977","https://openalex.org/W2954570610","https://openalex.org/W2954800457","https://openalex.org/W2964600154","https://openalex.org/W2965517593","https://openalex.org/W2966465234","https://openalex.org/W2968594040","https://openalex.org/W2969562402","https://openalex.org/W2969725855","https://openalex.org/W2970689561","https://openalex.org/W2970989965","https://openalex.org/W2971609950","https://openalex.org/W2973675164","https://openalex.org/W2976806592","https://openalex.org/W2979544789","https://openalex.org/W2979605572","https://openalex.org/W2980635874","https://openalex.org/W2982836600","https://openalex.org/W2983421360","https://openalex.org/W2983991556","https://openalex.org/W2990966408","https://openalex.org/W2993251659","https://openalex.org/W2994614717","https://openalex.org/W2997989618","https://openalex.org/W2998290717","https://openalex.org/W2998339210","https://openalex.org/W2999046456","https://openalex.org/W2999300804","https://openalex.org/W3005706188","https://openalex.org/W3006732525","https://openalex.org/W3007410422","https://openalex.org/W3007632958","https://openalex.org/W3008621629","https://openalex.org/W3010846908","https://openalex.org/W3010926675","https://openalex.org/W3011557809","https://openalex.org/W3014098394","https://openalex.org/W3015849911","https://openalex.org/W3016834001","https://openalex.org/W3019434847","https://openalex.org/W3023895371","https://openalex.org/W3026913959","https://openalex.org/W3028322523","https://openalex.org/W3037331248","https://openalex.org/W3038471178","https://openalex.org/W3038965129","https://openalex.org/W3043333601","https://openalex.org/W3047381606","https://openalex.org/W3048111935","https://openalex.org/W3059431577","https://openalex.org/W3081828681","https://openalex.org/W3084413106","https://openalex.org/W3085242393","https://openalex.org/W3087951185","https://openalex.org/W3092268290","https://openalex.org/W3092754589","https://openalex.org/W3093384529","https://openalex.org/W3093603374","https://openalex.org/W3098805434","https://openalex.org/W3100055007","https://openalex.org/W3105715144","https://openalex.org/W3106799097","https://openalex.org/W3111180271","https://openalex.org/W3111914682","https://openalex.org/W3113883099","https://openalex.org/W3114926512","https://openalex.org/W3115781608","https://openalex.org/W3123328370","https://openalex.org/W3124586815","https://openalex.org/W3126563441","https://openalex.org/W3129246356","https://openalex.org/W3131315926","https://openalex.org/W3132695547","https://openalex.org/W3137763012","https://openalex.org/W3137921586","https://openalex.org/W3141830626","https://openalex.org/W3152978556","https://openalex.org/W3153009923","https://openalex.org/W3163579061","https://openalex.org/W3163979544","https://openalex.org/W3170479691","https://openalex.org/W3174041955","https://openalex.org/W3185925261","https://openalex.org/W3193189414","https://openalex.org/W3194095060","https://openalex.org/W3194448077","https://openalex.org/W3195421093","https://openalex.org/W3197093293","https://openalex.org/W3197519902","https://openalex.org/W3201453418","https://openalex.org/W3201606483","https://openalex.org/W3204136558","https://openalex.org/W3205362354","https://openalex.org/W3207794909","https://openalex.org/W3208323813","https://openalex.org/W3209112781","https://openalex.org/W3214393784","https://openalex.org/W3217325149","https://openalex.org/W3217615439","https://openalex.org/W4200278185","https://openalex.org/W4205439723","https://openalex.org/W4206898151","https://openalex.org/W4210327852","https://openalex.org/W4210992315","https://openalex.org/W4224138674","https://openalex.org/W4225485337","https://openalex.org/W4246158195","https://openalex.org/W4252583974","https://openalex.org/W4281492315","https://openalex.org/W4283739763","https://openalex.org/W4288445889","https://openalex.org/W4288855303","https://openalex.org/W4294138012","https://openalex.org/W4296717084","https://openalex.org/W4297150887","https://openalex.org/W4308003252","https://openalex.org/W4309515975","https://openalex.org/W4311508909","https://openalex.org/W4313311843","https://openalex.org/W4315606096","https://openalex.org/W4316466633","https://openalex.org/W4319057841","https://openalex.org/W4319067669","https://openalex.org/W4319759383","https://openalex.org/W4320484239","https://openalex.org/W4322501918","https://openalex.org/W4360600919","https://openalex.org/W4362458679","https://openalex.org/W4362692322","https://openalex.org/W4377115786","https://openalex.org/W4381681524","https://openalex.org/W4383912358","https://openalex.org/W4386808342","https://openalex.org/W4387109893","https://openalex.org/W4393295565","https://openalex.org/W6941161416"],"related_works":["https://openalex.org/W2555093613","https://openalex.org/W7147170166","https://openalex.org/W2768202693","https://openalex.org/W7024745481","https://openalex.org/W4388781370","https://openalex.org/W4403116804","https://openalex.org/W7212409208","https://openalex.org/W4404348029","https://openalex.org/W7212174923","https://openalex.org/W4392187029"],"abstract_inverted_index":{"L'hidrad\u00e9nite":[0],"suppur\u00e9e":[1],"(HS)":[2],"est":[3,21,290],"une":[4,70,247,268,273,318,362,395],"dermatose":[5],"chronique,":[6],"d\u00e9bilitante":[7],"et":[8,17,45,105,155,189,194,272,327,375,399,446,453,489,525,530],"suppurative":[9],"des":[10,93,119,147,234,297,371,429,495,497],"plis.":[11],"Sa":[12],"physiopathologie":[13],"reste":[14],"mal":[15],"comprise":[16],"seule":[18],"la":[19,40,57,64,97,140,150,160,180,186,212,222,263,281,302,324,331,386,402,414,432,442,528,545,558],"chirurgie":[20],"curative":[22],"au":[23,79,219,404,416,466,487,547],"prix":[24],"d'ex\u00e9r\u00e8ses":[25],"parfois":[26,115],"d\u00e9labrantes.":[27],"Les":[28,336],"\u00e9tudes":[29,51],"sont":[30],"limit\u00e9es":[31],"du":[32,100,231,354,425,507],"fait":[33],"de":[34,36,39,42,46,56,63,72,74,123,129,139,149,172,175,182,185,199,221,236,260,262,283,292,301,308,310,321,330,356,364,373,376,385,401,427,434,439,450,457,472,503,509,513,517,527,531,544,562,572],"l'absence":[35],"mod\u00e8le":[37,126,204,241,390,521,551,579],"animal":[38],"maladie,":[41],"son":[43,47,569],"h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9":[44],"caract\u00e8re":[48],"multifactoriel.":[49],"Plusieurs":[50],"ont":[52],"montr\u00e9":[53,87],"le":[54,91,137,170,475,520],"r\u00f4le":[55],"dysbiose":[58],"cutan\u00e9e":[59],"dans":[60,90,109,202,239,287],"l'inflammation":[61,532],"chronique":[62],"maladie":[65],"pouvant":[66],"\u00eatre":[67,280],"caus\u00e9e":[68],"par":[69,157,209,267,339,411,501,568],"alt\u00e9ration":[71],"s\u00e9cr\u00e9tion":[73,200],"peptides":[75],"antimicrobiens":[76],"(PAMs)":[77],"li\u00e9e":[78],"dysfonctionnement":[80],"k\u00e9ratinocytaire.":[81],"La":[82],"th\u00e9rapie":[83],"photodynamique":[84],"(PDT)":[85],"a":[86,121,515],"un":[88,164,229,258,346,378,468,578],"rationnel":[89],"traitement":[92,476],"dermatoses":[94],"inflammatoires.":[95],"Cependant":[96],"faible":[98],"p\u00e9n\u00e9trance":[99],"PS":[101],"limite":[102],"l'action":[103],"th\u00e9rapeutique":[104],"donc":[106],"sa":[107],"pertinence":[108],"l'HS":[110,288],"due":[111],"aux":[112],"trajets":[113],"fistuleux":[114],"profonds.La":[116],"premi\u00e8re":[117],"partie":[118],"r\u00e9sultats":[120,575],"permis":[122,516],"caract\u00e9riser":[124,519],"notre":[125,203,240,313,340,389,407,491,550],"in":[127,242,391,522,552],"vitro":[128,243,523,553],"lign\u00e9e":[130,161,213,314,325,341,408],"k\u00e9ratinocytaire":[131,152,349],"humain":[132],"immortalis\u00e9":[133],"HaCaT,":[134],"mut\u00e9":[135],"sur":[136,388,406,533,549,577],"g\u00e8ne":[138],"Nicastrine":[141],"(mod\u00e8le":[142,480],"HS),":[143],"o\u00f9":[144,177,358],"nous":[145,167,178,227,381,463,566],"observons":[146,179,394],"troubles":[148],"diff\u00e9renciation":[151,237,332,365],"notamment":[153],"morphologique":[154],"prot\u00e9ique":[156],"rapport":[158,210,412],"\u00e0":[159,206,211,246,257,306,345,413,448,505],"sauvage.":[162],"Dans":[163,460],"second":[165,379],"temps,":[166,380],"avons":[168,382,419,464,484,538],"\u00e9valu\u00e9":[169],"s\u00e9cr\u00e9tome":[171],"nos":[173,574],"milieux":[174],"culture,":[176],"pr\u00e9sence":[181],"cytokines":[183],"pro-inflammatoires":[184],"voie":[187,363],"TH1":[188],"TH17":[190],"(IL-1\u03b2,":[191],"IL-17a,":[192],"IL-23":[193],"IFN-\u03b3)":[195],"ainsi":[196,295],"qu'un":[197],"d\u00e9faut":[198],"IL-10":[201],"KO":[205,316,343,410],"l'\u00e9tat":[207],"basal":[208],"sauvage":[214],"ce":[215,461],"qui":[216,255,289],"pourrait":[217],"participer":[218],"d\u00e9s\u00e9quilibre":[220],"r\u00e9ponse":[223,443],"inflammatoire.":[224],"Par":[225],"ailleurs,":[226],"montrons":[228],"changement":[230],"profil":[232,259],"d'expression":[233],"marqueurs":[235],"k\u00e9ratinocytaire,":[238],"d'HS,":[244],"expos\u00e9":[245],"inflammation":[248],"induite":[249],"(TNF-\u03b1":[250],"+":[251,253],"IL-6":[252],"LPS),":[254],"s'apparente":[256],"k\u00e9ratinocytes":[261,360],"couche":[264],"basale,":[265],"caract\u00e9ris\u00e9":[266],"capacit\u00e9":[269,320],"prolif\u00e9rative":[270],"\u00e9lev\u00e9e":[271],"survie":[274],"cellulaire":[275],"prolong\u00e9e.":[276],"Ces":[277],"propri\u00e9t\u00e9s":[278],"pourraient":[279],"cause":[282],"l'acanthose":[284],"\u00e9pidermique":[285],"d\u00e9crite":[286],"responsable":[291],"l'occlusion":[293],"folliculaire":[294],"que":[296,312,323,328],"cicatrices":[298],"hypertrophiques":[299],"caract\u00e9ristiques":[300,337],"maladie.":[303],"Nous":[304,393,418,483,537],"observons,":[305],"partir":[307,449,506],"test":[309],"blessure,":[311],"HaCaT":[315,342,409,535],"pr\u00e9sente":[317],"meilleure":[319],"cicatrisation":[322,357],"WT":[326],"l'induction":[329],"augmente":[333],"cette":[334],"capacit\u00e9.":[335],"pr\u00e9sentaient":[338],"s'apparentent":[344],"\u00e9tat":[347],"d'activation":[348],"d\u00e9crit":[350],"en":[351,422,541,560],"particulier":[352],"lors":[353],"processus":[355],"les":[359,534],"suivent":[361],"\u00e9pith\u00e9liale":[366],"alternative":[367],"leur":[368],"permettant":[369],"d'acqu\u00e9rir":[370],"capacit\u00e9s":[372],"migration":[374],"prolif\u00e9ration.Dans":[377],"test\u00e9":[383],"l'effet":[384],"PDT":[387,403,415,473,546],"vitro.":[392],"plus":[396],"grande":[397],"efficacit\u00e9":[398],"s\u00e9lectivit\u00e9":[400],"BdM":[405,548],"5-ALA.":[417],"\u00e9galement":[420,485,539],"obtenu,":[421],"parall\u00e8le,":[423],"l'autorisation":[424],"comit\u00e9":[426],"protection":[428],"personnes":[430],"pour":[431,474,557],"r\u00e9alisation":[433],"l'\u00e9tude":[435,563],"clinique":[436,564],"ImoHS":[437],"afin":[438],"pouvoir":[440],"\u00e9valuer":[441],"immunitaire":[444],"locale":[445],"syst\u00e9mique,":[447],"pr\u00e9l\u00e8vements":[451],"sanguins":[452],"d'explants":[454,477],"cutan\u00e9s":[455,478],"issus":[456],"patients":[458],"HS.":[459],"cadre,":[462],"mis":[465,486,540],"point":[467,488],"nouveau":[469],"dispositif":[470],"d'illumination":[471],"humains":[479],"ex":[481,580],"vivo).":[482],"valid\u00e9":[490],"strat\u00e9gie":[492],"d'analyse":[493],"d'\u00e9tude":[494],"sous-groupes":[496],"cellules":[498],"lympho\u00efdes":[499],"inn\u00e9es":[500],"cytom\u00e9trie":[502],"flux":[504],"sang":[508],"donneur":[510],"sain.Le":[511],"projet":[512],"th\u00e8se":[514],"mieux":[518],"d'HS":[524],"l'impact":[526],"diff\u00e9rentiation":[529],"KO.":[536],"\u00e9vidence":[542],"l'efficacit\u00e9":[543],"d'HS.":[554],"L'autorisation":[555],"obtenue":[556],"mise":[559],"place":[561],"ImoHS,":[565],"permettra":[567],"c\u00f4t\u00e9":[570],"translationnel,":[571],"valider":[573],"obtenus":[576],"vivo.":[581]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-05-01T00:00:00"}