{"id":"https://openalex.org/W4396524912","doi":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","title":"Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis","display_name":"Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4396524912","doi":"https://doi.org/10.31632/ijalsr.2024.v07i02.003"},"language":"en","primary_location":{"id":"doi:10.31632/ijalsr.2024.v07i02.003","doi":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","is_oa":true,"landing_page_url":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210213066","display_name":"International Journal of Advancement in Life Sciences Research","issn_l":"2581-4877","issn":["2581-4877"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advancement in Life Sciences Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046825914","display_name":"Kalpataru Halder","orcid":"https://orcid.org/0009-0007-8832-8092","observed_orcids":["https://orcid.org/0009-0007-8832-8092"]},"institutions":[{"id":"https://openalex.org/I4405277791","display_name":"Brahmananda Keshab Chandra College","ror":"https://ror.org/03xd28271","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405277791"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kalpataru Halder","raw_affiliation_strings":["Department of Molecular Biology & Biotechnology, Brahmananda Keshab Chandra College, 111/2 B.T Road, Kolkata700108, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology & Biotechnology, Brahmananda Keshab Chandra College, 111/2 B.T Road, Kolkata700108, West Bengal, India","institution_ids":["https://openalex.org/I4405277791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046825914"],"corresponding_institution_ids":["https://openalex.org/I4405277791"],"apc_list":null,"apc_paid":null,"fwci":0.6672,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"07","issue":"02","first_page":"17","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9710000157356262},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.9750000238418579},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/pro-apoptotic-agents","display_name":"pro-apoptotic agents","score":0.7829999923706055},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7877073884010315},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7271423935890198},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6467430591583252},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.6301716566085815},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.437139630317688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32165706157684326},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.16780129075050354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13671255111694336},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10047915577888489},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31632/ijalsr.2024.v07i02.003","doi":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","is_oa":true,"landing_page_url":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210213066","display_name":"International Journal of Advancement in Life Sciences Research","issn_l":"2581-4877","issn":["2581-4877"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advancement in Life Sciences Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31632/ijalsr.2024.v07i02.003","doi":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","is_oa":true,"landing_page_url":"https://doi.org/10.31632/ijalsr.2024.v07i02.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210213066","display_name":"International Journal of Advancement in Life Sciences Research","issn_l":"2581-4877","issn":["2581-4877"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advancement in Life Sciences Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":187,"referenced_works":["https://openalex.org/W111014857","https://openalex.org/W1517251865","https://openalex.org/W1533215988","https://openalex.org/W1581731557","https://openalex.org/W1668066705","https://openalex.org/W1902577542","https://openalex.org/W1977514126","https://openalex.org/W1980170993","https://openalex.org/W1989125392","https://openalex.org/W2000050049","https://openalex.org/W2002038028","https://openalex.org/W2016834188","https://openalex.org/W2023349699","https://openalex.org/W2033003773","https://openalex.org/W2033678594","https://openalex.org/W2044062274","https://openalex.org/W2052264066","https://openalex.org/W2056042156","https://openalex.org/W2060806180","https://openalex.org/W2061059838","https://openalex.org/W2064861225","https://openalex.org/W2070581271","https://openalex.org/W2072860434","https://openalex.org/W2073164616","https://openalex.org/W2082365934","https://openalex.org/W2085933321","https://openalex.org/W2086780062","https://openalex.org/W2090632754","https://openalex.org/W2097767970","https://openalex.org/W2107516157","https://openalex.org/W2113168515","https://openalex.org/W2135106949","https://openalex.org/W2141267324","https://openalex.org/W2149063105","https://openalex.org/W2156330379","https://openalex.org/W2156563694","https://openalex.org/W2157908924","https://openalex.org/W2169626634","https://openalex.org/W2196795346","https://openalex.org/W2235535864","https://openalex.org/W2235997771","https://openalex.org/W2275249742","https://openalex.org/W2300411058","https://openalex.org/W2485653171","https://openalex.org/W2520242613","https://openalex.org/W2549852019","https://openalex.org/W2558677829","https://openalex.org/W2577953296","https://openalex.org/W2591613371","https://openalex.org/W2611714093","https://openalex.org/W2729007679","https://openalex.org/W2738630992","https://openalex.org/W2741494659","https://openalex.org/W2761807003","https://openalex.org/W2763145619","https://openalex.org/W2769721849","https://openalex.org/W2783056471","https://openalex.org/W2789599622","https://openalex.org/W2791132728","https://openalex.org/W2791918181","https://openalex.org/W2791923388","https://openalex.org/W2792389397","https://openalex.org/W2793972506","https://openalex.org/W2794354720","https://openalex.org/W2795353688","https://openalex.org/W2796552195","https://openalex.org/W2802542587","https://openalex.org/W2802957028","https://openalex.org/W2803850864","https://openalex.org/W2804985859","https://openalex.org/W2808278107","https://openalex.org/W2809374624","https://openalex.org/W2809418529","https://openalex.org/W2889324944","https://openalex.org/W2902854367","https://openalex.org/W2915812778","https://openalex.org/W2935332994","https://openalex.org/W2941483908","https://openalex.org/W2965020403","https://openalex.org/W2965547724","https://openalex.org/W2969522726","https://openalex.org/W2970019959","https://openalex.org/W2971275989","https://openalex.org/W2982559190","https://openalex.org/W2984550196","https://openalex.org/W2984799663","https://openalex.org/W2990841045","https://openalex.org/W2991454308","https://openalex.org/W2991775645","https://openalex.org/W2996231268","https://openalex.org/W2997370174","https://openalex.org/W2999764480","https://openalex.org/W3002292920","https://openalex.org/W3003803008","https://openalex.org/W3004060585","https://openalex.org/W3005155026","https://openalex.org/W3005196658","https://openalex.org/W3009367721","https://openalex.org/W3010729777","https://openalex.org/W3011183964","https://openalex.org/W3015646919","https://openalex.org/W3019030153","https://openalex.org/W3021909056","https://openalex.org/W3028283095","https://openalex.org/W3036899246","https://openalex.org/W3037070782","https://openalex.org/W3043477990","https://openalex.org/W3069538828","https://openalex.org/W3088202095","https://openalex.org/W3088838661","https://openalex.org/W3104079531","https://openalex.org/W3105923034","https://openalex.org/W3107093794","https://openalex.org/W3115880421","https://openalex.org/W3118619927","https://openalex.org/W3119344794","https://openalex.org/W3124351350","https://openalex.org/W3127559070","https://openalex.org/W3128646645","https://openalex.org/W3134372476","https://openalex.org/W3137708143","https://openalex.org/W3138840859","https://openalex.org/W3145037012","https://openalex.org/W3154819335","https://openalex.org/W3155791645","https://openalex.org/W3176127157","https://openalex.org/W3179854736","https://openalex.org/W3183147912","https://openalex.org/W3185008715","https://openalex.org/W3191772847","https://openalex.org/W3192651840","https://openalex.org/W3192811719","https://openalex.org/W3198064628","https://openalex.org/W3198672584","https://openalex.org/W3200601212","https://openalex.org/W3203775163","https://openalex.org/W3205223194","https://openalex.org/W3211117713","https://openalex.org/W3213715506","https://openalex.org/W4200017038","https://openalex.org/W4205267152","https://openalex.org/W4206662285","https://openalex.org/W4206979450","https://openalex.org/W4206987954","https://openalex.org/W4213366301","https://openalex.org/W4213435625","https://openalex.org/W4214885022","https://openalex.org/W4220751744","https://openalex.org/W4221015989","https://openalex.org/W4223440591","https://openalex.org/W4229449988","https://openalex.org/W4280488282","https://openalex.org/W4280601790","https://openalex.org/W4283030571","https://openalex.org/W4283032811","https://openalex.org/W4283273621","https://openalex.org/W4283391086","https://openalex.org/W4285095102","https://openalex.org/W4293676945","https://openalex.org/W4300960642","https://openalex.org/W4302760621","https://openalex.org/W4304687342","https://openalex.org/W4305015474","https://openalex.org/W4306690359","https://openalex.org/W4309340577","https://openalex.org/W4310039989","https://openalex.org/W4310554287","https://openalex.org/W4311671280","https://openalex.org/W4313214410","https://openalex.org/W4313560176","https://openalex.org/W4313897948","https://openalex.org/W4317500708","https://openalex.org/W4317521198","https://openalex.org/W4319603095","https://openalex.org/W4319983518","https://openalex.org/W4321071963","https://openalex.org/W4362457925","https://openalex.org/W4362521538","https://openalex.org/W4366991250","https://openalex.org/W4383187135","https://openalex.org/W4384926002","https://openalex.org/W4385428514","https://openalex.org/W4385757318","https://openalex.org/W4386407407","https://openalex.org/W4388682033","https://openalex.org/W4388979460","https://openalex.org/W4389861133"],"related_works":["https://openalex.org/W4414669228","https://openalex.org/W3215423480","https://openalex.org/W2889324944","https://openalex.org/W3036429525","https://openalex.org/W4406113664","https://openalex.org/W4417459121","https://openalex.org/W2123898261","https://openalex.org/W3034601900","https://openalex.org/W2102382046","https://openalex.org/W2488283899"],"abstract_inverted_index":{"Chemotherapy":[0,145],"resistance":[1,23,34,109,146],"indicates":[2],"the":[3,9,45,56,111,115,126,131,135,163,172,191,207,215],"non-responsiveness":[4],"of":[5,14,41,47,67,72,76,91,118,196,217,224],"cancer":[6,26,77],"cells":[7,79],"to":[8,18,104,152,179,189],"cytotoxic":[10],"and":[11,63,70,80,99,120,142,155],"inhibitory":[12],"effects":[13,166],"chemo":[15,108],"drugs":[16],"attributed":[17],"either":[19],"intrinsic":[20],"or":[21],"extrinsic":[22],"mechanisms":[24],"in":[25,55,114],"cells.":[27],"Studies":[28],"so":[29],"far":[30],"indicate":[31],"that":[32],"drug":[33,48,57],"can":[35,102],"be":[36],"triggered":[37],"by":[38],"a":[39,149,222],"multitude":[40],"factors":[42,101],"such":[43,59,184,199],"as":[44,60,185,200],"over-expression":[46,66],"efflux":[49],"pumps,":[50],"DNA":[51],"repair":[52],"mechanisms,":[53],"modifications":[54],"target":[58],"point":[61],"mutations":[62],"gene":[64],"amplification,":[65],"anti-apoptotic":[68],"proteins":[69],"down-regulation":[71],"pro-apoptotic":[73,197],"signals,":[74],"presence":[75],"stem":[78],"immune-suppressive":[81],"cells,":[82],"excessive":[83],"cytokine":[84],"production,":[85],"tumor":[86],"heterogeneity,":[87],"epigenetic":[88],"changes,":[89],"activation":[90],"alternate":[92],"pro-survival":[93],"signaling":[94],"pathways,":[95],"etc.":[96,205],"Both":[97],"host":[98],"tumor-related":[100],"contribute":[103],"therapy":[105],"resistance.":[106],"Currently,":[107],"poses":[110],"foremost":[112],"setback":[113],"successful":[116],"treatment":[117,173],"cancer,":[119],"it":[121],"exerts":[122],"significant":[123],"stress":[124],"on":[125],"available":[127],"medical":[128],"resources.":[129],"Besides":[130],"costs":[132],"associated":[133,164],"with":[134],"treatment,":[136],"patients":[137],"go":[138],"through":[139],"severe":[140],"emotional":[141],"physical":[143],"trauma.":[144],"is":[147,158,210,220],"also":[148,211,221],"major":[150],"contributor":[151],"accelerated":[153],"metastasis":[154],"invasion.":[156],"Dose-escalation":[157],"not":[159],"always":[160],"practical":[161],"since":[162],"side":[165],"may":[167],"increase":[168],"apart":[169],"from":[170],"increasing":[171],"costs.":[174],"Several":[175],"studies":[176],"are":[177],"ongoing":[178],"address":[180],"this":[181],"issue":[182],"productively,":[183],"therapeutic":[186],"molecules":[187],"designed":[188],"restore":[190],"apoptotic":[192],"machinery.":[193],"Site-specific":[194],"delivery":[195],"agents":[198],"small":[201],"molecules,":[202],"antibodies,":[203],"peptides,":[204],"targeting":[206],"apoptosis":[208],"pathway":[209],"thoroughly":[212],"studied.":[213],"Moreover,":[214],"efficacy":[216],"combination":[218],"strategies":[219],"topic":[223],"research.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-01T00:00:00"}