{"id":"https://openalex.org/W4395000383","doi":"https://doi.org/10.1093/cei/uxae036","title":"Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity","display_name":"Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity","publication_year":2024,"publication_date":"2024-04-22","ids":{"openalex":"https://openalex.org/W4395000383","doi":"https://doi.org/10.1093/cei/uxae036","pmid":"https://pubmed.ncbi.nlm.nih.gov/38647337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11239558"},"language":"en","primary_location":{"id":"doi:10.1093/cei/uxae036","doi":"https://doi.org/10.1093/cei/uxae036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cei/uxae036","pdf_url":"https://academic.oup.com/cei/advance-article-pdf/doi/10.1093/cei/uxae036/57300185/uxae036.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cei/advance-article-pdf/doi/10.1093/cei/uxae036/57300185/uxae036.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033309472","display_name":"Athanasios Sachinidis","orcid":"https://orcid.org/0000-0002-3309-6032","observed_orcids":["https://orcid.org/0000-0002-3309-6032"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Athanasios Sachinidis","raw_affiliation_strings":["4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece"],"raw_orcid":"https://orcid.org/0000-0002-3309-6032","affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052851034","display_name":"Malamatenia Lamprinou","orcid":"https://orcid.org/0000-0002-5404-3132","observed_orcids":["https://orcid.org/0000-0002-5404-3132"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Malamatenia Lamprinou","raw_affiliation_strings":["4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece"],"raw_orcid":"https://orcid.org/0000-0002-5404-3132","affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075199538","display_name":"Theodoros Dimitroulas","orcid":"https://orcid.org/0000-0002-0364-1642","observed_orcids":["https://orcid.org/0000-0002-0364-1642"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodoros Dimitroulas","raw_affiliation_strings":["4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece"],"raw_orcid":"https://orcid.org/0000-0002-0364-1642","affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031697676","display_name":"Alexandros Garyfallos","orcid":"https://orcid.org/0000-0001-7289-1293","observed_orcids":["https://orcid.org/0000-0001-7289-1293"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Garyfallos","raw_affiliation_strings":["4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece"],"raw_orcid":"https://orcid.org/0000-0001-7289-1293","affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki , Thessaloniki , Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033309472"],"corresponding_institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"],"apc_list":{"value":3039,"currency":"GBP","value_usd":3884},"apc_paid":null,"fwci":0.3762,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.35990207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"217","issue":"2","first_page":"159","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-bet","display_name":"T-bet","score":1.0},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/age-associated-b-cells","display_name":"age-associated B cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/double-negative-b-cells","display_name":"double negative B cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.7839999794960022},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.906000018119812},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.5109999775886536},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7512894868850708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7069777250289917},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.48544842004776},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.481537401676178},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4698561429977417},{"id":"https://openalex.org/C2780862049","wikidata":"https://www.wikidata.org/wiki/Q25326844","display_name":"BET inhibitor","level":5,"score":0.4673132598400116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4319279193878174},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.42309486865997314},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4160116910934448},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41092804074287415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33350682258605957},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25315970182418823},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2531115412712097},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.12176162004470825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07473376393318176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07387584447860718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06061813235282898},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000098815","descriptor_name":"T-bet Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/cei/uxae036","doi":"https://doi.org/10.1093/cei/uxae036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cei/uxae036","pdf_url":"https://academic.oup.com/cei/advance-article-pdf/doi/10.1093/cei/uxae036/57300185/uxae036.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11239558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11239558","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11239558/pdf/uxae036.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:38647337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38647337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/cei/uxae036","doi":"https://doi.org/10.1093/cei/uxae036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cei/uxae036","pdf_url":"https://academic.oup.com/cei/advance-article-pdf/doi/10.1093/cei/uxae036/57300185/uxae036.pdf","source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395000383.pdf","grobid_xml":"https://content.openalex.org/works/W4395000383.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1997105134","https://openalex.org/W2076175897","https://openalex.org/W2077531651","https://openalex.org/W2125289493","https://openalex.org/W2126522707","https://openalex.org/W2267505920","https://openalex.org/W2487984467","https://openalex.org/W2556511870","https://openalex.org/W2560795313","https://openalex.org/W2590316543","https://openalex.org/W2594333172","https://openalex.org/W2618791720","https://openalex.org/W2735831942","https://openalex.org/W2751607427","https://openalex.org/W2791390833","https://openalex.org/W2805930941","https://openalex.org/W2806376977","https://openalex.org/W2896762729","https://openalex.org/W2897114391","https://openalex.org/W2898365748","https://openalex.org/W2899183984","https://openalex.org/W2905627013","https://openalex.org/W2921136352","https://openalex.org/W2989706285","https://openalex.org/W3002478134","https://openalex.org/W3090066346","https://openalex.org/W3110901620","https://openalex.org/W3134217775","https://openalex.org/W3164646638","https://openalex.org/W3186420002","https://openalex.org/W3217578001","https://openalex.org/W4206915011","https://openalex.org/W4213072278","https://openalex.org/W4224231640","https://openalex.org/W4225476287","https://openalex.org/W4233817719","https://openalex.org/W4280488613","https://openalex.org/W4285795889","https://openalex.org/W4307405415","https://openalex.org/W4312214410","https://openalex.org/W4313374751","https://openalex.org/W4321782318","https://openalex.org/W4323670115","https://openalex.org/W4367598717","https://openalex.org/W4382775383","https://openalex.org/W4386470730","https://openalex.org/W4391215347","https://openalex.org/W6752479880","https://openalex.org/W6808862168"],"related_works":["https://openalex.org/W2590316543","https://openalex.org/W2618791720","https://openalex.org/W4406774027","https://openalex.org/W2383347590","https://openalex.org/W2157217076","https://openalex.org/W2899183984","https://openalex.org/W2756411816","https://openalex.org/W2016403497","https://openalex.org/W3199806236","https://openalex.org/W2921136352"],"abstract_inverted_index":{"Apart":[0],"from":[1,93,135],"serving":[2],"as":[3,55,69],"a":[4,124],"Th1":[5],"lineage":[6],"commitment":[7],"regulator,":[8],"transcription":[9],"factor":[10],"T-bet":[11,32,64],"is":[12,33,105],"also":[13],"expressed":[14],"in":[15,44,48,118,166],"other":[16],"immune":[17],"cell":[18],"types":[19],"and":[20,46,82,132,139],"thus":[21],"orchestrates":[22],"their":[23,36],"functions.":[24],"In":[25,50,151],"case":[26],"of":[27,63,96,100,107,113,126,144,157],"B":[28,66,71,76,149,161],"cells,":[29,67],"more":[30],"specifically,":[31],"responsible":[34],"for":[35,129,163],"isotype":[37],"switching":[38],"to":[39,84,89],"specific":[40,102],"IgG":[41],"sub-classes":[42],"(IgG2a/c":[43],"mice":[45,94,131],"IgG1/3":[47],"humans).":[49],"various":[51],"autoimmune":[52,115,137],"disorders,":[53],"such":[54],"systemic":[56],"lupus":[57],"erythematosus":[58],"and/or":[59,74],"rheumatoid":[60],"arthritis,":[61],"subsets":[62],"expressing":[65],"known":[68],"age-associated":[70],"cells":[72,77,162],"(CD19+CD11c+CD21-T-bet+)":[73],"double-negative":[75],"(CD19+IgD-CD27-T-bet+),":[78],"display":[79],"an":[80,136],"expansion":[81],"seem":[83],"drive":[85],"disease":[86],"pathogenesis.":[87],"According":[88],"data,":[90],"mostly":[91],"derived":[92],"models":[95],"autoimmunity,":[97],"the":[98,109,114,142,155],"targeting":[99,159],"these":[101],"B-cell":[103],"populations":[104],"capable":[106],"ameliorating":[108],"general":[110],"health":[111],"status":[112],"subjects.":[116],"Here,":[117],"this":[119],"review":[120],"article,":[121],"we":[122,140,153],"present":[123],"variety":[125],"therapeutic":[127,164],"approaches":[128],"both":[130],"humans,":[133],"suffering":[134],"disease,":[138],"discuss":[141],"effects":[143],"each":[145],"approach":[146],"on":[147],"T-bet+":[148,160],"cells.":[150],"general,":[152],"highlight":[154],"importance":[156],"specifically":[158],"interventions":[165],"autoimmunity.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-23T00:00:00"}