{"id":"https://openalex.org/W4395031879","doi":"https://doi.org/10.2139/ssrn.4803290","title":"Nrf2 Regulates the Activation-Driven Expansion of CD4 T-Cells by Differentially Modulating Glucose and Glutamine Metabolism","display_name":"Nrf2 Regulates the Activation-Driven Expansion of CD4 T-Cells by Differentially Modulating Glucose and Glutamine Metabolism","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4395031879","doi":"https://doi.org/10.2139/ssrn.4803290"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4803290","doi":"https://doi.org/10.2139/ssrn.4803290","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4803290","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4803290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005074175","display_name":"Aprajita Tripathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aprajita Tripathi","raw_affiliation_strings":["University of Kansas - University of Kansas Medical Center","University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Debolina Dasgupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debolina Dasgupta","raw_affiliation_strings":["University of Kansas - University of Kansas Medical Center","University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014349263","display_name":"Anil Pant","orcid":"https://orcid.org/0000-0003-4914-1771","observed_orcids":["https://orcid.org/0000-0003-4914-1771"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Pant","raw_affiliation_strings":["Kansas State University","Kansas State University, Manhattan, KS 66506-4001, United States","Texas A&M University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State University","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"Kansas State University, Manhattan, KS 66506-4001, United States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"Texas A&M University","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092793800","display_name":"Ashlyn Bugbee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlyn Bugbee","raw_affiliation_strings":["Kansas State University","Kansas State University, Manhattan, KS 66506-4001, United States","St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State University","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"Kansas State University, Manhattan, KS 66506-4001, United States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051195406","display_name":"Nanda Kumar Yellapu","orcid":"https://orcid.org/0000-0002-3095-6375","observed_orcids":["https://orcid.org/0000-0002-3095-6375"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nanda  Kumar Yellapu","raw_affiliation_strings":["University of Kansas - University of Kansas Medical Center","University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ben  H.Y. Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben  H.Y. Choi","raw_affiliation_strings":["University of Kansas - University of Kansas Medical Center","University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093833473","display_name":"Zoya Giri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoya Giri","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033614715","display_name":"Kalyani Pyaram","orcid":"https://orcid.org/0000-0003-2744-7470","observed_orcids":["https://orcid.org/0000-0003-2744-7470"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kalyani Pyaram","raw_affiliation_strings":["University of Kansas - University of Kansas Medical Center","University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas - University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, United States","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033614715"],"corresponding_institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.781000018119812},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glutaminolysis","display_name":"glutaminolysis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.7680000066757202},{"id":"https://openalex.org/keywords/il-2-secretion","display_name":"IL-2 secretion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/t-cell-immunotherapy","display_name":"T cell therapy","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.7248255610466003},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7193202972412109},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.6590330004692078},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6236855983734131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4924076795578003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39905351400375366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3546760082244873},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.07348904013633728}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4803290","doi":"https://doi.org/10.2139/ssrn.4803290","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4803290","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4803290","doi":"https://doi.org/10.2139/ssrn.4803290","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4803290","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1687035583","https://openalex.org/W1785455093","https://openalex.org/W1859030154","https://openalex.org/W1918238463","https://openalex.org/W1970662865","https://openalex.org/W1975566288","https://openalex.org/W1993023349","https://openalex.org/W1993038196","https://openalex.org/W1999474968","https://openalex.org/W1999574084","https://openalex.org/W2006195504","https://openalex.org/W2010189440","https://openalex.org/W2011826815","https://openalex.org/W2025009691","https://openalex.org/W2035618305","https://openalex.org/W2038169247","https://openalex.org/W2039260444","https://openalex.org/W2053047691","https://openalex.org/W2071969437","https://openalex.org/W2072955396","https://openalex.org/W2073781183","https://openalex.org/W2094096693","https://openalex.org/W2099792161","https://openalex.org/W2100412095","https://openalex.org/W2102931781","https://openalex.org/W2114104545","https://openalex.org/W2115338196","https://openalex.org/W2116676186","https://openalex.org/W2135701656","https://openalex.org/W2138297168","https://openalex.org/W2146791037","https://openalex.org/W2147299173","https://openalex.org/W2151321691","https://openalex.org/W2151422820","https://openalex.org/W2154724678","https://openalex.org/W2167751983","https://openalex.org/W2505159449","https://openalex.org/W2548956301","https://openalex.org/W2560601914","https://openalex.org/W2574629025","https://openalex.org/W2594894796","https://openalex.org/W2606441315","https://openalex.org/W2770252540","https://openalex.org/W2787794728","https://openalex.org/W2791277314","https://openalex.org/W2801032953","https://openalex.org/W2936344227","https://openalex.org/W2968730953","https://openalex.org/W3015784228","https://openalex.org/W3019785310","https://openalex.org/W3020588740","https://openalex.org/W3028149335","https://openalex.org/W3038503389","https://openalex.org/W3045298676","https://openalex.org/W3048369682","https://openalex.org/W3087189378","https://openalex.org/W3112799247","https://openalex.org/W3116829754","https://openalex.org/W4200374506","https://openalex.org/W4212986367","https://openalex.org/W4220782743","https://openalex.org/W4229012848","https://openalex.org/W4288726114","https://openalex.org/W4294031309","https://openalex.org/W4296039306","https://openalex.org/W4311961297","https://openalex.org/W4362507275","https://openalex.org/W4367047772","https://openalex.org/W4385639016","https://openalex.org/W4388999629","https://openalex.org/W4392925327","https://openalex.org/W6779910493"],"related_works":["https://openalex.org/W4413607153","https://openalex.org/W4385687084","https://openalex.org/W4404167426","https://openalex.org/W4412050140","https://openalex.org/W7098497504","https://openalex.org/W2166196148","https://openalex.org/W4365517173","https://openalex.org/W4311961297","https://openalex.org/W7055515712","https://openalex.org/W2996391929"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-04-24T00:00:00"}
