{"id":"https://openalex.org/W4395037243","doi":"https://doi.org/10.1161/circ.138.suppl_1.16720","title":"Abstract 16720: Exercise-Stimulated Catecholamine Release Enhances Resolution of Acute Inflammation","display_name":"Abstract 16720: Exercise-Stimulated Catecholamine Release Enhances Resolution of Acute Inflammation","publication_year":2018,"publication_date":"2018-11-06","ids":{"openalex":"https://openalex.org/W4395037243","doi":"https://doi.org/10.1161/circ.138.suppl_1.16720"},"language":"en","primary_location":{"id":"doi:10.1161/circ.138.suppl_1.16720","doi":"https://doi.org/10.1161/circ.138.suppl_1.16720","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.138.suppl_1.16720","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078351346","display_name":"Jing\u2010Juan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing-Juan Zheng","raw_affiliation_strings":["Cardiovascular Medicine, Univ of Louisville, Louisville, KY","Jing-Juan Zheng Cardiovascular Medicine, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Jing-Juan Zheng Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018626502","display_name":"Ernesto Pena Calderin","orcid":"https://orcid.org/0000-0002-4403-9543","observed_orcids":["https://orcid.org/0000-0002-4403-9543"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto Pena Calderin","raw_affiliation_strings":["Cardiovascular Medicine, Univ of Louisville, Louisville, KY","Ernesto Pena Calderin Cardiovascular Medicine, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Ernesto Pena Calderin Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061922767","display_name":"Bradford G. Hill","orcid":"https://orcid.org/0000-0001-5332-8286","observed_orcids":["https://orcid.org/0000-0001-5332-8286"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford G Hill","raw_affiliation_strings":["Cardiovascular Medicine, Univ of Louisville, Louisville, KY","Bradford G Hill Cardiovascular Medicine, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Bradford G Hill Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012248310","display_name":"Aruni Bhatnagar","orcid":"https://orcid.org/0000-0001-6818-0384","observed_orcids":["https://orcid.org/0000-0001-6818-0384"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aruni Bhatnagar","raw_affiliation_strings":["Cardiovascular Medicine, Univ of Louisville, Louisville, KY","Aruni Bhatnagar Cardiovascular Medicine, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Aruni Bhatnagar Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072415149","display_name":"Jason L. Hellmann","orcid":"https://orcid.org/0000-0001-9573-6843","observed_orcids":["https://orcid.org/0000-0001-9573-6843"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Hellmann","raw_affiliation_strings":["Cardiovascular Medicine, Univ of Louisville, Louisville, KY","Jason Hellmann Cardiovascular Medicine, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Jason Hellmann Cardiovascular Medicine, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/catecholamine-release","display_name":"catecholamine release","score":0.824999988079071},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/resolvin-d1","display_name":"resolvin D1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.7929999828338623},{"id":"https://openalex.org/keywords/alox5","display_name":"ALOX5","score":0.9509999752044678},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neutrophil-clearance","display_name":"neutrophil clearance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.7059999704360962},{"id":"https://openalex.org/keywords/treadmill-exercise","display_name":"treadmill exercise","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9603627920150757},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.7988682985305786},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7039381861686707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3451569974422455},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32581210136413574}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.138.suppl_1.16720","doi":"https://doi.org/10.1161/circ.138.suppl_1.16720","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.138.suppl_1.16720","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2982041856","https://openalex.org/W2163213605","https://openalex.org/W3216801096","https://openalex.org/W2166102027","https://openalex.org/W4380794708","https://openalex.org/W7095370813","https://openalex.org/W2566213202","https://openalex.org/W4253944547","https://openalex.org/W3010755944","https://openalex.org/W7057916585"],"abstract_inverted_index":{"The":[0],"mechanisms":[1],"by":[2,28,34,154],"which":[3,128,151],"regular":[4],"exercise":[5,21,52,123,231],"prevents":[6],"the":[7,157,227,236],"development":[8],"and":[9,33,70,112,148,193,232],"progression":[10],"of":[11,25,89,212,230,238],"chronic":[12],"inflammatory":[13],"diseases":[14],"are":[15],"largely":[16],"unknown.":[17],"We":[18],"find":[19],"that":[20,206],"(Exe)":[22],"enhances":[23,210],"resolution":[24,211,243],"acute":[26,213],"inflammation":[27,214],"promoting":[29],"macrophage":[30],"(M\u0424)":[31],"phagocytosis":[32,185],"augmenting":[35],"resolvin":[36],"D1":[37],"(RvD1)":[38],"levels.":[39],"When":[40],"compared":[41],"with":[42,156],"sedentary":[43],"controls":[44],"(Sed),":[45],"mice":[46,85],"adapted":[47],"to":[48,235,241],"a":[49],"4-week":[50],"treadmill":[51],"regimen":[53],"displayed":[54,143],"1.48-fold":[55],"higher":[56,144],"M\u0424":[57,184],"phagocytotic":[58],"activity,":[59],"enhanced":[60],"RvD1":[61,113,149,194],"levels":[62,114],"(Sed":[63],"28.08\u00b11.5":[64],"vs":[65,95,106,118,177,188,198],"Exe":[66,96,107],"48.01\u00b18.6":[67],"pg/mL,":[68,120,201],"n=6),":[69],"earlier":[71],"neutrophilic":[72,171],"clearance":[73,172],"(\u0394R":[74],"i":[75],"~7":[76],"h)":[77],"during":[78],"peritonitis.":[79],"Peritonitis":[80],"cell":[81],"extracts":[82],"from":[83],"exercise-adapted":[84],"showed":[86],"elevated":[87],"expression":[88,147],"Alox15":[90],"(48":[91,102,115,173],"h:":[92,103,116,174],"Sed":[93,104],"0.97\u00b10.15":[94],"1.5\u00b10.16":[97],"relative":[98,109],"expression,":[99,110],"n=8-9),":[100],"Alox5":[101],"0.77\u00b10.15":[105],"1.7\u00b10.27":[108],"n=4-5),":[111],"29.0\u00b12.1":[117],"52.6\u00b18.9":[119],"n=5).":[121],"Because":[122],"stimulates":[124],"epinephrine":[125],"(Epi)":[126],"release,":[127],"has":[129],"immunomodulatory":[130],"effects,":[131],"we":[132],"questioned":[133],"if":[134],"Epi":[135,208],"exerts":[136],"pro-resolving":[137,228],"actions":[138],"on":[139],"macrophages.":[140],"Epi-treated":[141],"macrophages":[142],"15-lipoxygenase":[145],"1":[146],"levels,":[150],"were":[152],"prevented":[153],"incubation":[155],"\u03b11":[158],"adrenergic":[159],"receptor":[160],"(AR-\u03b11)":[161],"blocker,":[162],"Prazosin":[163],"(Praz).":[164],"During":[165],"zymosan-induced":[166],"peritonitis,":[167],"Praz":[168],"abrogated":[169],"exercise-enhanced":[170],"Exe+Veh":[175],"2.07\u00b10.41":[176],"Exe+Praz":[178,189,199],"5.2\u00b11.04":[179],"x10":[180],"6":[181],"PMN,":[182],"n=5),":[183],"(Exe+Veh":[186,196],"33463.0\u00b12174.0":[187],"8303.0\u00b12748.0":[190],"MFI,":[191],"n=5-7),":[192],"biosynthesis":[195],"211.0\u00b155.4":[197],"81.79\u00b111.8":[200],"n=6).":[202],"These":[203,220],"results":[204],"suggest":[205],"exercise-stimulated":[207],"release":[209],"in":[215],"an":[216],"AR-\u03b11":[217],"dependent":[218],"manner.":[219],"findings":[221],"provide":[222],"new":[223],"mechanistic":[224],"insights":[225],"into":[226],"effects":[229],"may":[233],"lead":[234],"identification":[237],"novel":[239],"pathways":[240],"stimulate":[242],"biology.":[244]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2024-04-24T00:00:00"}
