{"id":"https://openalex.org/W4396533136","doi":"https://doi.org/10.33854/heme.v6i1.1378","title":"Efek Anti-thrombosis Ekstrak Protease Fibrinolitik Asal Isolat Staphylococcus hominis HSFT-2","display_name":"Efek Anti-thrombosis Ekstrak Protease Fibrinolitik Asal Isolat Staphylococcus hominis HSFT-2","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4396533136","doi":"https://doi.org/10.33854/heme.v6i1.1378"},"language":"id","primary_location":{"id":"doi:10.33854/heme.v6i1.1378","doi":"https://doi.org/10.33854/heme.v6i1.1378","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v6i1.1378","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/1378/pdf","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/1378/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011461075","display_name":"Muhammad Ardi Afriansyah","orcid":"https://orcid.org/0000-0002-5368-6080","observed_orcids":["https://orcid.org/0000-0002-5368-6080"]},"institutions":[{"id":"https://openalex.org/I4210159899","display_name":"Universitas Muhammadiyah Semarang","ror":"https://ror.org/05hra0856","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210159899"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Ardi Afriansyah","raw_affiliation_strings":["Universitas Muhammadiyah Semarang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Muhammadiyah Semarang","institution_ids":["https://openalex.org/I4210159899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011461075"],"corresponding_institution_ids":["https://openalex.org/I4210159899"],"apc_list":null,"apc_paid":null,"fwci":0.328,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40640875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"6","issue":"1","first_page":"13","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinolytic-enzyme","display_name":"fibrinolytic enzyme","score":0.9070000052452087},{"id":"https://openalex.org/keywords/staphylococcus-hominis","display_name":"Staphylococcus hominis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/holothuria-scabra","display_name":"Holothuria scabra","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fibrin-clot-lysis","display_name":"fibrin clot lysis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.8629999756813049},{"id":"https://openalex.org/keywords/clot-retraction","display_name":"clot retraction","score":0.6790000200271606},{"id":"https://openalex.org/keywords/thrombolytic-agents","display_name":"thrombolytic agents","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6912676095962524},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5924658179283142},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.48837536573410034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41667309403419495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2896016240119934},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18333974480628967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10293695330619812}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33854/heme.v6i1.1378","doi":"https://doi.org/10.33854/heme.v6i1.1378","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v6i1.1378","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/1378/pdf","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33854/heme.v6i1.1378","doi":"https://doi.org/10.33854/heme.v6i1.1378","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v6i1.1378","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/1378/pdf","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396533136.pdf","grobid_xml":"https://content.openalex.org/works/W4396533136.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2055941854","https://openalex.org/W4285211554"],"related_works":["https://openalex.org/W3094706218","https://openalex.org/W2602610580","https://openalex.org/W4392056220","https://openalex.org/W4410005303","https://openalex.org/W4285148535","https://openalex.org/W4317434831","https://openalex.org/W3128251620","https://openalex.org/W4405263958","https://openalex.org/W4387197264","https://openalex.org/W4285131865"],"abstract_inverted_index":{"Latar":[0],"Belakang:":[1],"Gangguan":[2],"trombotik":[3,33],"menempati":[4],"urutan":[5],"3":[6],"besar":[7],"penyebab":[8],"kematian":[9,18,30],"pada":[10],"kelompok":[11],"penyakit":[12,32],"non":[13],"infeksi.":[14],"Telah":[15],"banyak":[16],"kasus":[17,44],"di":[19],"seluruh":[20],"dunia":[21],"yang":[22,56,64,104,161],"disebabkan":[23],"oleh":[24],"trombus.":[25],"Di":[26],"Amerika":[27],"Serikat":[28],"jumlah":[29],"akibat":[31],"tercatat":[34],"sebanyak":[35],"100.000":[36],"orang":[37],"setiap":[38],"tahunnya":[39],"dan":[40,90],"terus":[41],"meningkat":[42],"900.000":[43],"per":[45],"tahun.":[46],"Tujuan:":[47],"untuk":[48],"menguji":[49],"aktivitas":[50,102,132],"protease":[51,159],"fibrinolitik":[52,160],"dari":[53,58,79,163],"Staphylococcus":[54],"hominis":[55,165],"diisolasi":[57,162],"jaringan":[59],"otot":[60],"teripang":[61],"(Holothuria":[62],"scabra)":[63],"difermentasi":[65],"sebagai":[66],"agen":[67,169],"antitrombotik.":[68],"Metode:":[69],"Uji":[70],"antitrombosis":[71],"dilakukan":[72],"dengan":[73,106,136],"metode":[74,123],"gravimetri.":[75],"crude":[76],"enzim":[77,99,113,130,149],"diperoleh":[78],"isolat":[80],"S.hominis":[81],"HSFT-2":[82],"diuji":[83],"aktivitasnya":[84],"dalam":[85],"melisiskan":[86],"bekuan":[87,109,134],"darah":[88,92,118,135,153],"(anti-trombosis),":[89],"koagulasi":[91],"secara":[93,154],"in":[94],"vitro.":[95],"Hasil:":[96],"Ekstrak":[97,112,129],"kasar":[98,158],"bakteri":[100],"memiliki":[101,131],"trombolitik":[103],"ditunjukkan":[105],"persentase":[107],"lisis":[108],"sebesar":[110],"41,94%.":[111],"dapat":[114,150],"memperpanjang":[115],"waktu":[116],"pembekuan":[117,152],"hingga":[119],"16":[120],"detik":[121],"berdasarkan":[122],"aPTT":[124],"(Activated":[125],"Partial":[126],"Thromboplastin":[127],"Time).":[128],"retraksi":[133],"menunjukkan":[137],"perbedaan":[138],"12%":[139],"(lebih":[140],"tinggi)":[141],"dibandingkan":[142],"kontrol":[143],"(darah":[144],"tanpa":[145],"enzim).":[146],"Kesimpulan:":[147],"ekstrak":[148],"mencegah":[151],"parsial.":[155],"Kesimpulannya,":[156],"ekstra":[157],"S.":[164],"merupakan":[166],"sumber":[167],"potensial":[168],"antitrombolitik.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-05-01T00:00:00"}