{"id":"https://openalex.org/W4395076822","doi":"https://doi.org/10.1093/rheumatology/keae163.125","title":"P084 Gout symptom improvements and patient outcomes with SEL-212 in gout refractory to conventional therapy: DISSOLVE I & II phase 3, double-blind, placebo-controlled clinical trials","display_name":"P084 Gout symptom improvements and patient outcomes with SEL-212 in gout refractory to conventional therapy: DISSOLVE I & II phase 3, double-blind, placebo-controlled clinical trials","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4395076822","doi":"https://doi.org/10.1093/rheumatology/keae163.125"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/keae163.125","doi":"https://doi.org/10.1093/rheumatology/keae163.125","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keae163.125","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.125/57304213/keae163.125.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.125/57304213/keae163.125.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019605448","display_name":"Herbert S. B. Baraf","orcid":"https://orcid.org/0000-0002-0162-9930","observed_orcids":["https://orcid.org/0000-0002-0162-9930"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert S B Baraf","raw_affiliation_strings":["The Center for Rheumatology and Bone Research & The George Washington University Rheumatology , , Wheaton & Washington DC, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Rheumatology and Bone Research & The George Washington University Rheumatology , , Wheaton & Washington DC, WA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089460885","display_name":"Puja P. Khanna","orcid":"https://orcid.org/0000-0002-0264-1317","observed_orcids":["https://orcid.org/0000-0002-0264-1317"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puja Khanna","raw_affiliation_strings":["Division of Rheumatology, University of Michigan , Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Michigan , Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020571094","display_name":"Anand V Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anand Patel","raw_affiliation_strings":["Clinical Trials, Conquest Research , Winter Park, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials, Conquest Research , Winter Park, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069326305","display_name":"Joanna Sobierska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158749","display_name":"Swedish Orphan Biovitrum (Switzerland)","ror":"https://ror.org/05kymnn64","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210137624","https://openalex.org/I4210158749"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Joanna Sobierska","raw_affiliation_strings":["Swedish Orphan Biovitrum AG Rheumatolgy, , Basel, SWITZERLAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Orphan Biovitrum AG Rheumatolgy, , Basel, SWITZERLAND","institution_ids":["https://openalex.org/I4210158749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059530054","display_name":"Jacquie Christie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137624","display_name":"Swedish Orphan Biovitrum (Sweden)","ror":"https://ror.org/04asvbz37","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210137624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jacquie Christie","raw_affiliation_strings":["Swedish Orphan Biovitrum AG Rheumatolgy, , Cambridge, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Orphan Biovitrum AG Rheumatolgy, , Cambridge, UNITED KINGDOM","institution_ids":["https://openalex.org/I4210137624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059736360","display_name":"Wesley H. DeHaan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley DeHaan","raw_affiliation_strings":["Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064124511","display_name":"Rehan Azeem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehan Azeem","raw_affiliation_strings":["Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030568693","display_name":"Peter G. Traber","orcid":"https://orcid.org/0000-0002-5952-5720","observed_orcids":["https://orcid.org/0000-0002-5952-5720"]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G Traber","raw_affiliation_strings":["Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences, Inc Rheumatolgy, ., Watertown, MA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082669130","display_name":"Alan Kivitz","orcid":"https://orcid.org/0000-0002-1045-1310","observed_orcids":["https://orcid.org/0000-0002-1045-1310"]},"institutions":[{"id":"https://openalex.org/I4210112965","display_name":"Altoona Center for Clinical Research","ror":"https://ror.org/022q8ez38","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210112965"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Kivitz","raw_affiliation_strings":["Altoona Center for Clinical Research Rheumatolgy, , Duncansville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altoona Center for Clinical Research Rheumatolgy, , Duncansville, PA","institution_ids":["https://openalex.org/I4210112965"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3660,"currency":"GBP","value_usd":4679},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"63","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-gout","display_name":"refractory gout","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7889999747276306},{"id":"https://openalex.org/keywords/urate-oxidase","display_name":"uricase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/swollen-and-tender-joints","display_name":"swollen and tender joints","score":0.6830000281333923},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tophaceous-gout","display_name":"tophaceous gout","score":0.5989999771118164},{"id":"https://openalex.org/keywords/urate-lowering-therapy","display_name":"urate-lowering therapy","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9508579969406128},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.9155741930007935},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6876859068870544},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6777234077453613},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5504591464996338},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5142566561698914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49968862533569336},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.17062389850616455},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07543319463729858},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/rheumatology/keae163.125","doi":"https://doi.org/10.1093/rheumatology/keae163.125","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keae163.125","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.125/57304213/keae163.125.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/rheumatology/keae163.125","doi":"https://doi.org/10.1093/rheumatology/keae163.125","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keae163.125","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.125/57304213/keae163.125.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316014","display_name":"Fresenius Medical Care North America","ror":"https://ror.org/02avws951"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395076822.pdf","grobid_xml":"https://content.openalex.org/works/W4395076822.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399481509","https://openalex.org/W4399481403","https://openalex.org/W4379522230","https://openalex.org/W4399481863","https://openalex.org/W4384298121","https://openalex.org/W4403834638","https://openalex.org/W4366160578","https://openalex.org/W4385420193","https://openalex.org/W2952473066","https://openalex.org/W2892339408"],"abstract_inverted_index":{"Abstract":[0],"Background/Aims":[1],"Serum":[2],"uric":[3],"acid":[4],"(sUA)":[5],"\u22656.8":[6],"mg/dL":[7,192,197],"often":[8],"leads":[9],"to":[10,17],"severe":[11],"clinical":[12,91],"manifestations":[13],"in":[14,68,112,193,198,222,265,291,320,327,343,349],"gout":[15,170],"refractory":[16,71,113],"conventional":[18],"therapy.":[19],"Uricase-based":[20],"therapies":[21],"can":[22,27],"be":[23],"effective,":[24],"although":[25],"immunogenicity":[26],"reduce":[28],"efficacy":[29],"and":[30,58,61,77,84,128,140,160,167,175,195,220,225,313,339,352,355,373,476,484,504],"increase":[31],"infusion-reaction":[32],"risk.":[33],"SEL-212":[34,67,180,251,272,299,335],"is":[35],"a":[36,51,95],"novel,":[37],"once-monthly":[38],"treatment":[39],"of":[40,43,66,97,121,318,329,359,376,402,411,421,431,442,453,487],"sequential":[41],"infusions":[42],"tolerogenic":[44],"nanoparticles":[45],"containing":[46],"sirolimus":[47],"(SEL-110)":[48],"followed":[49],"by":[50],"pegylated":[52],"uricase":[53],"(pegadricase,":[54],"SEL-037).":[55],"DISSOLVE":[56],"I":[57],"II":[59],"(DI":[60],"DII)":[62,148],"evaluated":[63,94],"the":[64,209,223,309,330,357],"safety/efficacy":[65],"adults":[69],"with":[70,108,205,249,270,284],"gout.":[72,114],"Here":[73],"we":[74],"report":[75],"secondary":[76,302],"key":[78],"safety":[79],"endpoints.":[80],"Methods":[81],"DI":[82,194,294,321],"(US)":[83],"DII":[85],"(Global)":[86],"were":[87,149,245,262,304],"placebo-controlled,":[88],"double-blind,":[89],"randomised":[90],"trials":[92],"that":[93],"combination":[96],"SEL-110":[98],"at":[99,165],"either":[100],"0.15":[101],"mg/kg":[102,106],"[high-dose]":[103],"or":[104],"0.1":[105],"[low-dose]":[107],"SEL-037":[109],"(0.2":[110],"mg/kg)":[111],"Six-month":[115],"outcomes":[116],"included":[117],"sUA":[118,185,345],"reduction,":[119],"number":[120,358],"tender/swollen":[122,360],"joints,":[123,229,234,253],"tophus":[124],"burden,":[125],"health-related":[126],"quality-of-life,":[127],"safety.":[129],"Results":[130],"112":[131],"participants":[132,142],"(96%":[133],"male,":[134,144],"66%":[135],"aged":[136],"\u226550":[137,146],"years,":[138,147,157],"DI)":[139],"153":[141],"(97%":[143],"72%":[145],"dosed":[150],"(Table":[151],"1).":[152],"Mean":[153],"age":[154],"was":[155,172,281,336],"55":[156],"57%":[158],"(DI)":[159,174],"67%":[161],"(DII)":[162],"had":[163],"tophi":[164],"baseline,":[166],"time":[168],"since":[169],"diagnosis":[171],"12.9":[173],"11.0":[176],"years":[177],"(DII).":[178],"Both":[179],"doses":[181,273],"significantly":[182,217,247,282],"reduced":[183,248,356],"mean":[184,344],"levels":[186],"versus":[187,239,257,274,286,322],"placebo":[188,240,258,275,287],"over":[189,346],"6-months":[190],"(5.2-5.6":[191],"3.3-4.5":[196],"DII,":[199,213],"p":[200,230,235,254],"<":[201,236],"0.001":[202],"for":[203],"all),":[204],"marked":[206],"reductions":[207,342],"during":[208],"first-treatment":[210],"period.":[211],"In":[212,293],"tender":[214],"joints":[215,244],"declined":[216],"between":[218],"baseline":[219,315],"six-months":[221],"high-":[224],"low-dose":[226,285],"groups":[227],"(8.1":[228],"=":[231,255,289],"0.003;":[232],"9.2":[233],"0.001,":[237],"respectively)":[238],"(4.4":[241],"joints).":[242,260],"Swollen":[243],"also":[246],"high-dose":[250,332],"(5.7":[252],"0.013)":[256],"(3.4":[259],"There":[261],"significant":[263,296,341],"improvements":[264],"SF-36":[266,350],"physical":[267,351],"component":[268],"score":[269],"both":[271],"(p":[276,288],"\u2264":[277],"0.01),":[278],"while":[279],"HAQ-DI":[280,353],"improved":[283],"0.018)":[290],"DII.":[292,323],"non-statistically":[295],"trends":[297],"favouring":[298],"across":[300],"all":[301],"endpoints":[303],"observed.":[305],"This":[306],"may":[307],"reflect":[308],"smaller":[310],"sample":[311],"size":[312],"milder":[314],"symptom":[316],"burden":[317],"patients":[319],"Infusion":[324],"reactions":[325],"occurred":[326],"3.4%":[328],"combined":[331],"groups.":[333],"Conclusion":[334],"well":[337],"tolerated":[338],"provided":[340],"time,":[347],"improvement":[348],"measures":[354],"joints.":[361],"Disclosure":[362],"H.S.B.":[363],"Baraf:":[364],"Corporate":[365],"appointments;":[366],"Sobi,":[367],"Selecta":[368,395,427,432,438,443,449,454],"BioScience,":[369],"Gr\u00fcnenthal,":[370,469],"Fresenius":[371],"Kabi":[372],"Olatec.":[374],"Member":[375,401,486],"speakers\u2019":[377,403,488],"bureau;":[378,404,489],"Horizon":[379,383],"Pharmaceuticals.":[380,406],"Grants/research":[381],"support;":[382],"Pharmaceuticals,":[384],"Swedish":[385],"Orphan":[386],"Biovitrum.":[387],"P.":[388],"Khanna:":[389],"Consultancies;":[390,458],"Horizon,":[391,503],"Sobi.":[392,412,422],"Other;":[393,409,419,429,440,451],"Investigator:":[394],"Bioscience,":[396],"Dyve":[397],"Biosciences.":[398,428,433,439,450,455],"A.":[399,456],"Patel:":[400],"Lexicon":[405],"J.":[407,413],"Sobierska:":[408],"Employee":[410,420,430,441,452],"Christie:":[414],"Shareholder/stock":[415,425,436,447,478],"ownership;":[416,426,437,448,479],"GSK":[417],"Pharma.":[418],"W.":[423],"DeHaan:":[424],"R.":[434],"Azeem:":[435],"Biosciences;.":[444],"P.G.":[445],"Traber:":[446],"Kivitz:":[457],"AXDEV":[459],"Group,":[460],"Amgen,":[461,499],"Pfizer,":[462,480,496],"Janssen,":[463],"Boehringer":[464],"Ingelheim,":[465],"AbbVie,":[466,498],"Flexion,":[467,497],"Gilead,":[468,482],"Orion,":[470],"Regeneron,":[471,501],"Sun":[472],"Pharma":[473],"Advance":[474],"Research,":[475],"ECOR1.":[477],"GSK,":[481],"Novartis,":[483,495],"Amgen.":[485],"Merck":[490],"&":[491],"Co,":[492],"Eli":[493],"Lilly,":[494],"Genentech,":[500],"UCB,":[502],"GSK.":[505]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-25T00:00:00"}
