{"id":"https://openalex.org/W4395037029","doi":"https://doi.org/10.1161/circ.138.suppl_1.16914","title":"Abstract 16914: Structural and Functional Investigation of Myocardial Fiber Architecture in Genetic Mouse Models of Heterodoxy and Situs Inverses Totalis","display_name":"Abstract 16914: Structural and Functional Investigation of Myocardial Fiber Architecture in Genetic Mouse Models of Heterodoxy and Situs Inverses Totalis","publication_year":2018,"publication_date":"2018-11-06","ids":{"openalex":"https://openalex.org/W4395037029","doi":"https://doi.org/10.1161/circ.138.suppl_1.16914"},"language":"en","primary_location":{"id":"doi:10.1161/circ.138.suppl_1.16914","doi":"https://doi.org/10.1161/circ.138.suppl_1.16914","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.138.suppl_1.16914","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022501599","display_name":"Yijen Lin Wu","orcid":"https://orcid.org/0000-0001-9509-5417","observed_orcids":["https://orcid.org/0000-0001-9509-5417"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijen L Wu","raw_affiliation_strings":["DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","Yijen L Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Yijen L Wu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705102","display_name":"Xiaoqin Liu","orcid":"https://orcid.org/0000-0002-3615-3274","observed_orcids":["https://orcid.org/0000-0002-3615-3274"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqin Liu","raw_affiliation_strings":["DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","Xiaoqin Liu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Xiaoqin Liu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100740483","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0001-7210-5942","observed_orcids":["https://orcid.org/0000-0001-7210-5942"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","Yu Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Yu Chen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034119004","display_name":"Nathan Salamacha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Salamacha","raw_affiliation_strings":["DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","Nathan Salamacha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Nathan Salamacha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095843607","display_name":"Joyce Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Han","raw_affiliation_strings":["Geisel school of Medicine, Dartmouth College, Hanover, NH","Joyce Han"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisel school of Medicine, Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Joyce Han","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732002","display_name":"Daniel B. Ennis","orcid":"https://orcid.org/0000-0001-7435-1311","observed_orcids":["https://orcid.org/0000-0001-7435-1311","https://orcid.org/0000-0001-9051-3843"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel B Ennis","raw_affiliation_strings":["Deparment of Radiological Sciences, Univ of California Los Angeles, Los Angeles, CA","Daniel B Ennis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Radiological Sciences, Univ of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Daniel B Ennis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010131447","display_name":"Sameh S. Tadros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameh Tadros","raw_affiliation_strings":["DEPT OF Pedeatric Radiology, Children\u2019s Hosp of Pittsburgh, Pittsburgh, PA","Sameh Tadros"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF Pedeatric Radiology, Children\u2019s Hosp of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]},{"raw_affiliation_string":"Sameh Tadros","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022595874","display_name":"Cecilia W. Y. Lo","orcid":"https://orcid.org/0000-0003-4314-3434","observed_orcids":["https://orcid.org/0000-0003-4314-3434"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Lo","raw_affiliation_strings":["DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","Cecilia Lo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPT OF DEVELOPMENTAL BIOLOGY, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Cecilia Lo","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.26930001378059387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterotaxy","display_name":"heterotaxy syndrome","score":0.859000027179718},{"id":"https://openalex.org/keywords/situs-inversus-totalis","display_name":"situs inversus totalis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/situs-solitus","display_name":"situs solitus","score":0.9269999861717224},{"id":"https://openalex.org/keywords/myocardial-fiber-architecture","display_name":"myocardial fiber architecture","score":0.8820000290870667},{"id":"https://openalex.org/keywords/left-right-asymmetry","display_name":"left-right asymmetry","score":0.8460000157356262},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.42500001192092896},{"id":"https://openalex.org/keywords/myocardial-torsion","display_name":"myocardial torsion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/myocardial-rotation","display_name":"myocardial rotation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dobutamine-stress","display_name":"dobutamine stress","score":0.7360000014305115},{"id":"https://openalex.org/keywords/helix-angle","display_name":"helix angle","score":0.6579999923706055},{"id":"https://openalex.org/keywords/left-right-patterning","display_name":"left-right patterning","score":0.5509999990463257},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2779473644","wikidata":"https://www.wikidata.org/wiki/Q1992247","display_name":"Heterodoxy","level":3,"score":0.8747487664222717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.855763852596283},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C2778802261","wikidata":"https://www.wikidata.org/wiki/Q383258","display_name":"Orthodoxy","level":2,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.138.suppl_1.16914","doi":"https://doi.org/10.1161/circ.138.suppl_1.16914","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.138.suppl_1.16914","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063546639","https://openalex.org/W2762075678","https://openalex.org/W2145930728","https://openalex.org/W2964980818","https://openalex.org/W3087705910","https://openalex.org/W2150337102","https://openalex.org/W2107334229","https://openalex.org/W7042716436","https://openalex.org/W2889114078","https://openalex.org/W2115666493"],"abstract_inverted_index":{"Introduction:":[0],"Heterotaxy":[1],"(HTX)":[2],"patients":[3,37,279],"with":[4,38,47,73,108,169,280],"congenital":[5],"heart":[6,130],"disease":[7],"have":[8,249],"higher":[9],"risk":[10],"of":[11,23,114],"post-surgical":[12],"complications":[13],"and":[14,17,96,127,150,154,161,187,201,208,228,246,259],"increased":[15],"morbidity":[16],"mortality.":[18],"Given":[19],"HTX":[20,51,63,278],"involves":[21],"disruption":[22],"left-right":[24],"patterning,":[25],"this":[26],"suggests":[27],"laterality":[28,48,115],"disturbance":[29],"may":[30,270],"drive":[31],"the":[32,94,129,144,185,243,273],"poor":[33,274],"outcome":[34,276],"in":[35,93,112,117,148,180,184,235,255,277],"CHD":[36],"HTX.":[39,109],"To":[40],"investigate":[41],"this,":[42],"we":[43],"used":[44,141,164],"mouse":[45],"models":[46],"defects.":[49],"Although":[50],"mutant":[52,98,152,189,237,244],"mice":[53,68,99],"invariably":[54],"die":[55],"prenatally/neonatlly":[56],"from":[57],"complex":[58],"CHD,":[59],"many":[60],"mutations":[61],"causing":[62],"also":[64,204],"giive":[65],"rise":[66],"to":[67,88,100,133,142,165,272],"that":[69,122],"are":[70],"adult":[71],"viable":[72],"situs":[74,79],"inversus":[75],"totalis":[76],"(SIT),":[77],"or":[78,170],"solitus":[80],"(SS)":[81],"without":[82,171],"CHD.":[83,281],"Hence,":[84],"our":[85,240],"goal":[86],"is":[87],"delineate":[89,143],"myocardial":[90,119,145,212,223,251,268],"fiber":[91,120,146,213,224,252],"architecture":[92,121,253,269],"SIT":[95,149,186,200,236,247],"SS":[97,151,188,202,245],"gain":[101],"insights":[102],"into":[103],"possible":[104],"functional":[105],"deficits":[106],"associated":[107],"Hypothesis:":[110],"Disturbance":[111],"specification":[113],"results":[116],"abnormal":[118,256,267],"can":[123],"cause":[124],"cardiac":[125,167],"dysfunction":[126],"make":[128],"more":[131,229],"vulnerable":[132],"stress.":[134,173,199],"Methods:":[135],"Diffusion":[136],"tensor":[137],"imaging":[138],"(DTI)":[139],"was":[140],"organization":[147,225],"mice,":[153],"wild-type":[155],"(WT)":[156],"control":[157],"mice.":[158],"Cardiac":[159],"MRI":[160],"echocardiography":[162],"were":[163],"evaluate":[166],"function":[168,183],"dobutamine":[172,198],"Results:":[174],"Echocardiography":[175],"showed":[176,220,242],"no":[177],"significant":[178],"differences":[179],"global":[181],"systolic":[182],"hearts,":[190],"but":[191],"they":[192],"displayed":[193],"compromised":[194],"strain":[195,260],"rates":[196],"under":[197],"hearts":[203,248],"exhibited":[205],"reduced":[206],"rotation":[207],"torsion,":[209,257],"suggesting":[210],"altered":[211],"organization.":[214],"Myocardial":[215],"tractography":[216],"by":[217],"DTI":[218],"(Fig.A-D)":[219],"less":[221],"coherent":[222],"(Fig.":[226,233],"G-I)":[227],"diverse":[230],"helix":[231],"angles":[232],"K&M)":[234],"hearts.":[238],"Overall,":[239],"data":[241],"disrupted":[250],"resulting":[254],"rotation,":[258],"when":[261],"stressed.":[262],"Conclusions:":[263],"These":[264],"findings":[265],"suggest":[266],"contribute":[271],"clinical":[275]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-04-24T00:00:00"}
