{"id":"https://openalex.org/W4395083403","doi":"https://doi.org/10.21203/rs.3.rs-4104643/v1","title":"Age-dependent alterations in the human striatum identify a PPP1R15B-miR-196a node as a modifier of Huntington\u2019s disease phenotypes","display_name":"Age-dependent alterations in the human striatum identify a PPP1R15B-miR-196a node as a modifier of Huntington\u2019s disease phenotypes","publication_year":2024,"publication_date":"2024-04-10","ids":{"openalex":"https://openalex.org/W4395083403","doi":"https://doi.org/10.21203/rs.3.rs-4104643/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-4104643/v1","doi":"https://doi.org/10.21203/rs.3.rs-4104643/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4104643/v1","pdf_url":"https://www.researchsquare.com/article/rs-4104643/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-4104643/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091747215","display_name":"Andrew S.J. Yoo","orcid":"https://orcid.org/0000-0002-0304-3247","observed_orcids":["https://orcid.org/0000-0002-0304-3247"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Yoo","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":"https://orcid.org/0000-0002-0304-3247","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052825989","display_name":"Victoria A. Church","orcid":"https://orcid.org/0000-0002-7518-9624","observed_orcids":["https://orcid.org/0000-0002-7518-9624"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Church","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077567873","display_name":"Agnieszka Krzy\u017cosiak","orcid":"https://orcid.org/0000-0002-4330-3189","observed_orcids":["https://orcid.org/0000-0002-4330-3189"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210149847","display_name":"\u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development","ror":"https://ror.org/03rvn3n08","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210149847"]}],"countries":["GB","PL"],"is_corresponding":false,"raw_author_name":"Agnieszka Krzyzosiak","raw_affiliation_strings":["PORT Polish Center for Technology Development","MRC Laboratory of Molecular Biology; Francis Crick Avenue, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PORT Polish Center for Technology Development","institution_ids":["https://openalex.org/I4210149847"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology; Francis Crick Avenue, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046956303","display_name":"Shawei Chen","orcid":"https://orcid.org/0009-0007-8019-3285","observed_orcids":["https://orcid.org/0009-0007-8019-3285"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawei Chen","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077788392","display_name":"Ji\u2010Sun Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Sun Kwon","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","Program in Computational Systems Biology, Washington University School of Medicine, St. Louis, M.O., 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Program in Computational Systems Biology, Washington University School of Medicine, St. Louis, M.O., 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064624103","display_name":"Matheus B. Victor","orcid":"https://orcid.org/0000-0003-4364-4028","observed_orcids":["https://orcid.org/0000-0003-4364-4028"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matheus Victor","raw_affiliation_strings":["Massachusetts Institute of Technology","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083385355","display_name":"Benpeng Miao","orcid":"https://orcid.org/0000-0002-2070-2339","observed_orcids":["https://orcid.org/0000-0002-2070-2339"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benpeng Miao","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669407","display_name":"Bo Zhang","orcid":"https://orcid.org/0000-0003-2962-5314","observed_orcids":["https://orcid.org/0000-0003-2962-5314","https://orcid.org/0000-0001-6394-8497"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Washington University School of Medicine","Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center of Regenerative Medicine, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Developmental Biology, Washington University School of Medicine; St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000563525","display_name":"Sonika M Dahiya","orcid":"https://orcid.org/0000-0002-5585-0964","observed_orcids":["https://orcid.org/0000-0002-5585-0964"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonika Dahiya","raw_affiliation_strings":["Washington University School of Medicine","Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, M.O., 63110, USA"],"raw_orcid":"https://orcid.org/0000-0002-5585-0964","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, M.O., 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060495190","display_name":"Anne Bertolotti","orcid":"https://orcid.org/0000-0002-9185-0558","observed_orcids":["https://orcid.org/0000-0002-9185-0558"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Bertolotti","raw_affiliation_strings":["MRC Laboratory of Molecular Biology","MRC Laboratory of Molecular Biology; Francis Crick Avenue, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology; Francis Crick Avenue, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091747215"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mir-196a","display_name":"miR-196a","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polyglutamine-expansion","display_name":"polyglutamine expansion","score":0.875},{"id":"https://openalex.org/keywords/huntingtin-aggregation","display_name":"huntingtin aggregation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/medium-spiny-neurons","display_name":"medium spiny neurons","score":0.9300000071525574},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7319999933242798},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.8460115790367126},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6612144112586975},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.6576917171478271},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6251044869422913},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.5921903848648071},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5826046466827393},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5701102018356323},{"id":"https://openalex.org/C2910011555","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin Protein","level":5,"score":0.5526663064956665},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.5475642681121826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521001398563385},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5156427621841431},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37988531589508057},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34858906269073486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25481075048446655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25338929891586304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2475530207157135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21333682537078857},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.18404603004455566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-4104643/v1","doi":"https://doi.org/10.21203/rs.3.rs-4104643/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4104643/v1","pdf_url":"https://www.researchsquare.com/article/rs-4104643/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4104643/v1","doi":"https://doi.org/10.21203/rs.3.rs-4104643/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4104643/v1","pdf_url":"https://www.researchsquare.com/article/rs-4104643/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1114310655","display_name":null,"funder_award_id":"CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G119964413","display_name":null,"funder_award_id":"FP7/2007\u20132013","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1485266116","display_name":null,"funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G299873027","display_name":null,"funder_award_id":"#P30 CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4117032081","display_name":"Protein Misfolding: Prion-like Propagation and Cure.  Implications for Neurodegenerative Diseases.","funder_award_id":"309516","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G5255610963","display_name":"Modeling Neuronal Aging and Alzheimer's Disease in Human Neurons Directly Converted from Fibroblasts","funder_award_id":"RF1AG056296","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6140014625","display_name":"Protein quality control in health and disease","funder_award_id":"206367/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8038155481","display_name":null,"funder_award_id":"MC_U105185860","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8242737674","display_name":null,"funder_award_id":"CA91842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000319192","display_name":null,"funder_award_id":"CA91842","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308687","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320315130","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395083403.pdf","grobid_xml":"https://content.openalex.org/works/W4395083403.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1569891543","https://openalex.org/W1806909159","https://openalex.org/W1967729506","https://openalex.org/W1975934689","https://openalex.org/W2014946489","https://openalex.org/W2025000087","https://openalex.org/W2028349138","https://openalex.org/W2035016973","https://openalex.org/W2036897871","https://openalex.org/W2043823611","https://openalex.org/W2048432879","https://openalex.org/W2056013470","https://openalex.org/W2060148506","https://openalex.org/W2062473455","https://openalex.org/W2076159058","https://openalex.org/W2077475358","https://openalex.org/W2102050179","https://openalex.org/W2106563360","https://openalex.org/W2114144036","https://openalex.org/W2121642311","https://openalex.org/W2134629862","https://openalex.org/W2137586531","https://openalex.org/W2138207763","https://openalex.org/W2146512944","https://openalex.org/W2162143298","https://openalex.org/W2168583567","https://openalex.org/W2169456326","https://openalex.org/W2170256902","https://openalex.org/W2179438025","https://openalex.org/W2205546371","https://openalex.org/W2521543069","https://openalex.org/W2592811885","https://openalex.org/W2609977986","https://openalex.org/W2732380281","https://openalex.org/W2736116326","https://openalex.org/W2790780682","https://openalex.org/W2808710290","https://openalex.org/W2892023480","https://openalex.org/W2940964825","https://openalex.org/W3040771723","https://openalex.org/W3084142394","https://openalex.org/W3108982385","https://openalex.org/W3109210179","https://openalex.org/W3159328850","https://openalex.org/W3159873724","https://openalex.org/W3165570809","https://openalex.org/W3193847974","https://openalex.org/W3205583660","https://openalex.org/W4282972828","https://openalex.org/W4296816736","https://openalex.org/W4307498144","https://openalex.org/W4389487617","https://openalex.org/W4390399170"],"related_works":["https://openalex.org/W7214499613","https://openalex.org/W4307498144","https://openalex.org/W2004155733","https://openalex.org/W4391891952","https://openalex.org/W3126938602","https://openalex.org/W2102648007","https://openalex.org/W2804663373","https://openalex.org/W7214176931","https://openalex.org/W2122122399","https://openalex.org/W4211204321"],"abstract_inverted_index":{"Abstract":[0],"Polyglutamine":[1],"expansion":[2],"in":[3,15,46,81,143,159,174,189],"Huntingtin":[4],"(HTT)":[5],"causes":[6],"its":[7,119,162],"aggregation":[8],"and":[9,51,77,106,128,147,161,165,177,184],"progressive":[10],"loss":[11],"of":[12,43,93,102,111,134,170,179],"striatal":[13,35,85],"neurons":[14,88],"Huntington\u2019s":[16],"disease":[17,122],"(HD).":[18],"HD":[19,70,95],"is":[20,37],"a":[21,40,136],"mostly":[22],"adult-onset":[23],"neurodegenerative":[24],"disorder":[25],"with":[26,39],"no":[27],"disease-modifying":[28,187],"therapies.":[29],"Here":[30],"we":[31],"found":[32],"that":[33,138],"human":[34,126,144],"aging":[36],"associated":[38],"global":[41],"upregulation":[42],"genes":[44],"involved":[45],"translation,":[47],"including":[48],"the":[49,58,65,100,167],"translation":[50],"proteostasis":[52],"regulator":[53],"PPP1R15B":[54],"(R15B).":[55],"We":[56,181],"used":[57],"R15B":[59,72,112,145,164,185],"inhibitor":[60],"Raphin1":[61,98],"to":[62],"investigate":[63],"if":[64],"age-associated":[66],"changes":[67,173],"could":[68],"modify":[69],"pathology.":[71],"inhibition":[73],"rescued":[74],"early":[75],"learning":[76],"late":[78],"motor":[79],"deficits":[80],"HDYAC128":[82],"mice.":[83],"In":[84],"medium":[86],"spiny":[87],"directly":[89,139],"reprogrammed":[90,129],"from":[91,116],"fibroblasts":[92],"symptomatic":[94],"patients":[96],"(HD-MSNs),":[97],"reduced":[99],"formation":[101],"mutant":[103,151],"HTT":[104,152],"aggregates":[105],"neuronal":[107],"death.":[108],"Genetic":[109],"knockdown":[110],"also":[113],"protected":[114],"HD-MSNs":[115],"neurodegeneration":[117],"whereas":[118],"overexpression":[120],"exacerbated":[121],"phenotypes.":[123],"Moreover,":[124],"both":[125],"striatum":[127],"MSNs":[130],"exhibited":[131],"age-dependent":[132,157],"decline":[133],"miR-196a,":[135],"microRNA":[137],"targets":[140,188],"non-conserved":[141],"sites":[142],"3\u2019UTR":[146],"overexpressing":[148],"miR-196a":[149,160,183],"lowered":[150],"aggregation.":[153],"This":[154],"work":[155],"identifies":[156],"alterations":[158],"target":[163],"demonstrates":[166],"therapeutic":[168],"potential":[169],"reversing":[171],"these":[172],"diverse":[175],"models":[176],"readouts":[178],"HD.":[180,190],"propose":[182],"as":[186]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-04-25T00:00:00"}
