{"id":"https://openalex.org/W4395960755","doi":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","title":"Effects of the Low-Dose Colchicine Regimen on Left Ventricular Adverse Remodeling and Systolic Function in Acute Myocardial Infarction Patients with Anterior ST-Segment Elevation Undergoing Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial","display_name":"Effects of the Low-Dose Colchicine Regimen on Left Ventricular Adverse Remodeling and Systolic Function in Acute Myocardial Infarction Patients with Anterior ST-Segment Elevation Undergoing Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial","publication_year":2024,"publication_date":"2024-04-28","ids":{"openalex":"https://openalex.org/W4395960755","doi":"https://doi.org/10.21776/ub/hsj.2024.005.02.9"},"language":"en","primary_location":{"id":"doi:10.21776/ub/hsj.2024.005.02.9","doi":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","pdf_url":null,"source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095924213","display_name":"Fahreza Caesario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fahreza Caesario","raw_affiliation_strings":["Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060712352","display_name":"Indra Prasetya","orcid":"https://orcid.org/0000-0003-0431-7411","observed_orcids":["https://orcid.org/0000-0003-0431-7411"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Indra Prasetya","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang"],"raw_orcid":"https://orcid.org/0000-0003-0431-7411","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067526249","display_name":"Mohammad Saifur Rohman","orcid":"https://orcid.org/0000-0001-6461-2223","observed_orcids":["https://orcid.org/0000-0001-6461-2223","https://orcid.org/0009-0003-8194-8222"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mohammad Saifur Rohman","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang"],"raw_orcid":"https://orcid.org/0000-0001-6461-2223","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078932755","display_name":"Budi Satrijo","orcid":"https://orcid.org/0000-0003-0043-5672","observed_orcids":["https://orcid.org/0000-0003-0043-5672","https://orcid.org/0009-0002-1737-0844"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Budi Satrijo","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang"],"raw_orcid":"https://orcid.org/0000-0003-0043-5672","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060242794","display_name":"Setyasih Anjarwani","orcid":"https://orcid.org/0000-0001-5116-6535","observed_orcids":["https://orcid.org/0000-0001-5116-6535"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Setyasih Anjarwani","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang"],"raw_orcid":"https://orcid.org/0000-0001-5116-6535","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177055848"],"apc_list":null,"apc_paid":null,"fwci":1.3228,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80930408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"5","issue":"2","first_page":"51","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/low-dose-colchicine","display_name":"low-dose colchicine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.8109999895095825},{"id":"https://openalex.org/keywords/primary-percutaneous-coronary-intervention","display_name":"primary percutaneous coronary intervention","score":0.953000009059906},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.824999988079071},{"id":"https://openalex.org/keywords/systolic-function","display_name":"systolic function","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9760000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/left-ventricular-end-systolic-volume-index","display_name":"left ventricular end-systolic volume index","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.867334246635437},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8124205470085144},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.7790778875350952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7767321467399597},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7268961071968079},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.4869883954524994},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46858853101730347},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4594470262527466},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.45677536725997925}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21776/ub/hsj.2024.005.02.9","doi":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","pdf_url":null,"source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21776/ub/hsj.2024.005.02.9","doi":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub/hsj.2024.005.02.9","pdf_url":null,"source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1153335416","https://openalex.org/W1893844572","https://openalex.org/W1900592574","https://openalex.org/W2051395985","https://openalex.org/W2343539326","https://openalex.org/W2522665294","https://openalex.org/W2606547287","https://openalex.org/W2952329033","https://openalex.org/W2967383075","https://openalex.org/W2986700515","https://openalex.org/W3044968187","https://openalex.org/W3081761942","https://openalex.org/W3158220026","https://openalex.org/W3194925641","https://openalex.org/W4206105057","https://openalex.org/W4212962259","https://openalex.org/W4282840618","https://openalex.org/W4283820851","https://openalex.org/W4386153206","https://openalex.org/W4388816411"],"related_works":["https://openalex.org/W4400281516","https://openalex.org/W3194925641","https://openalex.org/W7146968059","https://openalex.org/W7170071232","https://openalex.org/W4385831126","https://openalex.org/W7217339693","https://openalex.org/W3132731324","https://openalex.org/W2981440824","https://openalex.org/W4409734754","https://openalex.org/W3107315595"],"abstract_inverted_index":{"Background:":[0],"Inflammation":[1],"in":[2,6,23,43,95,113,127,134,144,149,155,171,196,209,215,238,242,250],"reperfusion":[3],"injury":[4],"results":[5,193],"adverse":[7,38,102,260],"ventricular":[8,36],"remodeling":[9,39,104,140,157,261],"and":[10,40,61,105,116,131,141,163,185,203,223],"reduced":[11],"systolic":[12,41,106,145,198,263],"function.":[13,264],"The":[14],"anti-inflammatory":[15],"effects":[16,22,30],"of":[17,31,240],"colchicine":[18,33,80,129,162,202,244,248],"have":[19],"shown":[20],"beneficial":[21],"cardiovascular":[24],"disease.":[25],"Objective:":[26],"To":[27],"determine":[28],"the":[29,114,128,135,161,169,178,201,216,232,243],"low-dose":[32,79],"on":[34],"left":[35],"(LV)":[37],"function":[42,146,199],"acute":[44],"myocardial":[45],"infarction":[46],"with":[47,124,206],"anterior":[48,70,251],"ST-segment":[49],"elevation":[50],"(anterior":[51],"STEMI)":[52],"patients":[53,72,126,133,241,253],"undergoing":[54,254],"primary":[55],"percutaneous":[56],"coronary":[57],"intervention":[58],"(PPCI).":[59],"Material":[60],"Methods:":[62],"This":[63],"prospective,":[64],"randomized,":[65],"double-blinded":[66],"study":[67],"randomly":[68],"assigned":[69],"STEMI":[71,252],"who":[73],"underwent":[74],"PPCI":[75,255],"to":[76,97],"receive":[77],"either":[78],"(1mg":[81],"loading":[82],"dose":[83],"followed":[84],"by":[85,109,168],"0.5mg":[86],"daily)":[87],"or":[88,262],"a":[89,142,207],"matching":[90],"placebo":[91,136,164,204],"for":[92],"30":[93],"days":[94],"addition":[96],"standard":[98],"therapy.":[99],"Outcomes":[100],"included":[101],"LV":[103,139,156,172,197,210,259],"function,":[107],"determined":[108],"transthoracic":[110],"echocardiography":[111],"(TTE)":[112],"first":[115,179,217],"third":[117,186,224],"month.":[118],"Result:":[119],"Enrollment":[120],"comprised":[121],"196":[122],"patients,":[123],"92":[125],"group":[130],"104":[132],"group.":[137,245],"Adverse":[138,266],"decrease":[143],"were":[147,158,194],"observed":[148,159,214],"both":[150],"groups.":[151],"No":[152],"significant":[153],"differences":[154],"between":[160,200],"groups,":[165,205],"as":[166],"indicated":[167],"change":[170],"end-systolic":[173],"volume":[174],"index":[175],"(LVESVI)":[176],"at":[177],"month":[180,187,218,225],"(16.5%":[181],"vs.":[182,189,220,227],"18.25%":[183],"[p=0.091])":[184],"(19.5%":[188],"21.5%":[190],"[p=0.124]).":[191],"Similar":[192],"found":[195],"reduction":[208],"ejection":[211],"fraction":[212],"(LVEF)":[213],"(6.3%":[219],"8.95%":[221],"[p=0.083])":[222],"(9.5%":[226],"11.5%":[228],"[p=0.163]).":[229],"Diarrhea":[230],"was":[231],"only":[233],"reported":[234],"side":[235],"effect,":[236],"occurring":[237],"6.5%":[239],"Conclusion:":[246],"Low-dose":[247],"administration":[249],"did":[256],"not":[257],"reduce":[258],"Keyword:":[265],"Remodeling,":[267],"Colchicine,":[268],"Reperfusion":[269],"Injury,":[270],"STEMI,":[271],"Systolic":[272],"Function.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-29T00:00:00"}
