{"id":"https://openalex.org/W4395041106","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19599","title":"Abstract 19599: Loss of Alpha-Catenins Increases Nuclear Yap and Cardiomyocyte Proliferation and Improves Cardiac Function Following Myocardial Infarction","display_name":"Abstract 19599: Loss of Alpha-Catenins Increases Nuclear Yap and Cardiomyocyte Proliferation and Improves Cardiac Function Following Myocardial Infarction","publication_year":2012,"publication_date":"2012-11-20","ids":{"openalex":"https://openalex.org/W4395041106","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19599"},"language":"en","primary_location":{"id":"doi:10.1161/circ.126.suppl_21.a19599","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19599","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19599","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069170925","display_name":"Jifen Li","orcid":"https://orcid.org/0000-0001-8626-7707","observed_orcids":["https://orcid.org/0000-0001-8626-7707"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jifen Li","raw_affiliation_strings":["Medicine, Thomas Jefferson Univ, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Thomas Jefferson Univ, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044556689","display_name":"Erhe Gao","orcid":"https://orcid.org/0000-0002-5151-7857","observed_orcids":["https://orcid.org/0000-0002-5151-7857"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erhe Gao","raw_affiliation_strings":["Pharmacology, Temple Univ Sch of Medicine, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Temple Univ Sch of Medicine, Philadelphia, PA,","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644426","display_name":"Steven Goossens","orcid":"https://orcid.org/0000-0002-5693-8570","observed_orcids":["https://orcid.org/0000-0002-5693-8570"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Steven Goossens","raw_affiliation_strings":["Flanders Institute for Biotechnology, Ghent Univ, Belgium, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flanders Institute for Biotechnology, Ghent Univ, Belgium, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024953212","display_name":"Frans M. Van Roy","orcid":"https://orcid.org/0000-0003-4358-1039","observed_orcids":["https://orcid.org/0000-0003-4358-1039"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frans van Roy","raw_affiliation_strings":["Flanders Institute for Biotechnology, Ghent Univ, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flanders Institute for Biotechnology, Ghent Univ, Ghent, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008805727","display_name":"Glenn L. Radice","orcid":"https://orcid.org/0000-0002-2944-1059","observed_orcids":["https://orcid.org/0000-0002-2944-1059"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Radice","raw_affiliation_strings":["Medicine, Thomas Jefferson Univ, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Thomas Jefferson Univ, Philadelphia, PA,","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"suppl_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-catenin","display_name":"alpha-catenin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/alphae-catenin","display_name":"alphaE-catenin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.42399999499320984},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.905579149723053},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6539416313171387},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6140315532684326},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.6082862019538879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5995481014251709},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5583681464195251},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4816493093967438},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.31446629762649536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31361353397369385},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.18420889973640442},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17336347699165344},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14936131238937378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.126.suppl_21.a19599","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19599","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19599","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2099793239","https://openalex.org/W2610384926","https://openalex.org/W4413029422","https://openalex.org/W2788256001","https://openalex.org/W3035236807","https://openalex.org/W2101166356","https://openalex.org/W2058112316","https://openalex.org/W7160444319","https://openalex.org/W4395039983","https://openalex.org/W2808764469"],"abstract_inverted_index":{"Background:":[0],"Shortly":[1],"after":[2],"birth,":[3],"muscle":[4],"cells":[5,23,197],"of":[6,66,110,116,126,166,181,196,230],"the":[7,25,32,48,56,64,69,99,103,114,141,149,159,169,210,215],"mammalian":[8],"heart":[9,57,70,171,218],"lose":[10],"their":[11],"ability":[12],"to":[13,19,88,112,209,251],"divide.":[14],"Thus,":[15],"they":[16],"are":[17,227],"unable":[18],"effectively":[20],"replace":[21],"dying":[22],"in":[24,55,68,98,102,131,137,140,158,168,175,198,207,214],"injured":[26],"heart.":[27],"The":[28],"recent":[29],"discovery":[30],"that":[31,51,201,225,243],"transcriptional":[33,233],"co-activator":[34,234],"Yap":[35,53,147,191],"is":[36],"necessary":[37],"and":[38,74,93,106,120,134,148],"sufficient":[39],"for":[40,236],"cardiomyocyte":[41,132,138,156,202,237],"proliferation":[42,157,203],"has":[43],"gained":[44],"considerable":[45],"attention.":[46],"However,":[47,179],"upstream":[49],"regulators":[50,229],"control":[52],"activity":[54],"remain":[58],"largely":[59],"unknown.":[60],"Objective:":[61],"To":[62],"investigate":[63],"role":[65,115],"\u03b1-catenins":[67,117,127,167,182,226,245],"using":[71],"cardiac-specific":[72,85],"\u03b1E-":[73],"\u03b1T-catenin":[75,94],"double":[76],"knockout":[77],"(\u03b1-cat":[78],"DKO)":[79],"mice.":[80,144],"Methods:":[81],"We":[82],"used":[83],"two":[84],"Cre":[86],"transgenes":[87],"delete":[89],"both":[90],"\u03b1E-catenin":[91],"(Ctnna1)":[92],"(Ctnna3)":[95],"genes":[96],"either":[97],"perinatal":[100],"or":[101],"adult":[104,170],"heart,":[105],"performed":[107],"a":[108,129,176,232,248],"series":[109],"experiments":[111],"examine":[113],"under":[118],"normal":[119],"pathological":[121],"conditions.":[122],"Results:":[123],"Postnatal":[124],"depletion":[125],"caused":[128],"decrease":[130],"size":[133],"an":[135],"increase":[136],"number":[139,195],"\u03b1-cat":[142,160,216],"DKO":[143,161,217],"Increased":[145,189],"nuclear":[146,190],"cell":[150],"cycle":[151],"regulator":[152],"cyclin":[153],"D1":[154],"accompanied":[155],"hearts.":[162],"In":[163],"comparison,":[164],"ablation":[165],"did":[172],"not":[173],"result":[174],"proliferative":[177],"phenotype.":[178],"inactivation":[180],"improved":[183,211],"cardiac":[184],"function":[185,213],"following":[186,219,255],"myocardial":[187,253],"infarction.":[188],"along":[192],"with":[193],"increased":[194],"cytokinesis":[199],"indicated":[200],"contributed,":[204],"at":[205],"least":[206],"part,":[208],"contractile":[212],"injury.":[220,256],"Conclusions:":[221],"These":[222],"studies":[223],"demonstrate":[224],"critical":[228],"Yap,":[231],"essential":[235],"proliferation.":[238],"Furthermore,":[239],"we":[240],"provide":[241],"proof-of-concept":[242],"inhibiting":[244],"might":[246],"be":[247],"useful":[249],"strategy":[250],"promote":[252],"regeneration":[254]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-04-24T00:00:00"}