{"id":"https://openalex.org/W4395040965","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19347","title":"Abstract 19347: The Mouse Mast Cell Protease 4 is Involved in the Generation of Endothelin-1 in vitro and in vivo","display_name":"Abstract 19347: The Mouse Mast Cell Protease 4 is Involved in the Generation of Endothelin-1 in vitro and in vivo","publication_year":2012,"publication_date":"2012-11-20","ids":{"openalex":"https://openalex.org/W4395040965","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19347"},"language":"en","primary_location":{"id":"doi:10.1161/circ.126.suppl_21.a19347","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19347","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19347","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042038598","display_name":"Martin Houde","orcid":"https://orcid.org/0000-0001-8630-204X","observed_orcids":["https://orcid.org/0000-0001-8630-204X"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin Houde","raw_affiliation_strings":["Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","Martin Houde"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","institution_ids":["https://openalex.org/I135117807"]},{"raw_affiliation_string":"Martin Houde","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113510097","display_name":"Julie Labont\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Labonte\u0301","raw_affiliation_strings":["Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064709574","display_name":"Louisane Desbiens","orcid":"https://orcid.org/0000-0001-7861-9813","observed_orcids":["https://orcid.org/0000-0001-7861-9813"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Louisane Desbiens","raw_affiliation_strings":["Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","Louisane Desbiens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","institution_ids":["https://openalex.org/I135117807"]},{"raw_affiliation_string":"Louisane Desbiens","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091830781","display_name":"Marc-David Jamain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marc Jamain","raw_affiliation_strings":["Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","Marc Jamain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","institution_ids":["https://openalex.org/I135117807"]},{"raw_affiliation_string":"Marc Jamain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078126056","display_name":"Gunnar Pejler","orcid":"https://orcid.org/0000-0002-6779-391X","observed_orcids":["https://orcid.org/0000-0002-6779-391X"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnar Pejler","raw_affiliation_strings":["Anatomy, Physiology and Biochemistry, Swedish Univ of Agricultural Sciences, Uppsala, Sweden","Gunnar Pejler"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy, Physiology and Biochemistry, Swedish Univ of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]},{"raw_affiliation_string":"Gunnar Pejler","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084159015","display_name":"Michael F. Gurish","orcid":"https://orcid.org/0000-0002-7893-3156","observed_orcids":["https://orcid.org/0000-0002-7893-3156"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gurish","raw_affiliation_strings":["Rheumatology, Brigham and Women's Hosp, Boston, MA,","Michael Gurish"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Brigham and Women's Hosp, Boston, MA,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Michael Gurish","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038223019","display_name":"Shinji Takai","orcid":"https://orcid.org/0000-0003-3963-3983","observed_orcids":["https://orcid.org/0000-0003-3963-3983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinji Takai","raw_affiliation_strings":["Pharmacology, Osaka Med College, Osaka, Japan","Shinji Takai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, Osaka Med College, Osaka, Japan","institution_ids":[]},{"raw_affiliation_string":"Shinji Takai","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012952538","display_name":"Pedro D\u2019Orl\u00e9ans-Juste","orcid":"https://orcid.org/0000-0002-9863-3548","observed_orcids":["https://orcid.org/0000-0002-9863-3548"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pedro D'Orle\u0301ans-Juste","raw_affiliation_strings":["Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacologie, Universite\u0301 de Sherbrooke, Sherbrooke, Canada","institution_ids":["https://openalex.org/I135117807"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"suppl_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/big-endothelin-1","display_name":"big endothelin-1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chymase","display_name":"chymase","score":0.925000011920929},{"id":"https://openalex.org/keywords/endothelin-converting-enzyme","display_name":"endothelin-converting enzyme","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chymase-inhibitors","display_name":"chymase inhibitors","score":0.6830000281333923},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.722000002861023},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.578000009059906},{"id":"https://openalex.org/keywords/mast-cell-proteases","display_name":"mast cell proteases","score":0.5419999957084656},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.49900001287460327},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.844146728515625},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7945048809051514},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6736694574356079},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6615779399871826},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.634279191493988},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.49880099296569824},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.48177477717399597},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.381704717874527},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.363725483417511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3526947796344757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16322073340415955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15907040238380432},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1365969181060791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11269485950469971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06538423895835876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0584450364112854}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.126.suppl_21.a19347","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19347","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19347","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138823068","https://openalex.org/W1980546938","https://openalex.org/W2318592947","https://openalex.org/W2047523012","https://openalex.org/W3095368762","https://openalex.org/W2147046486","https://openalex.org/W2790229554","https://openalex.org/W7201923971","https://openalex.org/W7201926055","https://openalex.org/W2034320303"],"abstract_inverted_index":{"The":[0,17,115,233],"serine":[1],"protease":[2,21],"chymase":[3,49,144,290],"converts":[4],"intravenously":[5],"(iv)-":[6],"administered":[7],"big-endothelin-1":[8],"to":[9,45,121,137,152,240,254,277],"endothelin-1":[10],"(ET-1)":[11],"in":[12,15,33,53,71,77,80,85,118,132,154,163,170,184,191,220,230,234,249,268,292,298],"the":[13,34,54,62,65,72,86,149,183,287,293,299],"mouse":[14,18,300],"vivo.":[16],"mast":[19],"cell":[20],"4":[22],"(mMCP-4)":[23],"is":[24,31,51,226,286],"among":[25],"eight":[26],"chymase-like":[27],"murine":[28],"isoforms":[29],"and":[30,79,103,111,176,222,244],"involved":[32,52,289],"generation":[35],"of":[36,59,67,74,89,237,261,295],"angiotensin-II":[37],"(Ang-II)":[38],"from":[39,97,107,195,207,218,271,279],"its":[40],"precursor":[41],"Ang-I.":[42],"It":[43],"remains":[44],"be":[46],"determined":[47,70],"which":[48],"isoform":[50,291],"endothelin-converting":[55],"enzyme":[56],"-independent":[57],"production":[58,88,294],"ET-1.":[60,91],"In":[61,92],"present":[63],"study,":[64],"contribution":[66],"mMCP-4":[68,112,133,158,177,199,211,250,272,285],"was":[69,129,246],"conversion":[73,225,236],"exogenous":[75],"Big-ET-1":[76,153,219,239],"vitro":[78,93,185],"vivo":[81,235],"as":[82,84],"well":[83],"tissue":[87,259],"endogenous":[90,296],"analyses":[94],"were":[95,264],"performed":[96],"cardiac":[98],"left":[99],"ventricle,":[100],"aorta,":[101],"kidneys":[102],"lungs":[104],"homogenates":[105,270],"derived":[106,194],"wild":[108],"type":[109],"(WT)":[110],"KO":[113,134,159,178,200,212,251,273],"mice.":[114,160,179],"pressor":[116,150],"response":[117,151],"anaesthetized":[119],"mice":[120,135,166,213,252,274],"Big-ET-1,":[122],"but":[123,156,197,209],"not":[124,157,198,210],"ET-1":[125,128,216,242,245,263,297],"(1-31)":[126,217,243],"or":[127],"significantly":[130,147],"reduced":[131,148,248,265],"compared":[136,253,276],"their":[138,255],"WT":[139,155,175,196,208,231,256,280],"congeners.":[140,257,281],"Furthermore,":[141],"a":[142,187],"selective":[143],"inhibitor,":[145],"TY-51469,":[146],"Radio-telemetry":[161],"analysis":[162,203],"free-moving,":[164],"conscious":[165],"revealed":[167,204],"no":[168],"differences":[169],"basal":[171],"blood":[172],"pressure":[173],"between":[174],"TY-51469":[180,229],"also":[181,247],"inhibited":[182],"hydrolysis":[186],"chymotrypsin-sensitive":[188],"fluorogenic":[189],"peptide":[190],"soluble":[192],"fractions":[193],"tissues.":[201],"HPLC-MALDI-MS":[202],"that":[205,223,284],"supernatants":[206],"could":[214],"yield":[215],"vitro,":[221],"this":[224],"blocked":[227],"by":[228,266],"samples.":[232],"iv-administered":[238],"plasmatic":[241],"Finally,":[258],"levels":[260],"immunoreactive":[262],"40%":[267],"lung":[269],"when":[275],"those":[278],"We":[282],"conclude":[283],"predominantly":[288],"model.":[301]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-24T00:00:00"}
