{"id":"https://openalex.org/W4396516870","doi":"https://doi.org/10.1021/acs.chemrev.3c00894","title":"Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers","display_name":"Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396516870","doi":"https://doi.org/10.1021/acs.chemrev.3c00894","pmid":"https://pubmed.ncbi.nlm.nih.gov/38688034","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11122139"},"language":"en","primary_location":{"id":"doi:10.1021/acs.chemrev.3c00894","doi":"https://doi.org/10.1021/acs.chemrev.3c00894","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.chemrev.3c00894","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.chemrev.3c00894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095949998","display_name":"Maxwell Sigal","orcid":"https://orcid.org/0009-0007-1424-5593","observed_orcids":["https://orcid.org/0009-0007-1424-5593"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maxwell Sigal","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0009-0007-1424-5593","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048638268","display_name":"Satomi Matsumoto","orcid":"https://orcid.org/0009-0006-4285-2406","observed_orcids":["https://orcid.org/0009-0006-4285-2406"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satomi Matsumoto","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0009-0006-4285-2406","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015228689","display_name":"Adam T. Beattie","orcid":"https://orcid.org/0000-0003-1672-2756","observed_orcids":["https://orcid.org/0000-0003-1672-2756"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Adam Beattie","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1672-2756","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003170795","display_name":"Takayuki Katoh","orcid":"https://orcid.org/0000-0001-6550-6203","observed_orcids":["https://orcid.org/0000-0001-6550-6203"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takayuki Katoh","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6550-6203","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017224243","display_name":"Hiroaki Suga","orcid":"https://orcid.org/0000-0002-5298-9186","observed_orcids":["https://orcid.org/0000-0002-5298-9186"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroaki Suga","raw_affiliation_strings":["Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5298-9186","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003170795","https://openalex.org/A5017224243"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.262,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.7966648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"124","issue":"10","first_page":"6444","last_page":"6500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.9580000042915344},{"id":"https://openalex.org/keywords/genetic-code-expansion","display_name":"genetic code expansion","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ribosomal-translation","display_name":"ribosomal translation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/macrocyclic-peptides","display_name":"macrocyclic peptides","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cell-free-protein-synthesis","display_name":"cell-free protein synthesis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/translation-fidelity","display_name":"translation fidelity","score":0.628000020980835},{"id":"https://openalex.org/keywords/translation-efficiency","display_name":"translation efficiency","score":0.5090000033378601},{"id":"https://openalex.org/keywords/trna-editing","display_name":"tRNA editing","score":0.3100000023841858},{"id":"https://openalex.org/keywords/selenocysteine","display_name":"selenocysteine","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pyrrolysine","display_name":"pyrrolysine","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.8469622135162354},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.7033846974372864},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6703683137893677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6234232187271118},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5813276767730713},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5700033903121948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5031065344810486},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.49750402569770813},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4748114347457886},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.44787320494651794},{"id":"https://openalex.org/C2776087148","wikidata":"https://www.wikidata.org/wiki/Q408663","display_name":"Selenocysteine","level":4,"score":0.44354912638664246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.433176726102829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30026930570602417},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.28177428245544434},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1266184151172638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12355449795722961},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.09208673238754272},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.chemrev.3c00894","doi":"https://doi.org/10.1021/acs.chemrev.3c00894","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.chemrev.3c00894","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11122139","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11122139","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Rev","raw_type":"Text"},{"id":"pmid:38688034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38688034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.chemrev.3c00894","doi":"https://doi.org/10.1021/acs.chemrev.3c00894","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.chemrev.3c00894","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1354766901","display_name":"Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products","funder_award_id":"20H05618","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2261523059","display_name":"Ribosomal synthesis of peptidomimetics bearing non-amide backbones","funder_award_id":"21K18233","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3124509282","display_name":"Screening novel peptide drugs using ribosomally synthesized foldamer peptide library containing cyclic beta-amino acids","funder_award_id":"22H00439","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":641,"referenced_works":["https://openalex.org/W89221041","https://openalex.org/W199876327","https://openalex.org/W357746881","https://openalex.org/W415135089","https://openalex.org/W561763038","https://openalex.org/W1149835906","https://openalex.org/W1175086522","https://openalex.org/W1481100343","https://openalex.org/W1484204974","https://openalex.org/W1489489167","https://openalex.org/W1501954650","https://openalex.org/W1508132982","https://openalex.org/W1515865532","https://openalex.org/W1519996426","https://openalex.org/W1546767835","https://openalex.org/W1548506268","https://openalex.org/W1548556588","https://openalex.org/W1551583539","https://openalex.org/W1561396590","https://openalex.org/W1562298896","https://openalex.org/W1566760837","https://openalex.org/W1571289144","https://openalex.org/W1587481053","https://openalex.org/W1602817271","https://openalex.org/W1607154936","https://openalex.org/W1616799456","https://openalex.org/W1760388574","https://openalex.org/W1899616654","https://openalex.org/W1900117334","https://openalex.org/W1904477323","https://openalex.org/W1906506969","https://openalex.org/W1918344992","https://openalex.org/W1951639553","https://openalex.org/W1954517756","https://openalex.org/W1963958192","https://openalex.org/W1963986378","https://openalex.org/W1964078197","https://openalex.org/W1964787147","https://openalex.org/W1965294075","https://openalex.org/W1966087112","https://openalex.org/W1967304044","https://openalex.org/W1968072816","https://openalex.org/W1968321828","https://openalex.org/W1968879131","https://openalex.org/W1969170660","https://openalex.org/W1969303801","https://openalex.org/W1969435865","https://openalex.org/W1969449009","https://openalex.org/W1972101882","https://openalex.org/W1973268713","https://openalex.org/W1973731640","https://openalex.org/W1974067623","https://openalex.org/W1975586269","https://openalex.org/W1976954198","https://openalex.org/W1977059214","https://openalex.org/W1977243327","https://openalex.org/W1977837589","https://openalex.org/W1978635623","https://openalex.org/W1978667812","https://openalex.org/W1978858109","https://openalex.org/W1978957509","https://openalex.org/W1979428706","https://openalex.org/W1979755475","https://openalex.org/W1981322481","https://openalex.org/W1981582209","https://openalex.org/W1982826901","https://openalex.org/W1983082406","https://openalex.org/W1983167449","https://openalex.org/W1983169511","https://openalex.org/W1983534198","https://openalex.org/W1984854823","https://openalex.org/W1985686527","https://openalex.org/W1985857378","https://openalex.org/W1986826865","https://openalex.org/W1987293914","https://openalex.org/W1988858733","https://openalex.org/W1989760659","https://openalex.org/W1990175939","https://openalex.org/W1990734020","https://openalex.org/W1991959327","https://openalex.org/W1992455974","https://openalex.org/W1992516945","https://openalex.org/W1992848965","https://openalex.org/W1993111592","https://openalex.org/W1993446851","https://openalex.org/W1993723276","https://openalex.org/W1994671725","https://openalex.org/W1994766031","https://openalex.org/W1994839146","https://openalex.org/W1995427715","https://openalex.org/W1996613940","https://openalex.org/W1997727857","https://openalex.org/W1998014371","https://openalex.org/W1998961698","https://openalex.org/W2000064612","https://openalex.org/W2000215070","https://openalex.org/W2000693703","https://openalex.org/W2001319413","https://openalex.org/W2001838510","https://openalex.org/W2002336386","https://openalex.org/W2005471138","https://openalex.org/W2005499873","https://openalex.org/W2005514024","https://openalex.org/W2005894130","https://openalex.org/W2005902319","https://openalex.org/W2006951192","https://openalex.org/W2007639714","https://openalex.org/W2008545860","https://openalex.org/W2008815053","https://openalex.org/W2009060714","https://openalex.org/W2009181811","https://openalex.org/W2009358674","https://openalex.org/W2009828820","https://openalex.org/W2011431590","https://openalex.org/W2011710049","https://openalex.org/W2012340394","https://openalex.org/W2012387111","https://openalex.org/W2012499642","https://openalex.org/W2013194374","https://openalex.org/W2013876560","https://openalex.org/W2014205641","https://openalex.org/W2015128457","https://openalex.org/W2015330589","https://openalex.org/W2015365987","https://openalex.org/W2015422851","https://openalex.org/W2015887575","https://openalex.org/W2016206195","https://openalex.org/W2016906651","https://openalex.org/W2017184871","https://openalex.org/W2017320993","https://openalex.org/W2017875777","https://openalex.org/W2017947525","https://openalex.org/W2019661196","https://openalex.org/W2019729932","https://openalex.org/W2020320704","https://openalex.org/W2020651381","https://openalex.org/W2021008054","https://openalex.org/W2022519101","https://openalex.org/W2022838319","https://openalex.org/W2024156903","https://openalex.org/W2024420567","https://openalex.org/W2024790906","https://openalex.org/W2025445920","https://openalex.org/W2025994431","https://openalex.org/W2027226430","https://openalex.org/W2028119145","https://openalex.org/W2028493269","https://openalex.org/W2028780429","https://openalex.org/W2031094737","https://openalex.org/W2031291845","https://openalex.org/W2031536080","https://openalex.org/W2032233949","https://openalex.org/W2032558666","https://openalex.org/W2032757940","https://openalex.org/W2032771203","https://openalex.org/W2033306225","https://openalex.org/W2033843196","https://openalex.org/W2033929454","https://openalex.org/W2034703092","https://openalex.org/W2037720445","https://openalex.org/W2037780945","https://openalex.org/W2038379310","https://openalex.org/W2038535607","https://openalex.org/W2038545035","https://openalex.org/W2038589110","https://openalex.org/W2039698363","https://openalex.org/W2040275560","https://openalex.org/W2042637938","https://openalex.org/W2042700625","https://openalex.org/W2043163243","https://openalex.org/W2043249509","https://openalex.org/W2043872109","https://openalex.org/W2043938667","https://openalex.org/W2044553149","https://openalex.org/W2044762058","https://openalex.org/W2045391881","https://openalex.org/W2046750187","https://openalex.org/W2047289660","https://openalex.org/W2047412920","https://openalex.org/W2048284469","https://openalex.org/W2048562948","https://openalex.org/W2048786635","https://openalex.org/W2049575563","https://openalex.org/W2050991123","https://openalex.org/W2051883847","https://openalex.org/W2052195617","https://openalex.org/W2053552036","https://openalex.org/W2054808758","https://openalex.org/W2054882130","https://openalex.org/W2055584285","https://openalex.org/W2055760720","https://openalex.org/W2056093578","https://openalex.org/W2056473913","https://openalex.org/W2056766737","https://openalex.org/W2056781801","https://openalex.org/W2057008935","https://openalex.org/W2057102075","https://openalex.org/W2057565629","https://openalex.org/W2057683951","https://openalex.org/W2057781025","https://openalex.org/W2057830027","https://openalex.org/W2057892106","https://openalex.org/W2058487848","https://openalex.org/W2059217450","https://openalex.org/W2059253719","https://openalex.org/W2060391020","https://openalex.org/W2060508247","https://openalex.org/W2061224972","https://openalex.org/W2061539493","https://openalex.org/W2062609004","https://openalex.org/W2063308005","https://openalex.org/W2063804783","https://openalex.org/W2063947597","https://openalex.org/W2064242356","https://openalex.org/W2065164352","https://openalex.org/W2065691557","https://openalex.org/W2066775995","https://openalex.org/W2067013502","https://openalex.org/W2067844606","https://openalex.org/W2068694787","https://openalex.org/W2069524886","https://openalex.org/W2071804506","https://openalex.org/W2073149987","https://openalex.org/W2073207443","https://openalex.org/W2073253475","https://openalex.org/W2073484200","https://openalex.org/W2073738037","https://openalex.org/W2074244626","https://openalex.org/W2074869565","https://openalex.org/W2075369350","https://openalex.org/W2076992251","https://openalex.org/W2077686875","https://openalex.org/W2079097905","https://openalex.org/W2079838527","https://openalex.org/W2080064179","https://openalex.org/W2080064417","https://openalex.org/W2081446858","https://openalex.org/W2081578395","https://openalex.org/W2081690388","https://openalex.org/W2082589966","https://openalex.org/W2083050412","https://openalex.org/W2083630412","https://openalex.org/W2084879105","https://openalex.org/W2084922131","https://openalex.org/W2085063390","https://openalex.org/W2085123777","https://openalex.org/W2086293791","https://openalex.org/W2086344973","https://openalex.org/W2087181770","https://openalex.org/W2088000250","https://openalex.org/W2088161405","https://openalex.org/W2088175720","https://openalex.org/W2089686299","https://openalex.org/W2090053519","https://openalex.org/W2091283424","https://openalex.org/W2091836061","https://openalex.org/W2091971476","https://openalex.org/W2092203148","https://openalex.org/W2092889502","https://openalex.org/W2094599636","https://openalex.org/W2094654556","https://openalex.org/W2095146181","https://openalex.org/W2095370301","https://openalex.org/W2096463178","https://openalex.org/W2096823643","https://openalex.org/W2097861808","https://openalex.org/W2098146850","https://openalex.org/W2098419010","https://openalex.org/W2099965964","https://openalex.org/W2102759195","https://openalex.org/W2102899393","https://openalex.org/W2103429630","https://openalex.org/W2103563524","https://openalex.org/W2104735232","https://openalex.org/W2105161156","https://openalex.org/W2106687445","https://openalex.org/W2107167859","https://openalex.org/W2107511598","https://openalex.org/W2108563895","https://openalex.org/W2110235365","https://openalex.org/W2111158627","https://openalex.org/W2114691307","https://openalex.org/W2114810650","https://openalex.org/W2114948633","https://openalex.org/W2115028178","https://openalex.org/W2115495500","https://openalex.org/W2116266872","https://openalex.org/W2117430673","https://openalex.org/W2117436212","https://openalex.org/W2117449534","https://openalex.org/W2117506118","https://openalex.org/W2117508167","https://openalex.org/W2122490658","https://openalex.org/W2125881045","https://openalex.org/W2126358181","https://openalex.org/W2126576163","https://openalex.org/W2126581617","https://openalex.org/W2126780661","https://openalex.org/W2128580831","https://openalex.org/W2129342854","https://openalex.org/W2131701729","https://openalex.org/W2132049191","https://openalex.org/W2132367978","https://openalex.org/W2132429713","https://openalex.org/W2137033794","https://openalex.org/W2139273948","https://openalex.org/W2140665471","https://openalex.org/W2141735006","https://openalex.org/W2141997506","https://openalex.org/W2142152307","https://openalex.org/W2144773160","https://openalex.org/W2145852946","https://openalex.org/W2145978627","https://openalex.org/W2147488317","https://openalex.org/W2147565550","https://openalex.org/W2148090422","https://openalex.org/W2149850548","https://openalex.org/W2150058504","https://openalex.org/W2151194410","https://openalex.org/W2153379045","https://openalex.org/W2154764217","https://openalex.org/W2155376412","https://openalex.org/W2157680389","https://openalex.org/W2158001771","https://openalex.org/W2158350898","https://openalex.org/W2158787877","https://openalex.org/W2158984519","https://openalex.org/W2159346462","https://openalex.org/W2159943506","https://openalex.org/W2160663329","https://openalex.org/W2160795321","https://openalex.org/W2162209651","https://openalex.org/W2163076661","https://openalex.org/W2163628812","https://openalex.org/W2163959161","https://openalex.org/W2164378496","https://openalex.org/W2164428680","https://openalex.org/W2165980400","https://openalex.org/W2167017590","https://openalex.org/W2167867263","https://openalex.org/W2168179332","https://openalex.org/W2168281180","https://openalex.org/W2171108120","https://openalex.org/W2223861440","https://openalex.org/W2228084574","https://openalex.org/W2232582481","https://openalex.org/W2235780920","https://openalex.org/W2241427761","https://openalex.org/W2257342027","https://openalex.org/W2267911646","https://openalex.org/W2272368254","https://openalex.org/W2276625437","https://openalex.org/W2302307165","https://openalex.org/W2302860742","https://openalex.org/W2305154643","https://openalex.org/W2309245899","https://openalex.org/W2313185178","https://openalex.org/W2313773476","https://openalex.org/W2316055454","https://openalex.org/W2316719609","https://openalex.org/W2317644227","https://openalex.org/W2318033274","https://openalex.org/W2318402418","https://openalex.org/W2318596598","https://openalex.org/W2322059219","https://openalex.org/W2323525559","https://openalex.org/W2324187722","https://openalex.org/W2324597487","https://openalex.org/W2328456833","https://openalex.org/W2329888557","https://openalex.org/W2334450392","https://openalex.org/W2335208324","https://openalex.org/W2336207123","https://openalex.org/W2346962335","https://openalex.org/W2383675555","https://openalex.org/W2395410212","https://openalex.org/W2396732095","https://openalex.org/W2418946485","https://openalex.org/W2467866301","https://openalex.org/W2476466776","https://openalex.org/W2499777615","https://openalex.org/W2518508903","https://openalex.org/W2536333049","https://openalex.org/W2555829444","https://openalex.org/W2560828227","https://openalex.org/W2561421588","https://openalex.org/W2562372870","https://openalex.org/W2562682295","https://openalex.org/W2567495873","https://openalex.org/W2568160334","https://openalex.org/W2581539422","https://openalex.org/W2582445098","https://openalex.org/W2582888988","https://openalex.org/W2588345894","https://openalex.org/W2591043444","https://openalex.org/W2592035727","https://openalex.org/W2594502287","https://openalex.org/W2606478674","https://openalex.org/W2616877598","https://openalex.org/W2617704854","https://openalex.org/W2618351167","https://openalex.org/W2737457802","https://openalex.org/W2749668525","https://openalex.org/W2750726398","https://openalex.org/W2766089724","https://openalex.org/W2766599650","https://openalex.org/W2767046452","https://openalex.org/W2768867213","https://openalex.org/W2770490738","https://openalex.org/W2770708148","https://openalex.org/W2772031117","https://openalex.org/W2782722829","https://openalex.org/W2783384798","https://openalex.org/W2784576562","https://openalex.org/W2789971571","https://openalex.org/W2790208167","https://openalex.org/W2792491353","https://openalex.org/W2793864072","https://openalex.org/W2794932794","https://openalex.org/W2795534100","https://openalex.org/W2800198896","https://openalex.org/W2802179902","https://openalex.org/W2803047458","https://openalex.org/W2803722031","https://openalex.org/W2803832775","https://openalex.org/W2804658980","https://openalex.org/W2806520905","https://openalex.org/W2807903085","https://openalex.org/W2809149421","https://openalex.org/W2883738486","https://openalex.org/W2883988883","https://openalex.org/W2887310816","https://openalex.org/W2889279246","https://openalex.org/W2891252361","https://openalex.org/W2891469382","https://openalex.org/W2893702172","https://openalex.org/W2894236370","https://openalex.org/W2896287573","https://openalex.org/W2899439250","https://openalex.org/W2900111464","https://openalex.org/W2901520359","https://openalex.org/W2903981661","https://openalex.org/W2907002042","https://openalex.org/W2908443612","https://openalex.org/W2910080195","https://openalex.org/W2912930263","https://openalex.org/W2913162380","https://openalex.org/W2917003832","https://openalex.org/W2923401475","https://openalex.org/W2925236886","https://openalex.org/W2928228510","https://openalex.org/W2936502125","https://openalex.org/W2944969418","https://openalex.org/W2946131674","https://openalex.org/W2947921313","https://openalex.org/W2948072706","https://openalex.org/W2948928505","https://openalex.org/W2955378317","https://openalex.org/W2960825891","https://openalex.org/W2962967898","https://openalex.org/W2967252440","https://openalex.org/W2969763227","https://openalex.org/W2973934298","https://openalex.org/W2984786470","https://openalex.org/W2991277410","https://openalex.org/W2994693196","https://openalex.org/W2995463657","https://openalex.org/W2996169908","https://openalex.org/W2998121288","https://openalex.org/W3004491707","https://openalex.org/W3005051016","https://openalex.org/W3005477248","https://openalex.org/W3006890823","https://openalex.org/W3007828640","https://openalex.org/W3008003871","https://openalex.org/W3009230670","https://openalex.org/W3010669865","https://openalex.org/W3010920895","https://openalex.org/W3012602205","https://openalex.org/W3013225476","https://openalex.org/W3014321121","https://openalex.org/W3015450180","https://openalex.org/W3016984298","https://openalex.org/W3018495375","https://openalex.org/W3018541891","https://openalex.org/W3021391052","https://openalex.org/W3027349852","https://openalex.org/W3029464384","https://openalex.org/W3032151504","https://openalex.org/W3032808898","https://openalex.org/W3039911054","https://openalex.org/W3040626046","https://openalex.org/W3041428333","https://openalex.org/W3042830787","https://openalex.org/W3044982276","https://openalex.org/W3045966719","https://openalex.org/W3046203908","https://openalex.org/W3047202154","https://openalex.org/W3049668924","https://openalex.org/W3080645393","https://openalex.org/W3081080495","https://openalex.org/W3083585410","https://openalex.org/W3084387642","https://openalex.org/W3084705282","https://openalex.org/W3087180082","https://openalex.org/W3090019962","https://openalex.org/W3090029515","https://openalex.org/W3090968113","https://openalex.org/W3092617266","https://openalex.org/W3100492067","https://openalex.org/W3101923829","https://openalex.org/W3103359916","https://openalex.org/W3111460299","https://openalex.org/W3111524336","https://openalex.org/W3111662732","https://openalex.org/W3118824070","https://openalex.org/W3120304846","https://openalex.org/W3120705593","https://openalex.org/W3121552485","https://openalex.org/W3122097161","https://openalex.org/W3137648820","https://openalex.org/W3138030868","https://openalex.org/W3138573626","https://openalex.org/W3139012805","https://openalex.org/W3140799644","https://openalex.org/W3149145135","https://openalex.org/W3158987369","https://openalex.org/W3159998624","https://openalex.org/W3160534059","https://openalex.org/W3162651106","https://openalex.org/W3162965632","https://openalex.org/W3165839825","https://openalex.org/W3167927301","https://openalex.org/W3173928920","https://openalex.org/W3174323634","https://openalex.org/W3174881694","https://openalex.org/W3177145028","https://openalex.org/W3182820177","https://openalex.org/W3187465485","https://openalex.org/W3189646261","https://openalex.org/W3193933253","https://openalex.org/W3195294009","https://openalex.org/W3196105443","https://openalex.org/W3196149340","https://openalex.org/W3196622003","https://openalex.org/W3197905596","https://openalex.org/W3199130489","https://openalex.org/W3202524566","https://openalex.org/W3203820508","https://openalex.org/W3208713691","https://openalex.org/W3208736669","https://openalex.org/W3208739445","https://openalex.org/W3212528046","https://openalex.org/W3215195814","https://openalex.org/W4200064844","https://openalex.org/W4205434514","https://openalex.org/W4206654874","https://openalex.org/W4210467797","https://openalex.org/W4210541422","https://openalex.org/W4210715013","https://openalex.org/W4210938747","https://openalex.org/W4211030178","https://openalex.org/W4211217678","https://openalex.org/W4212810791","https://openalex.org/W4212959738","https://openalex.org/W4220725552","https://openalex.org/W4220826121","https://openalex.org/W4220853435","https://openalex.org/W4223475357","https://openalex.org/W4224870189","https://openalex.org/W4233309275","https://openalex.org/W4234176877","https://openalex.org/W4234760228","https://openalex.org/W4236875498","https://openalex.org/W4241735508","https://openalex.org/W4242105567","https://openalex.org/W4281680703","https://openalex.org/W4281888381","https://openalex.org/W4282932052","https://openalex.org/W4285077849","https://openalex.org/W4285744855","https://openalex.org/W4288690660","https://openalex.org/W4288707520","https://openalex.org/W4291427496","https://openalex.org/W4291997267","https://openalex.org/W4293162105","https://openalex.org/W4293767936","https://openalex.org/W4294024937","https://openalex.org/W4297991410","https://openalex.org/W4307339732","https://openalex.org/W4307362033","https://openalex.org/W4307391239","https://openalex.org/W4307778269","https://openalex.org/W4308181118","https://openalex.org/W4310641805","https://openalex.org/W4311028878","https://openalex.org/W4311934890","https://openalex.org/W4312112944","https://openalex.org/W4312114429","https://openalex.org/W4313379823","https://openalex.org/W4313644936","https://openalex.org/W4313856279","https://openalex.org/W4315631750","https://openalex.org/W4315753728","https://openalex.org/W4319293859","https://openalex.org/W4319591167","https://openalex.org/W4321749127","https://openalex.org/W4322744154","https://openalex.org/W4323319854","https://openalex.org/W4324135199","https://openalex.org/W4361001993","https://openalex.org/W4375948691","https://openalex.org/W4377293029","https://openalex.org/W4378905479","https://openalex.org/W4378909141","https://openalex.org/W4379057152","https://openalex.org/W4379141674","https://openalex.org/W4379967462","https://openalex.org/W4380357260","https://openalex.org/W4380792010","https://openalex.org/W4381251462","https://openalex.org/W4381571891","https://openalex.org/W4382919040","https://openalex.org/W4384662540","https://openalex.org/W4385787730","https://openalex.org/W4385932261","https://openalex.org/W4386209773","https://openalex.org/W4386543259","https://openalex.org/W4386726573","https://openalex.org/W4386878764","https://openalex.org/W4387871582","https://openalex.org/W4387909502","https://openalex.org/W4388038445","https://openalex.org/W4388464763","https://openalex.org/W4388714458","https://openalex.org/W4388730991","https://openalex.org/W4388869793","https://openalex.org/W4389325373","https://openalex.org/W4389775974","https://openalex.org/W4390706675","https://openalex.org/W4390706852"],"related_works":["https://openalex.org/W2737457802","https://openalex.org/W4408900156","https://openalex.org/W3105256584","https://openalex.org/W4400016879","https://openalex.org/W2021201341","https://openalex.org/W4377940809","https://openalex.org/W4399283747","https://openalex.org/W37508065","https://openalex.org/W4381189791","https://openalex.org/W2015552592"],"abstract_inverted_index":{"Ribosome-dependent":[0],"protein":[1],"biosynthesis":[2],"is":[3,90,181],"an":[4,172],"essential":[5,129],"cellular":[6,65],"process":[7],"mediated":[8],"by":[9],"transfer":[10],"RNAs":[11],"(tRNAs).":[12],"Generally,":[13],"ribosomally":[14],"synthesized":[15],"proteins":[16],"are":[17],"limited":[18],"to":[19,55,108],"the":[20,32,43,56,103,142,161,175,191],"22":[21],"proteinogenic":[22],"amino":[23],"acids":[24,29],"(pAAs:":[25],"20":[26],"l":[27],"-\u03b1-amino":[28],"present":[30],"in":[31,64,117,120,153,162],"standard":[33],"genetic":[34,136,154],"code,":[35],"selenocysteine,":[36],"and":[37,70,88,112,119,132,187],"pyrrolysine).":[38],"However,":[39],"engineering":[40,106,180],"tRNAs":[41,107],"for":[42,83,105,190],"ribosomal":[44],"incorporation":[45],"of":[46,58,74,81,134,145,150,165,174,178],"non-proteinogenic":[47],"monomers":[48],"(npMs)":[49],"as":[50,85],"building":[51],"blocks":[52],"has":[53],"led":[54],"creation":[57,133],"unique":[59],"polypeptides":[60,77],"with":[61,157,184],"broad":[62],"applications":[63],"biology,":[66],"material":[67],"science,":[68],"spectroscopy,":[69],"pharmaceuticals.":[71],"Ribosomal":[72],"polymerization":[73],"these":[75,110],"engineered":[76],"presents":[78],"a":[79,158],"variety":[80],"challenges":[82,186],"biochemists,":[84],"translation":[86,130],"efficiency":[87],"fidelity":[89],"often":[91],"insufficient":[92],"when":[93],"employing":[94],"npMs.":[95,170],"In":[96],"this":[97],"Review,":[98],"we":[99,147],"will":[100],"focus":[101,159],"on":[102,141,160],"methodologies":[104],"overcome":[109],"issues":[111],"explore":[113],"recent":[114],"advances":[115],"both":[116],"vitro":[118,163],"vivo":[121],".":[122],"These":[123],"efforts":[124],"include":[125],"increasing":[126],"orthogonality,":[127],"recruiting":[128],"factors,":[131],"expanded":[135],"codes.":[137],"After":[138],"our":[139],"review":[140],"biochemical":[143],"optimizations":[144],"tRNAs,":[146],"provide":[148],"examples":[149],"their":[151],"use":[152],"code":[155],"manipulation,":[156],"discovery":[164],"bioactive":[166],"macrocyclic":[167],"peptides":[168],"containing":[169],"Finally,":[171],"analysis":[173],"current":[176],"state":[177],"tRNA":[179],"presented,":[182],"along":[183],"existing":[185],"future":[188],"perspectives":[189],"field.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-01T00:00:00"}