{"id":"https://openalex.org/W4395082976","doi":"https://doi.org/10.1172/jci.insight.162449","title":"Endothelial HIF\u03b1/PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension","display_name":"Endothelial HIF\u03b1/PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension","publication_year":2024,"publication_date":"2024-04-23","ids":{"openalex":"https://openalex.org/W4395082976","doi":"https://doi.org/10.1172/jci.insight.162449","pmid":"https://pubmed.ncbi.nlm.nih.gov/38652543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11141934"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.162449","doi":"https://doi.org/10.1172/jci.insight.162449","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.162449","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1172/jci.insight.162449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047991792","display_name":"Fatima Zahra Saddouk","orcid":"https://orcid.org/0000-0003-2444-9729","observed_orcids":["https://orcid.org/0000-0003-2444-9729"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatima Z. Saddouk","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, Connecticut, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and"],"raw_orcid":"https://orcid.org/0000-0003-2444-9729","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092989579","display_name":"Andrew kuzemczak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Kuzemczak","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, Connecticut, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021847362","display_name":"Junichi Saito","orcid":"https://orcid.org/0000-0002-4297-727X","observed_orcids":["https://orcid.org/0000-0002-4297-727X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junichi Saito","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, Connecticut, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and"],"raw_orcid":"https://orcid.org/0000-0002-4297-727X","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088025612","display_name":"Daniel M. Greif","orcid":"https://orcid.org/0000-0002-9842-3751","observed_orcids":["https://orcid.org/0000-0002-9842-3751"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel M. Greif","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, Connecticut, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and"],"raw_orcid":"https://orcid.org/0000-0002-9842-3751","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, and","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088025612"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":4.0406,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.94597144,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pulmonary-arterioles","display_name":"pulmonary arterioles","score":0.6110000014305115},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6690000295639038},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":1.0},{"id":"https://openalex.org/keywords/pdgf-b","display_name":"PDGF-B","score":0.9610000252723694},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.871999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2780545995","wikidata":"https://www.wikidata.org/wiki/Q18030421","display_name":"PDGFB","level":5,"score":0.8867028951644897},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6538399457931519},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.6420693397521973},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6324765682220459},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6219441890716553},{"id":"https://openalex.org/C31194975","wikidata":"https://www.wikidata.org/wiki/Q20970095","display_name":"HIF1A","level":3,"score":0.6190701127052307},{"id":"https://openalex.org/C2779482390","wikidata":"https://www.wikidata.org/wiki/Q501908","display_name":"Arteriole","level":3,"score":0.6080430150032043},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5608202219009399},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4581723213195801},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.4120222330093384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4065977931022644},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.39354071021080017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3866938054561615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38273292779922485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3774351179599762},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34682080149650574},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3441388010978699},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.33168351650238037},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25001439452171326},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23455455899238586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22827458381652832},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.12328115105628967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0759689211845398},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000099162","descriptor_name":"Endothelial PAS Domain-Containing Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066253","descriptor_name":"Vascular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.162449","doi":"https://doi.org/10.1172/jci.insight.162449","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.162449","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11141934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11141934","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11141934/pdf/jciinsight-9-162449.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:38652543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38652543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:203224fb6a144faaa9fcc559adf45887","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/203224fb6a144faaa9fcc559adf45887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight, Vol 9, Iss 10 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.162449","doi":"https://doi.org/10.1172/jci.insight.162449","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.162449","pdf_url":null,"source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1295415879","display_name":"Reversal of Vascular Remodeling in Pulmonary hypertention","funder_award_id":"18POST34070007","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G1551930852","display_name":"Aging and clonality in atherosclerosis","funder_award_id":"R21AG062202","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4224723834","display_name":"Vascular disease pathogenesis: the interface of smooth muscle and immune cells","funder_award_id":"R01HL142674","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6634842880","display_name":"Pathological arterial muscularization and the role of integrins","funder_award_id":"R01HL125815","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G667973960","display_name":"Pericyte angiopoietin2 and neonatal intracranial hemorrhage","funder_award_id":"R21NS123469","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8799238577","display_name":"Mechanisms of reverse vascular remodeling in pulmonary hypertension","funder_award_id":"19EIA34660321","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G9000866368","display_name":"Novel vascular smooth muscle cell progenitors in development and disease","funder_award_id":"R35HL150766","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000872968","display_name":"Epigenetic-mediated Notch pathway activation promotes elastin aortopathy","funder_award_id":"R01HD110059","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1806289054","https://openalex.org/W1966954307","https://openalex.org/W1973472942","https://openalex.org/W1976409316","https://openalex.org/W1979129486","https://openalex.org/W1980111004","https://openalex.org/W1981586494","https://openalex.org/W1986624570","https://openalex.org/W1998486974","https://openalex.org/W2003047743","https://openalex.org/W2003790473","https://openalex.org/W2005868568","https://openalex.org/W2010503509","https://openalex.org/W2020277250","https://openalex.org/W2021822355","https://openalex.org/W2022270105","https://openalex.org/W2031414702","https://openalex.org/W2034849829","https://openalex.org/W2040031153","https://openalex.org/W2044257922","https://openalex.org/W2044290370","https://openalex.org/W2045450215","https://openalex.org/W2057274775","https://openalex.org/W2058923462","https://openalex.org/W2060104085","https://openalex.org/W2062002285","https://openalex.org/W2066800765","https://openalex.org/W2073537928","https://openalex.org/W2077651427","https://openalex.org/W2081046155","https://openalex.org/W2082025181","https://openalex.org/W2082510462","https://openalex.org/W2083950892","https://openalex.org/W2085898726","https://openalex.org/W2087377825","https://openalex.org/W2090798565","https://openalex.org/W2104010513","https://openalex.org/W2104135721","https://openalex.org/W2109730452","https://openalex.org/W2112008193","https://openalex.org/W2124051484","https://openalex.org/W2131676053","https://openalex.org/W2135336701","https://openalex.org/W2136496098","https://openalex.org/W2136861773","https://openalex.org/W2140265233","https://openalex.org/W2140319297","https://openalex.org/W2147944062","https://openalex.org/W2159494293","https://openalex.org/W2170779936","https://openalex.org/W2180845934","https://openalex.org/W2246612893","https://openalex.org/W2346478217","https://openalex.org/W2433384223","https://openalex.org/W2495079021","https://openalex.org/W2574765964","https://openalex.org/W2713861705","https://openalex.org/W2742204352","https://openalex.org/W2765876992","https://openalex.org/W2800122917","https://openalex.org/W2809094613","https://openalex.org/W2946646116","https://openalex.org/W2957037956","https://openalex.org/W2972400204","https://openalex.org/W2996734298","https://openalex.org/W3092060039","https://openalex.org/W3130269641","https://openalex.org/W3133289732","https://openalex.org/W4200124452","https://openalex.org/W6638364268","https://openalex.org/W6680106880"],"related_works":["https://openalex.org/W4387270314","https://openalex.org/W2980281125","https://openalex.org/W3133289732","https://openalex.org/W1980111004","https://openalex.org/W3023476158","https://openalex.org/W3016809690","https://openalex.org/W2800122917","https://openalex.org/W2180845934","https://openalex.org/W4312810433","https://openalex.org/W2800049907"],"abstract_inverted_index":{"Mechanisms":[0],"underlying":[1],"maintenance":[2],"of":[3,14,40,96,103,194,206],"pathological":[4,90,207],"vascular":[5,81],"hypermuscularization":[6],"are":[7],"poorly":[8],"delineated.":[9],"Herein,":[10],"we":[11],"investigated":[12],"retention":[13],"smooth":[15],"muscle":[16],"cells":[17,51],"(SMCs)":[18],"coating":[19],"normally":[20],"unmuscularized":[21],"distal":[22,97,143,148,178,208],"pulmonary":[23,26,80,113,128],"arterioles":[24],"in":[25,45,127,135,142,198],"hypertension":[27],"(PH)":[28],"mediated":[29,182],"by":[30,183],"chronic":[31,191],"hypoxia":[32,44,184,192],"with":[33,75,84,158,185],"or":[34,47,106,156,186],"without":[35,187],"Sugen":[36,188],"5416,":[37],"and":[38,58,67,99,119,146,167,180],"reversal":[39],"this":[41],"pathology.":[42],"With":[43],"mice":[46],"culture,":[48],"lung":[49,132],"endothelial":[50],"(ECs)":[52],"upregulated":[53,126,140],"hypoxia-inducible":[54],"factor":[55,64],"1\u03b1":[56],"(HIF1-\u03b1)":[57],"HIF2-\u03b1,":[59,117],"which":[60],"induce":[61],"platelet-derived":[62],"growth":[63],"B":[65],"(PDGF-B),":[66],"these":[68],"factors":[69],"were":[70,125],"reduced":[71],"to":[72],"normoxic":[73],"levels":[74],"re-normoxia.":[76],"Re-normoxia":[77],"reversed":[78],"hypoxia-induced":[79,137],"remodeling,":[82],"but":[83],"EC":[85,153],"HIF\u03b1":[86],"overexpression":[87],"during":[88],"re-normoxia,":[89,152],"changes":[91],"persisted.":[92],"Conversely,":[93],"after":[94,147],"establishment":[95],"muscularization":[98,149,179],"PH,":[100],"EC-specific":[101],"deletion":[102,174],"Hif1a,":[104],"Hif2a,":[105],"Pdgfb":[107,154],"induced":[108,175],"reversal.":[109],"In":[110],"human":[111],"idiopathic":[112],"artery":[114,129],"hypertension,":[115],"HIF1-\u03b1,":[116],"PDGF-B,":[118],"autophagy-mediating":[120],"gene":[121],"products,":[122],"including":[123],"Beclin1,":[124],"SMCs":[130],"and/or":[131],"lysates.":[133],"Furthermore,":[134],"mice,":[136],"EC-derived":[138],"PDGF-B":[139],"Beclin1":[141,166],"arteriole":[144,209],"SMCs,":[145],"was":[150],"established,":[151],"deletion,":[155],"treatment":[157],"STI571":[159],"(which":[160],"inhibits":[161],"PDGF":[162],"receptors)":[163],"downregulated":[164],"SMC":[165],"other":[168],"autophagy":[169],"products.":[170],"Finally,":[171],"SMC-specific":[172],"Becn1":[173],"apoptosis,":[176],"reversing":[177],"PH":[181],"5416.":[189],"Thus,":[190],"induction":[193],"the":[195],"HIF\u03b1/PDGF-B":[196],"axis":[197],"ECs":[199],"is":[200],"required":[201],"for":[202],"non-cell-autonomous":[203],"Beclin1-mediated":[204],"survival":[205],"SMCs.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-25T00:00:00"}
