{"id":"https://openalex.org/W4396502880","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","title":"Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF","display_name":"Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396502880","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B15. THE MACROPHAGE IN ALL ITS GLORY","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003435188","display_name":"S.-H. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.-H. Kim","raw_affiliation_strings":["Internal Medicine, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080282168","display_name":"Jessica Nouws","orcid":"https://orcid.org/0000-0003-3347-3595","observed_orcids":["https://orcid.org/0000-0003-3347-3595"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Nouws","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091762116","display_name":"Joseph C. Cooley","orcid":"https://orcid.org/0000-0002-4487-977X","observed_orcids":["https://orcid.org/0000-0002-4487-977X"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Cooley","raw_affiliation_strings":["Pulmonary and Critical Care, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082834998","display_name":"Farida Ahangari","orcid":"https://orcid.org/0000-0002-4144-9395","observed_orcids":["https://orcid.org/0000-0002-4144-9395"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Ahangari","raw_affiliation_strings":["Pulmonary, Yale School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Yale School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008065494","display_name":"Lin Leng","orcid":"https://orcid.org/0000-0002-0605-358X","observed_orcids":["https://orcid.org/0000-0002-0605-358X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Leng","raw_affiliation_strings":["Internal Medicine, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043504900","display_name":"Jack Angel Elias","orcid":"https://orcid.org/0000-0002-3124-8557","observed_orcids":["https://orcid.org/0000-0002-3124-8557"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. Elias","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, Providence, RI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, Providence, RI, United States","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088823841","display_name":"Naftali Kaminski","orcid":"https://orcid.org/0000-0001-5917-4601","observed_orcids":["https://orcid.org/0000-0001-5917-4601"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Kaminski","raw_affiliation_strings":["Department of Medicine, Yale School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101677869","display_name":"Patty J. Lee","orcid":"https://orcid.org/0000-0001-9906-1628","observed_orcids":["https://orcid.org/0000-0001-9906-1628"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Lee","raw_affiliation_strings":["Division of Pulmonary, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354882","display_name":"Elizabeth F. Redente","orcid":"https://orcid.org/0000-0002-8075-4325","observed_orcids":["https://orcid.org/0000-0002-8075-4325"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Redente","raw_affiliation_strings":["National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023170076","display_name":"Min\u2010Jong Kang","orcid":"https://orcid.org/0000-0003-3245-144X","observed_orcids":["https://orcid.org/0000-0003-3245-144X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.-J. Kang","raw_affiliation_strings":["Int Med Pulm, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Int Med Pulm, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039774753","display_name":"Huanxing Sun","orcid":"https://orcid.org/0000-0003-2397-4652","observed_orcids":["https://orcid.org/0000-0003-2397-4652"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Sun","raw_affiliation_strings":["Internal Medicine, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025135030","display_name":"Erica L. Herzog","orcid":"https://orcid.org/0000-0002-7508-8575","observed_orcids":["https://orcid.org/0000-0002-7508-8575"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Herzog","raw_affiliation_strings":["Pulmonary Medicine, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Medicine, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108552860","display_name":"Rick Bucala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bucala","raw_affiliation_strings":["Internal Medicine - Rheumatology, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine - Rheumatology, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027241081","display_name":"Antje Prasse","orcid":"https://orcid.org/0000-0002-7336-7458","observed_orcids":["https://orcid.org/0000-0002-7336-7458"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Prasse","raw_affiliation_strings":["Pulmonology, Medical School, Hannover,  Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonology, Medical School, Hannover,  Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017993625","display_name":"Maor Sauler","orcid":"https://orcid.org/0000-0001-5240-7978","observed_orcids":["https://orcid.org/0000-0001-5240-7978"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sauler","raw_affiliation_strings":["Pulmonary & Critical Care, Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary & Critical Care, Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A3001","last_page":"A3001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8859999775886536},{"id":"https://openalex.org/keywords/macrophage-heterogeneity","display_name":"macrophage heterogeneity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.532461941242218},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.4837051033973694},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.4777471423149109},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4543437659740448},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4133351445198059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4017815589904785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36772096157073975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36611950397491455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32864242792129517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2625572085380554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2342555820941925},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.10841706395149231},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10425180196762085},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.07835623621940613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B15. THE MACROPHAGE IN ALL ITS GLORY","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416965544","https://openalex.org/W2305268967","https://openalex.org/W4396505421","https://openalex.org/W2970311380","https://openalex.org/W2098640188","https://openalex.org/W4396500208","https://openalex.org/W2319424838","https://openalex.org/W4403295107","https://openalex.org/W2316345875","https://openalex.org/W6958239323"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-05-01T00:00:00"}