{"id":"https://openalex.org/W4395036747","doi":"https://doi.org/10.1161/circ.144.suppl_1.13070","title":"Abstract 13070: The Probiotic Bifidobacterium breve , Bif195, Supports the Defense Against Aspirin-Induced Gastrointestinal Mucosal Damage","display_name":"Abstract 13070: The Probiotic Bifidobacterium breve , Bif195, Supports the Defense Against Aspirin-Induced Gastrointestinal Mucosal Damage","publication_year":2021,"publication_date":"2021-11-16","ids":{"openalex":"https://openalex.org/W4395036747","doi":"https://doi.org/10.1161/circ.144.suppl_1.13070","mag":"3212670242"},"language":"en","primary_location":{"id":"doi:10.1161/circ.144.suppl_1.13070","doi":"https://doi.org/10.1161/circ.144.suppl_1.13070","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.144.suppl_1.13070","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061607952","display_name":"Anders B. Damholt","orcid":"https://orcid.org/0009-0007-1657-1659","observed_orcids":["https://orcid.org/0009-0007-1657-1659"]},"institutions":[{"id":"https://openalex.org/I38119467","display_name":"Chr. Hansen (Denmark)","ror":"https://ror.org/01mv6bt66","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I38119467","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"ANDERS B DAMHOLT","raw_affiliation_strings":["Chr. Hansen, n\u00e6rum, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chr. Hansen, n\u00e6rum, Denmark","institution_ids":["https://openalex.org/I38119467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005329210","display_name":"Nina L\u00f8n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nina Loen","raw_affiliation_strings":["Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","Nina Loen Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802582725"]},{"raw_affiliation_string":"Nina Loen Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020279582","display_name":"Sara Engel","orcid":"https://orcid.org/0000-0001-7026-2741","observed_orcids":["https://orcid.org/0000-0001-7026-2741"]},"institutions":[{"id":"https://openalex.org/I38119467","display_name":"Chr. Hansen (Denmark)","ror":"https://ror.org/01mv6bt66","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I38119467","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sara Engel","raw_affiliation_strings":["Chr. Hansen, DK-2970 H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chr. Hansen, DK-2970 H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I38119467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083678714","display_name":"Anne Birgitte Haaber","orcid":"https://orcid.org/0000-0001-5980-3367","observed_orcids":["https://orcid.org/0000-0001-5980-3367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Haaber","raw_affiliation_strings":["Mave Specialisten, DK-2950 Tr\u00f8r\u00f8d, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mave Specialisten, DK-2950 Tr\u00f8r\u00f8d, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002696775","display_name":"Anja Wellejus","orcid":"https://orcid.org/0000-0003-4350-6063","observed_orcids":["https://orcid.org/0000-0003-4350-6063"]},"institutions":[{"id":"https://openalex.org/I38119467","display_name":"Chr. Hansen (Denmark)","ror":"https://ror.org/01mv6bt66","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I38119467","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anja Wellejus","raw_affiliation_strings":["Chr. Hansen, Hoersholm, Denmark","Anja Wellejus Chr. Hansen, Hoersholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chr. Hansen, Hoersholm, Denmark","institution_ids":["https://openalex.org/I38119467"]},{"raw_affiliation_string":"Anja Wellejus Chr. Hansen, Hoersholm, Denmark","institution_ids":["https://openalex.org/I38119467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079352451","display_name":"Filip Krag Knop","orcid":"https://orcid.org/0000-0002-2495-5034","observed_orcids":["https://orcid.org/0000-0002-2495-5034"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Filip K Knop","raw_affiliation_strings":["Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","Filip K Knop Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802582725"]},{"raw_affiliation_string":"Filip K Knop Cntr for Clinical Metabolic Rsch, Gentofte Hosp, Univ of Copenhagen, DK-2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802582725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gastrointestinal-mucosal-injury","display_name":"gastrointestinal mucosal injury","score":0.902999997138977},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.7200000286102295},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gastroduodenoscopy","display_name":"gastroduodenoscopy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/duodenum","display_name":"duodenum","score":0.5929999947547913},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.6230000257492065},{"id":"https://openalex.org/keywords/ulcer-prevention","display_name":"ulcer prevention","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8955875635147095},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.8791210651397705},{"id":"https://openalex.org/C2779707754","wikidata":"https://www.wikidata.org/wiki/Q2902069","display_name":"Bifidobacterium breve","level":5,"score":0.8340821266174316},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.6206748485565186},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6050934791564941},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4225507080554962},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3672131299972534},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1863926351070404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16140711307525635},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14497900009155273},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.08292049169540405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05310326814651489},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1161/circ.144.suppl_1.13070","doi":"https://doi.org/10.1161/circ.144.suppl_1.13070","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.144.suppl_1.13070","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"mag:3212670242","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.13070","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389228660","https://openalex.org/W4233303064","https://openalex.org/W2137828970","https://openalex.org/W2608254964","https://openalex.org/W4390704555","https://openalex.org/W4395030218","https://openalex.org/W1966782015","https://openalex.org/W2946180204","https://openalex.org/W2118793695","https://openalex.org/W2164137037"],"abstract_inverted_index":{"Introduction:":[0],"Low-dose":[1],"aspirin":[2,19,115,267],"(50-325":[3],"mg":[4,114],"daily)":[5],"is":[6,20,231],"widely":[7],"recommended":[8],"for":[9,86],"the":[10,41,44,56,75,160,171,217,224,257],"prevention":[11],"of":[12,18,26,43,112,125,129,162,236,271],"cardiovascular":[13],"disease.":[14],"However,":[15,64],"daily":[16,109,126],"use":[17],"associated":[21],"with":[22,211],"an":[23],"increased":[24],"risk":[25,270],"gastrointestinal":[27],"mucosal":[28,184],"damage":[29,54,73,195,230,276],"including":[30],"gastric":[31,76,228],"and":[32,83,102,120,140,158,188,277],"duodenal":[33],"ulcers.":[34],"We":[35],"have":[36],"recently":[37],"published":[38],"data":[39],"on":[40],"ability":[42],"probiotic":[45],"Bifidobacterium":[46,130],"breve":[47,131],",":[48,132],"Bif195,":[49],"to":[50,106,122,153,214,247,265],"reduce":[51],"aspirin-induced":[52,71,272],"epithelial":[53],"in":[55,74,159,179,198,216,239,256],"small":[57],"intestine,":[58],"as":[59],"evaluated":[60],"by":[61,144,170,234],"capsule":[62],"endoscopy.":[63],"it":[65],"remains":[66],"undetermined":[67],"whether":[68],"Bif195":[69,212,237,259],"alters":[70],"mucosa":[72,229,275],"ventricle,":[77],"representing":[78],"a":[79,90,108,123,145,154,240,262],"more":[80],"aspirin-exposed":[81],"area":[82],"hostile":[84],"environment":[85],"probiotics.":[87],"Methods:":[88],"In":[89],"2x4":[91],"week":[92],"double-blinded,":[93],"placebo-controlled,":[94],"randomized,":[95],"crossover":[96],"clinical":[97],"trial,":[98],"25":[99],"healthy":[100],"men":[101],"women":[103],"were":[104,151,168,191],"asked":[105],"take":[107],"oral":[110,127],"dose":[111],"300":[113],"during":[116],"both":[117],"intervention":[118,164],"periods,":[119],"randomized":[121],"sequence":[124],"intake":[128,235],"Bif195\u2265":[133],"10":[134],"11":[135],"colony":[136],"forming":[137],"units)":[138],"capsules":[139],"placebo":[141],"capsules,":[142],"separated":[143],"6":[146],"weeks":[147],"washout":[148],"period.":[149,165],"Participants":[150],"subjected":[152],"gastroduodenoscopy":[155],"immediately":[156],"before":[157],"end":[161],"each":[163],"All":[166],"gastroduodenoscopies":[167],"performed":[169],"same":[172],"gastroenterologist.":[173],"The":[174,206],"primary":[175],"endpoint":[176],"was":[177,196,208,254],"change":[178],"Lanza":[180,244],"score":[181,204,207,245],"(0-5).":[182],"Furthermore,":[183],"biopsies,":[185],"luminal":[186],"fluids":[187],"blood":[189],"samples":[190],"collected.":[192],"Results:":[193],"Gastrointestinal":[194],"absent":[197],"all":[199],"subjects":[200],"at":[201],"baseline":[202],"(Lanza":[203],"0).":[205],"significantly":[209,232],"reduced":[210],"compared":[213,246],"placebo,":[215,248],"Gastric":[218],"ventricle.":[219],"Values":[220],"after":[221],"treatment,":[222],"see":[223],"table.":[225],"Conclusion:":[226],"Aspirin-induced":[227],"ameliorated":[233],"resulting":[238],"3":[241],"times":[242],"lower":[243],"whereas":[249],"no":[250],"statistically":[251],"significant":[252],"difference":[253],"observed":[255],"duodenum.":[258],"may":[260],"represent":[261],"beneficial":[263],"supplement":[264],"continuous":[266],"treatment":[268],"reducing":[269],"upper":[273],"GI":[274],"ulcer":[278],"formation.":[279]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-24T00:00:00"}
