{"id":"https://openalex.org/W4396501992","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","title":"Transcriptional Pathways in Small Airway Basal Cells Define Niches of Goblet Cell Metaplasia in Asthma","display_name":"Transcriptional Pathways in Small Airway Basal Cells Define Niches of Goblet Cell Metaplasia in Asthma","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396501992","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C19. CHARTING THE LUNG: INNOVATION IN MULTIOMICS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017306270","display_name":"Stephen A. Schworer","orcid":"https://orcid.org/0000-0001-7741-8972","observed_orcids":["https://orcid.org/0000-0001-7741-8972"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Schworer","raw_affiliation_strings":["Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000784991","display_name":"Kenichi Okuda","orcid":"https://orcid.org/0000-0001-9341-2730","observed_orcids":["https://orcid.org/0000-0001-9341-2730"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Okuda","raw_affiliation_strings":["Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043349619","display_name":"Hong Dang","orcid":"https://orcid.org/0000-0002-7305-4208","observed_orcids":["https://orcid.org/0000-0002-7305-4208"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Dang","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051247229","display_name":"Matthew R. Markovetz","orcid":"https://orcid.org/0000-0003-3931-0594","observed_orcids":["https://orcid.org/0000-0003-3931-0594"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Markovetz","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054224267","display_name":"Takafumi Kato","orcid":"https://orcid.org/0000-0003-2248-3376","observed_orcids":["https://orcid.org/0000-0003-2248-3376"]},"institutions":[{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kato","raw_affiliation_strings":["Center for Pulmonary Diseases, NHO Tokyo National Hospital, Kiyose City,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pulmonary Diseases, NHO Tokyo National Hospital, Kiyose City,  Japan","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059389959","display_name":"Takanori Asakura","orcid":"https://orcid.org/0000-0003-3122-6937","observed_orcids":["https://orcid.org/0000-0003-3122-6937"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Asakura","raw_affiliation_strings":["Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Minato-ku, Tokyo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Minato-ku, Tokyo,  Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083961166","display_name":"G. Chen","orcid":"https://orcid.org/0009-0004-0746-7938","observed_orcids":["https://orcid.org/0009-0004-0746-7938"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Chen","raw_affiliation_strings":["Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055523744","display_name":"Rodney C. Gilmore","orcid":"https://orcid.org/0000-0002-3821-8422","observed_orcids":["https://orcid.org/0000-0002-3821-8422"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Gilmore","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074376104","display_name":"Catharina A. van Heusden","orcid":"https://orcid.org/0009-0001-5403-5431","observed_orcids":["https://orcid.org/0009-0001-5403-5431"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. van Heusden","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114042018","display_name":"Mason Chua","orcid":"https://orcid.org/0009-0009-2974-4509","observed_orcids":["https://orcid.org/0009-0009-2974-4509"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Chua","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071068702","display_name":"Humberto E. Trejo Bittar","orcid":"https://orcid.org/0000-0003-2701-6531","observed_orcids":["https://orcid.org/0000-0003-2701-6531"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Trejo Bittar","raw_affiliation_strings":["Pathology, UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027495929","display_name":"B. Cody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Cody","raw_affiliation_strings":["Pathology, UPMC, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, UPMC, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057676970","display_name":"John B. Trudeau","orcid":"https://orcid.org/0000-0002-0473-2730","observed_orcids":["https://orcid.org/0000-0002-0473-2730"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Trudeau","raw_affiliation_strings":["Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055201103","display_name":"Wanda K. O\u2019Neal","orcid":"https://orcid.org/0000-0003-2412-5943","observed_orcids":["https://orcid.org/0000-0003-2412-5943"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.K. O'Neal","raw_affiliation_strings":["Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049641668","display_name":"Scott H. Randell","orcid":"https://orcid.org/0000-0001-5351-2841","observed_orcids":["https://orcid.org/0000-0001-5351-2841"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.H. Randell","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062793362","display_name":"Sally E. Wenzel","orcid":"https://orcid.org/0000-0002-4242-0164","observed_orcids":["https://orcid.org/0000-0002-4242-0164"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.E. Wenzel","raw_affiliation_strings":["Professor of Med PACCM, University of Pittsburgh, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Med PACCM, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001166056","display_name":"Richard C. Boucher","orcid":"https://orcid.org/0000-0002-5745-3989","observed_orcids":["https://orcid.org/0000-0002-5745-3989"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.C. Boucher","raw_affiliation_strings":["Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A5015","last_page":"A5015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/goblet-cell-metaplasia","display_name":"goblet cell metaplasia","score":0.925000011920929},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8069999814033508},{"id":"https://openalex.org/keywords/transcriptional-pathways","display_name":"transcriptional pathways","score":0.9300000071525574},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8489999771118164},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.62440425157547},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6040260195732117},{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.6029893159866333},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.542608380317688},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.5170124769210815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3841034770011902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36105668544769287},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3353699743747711},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2770901918411255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14980009198188782},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.11558783054351807},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5015","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C19. CHARTING THE LUNG: INNOVATION IN MULTIOMICS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7010074964","https://openalex.org/W4400313791","https://openalex.org/W2321062862","https://openalex.org/W4367608160","https://openalex.org/W4410076035","https://openalex.org/W2970473590","https://openalex.org/W2794323257","https://openalex.org/W2292904535","https://openalex.org/W3040897150","https://openalex.org/W2333189043"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-05-01T00:00:00"}