{"id":"https://openalex.org/W4396503003","doi":"https://doi.org/10.1016/j.molstruc.2024.138450","title":"Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target","display_name":"Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396503003","doi":"https://doi.org/10.1016/j.molstruc.2024.138450"},"language":"en","primary_location":{"id":"doi:10.1016/j.molstruc.2024.138450","doi":"https://doi.org/10.1016/j.molstruc.2024.138450","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2024.138450","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069682913","display_name":"Asmaa F. Kassem","orcid":"https://orcid.org/0000-0001-9020-9956","observed_orcids":["https://orcid.org/0000-0001-9020-9956"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asmaa F. Kassem","raw_affiliation_strings":["Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug institute, Research Institute, National Research Centre, El-Buhouth St., Dokki, P.O. Box 12622, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug institute, Research Institute, National Research Centre, El-Buhouth St., Dokki, P.O. Box 12622, Cairo, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003410855","display_name":"Gaber O. Moustafa","orcid":"https://orcid.org/0000-0002-2489-8228","observed_orcids":["https://orcid.org/0000-0002-2489-8228"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Gaber O. Moustafa","raw_affiliation_strings":["Peptide Chemistry Department, Chemical Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Chemistry Department, Chemical Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081787736","display_name":"Mervat Mostafa Omran","orcid":"https://orcid.org/0000-0003-1643-0104","observed_orcids":["https://orcid.org/0000-0003-1643-0104"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mervat M. Omran","raw_affiliation_strings":["Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034798032","display_name":"Walaa I. El-Sofany","orcid":"https://orcid.org/0000-0001-8838-6769","observed_orcids":["https://orcid.org/0000-0001-8838-6769"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Walaa I. El-Sofany","raw_affiliation_strings":["Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus Affiliation ID 60014618, 33 EL Buhouth St.,Dokki, Giza 12622, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-8838-6769","affiliations":[{"raw_affiliation_string":"Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus Affiliation ID 60014618, 33 EL Buhouth St.,Dokki, Giza 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034798032"],"corresponding_institution_ids":["https://openalex.org/I4210131959"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":1.2368,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73612754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"1312","issue":null,"first_page":"138450","last_page":"138450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrogen-containing-heterocycles","display_name":"nitrogen heterocycles","score":0.8709999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pharyngeal-squamous-cell-carcinoma","display_name":"pharyngeal squamous cell carcinoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pyridine-derivatives","display_name":"pyridine derivatives","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.9520000219345093},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9831222295761108},{"id":"https://openalex.org/C2993420144","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen atom","level":3,"score":0.8321182727813721},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.6243876814842224},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.610418975353241},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5096542835235596},{"id":"https://openalex.org/C58312451","wikidata":"https://www.wikidata.org/wiki/Q4817200","display_name":"Atom (system on chip)","level":2,"score":0.4460959732532501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4372374713420868},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3679375946521759},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3339160680770874},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3072804808616638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09297466278076172},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.09226542711257935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molstruc.2024.138450","doi":"https://doi.org/10.1016/j.molstruc.2024.138450","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2024.138450","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1590457525","https://openalex.org/W1965026439","https://openalex.org/W1978719655","https://openalex.org/W1995653081","https://openalex.org/W1998275489","https://openalex.org/W2006370393","https://openalex.org/W2022602911","https://openalex.org/W2060629599","https://openalex.org/W2069553052","https://openalex.org/W2090448036","https://openalex.org/W2096482056","https://openalex.org/W2103953491","https://openalex.org/W2109689528","https://openalex.org/W2128635872","https://openalex.org/W2162013152","https://openalex.org/W2338518461","https://openalex.org/W2340405474","https://openalex.org/W2552289982","https://openalex.org/W2577423442","https://openalex.org/W2596169881","https://openalex.org/W2604415318","https://openalex.org/W2606700261","https://openalex.org/W2607464274","https://openalex.org/W2626578280","https://openalex.org/W2760851148","https://openalex.org/W2788119193","https://openalex.org/W2794963028","https://openalex.org/W2805216211","https://openalex.org/W2807807923","https://openalex.org/W2885392670","https://openalex.org/W2894677841","https://openalex.org/W2906812440","https://openalex.org/W2911831872","https://openalex.org/W2940273691","https://openalex.org/W2945920085","https://openalex.org/W2950716575","https://openalex.org/W2952157055","https://openalex.org/W2962614487","https://openalex.org/W2968643071","https://openalex.org/W2969595198","https://openalex.org/W2974208524","https://openalex.org/W2974793213","https://openalex.org/W3016762617","https://openalex.org/W3020877438","https://openalex.org/W3028959432","https://openalex.org/W3036222576","https://openalex.org/W3048416463","https://openalex.org/W3088175515","https://openalex.org/W3095923999","https://openalex.org/W3126053626","https://openalex.org/W3127495805","https://openalex.org/W3165171933","https://openalex.org/W3187517745","https://openalex.org/W3204086239","https://openalex.org/W3206332629","https://openalex.org/W3206874144","https://openalex.org/W3207094872","https://openalex.org/W3208872739","https://openalex.org/W4200153106","https://openalex.org/W4205240904","https://openalex.org/W4206659503","https://openalex.org/W4220980679","https://openalex.org/W4224319036","https://openalex.org/W4225158300","https://openalex.org/W4226154407","https://openalex.org/W4283011039","https://openalex.org/W4283823426","https://openalex.org/W4287010204","https://openalex.org/W4291302430","https://openalex.org/W4296849223","https://openalex.org/W4297255797","https://openalex.org/W4306920662","https://openalex.org/W4307211384","https://openalex.org/W4310130625","https://openalex.org/W4312056695","https://openalex.org/W4313388962","https://openalex.org/W4319599125","https://openalex.org/W4320920545","https://openalex.org/W4323830784","https://openalex.org/W4382011205","https://openalex.org/W4382599519","https://openalex.org/W4385172864","https://openalex.org/W4385310768","https://openalex.org/W4386009506","https://openalex.org/W4386475968","https://openalex.org/W4387233502","https://openalex.org/W6673200264","https://openalex.org/W6777705810","https://openalex.org/W6789911618","https://openalex.org/W6811507003"],"related_works":["https://openalex.org/W2805397264","https://openalex.org/W2780167026","https://openalex.org/W4220932743","https://openalex.org/W2895966329","https://openalex.org/W2764147555","https://openalex.org/W3199238796","https://openalex.org/W4205345354","https://openalex.org/W4411256112","https://openalex.org/W2998639463","https://openalex.org/W2522706605"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-01T00:00:00"}