{"id":"https://openalex.org/W4396239201","doi":"https://doi.org/10.1080/14786419.2024.2347452","title":"Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation","display_name":"Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation","publication_year":2024,"publication_date":"2024-04-29","ids":{"openalex":"https://openalex.org/W4396239201","doi":"https://doi.org/10.1080/14786419.2024.2347452","pmid":"https://pubmed.ncbi.nlm.nih.gov/38684022"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2024.2347452","doi":"https://doi.org/10.1080/14786419.2024.2347452","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14786419.2024.2347452","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14786419.2024.2347452?needAccess=true","source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/14786419.2024.2347452?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091603881","display_name":"Joana Mota","orcid":"https://orcid.org/0009-0003-3659-8024","observed_orcids":["https://orcid.org/0009-0003-3659-8024"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4405268612","display_name":"Laborat\u00f3rio Associado TERRA","ror":"https://ror.org/01hkg7p16","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405268612"]},{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Mota","raw_affiliation_strings":["Faculty of Veterinary Medicine, Lus\u00f3fona University","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069012679","display_name":"Catarina Faria\u2010Silva","orcid":"https://orcid.org/0000-0002-8057-2548","observed_orcids":["https://orcid.org/0000-0002-8057-2548"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Faria-Silva","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057086541","display_name":"Ana R. Resendes","orcid":"https://orcid.org/0000-0001-9441-6813","observed_orcids":["https://orcid.org/0000-0001-9441-6813"]},"institutions":[{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Resendes","raw_affiliation_strings":["Faculty of Veterinary Medicine, Lus\u00f3fona University","Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085224546","display_name":"Maria Isabel Santos","orcid":"https://orcid.org/0000-0002-9421-9315","observed_orcids":["https://orcid.org/0000-0002-9421-9315"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4405268612","display_name":"Laborat\u00f3rio Associado TERRA","ror":"https://ror.org/01hkg7p16","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405268612"]},{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Isabel Santos","raw_affiliation_strings":["Faculty of Veterinary Medicine, Lus\u00f3fona University","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005703946","display_name":"Manuela Colla Carvalheiro","orcid":"https://orcid.org/0000-0002-6028-4717","observed_orcids":["https://orcid.org/0000-0002-6028-4717"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuela Colla Carvalheiro","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078218578","display_name":"Ana Lima","orcid":"https://orcid.org/0000-0001-8251-6286","observed_orcids":["https://orcid.org/0000-0001-8251-6286"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4405268612","display_name":"Laborat\u00f3rio Associado TERRA","ror":"https://ror.org/01hkg7p16","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405268612"]},{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Lima","raw_affiliation_strings":["Faculty of Veterinary Medicine, Lus\u00f3fona University","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine, Lus\u00f3fona University, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405268612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041385495","display_name":"Sandra Sim\u00f5es","orcid":"https://orcid.org/0000-0002-5685-1790","observed_orcids":["https://orcid.org/0000-0002-5685-1790"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Sandra Sim\u00f5es","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041385495"],"corresponding_institution_ids":["https://openalex.org/I141596103"],"apc_list":null,"apc_paid":null,"fwci":1.3229,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.79571293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"39","issue":"16","first_page":"4718","last_page":"4729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":1.0},{"id":"https://openalex.org/keywords/milk-thistle","display_name":"Silybum marianum","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gelatinase-inhibition","display_name":"gelatinase inhibition","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.6919999718666077},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ear-edema","display_name":"ear edema","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7607973217964172},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5187480449676514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4735637903213501},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38387608528137207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34980618953704834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21417748928070068}],"mesh":[{"descriptor_ui":"D000084282","descriptor_name":"HaCaT Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020944","descriptor_name":"Silybum marianum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/14786419.2024.2347452","doi":"https://doi.org/10.1080/14786419.2024.2347452","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14786419.2024.2347452","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14786419.2024.2347452?needAccess=true","source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:38684022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38684022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/25718919","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Silymarin_inhibits_dermal_gelatinolytic_activity_and_reduces_cutaneous_inflammation/25718919","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.25718919.v1","doi":"https://doi.org/10.6084/m9.figshare.25718919.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.25718919.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1080/14786419.2024.2347452","doi":"https://doi.org/10.1080/14786419.2024.2347452","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14786419.2024.2347452","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/14786419.2024.2347452?needAccess=true","source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2051880127","display_name":null,"funder_award_id":"04138","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396239201.pdf","grobid_xml":"https://content.openalex.org/works/W4396239201.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W148105776","https://openalex.org/W579473610","https://openalex.org/W1552145081","https://openalex.org/W1751092985","https://openalex.org/W1967143802","https://openalex.org/W1980463804","https://openalex.org/W1992226809","https://openalex.org/W1993660328","https://openalex.org/W2012859552","https://openalex.org/W2017679500","https://openalex.org/W2024837178","https://openalex.org/W2027501187","https://openalex.org/W2031322631","https://openalex.org/W2047698264","https://openalex.org/W2050378882","https://openalex.org/W2051271495","https://openalex.org/W2065289276","https://openalex.org/W2071926240","https://openalex.org/W2072755205","https://openalex.org/W2085138566","https://openalex.org/W2086769829","https://openalex.org/W2099296180","https://openalex.org/W2100932140","https://openalex.org/W2113115289","https://openalex.org/W2125652675","https://openalex.org/W2132902585","https://openalex.org/W2157657114","https://openalex.org/W2400594908","https://openalex.org/W2409710963","https://openalex.org/W2532309097","https://openalex.org/W2582073064","https://openalex.org/W2613674801","https://openalex.org/W2790829877","https://openalex.org/W2792363922","https://openalex.org/W2799986334","https://openalex.org/W2802621137","https://openalex.org/W2886246189","https://openalex.org/W2921230108","https://openalex.org/W2921648865","https://openalex.org/W2931400374","https://openalex.org/W2931501895","https://openalex.org/W2937875113","https://openalex.org/W2951872997","https://openalex.org/W2970406218","https://openalex.org/W2982604848","https://openalex.org/W3011302807","https://openalex.org/W3014066371","https://openalex.org/W3021868866","https://openalex.org/W3092157942","https://openalex.org/W3117027551","https://openalex.org/W3159970466","https://openalex.org/W3196210561","https://openalex.org/W3202054048","https://openalex.org/W3211078598","https://openalex.org/W3215010548","https://openalex.org/W3217345882","https://openalex.org/W4200214014","https://openalex.org/W4200520258","https://openalex.org/W4206379535","https://openalex.org/W4220987343","https://openalex.org/W4312211897"],"related_works":["https://openalex.org/W2521409851","https://openalex.org/W7100992499","https://openalex.org/W7015028752","https://openalex.org/W1976457127","https://openalex.org/W2898165161","https://openalex.org/W2788584973","https://openalex.org/W3153782596","https://openalex.org/W4313330388","https://openalex.org/W2587651954","https://openalex.org/W2018075260"],"abstract_inverted_index":{"Milk":[0],"thistle":[1],"(Silybum":[2],"marianum)":[3],"is":[4],"well-known":[5],"for":[6,22,46,134],"its":[7,25],"antioxidant":[8],"activity":[9,26,86],"due":[10],"to":[11,33,82,119,124],"the":[12,50,104],"presence":[13,51],"of":[14,52],"silymarin.":[15],"Albeit":[16],"some":[17],"studies":[18],"show":[19],"a":[20,69],"potential":[21,133],"skin":[23,137],"inflammation,":[24],"against":[27],"dermal":[28,57],"MMP-9":[29,54],"and":[30,55,93,126],"MMP-2":[31],"remains":[32],"be":[34],"studied.":[35],"Silymarin":[36,61,79],"isolated":[37,53,105],"from":[38],"an":[39,108],"S.":[40],"marianum":[41],"herbal":[42],"extract":[43],"was":[44,62,80,97,117],"tested":[45,65],"gelatinase":[47,141],"inhibition":[48,96],"in":[49,56,66,87,100,136],"adenocarcinome":[58],"HaCaT":[59],"cells.":[60],"then":[63],"further":[64],"vivo,":[67,115],"using":[68],"cutaneous":[70],"inflammation":[71],"mice":[72],"model":[73],"mediated":[74],"by":[75],"reactive":[76],"oxygen":[77],"species.":[78],"able":[81,118],"significantly":[83],"inhibit":[84],"gelatinolytic":[85],"vitro":[88],"without":[89],"impairing":[90],"cell":[91],"growth":[92],"viability.":[94],"Furthermore,":[95],"more":[98],"pronounced":[99],"cells":[101],"than":[102],"with":[103],"gelatinase,":[106],"suggesting":[107],"additional":[109],"effect":[110],"upon":[111],"metabolic":[112],"pathways.":[113],"In":[114],"silymarin":[116,132],"reduce":[120],"ear":[121],"edema":[122],"up":[123],"74%":[125],"attenuated":[127],"histological":[128],"lesions.":[129],"Results":[130],"highlight":[131],"application":[135],"inflammatory":[138],"disorders":[139],"via":[140],"inhibition.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-30T00:00:00"}
