{"id":"https://openalex.org/W4395028511","doi":"https://doi.org/10.1097/01.gox.0001015392.83275.08","title":"75. Trametinib Prevents Formation of Vascular Lesions in a MAP2k1-p.K57N Arteriovenous Malformation Mouse Model","display_name":"75. Trametinib Prevents Formation of Vascular Lesions in a MAP2k1-p.K57N Arteriovenous Malformation Mouse Model","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4395028511","doi":"https://doi.org/10.1097/01.gox.0001015392.83275.08"},"language":"en","primary_location":{"id":"doi:10.1097/01.gox.0001015392.83275.08","doi":"https://doi.org/10.1097/01.gox.0001015392.83275.08","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.gox.0001015392.83275.08","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1097/01.gox.0001015392.83275.08","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005955368","display_name":"Patrick J. Smits","orcid":"https://orcid.org/0000-0002-4552-6730","observed_orcids":["https://orcid.org/0000-0002-4552-6730"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick J. Smits","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108369629","display_name":"Yu Sheng Cheng","orcid":"https://orcid.org/0000-0003-2016-8153","observed_orcids":["https://orcid.org/0000-0003-2016-8153"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Sheng Cheng","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017471406","display_name":"Michal Ad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal Ad","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113184617","display_name":"Mattew Vivero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mattew Vivero","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050006243","display_name":"Arin K. Greene","orcid":"https://orcid.org/0000-0003-0722-8641","observed_orcids":["https://orcid.org/0000-0003-0722-8641"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arin Greene","raw_affiliation_strings":["Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Oral Surgery, Boston Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005955368"],"corresponding_institution_ids":["https://openalex.org/I1288882113"],"apc_list":{"value":2195,"currency":"USD","value_usd":2195},"apc_paid":{"value":2195,"currency":"USD","value_usd":2195},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"S4","first_page":"50","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracranial-arteriovenous-malformations","display_name":"extracranial arteriovenous malformations","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6269999742507935},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.7224289178848267},{"id":"https://openalex.org/C2779603958","wikidata":"https://www.wikidata.org/wiki/Q1584110","display_name":"Arteriovenous malformation","level":2,"score":0.6903517842292786},{"id":"https://openalex.org/C3019347889","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Vascular network","level":2,"score":0.5652199983596802},{"id":"https://openalex.org/C2777507709","wikidata":"https://www.wikidata.org/wiki/Q121576","display_name":"Vascular malformation","level":2,"score":0.5179790258407593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4732551872730255},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3350698947906494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3242414593696594},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24188914895057678},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20577147603034973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14072895050048828},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08786174654960632},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.0},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/01.gox.0001015392.83275.08","doi":"https://doi.org/10.1097/01.gox.0001015392.83275.08","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.gox.0001015392.83275.08","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11041222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11041222","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11041222/pdf/gox-12-050b.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plast Reconstr Surg Glob Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9e64c19e7039455c83864a9c024e1747","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9e64c19e7039455c83864a9c024e1747","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plastic and Reconstructive Surgery, Global Open, Vol 12, Iss S4, Pp 50-51 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/01.gox.0001015392.83275.08","doi":"https://doi.org/10.1097/01.gox.0001015392.83275.08","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.gox.0001015392.83275.08","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395028511.pdf","grobid_xml":"https://content.openalex.org/works/W4395028511.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3039828689","https://openalex.org/W4410812824","https://openalex.org/W4292064172","https://openalex.org/W4396919924","https://openalex.org/W4318763604","https://openalex.org/W4394964937","https://openalex.org/W4377047211","https://openalex.org/W4293792731","https://openalex.org/W4283328722","https://openalex.org/W2587169534"],"abstract_inverted_index":{"Purpose:":[0],"Extracranial":[1],"arteriovenous":[2],"malformation":[3],"(AVM)":[4],"is":[5],"caused":[6,41],"by":[7,23],"a":[8,18,62,114,216],"MAP2K1":[9,26,63,115,125,197],"mutation":[10,28,38],"in":[11,39,47,72,136,163,206],"endothelial":[12],"cells":[13],"(ECs).":[14],"We":[15],"previously":[16],"generated":[17],"mouse":[19],"model":[20],"of":[21,36,53,69,88,95,147,182,186,201,213],"AVM":[22],"introducing":[24],"the":[25,30,37,67,85,89,124,164,180,187,211],"p.K57N":[27],"into":[29],"ROSA":[31],"(R26)":[32],"locus":[33],"genome.":[34],"Activation":[35],"ECs":[40],"AVM-like":[42],"vascular":[43,70,104,148,161,183,193,204],"malformations":[44,162,205],"most":[45],"prominent":[46],"brain,":[48],"and":[49,145,166,174],"intestines.":[50,167],"The":[51],"goal":[52],"this":[54],"study":[55],"was":[56],"to":[57,102],"determine":[58],"if":[59],"pharmacotherapy":[60],"using":[61],"inhibitor":[64,126,198],"would":[65],"prevent":[66],"formation":[68,200],"lesions":[71],"mutant":[73,79],"mice.":[74,207],"Methods:":[75],"12":[76],"R26GT-Map2k1-GFP/+;":[77],"Tg-Cdh5CreER+/-":[78],"pups":[80],"were":[81,110,121,141,175],"treated":[82,112,122,189],"topically":[83],"on":[84],"dorsal":[86],"skin":[87],"left":[90],"ear":[91],"with":[92,113,123,190,220],"50":[93],"ug":[94],"4-OH-tamoxifen":[96],"at":[97,129,177],"postnatal":[98],"day":[99],"10":[100],"(P10)":[101],"generate":[103],"lesions.":[105,149],"Six":[106,117],"mice":[107,118,154,170,188],"(Group":[108,119],"1)":[109],"not":[111],"inhibitor.":[116],"2)":[120],"trametinib":[127,191,214],"starting":[128],"P21":[130],"(weaning)":[131],"(3":[132],"ug/ml":[133],"ad":[134],"libitum":[135],"drinking":[137],"water).":[138],"Both":[139],"groups":[140],"followed":[142],"for":[143,179,218],"survival":[144],"development":[146],"Results:":[150],"Group":[151,168],"1":[152],"non-treated":[153],"died":[155],"between":[156],"P30-P45.":[157],"All":[158],"animals":[159],"contained":[160],"brain":[165],"2":[169],"all":[171],"survived":[172],"long-term":[173],"analyzed":[176],"P52":[178],"presence":[181],"anomalies.":[184],"None":[185],"developed":[192],"malformations.":[194],"Conclusion:":[195],"A":[196],"prevents":[199],"Map2k1-K57N":[202],"induced":[203],"These":[208],"findings":[209],"support":[210],"use":[212],"as":[215],"treatment":[217],"patients":[219],"extracranial":[221],"AVM.":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-24T00:00:00"}