{"id":"https://openalex.org/W4396502425","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","title":"Alveolar Epithelial Mitochondrial Impairments in Pulmonary Fibrosis: The Role of AMPK Signaling","display_name":"Alveolar Epithelial Mitochondrial Impairments in Pulmonary Fibrosis: The Role of AMPK Signaling","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396502425","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C28. MORE THAN MEET THE EYE: NOVEL INSIGHTS IN IPF PATHOGENESIS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075364953","display_name":"Konstantinos\u2013Dionysios Alysandratos","orcid":"https://orcid.org/0000-0002-5611-0343","observed_orcids":["https://orcid.org/0000-0002-5611-0343"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.-D. Alysandratos","raw_affiliation_strings":["Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026948652","display_name":"L. Raposo Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-7176-0697","observed_orcids":["https://orcid.org/0000-0001-7176-0697"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.R. Rodriguez","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003278885","display_name":"Kasey Minakin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Minakin","raw_affiliation_strings":["Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050890684","display_name":"Aditi Murthy","orcid":"https://orcid.org/0009-0004-6983-4836","observed_orcids":["https://orcid.org/0009-0004-6983-4836"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Murthy","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052942641","display_name":"Yaniv Tomer","orcid":"https://orcid.org/0000-0002-8131-7258","observed_orcids":["https://orcid.org/0000-0002-8131-7258"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Tomer","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074142636","display_name":"Katrina Chavez","orcid":"https://orcid.org/0009-0000-2094-7275","observed_orcids":["https://orcid.org/0009-0000-2094-7275"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Chavez","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068932966","display_name":"Rebeca Ac\u00edn\u2010P\u00e9rez","orcid":"https://orcid.org/0000-0001-9553-8337","observed_orcids":["https://orcid.org/0000-0001-9553-8337"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Ac\u00edn-P\u00e9rez","raw_affiliation_strings":["Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060882865","display_name":"Anton Petcherski","orcid":"https://orcid.org/0000-0002-3143-3867","observed_orcids":["https://orcid.org/0000-0002-3143-3867"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Petcherski","raw_affiliation_strings":["Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029650508","display_name":"Orian S. Shirihai","orcid":"https://orcid.org/0000-0001-8466-3431","observed_orcids":["https://orcid.org/0000-0001-8466-3431","https://orcid.org/0000-0001-9846-736X","https://orcid.org/0000-0002-9502-2661"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. Shirihai","raw_affiliation_strings":["Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Endocrinology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110851883","display_name":"M.F. Beers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.F. Beers","raw_affiliation_strings":["Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046812442","display_name":"Darrell N. Kotton","orcid":"https://orcid.org/0000-0002-9604-8476","observed_orcids":["https://orcid.org/0000-0002-9604-8476"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.N. Kotton","raw_affiliation_strings":["Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine and The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A5204","last_page":"A5204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.12210000306367874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.6763959527015686},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6365691423416138},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47682255506515503},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.46269211173057556},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4274560213088989},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37469685077667236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34677910804748535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23661231994628906},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21209576725959778},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.09536266326904297},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.08971583843231201}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C28. MORE THAN MEET THE EYE: NOVEL INSIGHTS IN IPF PATHOGENESIS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4399999976158142}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2811226269","https://openalex.org/W3016578706","https://openalex.org/W4411872506","https://openalex.org/W7085154133","https://openalex.org/W7084857821","https://openalex.org/W7085214858","https://openalex.org/W7084915581","https://openalex.org/W7084895726","https://openalex.org/W4396505421","https://openalex.org/W3041116745"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-05-01T00:00:00"}