{"id":"https://openalex.org/W4396504147","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","title":"APG808, A Fully Human Monoclonal IgG1 Antibody, Binds to IL-4R\u03b1 With High Affinity and Blocks IL-13 and IL-4 Mediated Signalling in Multiple In Vitro Assays","display_name":"APG808, A Fully Human Monoclonal IgG1 Antibody, Binds to IL-4R\u03b1 With High Affinity and Blocks IL-13 and IL-4 Mediated Signalling in Multiple In Vitro Assays","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396504147","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C34. BIOLOGIC THERAPY IN THE FIGHT AGAINST ASTHMA AND ALLERGIC INFLAMMATION","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022827775","display_name":"Lukas Dillinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Dillinger","raw_affiliation_strings":["Apogee Therapeutics, Waltham, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apogee Therapeutics, Waltham, MA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089057638","display_name":"Rebecca L. Dabora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Dabora","raw_affiliation_strings":["Apogee Therapeutics, Waltham, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apogee Therapeutics, Waltham, MA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Shaheen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Shaheen","raw_affiliation_strings":["Paragon Therapeutics, Waltham, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paragon Therapeutics, Waltham, MA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Oh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Oh","raw_affiliation_strings":["Paragon Therapeutics, Waltham, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paragon Therapeutics, Waltham, MA, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035543984","display_name":"Eric F. Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Zhu","raw_affiliation_strings":["Paragon Therapeutics, Waltham, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paragon Therapeutics, Waltham, MA, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A5385","last_page":"A5385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8560000061988831},{"id":"https://openalex.org/keywords/il-4-receptor-alpha","display_name":"IL-4 receptor alpha","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.7440000176429749},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9860000014305115},{"id":"https://openalex.org/keywords/receptor-antagonism","display_name":"receptor antagonism","score":0.5849999785423279},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.773725152015686},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.612678587436676},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5895296931266785},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47707808017730713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4289016127586365},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.41537004709243774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40694254636764526},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3855404853820801},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3641526401042938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31944745779037476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1410747766494751}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5385","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C34. BIOLOGIC THERAPY IN THE FIGHT AGAINST ASTHMA AND ALLERGIC INFLAMMATION","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396530736","https://openalex.org/W4390904794","https://openalex.org/W2044594596","https://openalex.org/W4415925180","https://openalex.org/W1996426755","https://openalex.org/W4400825273","https://openalex.org/W1638655950","https://openalex.org/W4416634870","https://openalex.org/W2169594043","https://openalex.org/W4234691208"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-01T00:00:00"}