{"id":"https://openalex.org/W4394970747","doi":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","title":"Exploring the Clinical Characteristics, Chromosomal Analysis, and Emotional and Social Considerations in Parents of Children with Down Syndrome","display_name":"Exploring the Clinical Characteristics, Chromosomal Analysis, and Emotional and Social Considerations in Parents of Children with Down Syndrome","publication_year":2024,"publication_date":"2024-04-20","ids":{"openalex":"https://openalex.org/W4394970747","doi":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090"},"language":"en","primary_location":{"id":"doi:10.38124/ijisrt/ijisrt24mar2090","doi":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","is_oa":true,"landing_page_url":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","pdf_url":"https://www.ijisrt.com/assets/upload/files/IJISRT24MAR2090.pdf","source":{"id":"https://openalex.org/S4210189963","display_name":"International Journal of Innovative Science and Research Technology (IJISRT)","issn_l":"2456-2165","issn":["2456-2165"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Science and Research Technology (IJISRT)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijisrt.com/assets/upload/files/IJISRT24MAR2090.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094258698","display_name":"Sachin Padman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sachin Padman","raw_affiliation_strings":["Director of Pediatric and Neonatal Divison , Sunrise Hospital , Kanhangad , Kerala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Director of Pediatric and Neonatal Divison , Sunrise Hospital , Kanhangad , Kerala","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095785249","display_name":"Kusuma Sachin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kusuma Sachin","raw_affiliation_strings":["Medical Officer , Sunrise Hospital , Kanhangad , Kerala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Officer , Sunrise Hospital , Kanhangad , Kerala","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092162604","display_name":"Venugopal Reddy Iragamreddy","orcid":"https://orcid.org/0000-0002-2272-0004","observed_orcids":["https://orcid.org/0000-0002-2272-0004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venugopal Reddy I.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3288,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53109422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"3016","last_page":"3023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11632","display_name":"Family and Disability Support Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":1.0},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chromosome-analysis","display_name":"chromosome analysis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/developmental-delay","display_name":"developmental delay","score":0.7630000114440918},{"id":"https://openalex.org/keywords/recurrent-respiratory-tract-infections","display_name":"recurrent respiratory infections","score":0.6819999814033508},{"id":"https://openalex.org/keywords/microcephaly","display_name":"microcephaly","score":0.8019999861717224},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8640000224113464},{"id":"https://openalex.org/keywords/atrioventricular-septal-defect","display_name":"atrioventricular septal defect","score":0.9359999895095825},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ventricular-septal-defect","display_name":"ventricular septal defect","score":0.7429999709129333},{"id":"https://openalex.org/keywords/patent-ductus-arteriosus","display_name":"patent ductus arteriosus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.7519999742507935},{"id":"https://openalex.org/keywords/consanguinity","display_name":"consanguinity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hypotonia","display_name":"hypotonia","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5502132177352905},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4891064763069153},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3551762104034424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.38124/ijisrt/ijisrt24mar2090","doi":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","is_oa":true,"landing_page_url":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","pdf_url":"https://www.ijisrt.com/assets/upload/files/IJISRT24MAR2090.pdf","source":{"id":"https://openalex.org/S4210189963","display_name":"International Journal of Innovative Science and Research Technology (IJISRT)","issn_l":"2456-2165","issn":["2456-2165"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Science and Research Technology (IJISRT)","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.38124/ijisrt/ijisrt24mar2090","doi":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","is_oa":true,"landing_page_url":"https://doi.org/10.38124/ijisrt/ijisrt24mar2090","pdf_url":"https://www.ijisrt.com/assets/upload/files/IJISRT24MAR2090.pdf","source":{"id":"https://openalex.org/S4210189963","display_name":"International Journal of Innovative Science and Research Technology (IJISRT)","issn_l":"2456-2165","issn":["2456-2165"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Science and Research Technology (IJISRT)","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394970747.pdf","grobid_xml":"https://content.openalex.org/works/W4394970747.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1504885390","https://openalex.org/W1506286104","https://openalex.org/W1965268983","https://openalex.org/W1972913715","https://openalex.org/W1973411450","https://openalex.org/W1974005387","https://openalex.org/W1993095515","https://openalex.org/W1993194458","https://openalex.org/W1996383474","https://openalex.org/W2004830407","https://openalex.org/W2006932178","https://openalex.org/W2018376454","https://openalex.org/W2018690416","https://openalex.org/W2034184845","https://openalex.org/W2041462984","https://openalex.org/W2047101086","https://openalex.org/W2048032231","https://openalex.org/W2060382295","https://openalex.org/W2067235410","https://openalex.org/W2068985810","https://openalex.org/W2072961579","https://openalex.org/W2073866134","https://openalex.org/W2077415974","https://openalex.org/W2079355316","https://openalex.org/W2088620953","https://openalex.org/W2089540249","https://openalex.org/W4205987157","https://openalex.org/W4212878078","https://openalex.org/W4231706556","https://openalex.org/W4300815553","https://openalex.org/W4392664198","https://openalex.org/W4392915167","https://openalex.org/W4393345205","https://openalex.org/W4394854456"],"related_works":["https://openalex.org/W1540607122","https://openalex.org/W2313602712","https://openalex.org/W3133398386","https://openalex.org/W4210424055","https://openalex.org/W4394953850","https://openalex.org/W2205837294","https://openalex.org/W2239551702","https://openalex.org/W2100763543","https://openalex.org/W4413915673","https://openalex.org/W3017205780"],"abstract_inverted_index":{"Down":[0,54,74],"syndrome,":[1,75],"also":[2],"known":[3],"as":[4],"trisomy":[5],"21,":[6],"is":[7,21],"a":[8,77,93,99,133,182],"common":[9,145,232],"chromosomal":[10],"disorder":[11],"that":[12,127],"affects":[13],"one":[14],"in":[15,149,216,233,245],"every":[16],"750/1000":[17],"live":[18],"births.":[19],"It":[20],"characterized":[22],"by":[23,156,237],"delayed":[24],"milestones":[25],"and":[26,47,98,137,167,194,209,240],"repeated":[27,48],"chest":[28],"infections,":[29],"with":[30,70,76,92,114,162,220],"most":[31,144,226,231],"children":[32,69,118,190,218],"having":[33,164,169],"microcephaly,":[34],"low":[35,179],"set":[36,180],"ears,":[37,181],"flat":[38,183],"nasal":[39,184],"bridge,":[40],"simian":[41,192],"crease,":[42],"umbilical":[43,195],"hernia,":[44],"CVS":[45],"findings,":[46],"ear":[49],"infections.":[50],"The":[51,84,104,124,143],"risk":[52],"of":[53,73,82,95,101,116,121,129,135,151,172,188],"syndrome":[55],"increases":[56],"to":[57,79],"1:20":[58],"for":[59],"mothers":[60,131],"over":[61],"40":[62],"years":[63,97],"old.":[64],"A":[65],"study":[66,125],"examined":[67],"30":[68],"phenotype":[71],"suggestive":[72],"male":[78],"female":[80],"ratio":[81],"0.76:1.":[83],"median":[85],"age":[86,107],"at":[87,108],"presentation":[88],"was":[89,111,147,230,243],"7":[90],"years,":[91,113],"minimum":[94],"3":[96],"maximum":[100],"12":[102,234],"years.":[103],"mean":[105],"maternal":[106],"child":[109],"birth":[110],"32":[112],"13.3%":[115],"the":[117,130,189,201,225],"born":[119],"out":[120],"consanguineous":[122],"marriage.":[123],"found":[126,215],"none":[128],"had":[132,139,191],"history":[134,171],"abortions,":[136],"6.7%":[138],"complications":[140],"during":[141],"pregnancy.":[142],"complaint":[146],"delay":[148],"attainment":[150],"mile":[152],"stones":[153],"(96.7%)":[154],"followed":[155,236],"recurrent":[157],"LRTI":[158],"&":[159],"URTI":[160],"(13.2%),":[161],"2":[163],"heart":[165],"disease":[166],"1":[168],"family":[170],"asthma.":[173],"Physical":[174],"characteristics":[175],"included":[176],"microcephaly":[177],"(86.7%),":[178],"bridge":[185],"(96.7%),":[186],"half":[187],"crease":[193],"hernia":[196],"(50%),":[197,219],"excessive":[198],"skin":[199],"on":[200],"back":[202],"(76.7%),":[203],"muscular":[204],"hypotonia":[205],"(66.7%),":[206],"dermatoses":[207],"(26.7%),":[208],"hypothyroidism":[210],"(10%).":[211],"Cerebral":[212],"findings":[213],"were":[214],"15":[217],"endocardial":[221],"cushion":[222],"defects":[223],"being":[224],"common.":[227],"ASD":[228],"(13.04%)":[229],"children,":[235],"VSD":[238],"(10.86%),":[239],"PDA":[241],"(4.3%)":[242],"present":[244],"4.3%.":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-04-20T00:00:00"}