{"id":"https://openalex.org/W4396495576","doi":"https://doi.org/10.1089/jmf.2023.0185","title":"Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects","display_name":"Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects","publication_year":2024,"publication_date":"2024-04-30","ids":{"openalex":"https://openalex.org/W4396495576","doi":"https://doi.org/10.1089/jmf.2023.0185","pmid":"https://pubmed.ncbi.nlm.nih.gov/38686523"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2023.0185","doi":"https://doi.org/10.1089/jmf.2023.0185","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1089/jmf.2023.0185","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jmf.2023.0185?download=true","source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.liebertpub.com/doi/pdf/10.1089/jmf.2023.0185?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101777155","display_name":"Tanja Wagner","orcid":"https://orcid.org/0000-0003-2377-3308","observed_orcids":["https://orcid.org/0000-0003-2377-3308"]},"institutions":[{"id":"https://openalex.org/I4210113249","display_name":"BioTeSys (Germany)","ror":"https://ror.org/0266fnb18","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113249"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Wagner","raw_affiliation_strings":["BioTeSys GmbH, Esslingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTeSys GmbH, Esslingen, Germany","institution_ids":["https://openalex.org/I4210113249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044850552","display_name":"Roland Wacker","orcid":"https://orcid.org/0000-0002-5011-6584","observed_orcids":["https://orcid.org/0000-0002-5011-6584"]},"institutions":[{"id":"https://openalex.org/I4210113249","display_name":"BioTeSys (Germany)","ror":"https://ror.org/0266fnb18","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113249"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Wacker","raw_affiliation_strings":["BioTeSys GmbH, Esslingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTeSys GmbH, Esslingen, Germany","institution_ids":["https://openalex.org/I4210113249"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157887","display_name":"Apomedica (Austria)","ror":"https://ror.org/04qstxt95","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210157887"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Klein","raw_affiliation_strings":["Apomedica Pharmazeutische Produkte GmbH, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apomedica Pharmazeutische Produkte GmbH, Graz, Austria","institution_ids":["https://openalex.org/I4210157887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028498458","display_name":"Albert Kompek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157887","display_name":"Apomedica (Austria)","ror":"https://ror.org/04qstxt95","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210157887"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Albert Kompek","raw_affiliation_strings":["Apomedica Pharmazeutische Produkte GmbH, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apomedica Pharmazeutische Produkte GmbH, Graz, Austria","institution_ids":["https://openalex.org/I4210157887"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074473559","display_name":"Christiane Sch\u00f6n","orcid":"https://orcid.org/0000-0003-3787-5268","observed_orcids":["https://orcid.org/0000-0003-3787-5268"]},"institutions":[{"id":"https://openalex.org/I4210113249","display_name":"BioTeSys (Germany)","ror":"https://ror.org/0266fnb18","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113249"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Sch\u00f6n","raw_affiliation_strings":["BioTeSys GmbH, Esslingen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3787-5268","affiliations":[{"raw_affiliation_string":"BioTeSys GmbH, Esslingen, Germany","institution_ids":["https://openalex.org/I4210113249"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3067,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42409403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"27","issue":"5","first_page":"396","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.9570000171661377},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oil-based-formulation","display_name":"oil formulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tetrahydrocurcumin","display_name":"tetrahydrocurcumin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8989999890327454},{"id":"https://openalex.org/keywords/soft-gelatin-capsules","display_name":"soft gelatin capsules","score":0.8360000252723694},{"id":"https://openalex.org/keywords/curcumin-metabolites","display_name":"curcumin metabolites","score":0.5979999899864197},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9517393112182617},{"id":"https://openalex.org/C2777070074","wikidata":"https://www.wikidata.org/wiki/Q5194671","display_name":"Curcuminoid","level":3,"score":0.9364128708839417},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7953686714172363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7689502835273743},{"id":"https://openalex.org/C2777230291","wikidata":"https://www.wikidata.org/wiki/Q33551","display_name":"Curcuma","level":2,"score":0.6154659986495972},{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.5333089232444763},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5026628971099854},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.4866953194141388},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4756719172000885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36305302381515503},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.34117937088012695},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.20345887541770935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17007479071617126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11160629987716675},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08448517322540283}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004063","descriptor_name":"Digestion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030024","descriptor_name":"Curcuma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jmf.2023.0185","doi":"https://doi.org/10.1089/jmf.2023.0185","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1089/jmf.2023.0185","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jmf.2023.0185?download=true","source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmid:38686523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38686523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1089/jmf.2023.0185","doi":"https://doi.org/10.1089/jmf.2023.0185","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1089/jmf.2023.0185","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jmf.2023.0185?download=true","source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396495576.pdf","grobid_xml":"https://content.openalex.org/works/W4396495576.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2040350223","https://openalex.org/W2073798776","https://openalex.org/W2155397034","https://openalex.org/W2171282555","https://openalex.org/W2296503174","https://openalex.org/W2297555457","https://openalex.org/W2324360643","https://openalex.org/W2433713077","https://openalex.org/W2588605196","https://openalex.org/W2762362735","https://openalex.org/W2964976657","https://openalex.org/W2972100969","https://openalex.org/W2993639932","https://openalex.org/W3092560102","https://openalex.org/W3135868875","https://openalex.org/W3155739598","https://openalex.org/W3207242288","https://openalex.org/W4200322818","https://openalex.org/W4226241041","https://openalex.org/W4281772238","https://openalex.org/W4313556627","https://openalex.org/W4324029158"],"related_works":["https://openalex.org/W2762362735","https://openalex.org/W4312195738","https://openalex.org/W2155397034","https://openalex.org/W2043866497","https://openalex.org/W7024479082","https://openalex.org/W3206880052","https://openalex.org/W4415611247","https://openalex.org/W2016690269","https://openalex.org/W2516995164","https://openalex.org/W160013988"],"abstract_inverted_index":{"Curcumin,":[0],"the":[1,12,33,38,80,89,95,101,142,155,158,186,219,229,235,253],"fat-soluble":[2,85],"active":[3],"ingredient":[4],"and":[5,22,26,256],"major":[6],"compound":[7],"of":[8,73,84,92,136,157,222,252],"curcuminoids":[9,49,74,93,103,124,163,188,224,231,237,250],"contained":[10],"in":[11,50,94,108,183],"curcuma":[13],"root,":[14],"is":[15],"known":[16],"for":[17,161,174,196],"its":[18,258],"physiological":[19],"low":[20],"absorption":[21],"bioavailability.":[23],"Various":[24],"formulations":[25],"galenic":[27],"technologies":[28,61],"are":[29],"currently":[30],"available":[31],"on":[32,249],"market.":[34],"In":[35,87,217],"this":[36],"study,":[37],"product":[39],"tested":[40],"was":[41,68,98,192,225],"provided":[42],"as":[43,75,77,139,141,171,173],"a":[44,109],"soft":[45],"gelatin":[46],"capsule":[47],"containing":[48],"an":[51,246],"oily":[52],"matrix":[53],"mixed":[54],"with":[55,100,228,234],"phospholipids":[56],"(oil/phospholipids":[57],"[PL]-based,":[58],"no":[59],"new":[60],"applied":[62],"or":[63],"artificial":[64],"excipients":[65],"added).":[66],"This":[67],"intended":[69],"to":[70,78,185],"improve":[71],"bioavailability":[72,91],"well":[76,140,172],"mimic":[79],"natural":[81],"digestion":[82],"process":[83],"substances.":[86],"particular,":[88],"oral":[90,113],"oil/PL-based":[96,159,230,254],"formulation":[97,160,232,255],"compared":[99,233],"pure":[102,187,236],"extract":[104,238],"alone":[105],"(reference":[106],"product),":[107],"randomized,":[110],"cross-over,":[111],"single":[112],"dose":[114],"study":[115],"design.":[116],"Twelve":[117],"healthy":[118],"subjects":[119],"were":[120,130],"administered":[121],"200":[122],"mg":[123],"under":[125],"fasting":[126],"conditions.":[127],"Pharmacokinetic":[128],"parameters":[129,198],"analyzed":[131,199],"from":[132],"individual":[133],"concentration\u2013time":[134],"curves":[135],"total":[137,162,223],"curcuminoids,":[138],"curcumin":[143],"metabolite":[144],"tetrahydrocurcumin":[145],"(THC).":[146],"Results":[147],"showed":[148],"significantly":[149,194,226],"higher":[150,195],"AUC":[151],"0-8h":[152],"levels":[153],"after":[154],"intake":[156],"(205.60":[164],"vs.":[165,177,203,211],"112.50":[166],"ng/mL*h,":[167,179],"P":[168,180,206,214,240],"=":[169,207,241],".0001)":[170,182],"THC":[175],"(347.30":[176],"118.90":[178],"<":[181,215],"comparison":[184],"extract.":[189],"C":[190],"max":[191],"also":[193],"both":[197],"(total":[200],"curcuminoids:":[201],"47.54":[202],"21.16":[204],"ng/mL,":[205,213],".0001;":[208],"THC:":[209],"96.69":[210],"29.83":[212],".0001).":[216],"addition,":[218],"uptake":[220,251],"kinetic":[221],"fastened":[227],"(":[239],".0446).":[242],"These":[243],"data":[244],"suggest":[245],"improved":[247],"impact":[248],"confirms":[257],"good":[259],"tolerability.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-01T00:00:00"}