{"id":"https://openalex.org/W4396501440","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","title":"Activation of mTOR Signaling in Adult Lung Microvascular Progenitor Cells Accelerates Lung Aging and Defines a Capillary Progenitor Niche","display_name":"Activation of mTOR Signaling in Adult Lung Microvascular Progenitor Cells Accelerates Lung Aging and Defines a Capillary Progenitor Niche","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396501440","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D18. DEVELOPMENT AND REGENERATION: UNVEILING THE SECRETS OF LUNG RENEWAL","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046708690","display_name":"Evan Lundberg","orcid":"https://orcid.org/0009-0002-6280-1076","observed_orcids":["https://orcid.org/0009-0002-6280-1076"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.P. Lundberg","raw_affiliation_strings":["Department of Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111185101","display_name":"Emma C. Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.C. Mason","raw_affiliation_strings":["Department of Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053572940","display_name":"Swapna Menon","orcid":"https://orcid.org/0000-0002-0429-2472","observed_orcids":["https://orcid.org/0000-0002-0429-2472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Menon","raw_affiliation_strings":["AnalyzeDat Consulting Services, Kerala,  India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnalyzeDat Consulting Services, Kerala,  India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M.M. Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M. Dawson","raw_affiliation_strings":["Department of Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052447524","display_name":"Camille M. Moore","orcid":"https://orcid.org/0000-0002-7363-8684","observed_orcids":["https://orcid.org/0000-0002-7363-8684","https://orcid.org/0000-0002-3324-789X"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.M. Moore","raw_affiliation_strings":["Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080593446","display_name":"Bradley W. Richmond","orcid":"https://orcid.org/0000-0001-6200-5235","observed_orcids":["https://orcid.org/0000-0001-6200-5235"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.W. Richmond","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001488233","display_name":"Jonathan A. Kropski","orcid":"https://orcid.org/0000-0002-8923-1344","observed_orcids":["https://orcid.org/0000-0002-8923-1344"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. Kropski","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042419219","display_name":"James D. West","orcid":"https://orcid.org/0000-0002-6004-0202","observed_orcids":["https://orcid.org/0000-0002-6004-0202"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.D. West","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017782179","display_name":"Patrick M. Geraghty","orcid":"https://orcid.org/0000-0003-1647-5505","observed_orcids":["https://orcid.org/0000-0003-1647-5505"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.M. Geraghty","raw_affiliation_strings":["Department of Pulmonary & Critical Care Medicine, SUNY Downstate Health Sciences University, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary & Critical Care Medicine, SUNY Downstate Health Sciences University, New York, NY, United States","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087202502","display_name":"Brigitte N. Gomperts","orcid":"https://orcid.org/0000-0002-1809-723X","observed_orcids":["https://orcid.org/0000-0002-1809-723X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.N. Gomperts","raw_affiliation_strings":["Pediatrics Division of Pulmonary Medicine, UCLA Broad Stem Cell Research Center, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics Division of Pulmonary Medicine, UCLA Broad Stem Cell Research Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038543981","display_name":"Fabienne Gally","orcid":"https://orcid.org/0000-0003-0503-7411","observed_orcids":["https://orcid.org/0000-0003-0503-7411"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.S. Gally","raw_affiliation_strings":["Department of Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090398738","display_name":"Susan M. Majka","orcid":"https://orcid.org/0000-0002-1005-1552","observed_orcids":["https://orcid.org/0000-0002-1005-1552"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.M. Majka","raw_affiliation_strings":["Department of Medicine, National Jewish Health, Denver, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Health, Denver, CO, United States","institution_ids":["https://openalex.org/I3019586173"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A6957","last_page":"A6957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-aging","display_name":"lung aging","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.546999990940094},{"id":"https://openalex.org/keywords/lung-microvasculature","display_name":"lung microvasculature","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.823535144329071},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.6756452918052673},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.592719316482544},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.5668733716011047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5657767653465271},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4778323173522949},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4228341579437256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37961867451667786},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28871989250183105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22939762473106384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21925243735313416},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08616700768470764}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","doi":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6957","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D18. DEVELOPMENT AND REGENERATION: UNVEILING THE SECRETS OF LUNG RENEWAL","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387909098","https://openalex.org/W4231331334","https://openalex.org/W2068377942","https://openalex.org/W2970635179","https://openalex.org/W7095301457","https://openalex.org/W4392953608","https://openalex.org/W4307510408","https://openalex.org/W2971236157","https://openalex.org/W2170796380","https://openalex.org/W2092782033"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-01T00:00:00"}
