{"id":"https://openalex.org/W4395055165","doi":"https://doi.org/10.18596/jotcsa.1367877","title":"Competitive Inhibition and Synergistic Effects of Nutraceutical and Metabolite Molecules on Anti-Acetylcholinesterase Activity","display_name":"Competitive Inhibition and Synergistic Effects of Nutraceutical and Metabolite Molecules on Anti-Acetylcholinesterase Activity","publication_year":2024,"publication_date":"2024-04-23","ids":{"openalex":"https://openalex.org/W4395055165","doi":"https://doi.org/10.18596/jotcsa.1367877"},"language":"en","primary_location":{"id":"doi:10.18596/jotcsa.1367877","doi":"https://doi.org/10.18596/jotcsa.1367877","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.1367877","pdf_url":"https://dergipark.org.tr/en/download/article-file/3440218","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society Section A: Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/3440218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076044101","display_name":"M\u00fcnteha Girgin","orcid":"https://orcid.org/0000-0002-4916-7069","observed_orcids":["https://orcid.org/0000-0002-4916-7069"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Munteha Girgin","raw_affiliation_strings":["USKUDAR UNIVERSITY"],"raw_orcid":"https://orcid.org/0000-0002-4916-7069","affiliations":[{"raw_affiliation_string":"USKUDAR UNIVERSITY","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037405893","display_name":"Shirin Tarbiat","orcid":"https://orcid.org/0000-0001-7931-1546","observed_orcids":["https://orcid.org/0000-0001-7931-1546"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Shirin Tarbiat","raw_affiliation_strings":["USKUDAR UNIVERSITY"],"raw_orcid":"https://orcid.org/0000-0001-7931-1546","affiliations":[{"raw_affiliation_string":"USKUDAR UNIVERSITY","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026052157","display_name":"Sevim I\u015f\u0131k","orcid":"https://orcid.org/0000-0001-7687-6082","observed_orcids":["https://orcid.org/0000-0001-7687-6082"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevim I\u015f\u0131k","raw_affiliation_strings":["USKUDAR UNIVERSITY"],"raw_orcid":"https://orcid.org/0000-0001-7687-6082","affiliations":[{"raw_affiliation_string":"USKUDAR UNIVERSITY","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020239421","display_name":"Nigar Kantarci-Carsibasi","orcid":"https://orcid.org/0000-0003-1013-6668","observed_orcids":["https://orcid.org/0000-0003-1013-6668"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nigar Kantarc\u0131-cars\u0131bas\u0131","raw_affiliation_strings":["USKUDAR UNIVERSITY"],"raw_orcid":"https://orcid.org/0000-0003-1013-6668","affiliations":[{"raw_affiliation_string":"USKUDAR UNIVERSITY","institution_ids":["https://openalex.org/I1281256770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1281256770"],"apc_list":null,"apc_paid":null,"fwci":1.1426,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74365368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"11","issue":"2","first_page":"575","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.902999997138977},{"id":"https://openalex.org/keywords/queuine","display_name":"queuine","score":0.7649999856948853},{"id":"https://openalex.org/keywords/thiamine","display_name":"thiamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.9929999709129333},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.7910000085830688},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7467645406723022},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.7440975904464722},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7404237389564514},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7386177182197571},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.7158492207527161},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.6373136639595032},{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.6122315526008606},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5543637275695801},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.5479795336723328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5150744318962097},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4944465160369873},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3135823607444763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10281842947006226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10145029425621033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.059450119733810425},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18596/jotcsa.1367877","doi":"https://doi.org/10.18596/jotcsa.1367877","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.1367877","pdf_url":"https://dergipark.org.tr/en/download/article-file/3440218","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society Section A: Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1367877","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jotcsa/issue/82621/1367877","pdf_url":"https://dergipark.org.tr/tr/download/article-file/3440218","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Turkish Chemical Society Section A: Chemistry","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18596/jotcsa.1367877","doi":"https://doi.org/10.18596/jotcsa.1367877","is_oa":true,"landing_page_url":"https://doi.org/10.18596/jotcsa.1367877","pdf_url":"https://dergipark.org.tr/en/download/article-file/3440218","source":{"id":"https://openalex.org/S2739349281","display_name":"Journal of the Turkish Chemical Society Section A Chemistry","issn_l":"2149-0120","issn":["2149-0120"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318398","host_organization_name":"Turkish Chemical Society","host_organization_lineage":["https://openalex.org/P4310318398"],"host_organization_lineage_names":["Turkish Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish Chemical Society Section A: Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395055165.pdf","grobid_xml":"https://content.openalex.org/works/W4395055165.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1971048984","https://openalex.org/W1976042714","https://openalex.org/W2002327292","https://openalex.org/W2003633347","https://openalex.org/W2014976066","https://openalex.org/W2044144795","https://openalex.org/W2085907924","https://openalex.org/W2087538505","https://openalex.org/W2093761678","https://openalex.org/W2293608890","https://openalex.org/W2296053803","https://openalex.org/W2466168975","https://openalex.org/W2516095571","https://openalex.org/W2524988370","https://openalex.org/W2748334788","https://openalex.org/W2762897579","https://openalex.org/W2793396768","https://openalex.org/W2913809295","https://openalex.org/W2964000120","https://openalex.org/W2986325516","https://openalex.org/W3014513386","https://openalex.org/W3034522490","https://openalex.org/W3112948680","https://openalex.org/W3128108545","https://openalex.org/W3187719026","https://openalex.org/W3207914367","https://openalex.org/W4367173823","https://openalex.org/W4376129335","https://openalex.org/W4378907190","https://openalex.org/W4379523322"],"related_works":["https://openalex.org/W3128108545","https://openalex.org/W4405485601","https://openalex.org/W4390952972","https://openalex.org/W2986325516","https://openalex.org/W2032078683","https://openalex.org/W3093586974","https://openalex.org/W3197748178","https://openalex.org/W3086094538","https://openalex.org/W2039861748","https://openalex.org/W3092032238"],"abstract_inverted_index":{"The":[0,87,109],"rapidly":[1],"increasing":[2],"prevalence":[3],"of":[4,48,59,73,89,112,196,204,217,229],"Alzheimer's":[5],"disease":[6],"(AD)":[7],"poses":[8],"a":[9,35,222,238],"significant":[10,185],"global":[11],"public":[12],"health":[13],"threat.":[14],"While":[15],"medications":[16],"such":[17],"as":[18,148,221,237],"Donepezil,":[19,76,155],"Galantamine,":[20],"and":[21,29,63,69,78,96,152,158,171,181,213,219,232],"Rivastigmine":[22],"are":[23,41],"used,":[24],"their":[25],"serious":[26],"side":[27],"effects":[28,88],"limited":[30],"healing":[31],"fail":[32],"to":[33,44,54,134,179],"provide":[34],"definite":[36],"cure.":[37],"Consequently,":[38],"combination":[39,225],"therapies":[40],"being":[42,177],"explored":[43],"enhance":[45],"the":[46,56,90,118,123,127,145,173,193,201,205,214,227],"efficacy":[47],"existing":[49],"drugs.":[50],"This":[51,198],"study":[52,199],"aims":[53],"evaluate":[55],"anti-acetylcholinesterase":[57],"activities":[58,138],"previously":[60],"identified":[61],"nutraceutical":[62,206],"metabolite":[64],"compounds,":[65],"namely":[66],"Queuine,":[67,157],"Etoperidone,":[68,77,156],"Thiamine.":[70],"Combined":[71],"use":[72],"Queuine":[74,218,231],"with":[75,192],"Thiamine":[79],"on":[80,93,117,210],"acetylcholinesterase":[81,97,211],"enzyme":[82,174],"inhibition":[83,98,146,167,175,195,212],"is":[84],"also":[85],"evaluated.":[86],"drug":[91,113,130,162,224],"combinations":[92,114,131,163],"cell":[94,120],"viability":[95],"were":[99,132,139,164],"investigated":[100,116],"by":[101,141,242],"using":[102,122],"safe":[103],"doses":[104],"determined":[105],"for":[106,154,169,190],"each":[107],"drug.":[108],"cytotoxic":[110],"effect":[111,187,216],"was":[115,188],"SH-SY5Y":[119],"line":[121],"RTCA":[124],"method.":[125],"All":[126],"individual":[128],"or":[129],"non-toxic":[133],"neuronal":[135],"cells.":[136],"Anti-acetylcholinesterase":[137],"estimated":[140],"Ellman\u2019s":[142],"method":[143],"yielding":[144],"percentages":[147,176],"70%,":[149],"61%,":[150],"45%,":[151],"51%":[153],"Thiamine,":[159],"respectively.":[160,183],"When":[161],"analyzed,":[165],"competitive":[166],"resulted":[168],"Queuine+Donepezil":[170],"Queuine+Thiamine,":[172],"diminished":[178],"47%":[180],"21%,":[182],"A":[184],"synergistic":[186,215],"observed":[189],"Queuine+Etoperidone":[191],"highest":[194],"74%.":[197],"provides":[200],"first":[202],"evidence":[203],"molecule":[207],"Queuine's":[208],"impact":[209],"Etoperidone":[220,233],"potent":[223],"surpassing":[226],"effectiveness":[228],"Donepezil.":[230],"synergism":[234],"may":[235],"serve":[236],"potential":[239],"AD":[240],"treatment":[241],"further":[243],"in":[244],"vivo":[245],"validations.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-09-08T07:41:39.490200","created_date":"2024-04-24T00:00:00"}