{"id":"https://openalex.org/W4396530349","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","title":"Inhibition of Serine Glycine One Carbon Metabolism Attenuates Pulmonary Fibrosis in Mice","display_name":"Inhibition of Serine Glycine One Carbon Metabolism Attenuates Pulmonary Fibrosis in Mice","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396530349","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"A74. MITOCHONDRIA AND METABOLISM IN LUNG HEALTH AND DISEASE","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112096955","display_name":"Angelo Y. Meliton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.Y. Meliton","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113250721","display_name":"Kun Woo D Shin","orcid":"https://orcid.org/0009-0000-0477-153X","observed_orcids":["https://orcid.org/0009-0000-0477-153X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.W.D. Shin","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037440533","display_name":"Reng\u00fcl \u00c7etin-Atalay","orcid":"https://orcid.org/0000-0003-2408-6606","observed_orcids":["https://orcid.org/0000-0003-2408-6606"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Cetin-Atalay","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110019798","display_name":"T. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Cho","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082102722","display_name":"Jennifer C. Houpy Szafran","orcid":"https://orcid.org/0000-0001-6154-5205","observed_orcids":["https://orcid.org/0000-0001-6154-5205"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.H. Szafran","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079814684","display_name":"Parker S. Woods","orcid":"https://orcid.org/0000-0002-9054-4196","observed_orcids":["https://orcid.org/0000-0002-9054-4196"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.S. Woods","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080338987","display_name":"K. Sun","orcid":"https://orcid.org/0000-0001-8597-3837","observed_orcids":["https://orcid.org/0000-0001-8597-3837"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Sun","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045464318","display_name":"Obada R. Shamaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O.R. Shamaa","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059656427","display_name":"G\u00f6khan M. Mutlu","orcid":"https://orcid.org/0000-0002-2056-612X","observed_orcids":["https://orcid.org/0000-0002-2056-612X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.M. Mutlu","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066414145","display_name":"Robert B. Hamanaka","orcid":"https://orcid.org/0000-0002-8909-356X","observed_orcids":["https://orcid.org/0000-0002-8909-356X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.B. Hamanaka","raw_affiliation_strings":["The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A2609","last_page":"A2609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-glycine-metabolism","display_name":"serine/glycine metabolism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metabolic-inhibition","display_name":"metabolic inhibition","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.751524031162262},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7446258664131165},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6555470824241638},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.45804306864738464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44565534591674805},{"id":"https://openalex.org/C140205800","wikidata":"https://www.wikidata.org/wiki/Q5860","display_name":"Carbon fibers","level":3,"score":0.4385419189929962},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3641367554664612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3311919867992401},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25291112065315247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24587583541870117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1785300076007843},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1675567924976349},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08815661072731018},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2609","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"A74. MITOCHONDRIA AND METABOLISM IN LUNG HEALTH AND DISEASE","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2970731426","https://openalex.org/W2970788999","https://openalex.org/W2964509294","https://openalex.org/W4367606532","https://openalex.org/W3042176444","https://openalex.org/W4229835287","https://openalex.org/W4367607255","https://openalex.org/W3040731644","https://openalex.org/W4415358277","https://openalex.org/W2928749667"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-05-01T00:00:00"}
