{"id":"https://openalex.org/W4395092448","doi":"https://doi.org/10.31254/jmr.2024.10108","title":"Human hepatocytes response to pathological shifts in liver fibrosis","display_name":"Human hepatocytes response to pathological shifts in liver fibrosis","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4395092448","doi":"https://doi.org/10.31254/jmr.2024.10108"},"language":"en","primary_location":{"id":"doi:10.31254/jmr.2024.10108","doi":"https://doi.org/10.31254/jmr.2024.10108","is_oa":true,"landing_page_url":"https://doi.org/10.31254/jmr.2024.10108","pdf_url":"https://doi.org/10.31254/jmr.2024.10108","source":{"id":"https://openalex.org/S4210195398","display_name":"The Journal of Medical Research","issn_l":"2395-7565","issn":["2395-7565","3051-0546"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31254/jmr.2024.10108","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018687304","display_name":"Chukwuma Sr Chrysanthus","orcid":"https://orcid.org/0000-0001-9162-6604","observed_orcids":["https://orcid.org/0000-0001-9162-6604"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chrysanthus Chukwuma","raw_affiliation_strings":["The Chrysanthus Centre for Future-oriented Studies, Abakaliki, Ebonyi State, Nigeria"],"raw_orcid":"https://orcid.org/0000-0001-9162-6604","affiliations":[{"raw_affiliation_string":"The Chrysanthus Centre for Future-oriented Studies, Abakaliki, Ebonyi State, Nigeria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018687304"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4961,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5961837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"10","issue":"1","first_page":"37","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.968999981880188},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.4259999990463257},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7620000243186951},{"id":"https://openalex.org/keywords/fibrogenic-factors","display_name":"fibrogenic factors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7179999947547913},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.7439766526222229},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6325350999832153},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.6253379583358765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4193165600299835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39098620414733887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3230275511741638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31254/jmr.2024.10108","doi":"https://doi.org/10.31254/jmr.2024.10108","is_oa":true,"landing_page_url":"https://doi.org/10.31254/jmr.2024.10108","pdf_url":"https://doi.org/10.31254/jmr.2024.10108","source":{"id":"https://openalex.org/S4210195398","display_name":"The Journal of Medical Research","issn_l":"2395-7565","issn":["2395-7565","3051-0546"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Medical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31254/jmr.2024.10108","doi":"https://doi.org/10.31254/jmr.2024.10108","is_oa":true,"landing_page_url":"https://doi.org/10.31254/jmr.2024.10108","pdf_url":"https://doi.org/10.31254/jmr.2024.10108","source":{"id":"https://openalex.org/S4210195398","display_name":"The Journal of Medical Research","issn_l":"2395-7565","issn":["2395-7565","3051-0546"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395092448.pdf","grobid_xml":"https://content.openalex.org/works/W4395092448.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1983417944","https://openalex.org/W2068084277","https://openalex.org/W2119792393","https://openalex.org/W2275249742","https://openalex.org/W2307551625","https://openalex.org/W2467104928","https://openalex.org/W2529961457","https://openalex.org/W2565367159","https://openalex.org/W2613180696","https://openalex.org/W2765946949","https://openalex.org/W2776677355","https://openalex.org/W2792762573","https://openalex.org/W2800237150","https://openalex.org/W2810423511","https://openalex.org/W3005214954","https://openalex.org/W3010014786","https://openalex.org/W3011968644","https://openalex.org/W3017296042","https://openalex.org/W3045287874","https://openalex.org/W3046614763","https://openalex.org/W3104053913","https://openalex.org/W3140360685","https://openalex.org/W3162596846","https://openalex.org/W3183465125","https://openalex.org/W3199014335","https://openalex.org/W3208498374","https://openalex.org/W3208550315","https://openalex.org/W4233453198","https://openalex.org/W4243729710","https://openalex.org/W4254976170","https://openalex.org/W4280524965","https://openalex.org/W4280594044","https://openalex.org/W4282934187","https://openalex.org/W4288726757","https://openalex.org/W4295345187","https://openalex.org/W4297781391","https://openalex.org/W4309651008","https://openalex.org/W4310680265","https://openalex.org/W4319752420","https://openalex.org/W4365455620","https://openalex.org/W4386314625","https://openalex.org/W4386335802","https://openalex.org/W4386935790","https://openalex.org/W4388461418","https://openalex.org/W4389306566","https://openalex.org/W4389355512","https://openalex.org/W6631320076"],"related_works":["https://openalex.org/W3000585291","https://openalex.org/W2000384470","https://openalex.org/W2498228549","https://openalex.org/W4386524621","https://openalex.org/W2982029884","https://openalex.org/W2028612481","https://openalex.org/W2376658362","https://openalex.org/W2770634512","https://openalex.org/W2565367159","https://openalex.org/W3011968644"],"abstract_inverted_index":{"Protracted":[0],"liver":[1,29,35,87,93,101,120,150,164,190,199,213],"assault":[2],"results":[3,95],"in":[4,86,96,186,206,230],"hepatic":[5,11,193],"fibrosis,":[6],"frequently":[7],"advancing":[8],"into":[9,117,153],"cirrhosis,":[10,178],"failure,":[12],"portal":[13,223],"hypertension":[14],"and":[15,44,65,89,136,179,182,210,226,235],"hepatocellular":[16,70,90,123],"carcinoma":[17],"or":[18,48,80,100,122,156,170],"degeneration.":[19,124],"Hepatic":[20],"fibrosis":[21,102,137,157,200,214],"emanates":[22],"from":[23,165],"the":[24,28,46,55,106,141,163,184,187,207,216,231],"wound-healing":[25],"response":[26],"of":[27,54,58,75,109,119,143,161,172,189,212,218,233,238],"to":[30,61,145],"persistent":[31,81],"assault.":[32],"Following":[33],"acute":[34],"insult,":[36],"such":[37],"as":[38,148,201],"viral":[39],"hepatitis,":[40],"parenchymal":[41],"cells":[42,195],"regenerate":[43],"substitute":[45],"necrotic":[47],"apoptotic":[49],"cells.":[50],"A":[51,168],"salient":[52],"proportion":[53],"affected":[56],"population":[57],"NAFLD":[59],"advances":[60],"nonalcoholic":[62],"steatohepatitis,":[63],"NASH,":[64],"is":[66,138,159],"characterised":[67],"by":[68,128],"inflammation,":[69],"swelling,":[71],"with":[72,175],"ensuing":[73],"eruption":[74],"deteriorating":[76],"fibrosis.":[77,239],"An":[78],"untreated":[79],"NASH":[82,135,144,176],"can":[83],"progressively":[84],"culminate":[85],"cirrhosis":[88,146],"carcinoma.":[91],"Chronic":[92],"derangement":[94],"pathologic":[97],"ECM":[98,111],"protein":[99],"aggregation.":[103],"In":[104],"essence,":[105],"encompassing":[107],"characterisation":[108],"human":[110],"molecular":[112],"composition":[113],"provides":[114],"for":[115,198],"excursions":[116],"mechanisms":[118],"disease":[121],"Hepatocytes":[125],"are":[126,196,203],"characterized":[127],"elevated":[129],"mitochondrial":[130],"concentrations.":[131],"The":[132,192],"difference":[133],"between":[134],"evident":[139],"that":[140,158],"progression":[142],"commences":[147],"inflamed":[149],"tissue":[151,155],"evolves":[152],"scar":[154],"capable":[160],"obliterating":[162],"optimum":[166],"functionality.":[167],"third":[169],"more":[171],"persons":[173],"presenting":[174],"develop":[177],"also":[180],"elevates":[181],"accelerates":[183],"risk":[185],"development":[188],"cancer.":[191],"stellate":[194],"responsible":[197],"they":[202],"substantially":[204],"involved":[205],"initiation,":[208],"progression,":[209],"regression":[211],"via":[215],"secretion":[217],"fibrogenic":[219],"factors":[220],"which":[221],"promote":[222],"fibrocytes,":[224],"fibroblasts,":[225],"bone":[227],"marrow-derived":[228],"myofibroblasts":[229],"formation":[232],"collagen,":[234],"consequential":[236],"propagation":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-25T00:00:00"}