{"id":"https://openalex.org/W4395673193","doi":"https://doi.org/10.33886/ajpas.v4i1.373","title":"Repurpose of Mefloquine-Cotrimoxazole Combination as Anti-Plasmodial Agents in Mice Infected with Pasmodium Berghei","display_name":"Repurpose of Mefloquine-Cotrimoxazole Combination as Anti-Plasmodial Agents in Mice Infected with Pasmodium Berghei","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4395673193","doi":"https://doi.org/10.33886/ajpas.v4i1.373"},"language":"en","primary_location":{"id":"doi:10.33886/ajpas.v4i1.373","doi":"https://doi.org/10.33886/ajpas.v4i1.373","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33886/ajpas.v4i1.373","pdf_url":"https://journals.ku.ac.ke/index.php/AJPAS/article/download/373/185","source":{"id":"https://openalex.org/S4210203558","display_name":"African Journal of Pure and Applied Sciences","issn_l":"2710-0758","issn":["2710-0758"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I153975220","host_organization_name":"Kenyatta University","host_organization_lineage":["https://openalex.org/I153975220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pure and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.ku.ac.ke/index.php/AJPAS/article/download/373/185","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059288096","display_name":"LeBari Barine Gboeloh","orcid":"https://orcid.org/0000-0002-6346-9522","observed_orcids":["https://orcid.org/0000-0002-6346-9522"]},"institutions":[{"id":"https://openalex.org/I4391768163","display_name":"Ignatius Ajuru University of Education","ror":"https://ror.org/02jv0j195","country_code":"NG","type":"education","lineage":["https://openalex.org/I4391768163"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"L. B. Gboeloh","raw_affiliation_strings":["Ignatius Ajuru University of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignatius Ajuru University of Education","institution_ids":["https://openalex.org/I4391768163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008762842","display_name":"Confidence Ogechi Nworgu","orcid":"https://orcid.org/0000-0002-6591-1628","observed_orcids":["https://orcid.org/0000-0002-6591-1628"]},"institutions":[{"id":"https://openalex.org/I4391768163","display_name":"Ignatius Ajuru University of Education","ror":"https://ror.org/02jv0j195","country_code":"NG","type":"education","lineage":["https://openalex.org/I4391768163"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. O. Nworgu","raw_affiliation_strings":["Ignatius Ajuru University of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignatius Ajuru University of Education","institution_ids":["https://openalex.org/I4391768163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4391768163"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":"24","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mefloquine","display_name":"mefloquine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasmodium-berghei","display_name":"Plasmodium berghei","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antimalarial-activity","display_name":"antimalarial activity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/parasitemia","display_name":"parasitemia","score":0.6380000114440918},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.7360000014305115},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7250000238418579},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.6209999918937683},{"id":"https://openalex.org/keywords/malaria-treatment","display_name":"malaria treatment","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.9359192848205566},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.8345844745635986},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5819268822669983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47857382893562317},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.40065133571624756},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3308783769607544},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.28798091411590576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1865828037261963},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.1624988615512848}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33886/ajpas.v4i1.373","doi":"https://doi.org/10.33886/ajpas.v4i1.373","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33886/ajpas.v4i1.373","pdf_url":"https://journals.ku.ac.ke/index.php/AJPAS/article/download/373/185","source":{"id":"https://openalex.org/S4210203558","display_name":"African Journal of Pure and Applied Sciences","issn_l":"2710-0758","issn":["2710-0758"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I153975220","host_organization_name":"Kenyatta University","host_organization_lineage":["https://openalex.org/I153975220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pure and Applied Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33886/ajpas.v4i1.373","doi":"https://doi.org/10.33886/ajpas.v4i1.373","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33886/ajpas.v4i1.373","pdf_url":"https://journals.ku.ac.ke/index.php/AJPAS/article/download/373/185","source":{"id":"https://openalex.org/S4210203558","display_name":"African Journal of Pure and Applied Sciences","issn_l":"2710-0758","issn":["2710-0758"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I153975220","host_organization_name":"Kenyatta University","host_organization_lineage":["https://openalex.org/I153975220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pure and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395673193.pdf","grobid_xml":"https://content.openalex.org/works/W4395673193.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1522083756","https://openalex.org/W1780134154","https://openalex.org/W1963728755","https://openalex.org/W1967819240","https://openalex.org/W1972167875","https://openalex.org/W1977225260","https://openalex.org/W1977797146","https://openalex.org/W1992713426","https://openalex.org/W2031513823","https://openalex.org/W2033634323","https://openalex.org/W2052589194","https://openalex.org/W2057058998","https://openalex.org/W2095337039","https://openalex.org/W2114059169","https://openalex.org/W2128485653","https://openalex.org/W2136091414","https://openalex.org/W2152568636","https://openalex.org/W2159287794","https://openalex.org/W2161771297","https://openalex.org/W2256455200","https://openalex.org/W2294013332","https://openalex.org/W2588455556","https://openalex.org/W2596340280","https://openalex.org/W2740619597","https://openalex.org/W2757952955","https://openalex.org/W2764166192","https://openalex.org/W2802238116","https://openalex.org/W2916225070","https://openalex.org/W2982245022","https://openalex.org/W3085621591","https://openalex.org/W3103944492","https://openalex.org/W3157952769","https://openalex.org/W4229960484","https://openalex.org/W4239981293","https://openalex.org/W4249095122","https://openalex.org/W4295956791","https://openalex.org/W4312168496","https://openalex.org/W4312655139"],"related_works":["https://openalex.org/W4408499454","https://openalex.org/W4408060306","https://openalex.org/W4225533081","https://openalex.org/W2168810016","https://openalex.org/W2041148757","https://openalex.org/W7117112023","https://openalex.org/W4226161239","https://openalex.org/W2063067410","https://openalex.org/W2627046708","https://openalex.org/W2077001259"],"abstract_inverted_index":{"The":[0,12,104,123,175,217,284],"keystone":[1],"for":[2,100,116,189,298],"the":[3,37,61,158,195,207,212,258,299],"treatment":[4],"of":[5,14,40,50,56,95,139,198,250,260,301],"malaria":[6],"is":[7,32],"artemisininbased":[8],"combination":[9,94,128,149,185,218],"therapy":[10],"(ACT).":[11],"vulnerability":[13],"parasites":[15],"to":[16,194],"ACT":[17],"has,":[18],"regrettably,":[19],"declined.":[20],"Determining":[21],"new":[22],"medications":[23],"or":[24],"drug":[25,295],"combinations":[26],"that":[27,126,257,276,287],"would":[28],"mitigate":[29],"parasite":[30],"resistance":[31],"therefore":[33],"pertinent.":[34],"Thisstudy":[35],"assessed":[36],"antimalarial":[38],"property":[39],"mefloquinecotrimoxazole":[41],"in":[42,211,224,237],"parasitized":[43],"mice.":[44],"Thirty":[45],"adult":[46],"Swiss":[47],"albino":[48],"mice":[49,58,62],"(18-30g)":[51],"were":[52,63,82,112,277],"grouped":[53],"into":[54],"five":[55,101],"6":[57],"each.":[59],"All":[60],"inoculated":[64],"with":[65,84,136,157,247,296],"Plasmodium":[66],"berghei":[67],"and":[68,80,92,109,114,120,141,146,153,172,200,214,235,243,252,273],"orally":[69],"treated.":[70],"Group":[71],"1":[72],"was":[73,280],"not":[74],"treated":[75,83],"while":[76],"groups":[77],"2,3,":[78],"4":[79],"5":[81],"chloroquine":[85],"(10mg/":[86,97],"kg),":[87],"mefloquine":[88,145,147,166,181,183,253,297],"(10mg/kg),":[89],"cotrimoxazole":[90,140,179,199,251,288],"(10mg/kg)":[91],"a":[93],"mefloquine/cotrimoxazole":[96,127,202],"kg)":[98],"respectively":[99],"(5)":[102],"days.":[103],"mean":[105,208],"survival":[106,209],"timewas":[107],"determined":[108],"blood":[110,233,239],"samples":[111],"collected":[113],"evaluated":[115],"percentage":[117,132],"parasitemia,":[118],"hematological":[119],"biochemical":[121],"markers.":[122],"results":[124],"showed":[125,256,286],"significantly":[129,204],"(p<0.05)":[130,205,222],"reduced":[131],"parasitemia":[133],"when":[134,245],"compared":[135,193,246],"single":[137,248],"doses":[138,197,249],"mefloquine.":[142],"Curatively,":[143],"cotrimoxazole,":[144,164],"/cotrimoxazole":[148,167,184],"produced":[150,220],"84.90%,":[151],"98.95%":[152],"96.96%":[154],"respectively,":[155],"whencontrasted":[156],"90.84%":[159],"delivered":[160,169,178],"by":[161,227,282],"chloroquine.":[162],"Suppressively,":[163],"mefloquine,":[165],"combination,":[168],"84.62%,":[170],"90.20%":[171],"97.55%":[173],"respectively.":[174,254],"prophylactic":[176],"test":[177],"(61.04%),":[180],"(75.23%),":[182],"(89.94%)":[186],"parasitamia":[187],"inhibition":[188],"day":[190],"4.":[191],"When":[192],"individual":[196],"mefloquine,the":[201],"combo":[203],"prolonged":[206],"time":[210],"curative,prophylactic,":[213],"suppressive":[215],"tests.":[216],"also":[219],"significant":[221],"reduction":[223],"anemia":[225],"characterized":[226],"increased":[228],"packed":[229],"cell":[230],"volume,":[231],"hemoglobin,red":[232],"cells":[234],"decrease":[236],"white":[238],"cells,":[240],"neutrophils":[241],"lymphocytes":[242],"monocytes":[244],"Theresult":[255],"levels":[259],"aspertate":[261],"transferase,alanine":[262],"alanine":[263],"transferase,":[264],"alkaline":[265],"phosphate":[266],"total":[267,269],"protein,":[268],"bilirubin,":[270],"urea,":[271],"creatinine":[272],"uric":[274],"acid":[275],"slightly":[278],"altered":[279],"curtailed":[281],"mefloquine/cotrimoxazole.":[283],"study":[285],"can":[289],"be":[290],"utilized":[291],"as":[292],"an":[293],"accomplice":[294],"management":[300],"malaria.":[302]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-04-27T00:00:00"}
