{"id":"https://openalex.org/W4394977366","doi":"https://doi.org/10.1093/sleep/zsae067.0628","title":"0628 Consistent Efficacy of Once-Nightly Sodium Oxybate Across Patient Demographic and Baseline Disease Characteristics","display_name":"0628 Consistent Efficacy of Once-Nightly Sodium Oxybate Across Patient Demographic and Baseline Disease Characteristics","publication_year":2024,"publication_date":"2024-04-20","ids":{"openalex":"https://openalex.org/W4394977366","doi":"https://doi.org/10.1093/sleep/zsae067.0628"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/zsae067.0628","doi":"https://doi.org/10.1093/sleep/zsae067.0628","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/zsae067.0628","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038093846","display_name":"Michael J. Thorpy","orcid":"https://orcid.org/0000-0002-3993-2230","observed_orcids":["https://orcid.org/0000-0002-3993-2230"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Thorpy","raw_affiliation_strings":["Montefiore Medial Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medial Center","institution_ids":["https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Sleep Disorders and Research Center, Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders and Research Center, Henry Ford Health System","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056529315","display_name":"Clete A. Kushida","orcid":"https://orcid.org/0000-0002-9430-3752","observed_orcids":["https://orcid.org/0000-0002-9430-3752","https://orcid.org/0000-0002-7535-1986"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clete Kushida","raw_affiliation_strings":["Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032165365","display_name":"Anne Marie Morse","orcid":"https://orcid.org/0000-0003-4494-0195","observed_orcids":["https://orcid.org/0000-0003-4494-0195"]},"institutions":[{"id":"https://openalex.org/I54713919","display_name":"Geisinger Health System","ror":"https://ror.org/02qdbgx97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Morse","raw_affiliation_strings":["Geisinger"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisinger","institution_ids":["https://openalex.org/I54713919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055545080","display_name":"John Harsh","orcid":"https://orcid.org/0000-0001-6532-9278","observed_orcids":["https://orcid.org/0000-0001-6532-9278"]},"institutions":[{"id":"https://openalex.org/I4210158431","display_name":"Colorado Sleep Institute","ror":"https://ror.org/04n43dm09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210158431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Harsh","raw_affiliation_strings":["Colorado Sleep Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado Sleep Institute","institution_ids":["https://openalex.org/I4210158431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luis Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098865","display_name":"Johns Hopkins All Children's Hospital","ror":"https://ror.org/013x5cp73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210098865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Ortiz","raw_affiliation_strings":["Johns Hopkins Medical Institutions, Johns Hopkins All Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medical Institutions, Johns Hopkins All Children's Hospital","institution_ids":["https://openalex.org/I4210098865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080421641","display_name":"Jennifer Gudeman","orcid":"https://orcid.org/0000-0002-7375-5020","observed_orcids":["https://orcid.org/0000-0002-7375-5020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Gudeman","raw_affiliation_strings":["Avadel Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avadel Pharmaceuticals","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088488166","display_name":"Yves A Dauvilliers","orcid":"https://orcid.org/0000-0003-0683-6506","observed_orcids":["https://orcid.org/0000-0003-0683-6506","https://orcid.org/0009-0009-0974-5168"]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Dauvilliers","raw_affiliation_strings":["University Montpellier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Montpellier","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4607,"currency":"USD","value_usd":4607},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"Supplement_1","first_page":"A268","last_page":"A268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-oxybate","display_name":"sodium oxybate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/narcolepsy-type-1","display_name":"narcolepsy type 1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/narcolepsy-type-2","display_name":"narcolepsy type 2","score":1.0},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cataplexy","display_name":"cataplexy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6830000281333923},{"id":"https://openalex.org/keywords/race","display_name":"race","score":0.49399998784065247},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4390000104904175},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4880000054836273},{"id":"https://openalex.org/keywords/clinical-global-impression-improvement","display_name":"CGI-I","score":0.7929999828338623},{"id":"https://openalex.org/keywords/epworth-sleepiness-scale","display_name":"Epworth Sleepiness Scale","score":0.9509999752044678},{"id":"https://openalex.org/keywords/maintenance-of-wakefulness-test","display_name":"maintenance of wakefulness test","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.511504054069519},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.45960405468940735},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/sleep/zsae067.0628","doi":"https://doi.org/10.1093/sleep/zsae067.0628","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/zsae067.0628","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4394622321","https://openalex.org/W4281671040","https://openalex.org/W4394977748","https://openalex.org/W4410502798","https://openalex.org/W4408720993","https://openalex.org/W4293067375","https://openalex.org/W4408720971","https://openalex.org/W4410502714","https://openalex.org/W4281907230","https://openalex.org/W4378640206"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Once-nightly":[2],"sodium":[3],"oxybate":[4],"(ON-SXB;":[5],"LUMRYZ\u2122)":[6],"was":[7],"investigated":[8],"in":[9,19,48,86,131,201,236,276,288,292],"patients":[10],"with":[11,26,96,309,321],"narcolepsy":[12,173,224],"type":[13],"1":[14,107],"(NT1)":[15],"or":[16,98,121,246],"2":[17,111],"(NT2)":[18],"the":[20,41,53,72,206,300,322,329,340],"phase":[21],"3":[22,327],"REST-ON":[23,90],"trial;":[24],"treatment":[25],"6,":[27],"7.5,":[28],"and":[29,64,71,148,150,172,226,267,297,328,347],"9":[30,117,197,240,280,311],"g":[31,198,241,281,312],"demonstrated":[32],"significant":[33,212,235,275,305],"improvements":[34,213,306],"vs":[35,137,199,242,282,313],"placebo":[36,122,138,200,243,283],"(all":[37],"P<":[38],"0.001)":[39],"for":[40,123,135,139,153,195,216,244,257,284],"coprimary":[42],"endpoints":[43],"of":[44,55,67,238,278,343],"change":[45,202,285],"from":[46,133,203,286],"baseline":[47,134,162,204,287],"mean":[49,128,140],"sleep":[50,141],"latency":[51,142],"on":[52,143,157,205,219,250],"Maintenance":[54],"Wakefulness":[56],"Test":[57],"(MWT),":[58],"Clinical":[59],"Global":[60],"Impression-Improvement":[61],"(CGI-I)":[62],"rating,":[63],"weekly":[65],"number":[66],"cataplexy":[68],"episodes":[69],"(NCA),":[70],"secondary":[73],"endpoint":[74],"Epworth":[75],"Sleepiness":[76],"Scale":[77],"(ESS)":[78],"score.":[79],"This":[80],"post-hoc":[81],"analysis":[82],"assessed":[83],"ON-SXB":[84,104,136,196,239,279,310,344],"efficacy":[85,342],"various":[87],"subgroups.":[88,181,349],"Methods":[89],"(NCT02720744)":[91],"participants":[92,189],"aged":[93],"\u226516":[94],"years":[95],"NT1":[97],"NT2":[99],"were":[100,159,234,274,319],"randomized":[101],"1:1":[102],"to":[103],"(4.5":[105],"g,":[106,110,114,118],"week;":[108],"6":[109],"weeks;":[112,116],"7.5":[113],"5":[115,119],"weeks)":[120],"13":[124,210,254],"weeks.":[125],"Least":[126],"squares":[127],"differences":[129,318],"(LSMDs)":[130],"changes":[132],"MWT,":[144],"NCA":[145,289],"(NT1":[146],"only),":[147],"ESS,":[149,301],"odds":[151],"ratios":[152,233],"\u201cmuch\u201d/\u201cvery":[154],"much\u201d":[155,248],"improved":[156,249],"CGI-I,":[158],"compared":[160],"among":[161],"demographic":[163,346],"(age,":[164],"sex,":[165,221,262],"race,":[166,222],"body":[167],"mass":[168],"index":[169],"[BMI]":[170],"category)":[171],"disease":[174],"characteristic":[175],"(NT1/NT2;":[176],"concomitant":[177],"alerting":[178,227,229,268,270],"agent":[179,230,271],"use)":[180],"Results":[182],"The":[183],"modified":[184],"intent-to-treat":[185],"population":[186],"included":[187],"190":[188],"(ON-SXB,":[190],"n=97;":[191],"placebo,":[192,314],"n=93).":[193],"LSMDs":[194,273],"MWT":[207],"at":[208,252,325,332],"week":[209,253],"revealed":[211],"(P<":[214,255,290,307],"0.05)":[215,256,291,308],"subgroups":[217,303],"based":[218],"age,":[220,260],"BMI,":[223,265],"type,":[225],"agent/no":[228,269],"use.":[231,272],"Odds":[232],"favor":[237,277],"\u201cmuch\u201d":[245],"\u201cvery":[247],"CGI-I":[251],"both":[258],"low/high":[259],"female":[261],"white/non-white,":[263],"high":[264],"NT1,":[266],"all":[293,302],"subgroups,":[294],"except":[295,315],"non-white":[296],"male.":[298],"For":[299],"exhibited":[304],"NT2.":[316],"Comparable":[317],"found":[320],"6-g":[323],"dose":[324,331],"Week":[326,333],"7.5-g":[330],"8.":[334],"Conclusion":[335],"Post-hoc":[336],"subgroup":[337],"analyses":[338],"demonstrate":[339],"robust":[341],"across":[345],"clinical":[348],"Support":[350],"(if":[351],"any)":[352],"Avadel":[353],"Pharmaceuticals":[354]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2024-04-21T00:00:00"}