{"id":"https://openalex.org/W4396243116","doi":"https://doi.org/10.1038/s42003-024-06202-9","title":"Wnt/\u03b2-catenin signaling regulates amino acid metabolism through the suppression of CEBPA and FOXA1 in liver cancer cells","display_name":"Wnt/\u03b2-catenin signaling regulates amino acid metabolism through the suppression of CEBPA and FOXA1 in liver cancer cells","publication_year":2024,"publication_date":"2024-04-29","ids":{"openalex":"https://openalex.org/W4396243116","doi":"https://doi.org/10.1038/s42003-024-06202-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/38684876","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11058205"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-024-06202-9","doi":"https://doi.org/10.1038/s42003-024-06202-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-024-06202-9","pdf_url":"https://www.nature.com/articles/s42003-024-06202-9.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-024-06202-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058880766","display_name":"Saya Nakagawa","orcid":"https://orcid.org/0000-0002-5893-1663","observed_orcids":["https://orcid.org/0000-0002-5893-1663"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saya Nakagawa","raw_affiliation_strings":["Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5893-1663","affiliations":[{"raw_affiliation_string":"Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015396057","display_name":"Kiyoshi Yamaguchi","orcid":"https://orcid.org/0000-0003-2113-4369","observed_orcids":["https://orcid.org/0000-0003-2113-4369"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kiyoshi Yamaguchi","raw_affiliation_strings":["Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. kiyamagu@g.ecc.u-tokyo.ac.jp"],"raw_orcid":"https://orcid.org/0000-0003-2113-4369","affiliations":[{"raw_affiliation_string":"Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. kiyamagu@g.ecc.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003518645","display_name":"Kiyoko Takane","orcid":"https://orcid.org/0000-0002-2467-1509","observed_orcids":["https://orcid.org/0000-0002-2467-1509"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoko Takane","raw_affiliation_strings":["Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025743968","display_name":"Sho Tabata","orcid":"https://orcid.org/0000-0001-8956-9241","observed_orcids":["https://orcid.org/0000-0001-8956-9241"]},"institutions":[{"id":"https://openalex.org/I4210087348","display_name":"National Cancer Centre Japan","ror":"https://ror.org/0025ww868","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Tabata","raw_affiliation_strings":["Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata, 997-0052, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8956-9241","affiliations":[{"raw_affiliation_string":"Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata, 997-0052, Japan","institution_ids":["https://openalex.org/I4210087348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070235973","display_name":"Tsuneo Ikenoue","orcid":"https://orcid.org/0000-0001-8264-2573","observed_orcids":["https://orcid.org/0000-0001-8264-2573"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Ikenoue","raw_affiliation_strings":["Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018161559","display_name":"Yoichi Furukawa","orcid":"https://orcid.org/0000-0003-0462-8631","observed_orcids":["https://orcid.org/0000-0003-0462-8631"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Furukawa","raw_affiliation_strings":["Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. yofurukawa@g.ecc.u-tokyo.ac.jp"],"raw_orcid":"https://orcid.org/0000-0003-0462-8631","affiliations":[{"raw_affiliation_string":"Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan. yofurukawa@g.ecc.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015396057","https://openalex.org/A5018161559"],"corresponding_institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":3.475,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.94811404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"510","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7329999804496765},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cebpa","display_name":"CEBPA","score":0.8949999809265137},{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":1.0},{"id":"https://openalex.org/keywords/histidine-ammonia-lyase","display_name":"histidine ammonia-lyase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.8859999775886536},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.6060000061988831},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.8489999771118164},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":0.9010000228881836},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6028217077255249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5893656015396118},{"id":"https://openalex.org/C154456304","wikidata":"https://www.wikidata.org/wiki/Q18027046","display_name":"FOXA1","level":4,"score":0.5818547010421753},{"id":"https://openalex.org/C45091340","wikidata":"https://www.wikidata.org/wiki/Q17861031","display_name":"CEBPA","level":4,"score":0.534682035446167},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5068889260292053},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47600850462913513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4415540099143982},{"id":"https://openalex.org/C148397407","wikidata":"https://www.wikidata.org/wiki/Q21107432","display_name":"FOXA2","level":4,"score":0.42100241780281067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38861802220344543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31685566902160645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1145380437374115}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051541","descriptor_name":"Hepatocyte Nuclear Factor 3-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051541","descriptor_name":"Hepatocyte Nuclear Factor 3-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s42003-024-06202-9","doi":"https://doi.org/10.1038/s42003-024-06202-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-024-06202-9","pdf_url":"https://www.nature.com/articles/s42003-024-06202-9.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11058205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11058205","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11058205/pdf/42003_2024_Article_6202.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmid:38684876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38684876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cfe714ca98a74825ba13266f4890aa9e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cfe714ca98a74825ba13266f4890aa9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s42003-024-06202-9","doi":"https://doi.org/10.1038/s42003-024-06202-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-024-06202-9","pdf_url":"https://www.nature.com/articles/s42003-024-06202-9.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5007844972","display_name":null,"funder_award_id":"JP20K07563","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G664942157","display_name":"Understanding of Wnt-addicted cancer cells using comprehensives transcriptome data","funder_award_id":"20K07563","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320336716","display_name":"Institute of Medical Science, University of Tokyo","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396243116.pdf","grobid_xml":"https://content.openalex.org/works/W4396243116.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1554815317","https://openalex.org/W1572965758","https://openalex.org/W1934207236","https://openalex.org/W1946371345","https://openalex.org/W1969855284","https://openalex.org/W1974351849","https://openalex.org/W1978125302","https://openalex.org/W1988728360","https://openalex.org/W1999574084","https://openalex.org/W2014677321","https://openalex.org/W2018507034","https://openalex.org/W2019036635","https://openalex.org/W2025840988","https://openalex.org/W2026531690","https://openalex.org/W2043129312","https://openalex.org/W2046997551","https://openalex.org/W2048177238","https://openalex.org/W2060878129","https://openalex.org/W2065672772","https://openalex.org/W2067284696","https://openalex.org/W2069092694","https://openalex.org/W2081463586","https://openalex.org/W2087527471","https://openalex.org/W2092664001","https://openalex.org/W2097250980","https://openalex.org/W2104287126","https://openalex.org/W2106016059","https://openalex.org/W2113020073","https://openalex.org/W2119347606","https://openalex.org/W2124000950","https://openalex.org/W2125041348","https://openalex.org/W2134359750","https://openalex.org/W2157230165","https://openalex.org/W2159778357","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2223535266","https://openalex.org/W2262414037","https://openalex.org/W2326793430","https://openalex.org/W2523089582","https://openalex.org/W2534801061","https://openalex.org/W2592095613","https://openalex.org/W2741265341","https://openalex.org/W2775414517","https://openalex.org/W2796153225","https://openalex.org/W2801967759","https://openalex.org/W2866743330","https://openalex.org/W2887301398","https://openalex.org/W2956820547","https://openalex.org/W3006417555","https://openalex.org/W3204545714","https://openalex.org/W3207384678","https://openalex.org/W4206120892","https://openalex.org/W4220833476","https://openalex.org/W4283017342","https://openalex.org/W4283162320","https://openalex.org/W4362455152"],"related_works":["https://openalex.org/W4393084946","https://openalex.org/W2885121626","https://openalex.org/W1994652351","https://openalex.org/W2087527471","https://openalex.org/W1970337657","https://openalex.org/W2010942899","https://openalex.org/W1998817605","https://openalex.org/W2797855519","https://openalex.org/W3213619141","https://openalex.org/W2944703174"],"abstract_inverted_index":{"Deregulation":[0],"of":[1,10,40,75,87,101,109,121,133,139,153,155,191],"the":[2,8,31,38,44,56,73,99,107,127,131,137,140,151,156,169,177,182,185,189],"Wnt/\u03b2-catenin":[3,186],"pathway":[4,187],"is":[5,70],"associated":[6],"with":[7,84],"development":[9],"human":[11],"cancer":[12,36,145],"including":[13,195],"colorectal":[14],"and":[15,61,64,89,123,125,159,197],"liver":[16,35,144,183],"cancer.":[17],"Although":[18],"we":[19,53],"previously":[20],"showed":[21],"that":[22,93,105,114,126,150],"histidine":[23,122],"ammonia":[24],"lyase":[25],"(HAL)":[26],"was":[27],"transcriptionally":[28],"reduced":[29],"by":[30,43,72,168,184],"\u03b2-catenin/TCF":[32],"complex":[33,45],"in":[34,143,181],"cells,":[37],"mechanism(s)":[39],"its":[41,162],"down-regulation":[42],"remain":[46],"to":[47],"be":[48],"clarified.":[49],"In":[50,79],"this":[51],"study,":[52],"search":[54],"for":[55],"transcription":[57,193],"factor(s)":[58],"regulating":[59],"HAL,":[60],"identify":[62],"CEBPA":[63,196],"FOXA1,":[65],"two":[66,95],"factors":[67,96,194],"whose":[68],"expression":[69,100],"suppressed":[71],"knockdown":[74],"\u03b2-catenin":[76],"or":[77],"TCF7L2.":[78],"addition,":[80],"RNA-seq":[81],"analysis":[82,112,148],"coupled":[83],"genome-wide":[85],"mapping":[86],"CEBPA-":[88],"FOXA1-binding":[90],"regions":[91],"reveals":[92,149],"these":[94],"also":[97,129,166],"increase":[98],"arginase":[102],"1":[103],"(ARG1)":[104],"catalyzes":[106],"hydrolysis":[108],"arginine.":[110],"Metabolome":[111],"discloses":[113],"activated":[115],"Wnt":[116,170],"signaling":[117],"augments":[118],"intracellular":[119],"concentrations":[120],"arginine,":[124],"signal":[128],"increases":[130],"level":[132],"lactic":[134],"acid":[135],"suggesting":[136],"induction":[138],"Warburg":[141],"effect":[142],"cells.":[146],"Further":[147],"levels":[152],"metabolites":[154],"urea":[157],"cycle":[158],"genes":[160],"coding":[161],"related":[163],"enzymes":[164],"are":[165],"modulated":[167],"signaling.":[171],"These":[172],"findings":[173],"shed":[174],"light":[175],"on":[176],"altered":[178],"cellular":[179],"metabolism":[180],"through":[188],"suppression":[190],"liver-enriched":[192],"FOXA1.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-04-30T00:00:00"}
